The purpose of the study was to determine the characteristics of the functional indicators of the circulatory system of young men engaged in sports, depending on the type of hemodynamics. The assessment of the functional state of the circulatory system was carried out taking into account the type of hemodynamics of the examined persons. The majority of the examined athletes had eukinetic and hyperkinetic types of hemodynamics. Overall indicators of young men, depending on the type of hemodynamics, had no statistically significant differences. According to the Kerdo index, the predominance of the parasympathetic department of the autonomic nervous system was revealed in all the examined young men. Young men with hyperkinetic type of hemodynamics were characterized by high values of pulse pressure, heart rate, double product and coefficient of efficiency of blood circulation. The obtained results indicate the need to take into account the type of hemodynamics in the athlete's training process and the level of physical exertion.

The aim of our work was to study the structure of risk factors for malignant neoplasms of reproductive organs in conjunction with individual personal and emotional characteristics of female doctors and researchers. A significant number of risk factors for the reproductive organs malignant neoplasms development were identified in female doctors and researchers. Female doctors, in comparison with female researchers, are significantly better informed about the structure and significance of risk factors and have more responsibility towards their health. At the same time, in relation to preventive measures and risk factors correction, female researchers are more active than female doctors. Personal profile of the female doctors: sociable, willing to co-operate, average level of intelligence, emotionally sensitive to the external environment, prefer to make decisions in cooperation, focusing on social approval. Personal profile of scientific workers: often closed, focused on personal experience but not on external circumstances, high level of intelligence, independence in judgments, tendency to dominance, they poorly control their emotions and subjected to frustration. All women had low self-esteem, but it was significantly lower among doctors, more than half of women have a feeling of mental exhaustion, as a result of which the effectiveness of professional interaction and the quality of life in general decreases.

Disruption of serotonin metabolism may play a role in the pathogenesis of Parkinson's disease (PD). An analysis of the association of polymorphic variants of the genes of the serotonergic system was carried out: Stin2 and 5-HTTLPR loci of the 5-HTT gene (serotonin transporter), rs6296 of the HTR1B gene, rs6311 of the HTR2A gene, rs6318 of the HTR2C gene (serotonin receptors) and rs1800532 TPH1 gene (tryptophan hydroxylase) with PD and its clinical forms in patients of Tatar ethnicity living in the Republic of Bashkortostan. The study included 257 patients with sporadic PD and 368 healthy individuals. As a result of the study with the development of PD in general and with its akinetic-rigid subtype, associations of the rs1800532*G allele and the rs1800532*G/G genotype of the TPH1 gene were established. Associations of the rs6296*G/C genotypes of the HTR1B gene and rs6318*C/C of the HTR2C gene were also revealed with the akinetic-rigid subtype of PD. The association of the STin2*12 allele of the 5-HTT gene was found with PD and the akinetic-rigid subtype with tremor (mixed subtype). An analysis of the influence of the studied polymorphic variants of genes on the age of PD manifestation revealed an association of the STin2*12 allele of the 5-HTT gene with a later age of disease development (after 60 years), and an association of the rs6318*C allele of the HTR2C gene (in men) and the rs1800532*G allele of the TPH1 gene with the onset of the disease from 45 to 60 years old.

Systemic and topical markers of cardiovascular remodeling were determined in individuals with a history of smoking and early stages of arterial hypertension (AH) and COPD by assessing serum levels of growth factors (TGF-β, VEGF, ST-2 protein) and endothelin, as well as duplex scanning of the carotid arteries and strain echocardiography. Of the studied systemic markers of cardiovascular remodeling in the early stages of COPD and hypertension in active smokers VEGF and ET-1 are the most significant determinants. Despite the absence of differences in lipid metabolism between the examined groups, it is smokers with COPD and hypertension who have more pronounced signs of atherosclerosis in carotid arteries. Also, in the early stages of COPD and AH, disorders of local myocardial contractility are observed. Topical changes in vessels of the elastic type and myocardium in smokers with COPD and AH have a relationship in smokers of all groups with ST2 content, in patients with COPD and AH with VEGF levels.

This research studies the reaction of microcirculation of the cerebral cortex of rats with hemodynamic stability and the blood loss, with continuous exposure to decreasing body temperature till to the hypothermal arrest of the animal's breathing. The results were obtained that in the group of animals without hemorrhage, the cooling led to an initial short-term vasodilation and subsequent vasoconstriction up to 10-20% of the norm. In the group of animals with a pre-caused by hemorrhage, the narrowing of the vessels was 20% at the normothermia and intensified during the animal immersion in water on 35% of the initial state of the vessels. However, the functional state of the animal during blood loss and the subsequent cooling slightly differed from the normovolemic state of the body under hypothermic influence.

