The analysis of results of histological research of operational materials from 294 women with the breast cancer with the subsequent immunohistochemistry (IHC) definition of estrogen (ER) – and progesterone (PgR) – receptors, proliferative activity (Ki-67) expression of mutation suppressor gene (p53) and gene-inhibitor of apoptosis (bcl-2) was carried out. The obtained data testify that IHC-research of the tumor progression markers is a defining part in the forecast of course, optimization of therapeutic approaches with an individualization of chemo-, hormonal and beam therapy of mammary cancer, the decision of a question of medicamentous and/or surgical shutdown of the ovaries, based on the research results of the biological activity markers of the tumor.

We have studied the clinical manifestations, respiratory function in patients with combined course of chronic bronchitis and chronic obstructive pulmonary disease (COPD) and metabolic syndrome in Yakut ethnic group. We found more severe clinical manifestations in the combined course of CB/COPD and MS in Yakut ethnic group, in comparison with the group without metabolic syndrome. We also found that in the combined course of the diseases in Yakut ethnic group lung function compared with isolated course were not significantly different. However, in the combined course more pronounced disorders of respiratory function in the form of reduced forced vital capacity (FVC), decline in forced expiratory volume in one second FEV1, FEV1/FVC ratio increase > 70% were observed in our research. 

Experience of adjuvant therapy of patients with gastrointestinal stromal tumors (GISTs) has demonstrated high efficacy allowing almost two-fold increase of patients’ recurrence-free survival. Currently, low risk patients after radical surgical treatment are closely followed up; moderate risk GIST patients are recommended adjuvant therapy with imatinib for 1 year whereas those of high risk – for 3 years. This article presents the review of significant predictors, analysis of which shall let a clinical oncologist stratify patients into risk groups most precisely thus improving the efficacy of target therapy.

Comparative analysis of two-step (non-severe, severe) and three-step (mild, moderate, severe) assessment of the severity of community- acquired pneumonia in the military men, performing military service is done.

It is shown that a three-stage evaluation of the severity of pneumonia allows more adequately assess the degree of severity of the disease and thus provide not only more accurate triage on site selection of treatment, but convincingly decide on the hospitalization need and determine the most rational treatment of the disease.

The peculiarities of collagen structure in the skin and aponeurosis were investigated in patients with and without ventral hernias.

The investigation of collagen fibers presented the heterogeneity of their structure. In each bunch of fibers there were found longitudinal fibrillation. The comparison of the results of aponeurosis architecture investigation in patients with anterior abdominal wall pathology revealed that in the group of patients with ventral hernias collagen fibers are localized in different directions and plans in 42% of all cases, in 53% the collagen fibers were branching in separate thin fibers, in the patients without hernia in 63% of cases interfiber spaces are significantly more in sizes in comparison with the aponeurosis architecture in patients of the group without ventral hernias. The patients with the hernias of the anterior abdominal wall possess lower index of collagen fibers density and interfiber spaces in the skin in comparison with patients without this pathology.

The collagen fibers of aponeurosis in patients with ventral hernias possess more porous structure. This causes weakness of the anterior abdominal wall and leads to hernia defects formation.

In 100 HIV-infected men aged 20-25, who need prosthetics, with generalized forms of periodontitis and candidal glossitis / stomatitis special antifungal therapy of oral mucosa was conducted. Application of this technique has allowed increasing the effectiveness of orthopedic treatment of patients, as well as at orthopedic treatment stages, and at the control examinations after 4-6 months. With this technique inflammations, bleeding, soreness of the oral mucosa were eliminated or significantly reduced, a fungal infection was eliminated.

In the study comparative characteristic of ultrasonic and anthropometric parameters in adolescent girls and women of indigenous and non- indigenous population of Yakutia was conducted. Adolescent girls and women of Russian nationality are significantly higher at comparison with the indigenous women of the RS (Y). From 10-11 years in all the girls of the Yakut and Evenki origin rapid expansion of the pelvic bones begins.

Uterine size in adolescent girls of the RS (Y) indigenous population was significantly smaller at comparison with the girls of the Russian nationality.

The state of lipid peroxidation and antioxidant system in athletes – freestyle wrestlers of Yakutia before and after taking vitamin drink “Valetek-SP Aktiv” was under study. Thus, it was found that vitamin and mineral complex “Valetek-SP Ackiv” reduced the intensity of lipid peroxidation and had a supportive effect of antioxidant protection of athletes.

In the article the possibilities, value and a role of screening researches in the Health Centre for formation of a healthy way of life for children and teenagers are considered. The state of health of children is studied on the basis of results of the testing on a hardware-software complex and inspections on the installed equipment. In structure of morpho-functional pathologies on the 1 place are functional infringements of cardiovascular system; on the 2 place is oral cavity pathology, further – disharmonious physical development.

The article presents information on the main clinical manifestations and the real difficulties in the diagnosis of reactive arthritis in outpatient conditions. Causes of chronic disease were revealed.