The genotoxicity of an extract from the cell culture of hemlock spotted in vivo in metaphase bone marrow plates of CBA mice and somatic cells of D. melanogaster, standardized by the amount and ratio of furocoumarins was studied. It was determined that using of the hemlock spotted cell culture extract does not induce genetic damage in CBA and D. melanogaster mice , which is one of the objective criteria for its safety. The results obtained determine possible prospects for continuing research in terms of developing a new herbal medicinal product.

Ethnic and age-related characteristics of emotional disorders in persons with chronic cerebral ischemia (CCI) were studied. Many patients had a combination of both anxiety and depressive symptoms. With the aggravation of the CCI stage, more pronounced symptoms of anxiety disorders were noted. Emotional disorders prevailed in elderly and senile Russians, less pronounced in elderly Evens. There were no gender differences among them.

The results of a comparative analysis of the effect of the timing of the start of antihypertensive therapy on the state of target organs (left ventricular (LV) myocardium, kidneys) in pregnant women with chronic arterial hypertension (CAH) and with the development of preeclampsia (PE) on its background are presented.

Early antihypertensive therapy makes it possible to implement a protective effect on the target organs of pregnant women with CAH (adaptive remodeling of the LV myocardium, renal endothelium (MAU) and purine metabolism (synthesis of uric acid)). Delayed hypotensive therapy (after 15-20 weeks of pregnancy) contributes to the dominance of maladaptive mechanisms of regulating the activity of the cardiovascular system. These pregnant women are distinguished by the progression of morphofunctional changes in the LV myocardium (concentric hypertrophy and diastolic dysfunction), to the greatest extent with the development of PE. The highest frequency of disturbances in the circadian rhythm of blood pressure (non-dipper and night-picker types) and metabolic changes (hyperuricemia, MAU) was revealed in pregnant women with the development of PE.

The features of the formation of the chewing reflex in people with missing teeth after dental rehabilitation with orthopedic structures on dental and / or zygomatic implants were studied. As a result of the work carried out, it was noted that the treatment of complete loss of teeth in one or both jaws with the help of dental and zygomatic implants according to EMG data during the observation period of more than 2 years after the installation of permanent orthopedic structures does not lead to disruption of the neuro-physiological processes of the masticatory-speech apparatus and contributes to the patient's complete adaptation to the restored occlusal relationship, although it is characterized by a slight increase in the resting tone and contraction of the masticatory muscle according to myotonometry data and the force of compression of the dentition according to gnathodynamometry data.

The variant anatomy of the portal vein confluence formation and its branching in the cut and non-indigenous population of Republic of Sakha (Yakutia) was studied by means of the vascular reconstruction of computed tomography data in patients who underwent CT with intravenous contrast enhancement without pathology of the hepatobiliary zone. The obtained results of the study indicate the presence of a role for the ethnic component in the formation of confluence and branching (division) of IWs in the studied groups. However, one should take into account the small sample size of patients on the obtained results of the study.

The sensitivity and prognostic value of laboratory tests and methods for assessing pharmacodynamics in relation to the system of regulation of the aggregate state of blood after a single dose of dabigatran etexilate at a dosage of 150 mg were investigated.

According to the results of LPTEG, the maximum severity of the direct pharmacodynamic effect of dabigatran etexilate was recorded at the 4^th hour after taking the drug, which was reflected by a pronounced decrease in the efficiency of the proteolytic stage of fibrinogenesis, with the return of the activity of the proteolytic stage of fibrinogenesis to the initial level at the 8th hour with the preservation of residual antithrombotic activity up to 12 hours.

The use of thromboelastography was limited to a 4-hour interval, while the ACTV test was limited to 2 hours from the moment of taking the drug, after which the level of indicators returned to the initial value.

The equilibrium plasma concentration of isoniazid in patients with pulmonary tuberculosis living in the Republic of Sakha (Yakutia) was determined by the method of high performance liquid chromatography. The high individual variability of pharmacokinetic parameters was confirmed : the maximum equilibrium concentration of the drug, the area under the pharmacokinetic curve, the average stationary concentration of the drug, the degree of fluctuation in the concentration of isoniazid in the blood plasma of patients with tuberculosis. Individual differences in the pharmacokinetic parameters of isoniazid indicate the need for therapeutic drug monitoring when prescribing isoniazid.

The article presents the results of an epidemiological study of the micronutrient composition of the actual diet of the population of Yakutsk aged 60 years and older. The data obtained allowed us to conclude that the profile of vitamins and minerals in the diet of the examined population was deficient, especially there was a decrease with older age. Gender differences in the content of vitamins and minerals in the diet were revealed. Significant micronutrient deficiencies contribute to the development and progression of geriatric syndromes in the elderly.

The purpose of this study was to assess the levels of testosterone in the blood serum depending on the body mass index (BMI) in young men in Yakutia. It was found that in overweight individuals, testosterone levels were significantly lower, compared with those who had underweight or normal weight. A comparative analysis of testosterone levels according to global data confirmed the inverse correlation of testosterone levels with BMI. The heterogeneity of the studies was within the average heterogeneity, which may indicate a negative correlation of testosterone levels with BMI, regardless of race and ethnicity.

In the course of a comparative analysis of the health status of military populations in the Black Sea and Arctic regions, significant differences were identified and regularities were established. The results of the study make it possible to conclude that there are significant differences in the health status of military populations in the Arctic and Black Sea regions due to a different combination of climatogeographic, heliocosmic and latitudinal factors. The Arctic region is characterized by both higher rates of primary morbidity in general and higher rates of X, XIII, XI, IX, VI and VII classes of diseases incident with a proportion in the overall primary morbidity structure.

In order to assess the impact of invasive interventions on the prognosis of urinary tract infections (UTIs) associated with the provision of medical care among patients of older age groups. The results of this study showed that when assessing the impact of invasive factors, surgical intervention in the kidney and bladder has a greater impact on the development of UTI than bladder catheterization. In order to improve the information subsystem of epidemiological surveillance of UTIs related to the provision of medical care, it is necessary to use standard operating procedures for the organization of disinfection and sterilization regime in medical organizations. The use of the discriminant analysis method makes it possible to predict the development of UTIs associated with the provision of medical care in patients of older age groups when planning invasive interventions.

The dynamic analysis of prevalence, morbidity, mortality rate and case fatality rate from COVID-19 for the period from April 1, 2021 to September 30, 2021 was carried out. The highest prevalence of COVID-19 is registered in the USA, the UK, France. China has consistently low levels of prevalence and morbidity of new coronavirus infection. Increase in the proportion of fully vaccinated persons reduces morbidity of COVID-19.

Surgery is one of the main methods of treating patients with liver neoplasms. Today in medicine there is an important tendency to reduce trauma. The aim of the study was to select the optimal tactics for the surgical treatment of children with liver tumors. The analysis included the results of treatment of patients with hepatoblastomas who underwent laparoscopic liver resections. The use of laparoscopic technologies made it possible to reduce the operation time, reduce the amount of blood loss and prevent the development of complications both intraoperatively and in the postoperative period, shorten the duration of inpatient treatment, start early patient mobilization, enteral load, chemotherapy, reduce the drug load, and carry out radical surgery.

The article describes a study of the duration of the disease in patients with different forms of motor neuron disease (MND) in the Republic of Sakha (Yakutia), depending on ethnicity, age and gender. The obtained results correlate with the data of researchers in the world and depend on the combined or isolated lesion of the motor neuron.

The analysis of chronic fatigue syndrome and the level of anxiety and depression was conducted in 161 patients aged 20 to 72 years who had an acute infection with COVID-19 from 3 to 12 months ago. Young and middle-aged women are more susceptible to COVID-19 viral pneumonia in severe and critically severe form. Men are more severely affected by COVID-19 compared to women aged 32-51 and 61-70. Anxiety-depressive disorders and chronic fatigue syndrome can develop at any time in the post-ovarian period, from 3 months to 12 months.

A study of IgM and IgG antibodies to SARS-COV-2 was carried out in 161 residents of Yakutsk at the age of 20 to 72 years old who had a new coronavirus infection COVID-19 from 3, 6, 9 and 12 months ago. The aim of the work was to evaluate serum immunoglobulins IgM and IgG to SARS-COV-2 in persons who have had COVID-19, depending on the duration and severity of the disease. The intensity of the immune response was assessed using the coefficient of positivity (CP) as the ratio of the optical density of the sample to the critical value of the optical density. According to the results of the study, the seroprevalence in all 4 groups of Covid-19 patients was 100%. Antibodies Ig G and IgM to SARS-CoV-2 in patients with COVID-19 persisted up to 12 months and depended on the postcoid period, age and severity of lung lesions on CT.

Our aim is to study the content of tryptophan metabolites in blood serum and feces in patients with NSCLC for further estimation of possible correction of microbiomes` functional state and its role in the providence of the efficiency of treatment. The levels of tryptophan metabolites in blood serum and feces of 100 patients with NSCLC in comparison with 100 healthy donors were studied. A number of differences were obtained: in serum of patients a statistically significant decrease in the levels of tryptophan, its` dominant metabolites of microbiotic origin - tryptamine, serotonin, downtrend for xanthurenic acid along with an increase of the levels of quinolinic acid (in tendency). In feces the levels of indole in patients had an uptrend in comparison with donors. We consider that the decrease of tryptophan and its` dominant metabolites in serum of patients with NSCLC may be due to the utilization of tryptophan by tumor cells.

In this work the expression profile in peripheral blood mononuclear cells of markers of brown adipose tissue activity (CIDEA, PRDM 16), markers of browning of white adipocytes (HOXC9, Slc27A1) and the marker of β-oxidation of fatty acids (Cpt1a) was analyzed in 150 indigenous residents of Yakutia, miners of a diamond mining company, who were exposed to natural cold for 3 months. To determine the metabolic status, anthropometric data, glucose level and blood lipid profile of were evaluated.

To identify territories of the Arctic in which urgent measures are needed for prevention of cervical cancer (CC), including vaccine prevention, a comparative analysis of cervical cancer incidence was carried out among the Arkhangelsk, Murmansk regions, the republics Karelia, Komi, Sakha (Yakutia), Krasnoyarski Krai, Chukotka , Yamalo-Nenets and Nenets Autonomous Okrugs and Russia as a whole. The analysis includes the annual cervical cancer incidence rates per 100 thousand populations, standardized by age. Multiple and paired rank analyzes, as well as the calculation of changes in the annual baseline cervical cancer incidence, showed that cervical cancer prevention is an important task in these territories, and the population of the Nenets Autonomous Okrug, which is characterized by a significant proportion of indigenous people and ethnic minorities, needs it most urgently.

A review of the literature on studies of the intestinal microflora in children is presented. The research for recent years has demonstrated the importance of the impact of the gut microbiome on children's health. The current understanding of the intestinal microbiome is introduced. A brief description of the composition of the intestinal microflora and its impact on the health of the child is given.

This review discusses the main methods for predicting the development of destructive forms of acute cholecystitis. Various methods based on the creation of mathematical models and programs for predicting acute calculous cholecystitis in emergency patients are described. At the same time, an algorithm for using these methods in patients with acute cholecystitis is presented, as well as prospects for further search for effective methods for predicting the destruction of the gallbladder, acceptable for use in a wide clinical practice. In recent years, new methods have been sought that would allow predicting the risk of developing destructive forms of acute cholecystitis at an early stage of the disease and determining the most rational treatment tactics.

A comprehensive clinical and biometric study of anatomical deformities of the upper jaw, taking into account congenital deformities of the hard palate in children and adolescents with various degrees of severity of connective tissue dysplasia, was carried out in order to determine the degree of narrowing of the dentition. The results obtained contribute to an increase in the efficiency of treatment of dentoalveolar deformities, in particular with anatomical deformities of the height of the fornix of the hard palate, due to the prompt implementation of complex therapy with dynamic monitoring at the stages of correction of dentoalveolar anomalies. The developed method makes it possible to increase the efficiency of treatment of deformities of the dentition and anomalies of the occlusion of the upper jaw.

The article describes a clinical example of the rare hereditary disease SARS-syndrome in a Sakha child. The observation of the child with this disease, features of diagnosis and management of the patient are described.

The article presents a clinical case of primary malignant fibrous histiocytoma of the heart from the practice of the cardiology department of the Yakutsk Republican Clinical Hospital. The tumor was located in the right ventricle, which is rare and the clinical picture was dominated by symptoms of chronic pulmonary embolism with hypertension. On echocardiography and computed tomography, the volumetric lesion was regarded as a thrombus. Autopsy and histological examination revealed malignant fibrous histiocytoma of the heart. The complexity of the diagnosis was associated with the nonspecific polymorphic clinical picture and the different structure of the neoplasm itself.

A description of the case of prenatal diagnosis of caudal regression syndrome at 15 weeks of pregnancy is presented. The description of ultrasound markers, stages of prenatal ultrasound diagnostics, taking into account the complications from external factors is given. The diagnosis is based on the basic signs characteristic of this syndrome. Due to the caudal regression syndrome's severe form, the family decided to terminate the pregnancy. Pathomorphological and postmortal X-ray examination of the abortus confirmed the echographic changes identified in the prenatal period.

The article presents a clinical case of acute coronary syndrome with an electrocardiogram ST segment elevation complicated by cardiogenic shock. Timely reperfusion therapy - percutaneous intervention on the infarction-associated antero-descending coronary artery has made it possible to improve the prognosis and outcome of acute myocardial infarction with acute heart failure KILLIP class IV.