The article deals with the study on the possibility of using cross-linking in patients with endothelial- epithelial dystrophy of the cornea. It was revealed that corneal collagen cross - linking in patients with bullous keratopathy in the early postoperative period could reduce swelling, increase the transparency of the cornea, improve visual acuity and corneal arrest syndrome.

The study included women with uterine myoma after various treatment technologies (laparotomy and laparoscopic myomectomies, uterine artery embolization). The features of adaptive variability and immunoreactivity in the early and late postoperative period were under study.

These adaptive- immune profile features allow predicting the likelihood of complications and disease recurrence after breast-conserving various interventions depending on the availability of therapeutic measures.

Research organization of drug supply in rural areas, including changes with the introduction of the Federal Law of 12.04.2010 № 61-FZ “On Circulation of Medicines” were held. Availability medicinal aid in settlements of the region, the degree of public satisfaction, range and quality of pharmaceutical care in the area were evaluated.

The article is focused on the problem of medical care in the rural areas of the North, since this is the most socially significant task, and has a big load of negative experiences, gender stereotypes and scientific and methodological errors. The article presents the view of medical personnel of the northern and Arctic regions of the Republic to make management decisions in health care. According to the respondents, the following factors: a shortage of specialized professionals, poor infrastructure, low levels of income affect the work in a health care institution.

The proposals were introduced by the Ministry of health of the respondents in the framework of the modernization of the health care in 2012-2013, especially in salary, equipment facilities, equipping the new information technologies.

The structure of congenital heart diseases (CHD) and large vessels in the newborn in the Republic of Sakha (Yakutia) was under study. All the share of septal defects group combined with 

functioning arterial duct and pulmonary artery valve stenosis was 82,20% of the all CHD (899). The CM of large vessels was 8, 90% (80) of all diagnosed cases of CHD. Complex, combined CHD were 4, 67% (46) of the total number of detected CHD. Mortality rate was 1.22% (11 cases) of the total number of children with CHD (899) and was formed by obstructive lesions of the aorta and complex defects. The CHD structure has a preponderance of boys: 476/52, 94%. The absolute predominance of children Yakuts with CHD was revealed: 72, 08% (648) of all diagnosed cases of CHD.

The paper is devoted to consideration of opportunities how to use distant learning in the course of training of healthcare workers. The developed and approved technology of professional development is presented in the article, the difficulties connected with distant learning of medical workers are specified, perspectives of the organization of distant learning are analyzed and necessary conditions for training of highly skilled medical workers are considered.

Heterogeneity of hepatitis B virus and its link with clinical course of infection and its outcomes remains one of priority directions of researches in Republic Sakha (Yakutia), as the region with high incidence of this disease. Blood serum samples with chronic hepatitis, registered in dispensary of various regions of the Republic Sakha (Yakutia), have been investigated. On the basis of results of the research by means of molecular – biological methods in the republic a genotype D was considered as the dominating genotype at patients with CHB, and sufficiently a large number of patients are infected simultaneously by two genotypes, most intensively circulating in the territory of Republic (A, D, C). For adequate therapy of such diseases it is necessary to consider characteristics of excreted isolates.

We studied characteristics of clinical progression and immunological indicators in children and adolescents with drug-resistant tuberculosis. Control group consisted of patients with drug-sensitive tuberculosis. It was concluded that drug resistance of M. tuberculosis adversely influences the clinical progression and results in markedly suppressed immune system indicators in children and adolescents.

The effectiveness of personalized diet therapy with the inclusion of a specialized food for enteral nutrition (EN) on the anthropometric and body composition, carbohydrate and lipid metabolism in patients with type 2 diabetes was investigated.

Studies have shown that personalization of diet inclusion of specialized food for EA allows not only to optimize the protein, carbohydrate and fatty acid composition of the diet, but also contributes to the effective correction of the broken indicators of nutritional status in patients with type 2 diabetes and I-III degree obesity (weight loss, BMI, WC, ON, the content of body fat and visceral fat area, improved glycemic control and lipid profile parameters).

The efficiency of electrophoretic applying of AEM (aqueous extract of mud) at periodontal diseases in patients was studied in the sanatorium. It was revealed, that AEM applying in combination with mouthwash by thermal water leads to positive results in the treatment of inflammatory and degenerative diseases of the paradontium and is an example of effective using of natural remedies and treatment.

A comparison of the structure of the fish population in the waters of Yakutia was carried out. It revealed deterioration in water quality and changes in the population structure of invertebrate organisms, which reflected in the final producers - fish. As a result of enterprises processing of raw mineral materials in the waters of the republic following trends in water quality emerged: salinity was growing, ionic composition changed in the direction of increasing the sulfate content, due to elevated levels of suspended particles water clarity decreased, bottom sedimentation with industry solid waste occurred and water accumulated toxic compound.

According to toxicology cadmium is considered to be particularly dangerous ecotoxicant to human health. This paper analyzes the results of the accumulation of heavy metals - cadmium in the organs and tissues of freshwater fish in the waters of Yakutia, which are one of links of the food chain «water-fish-man». Information related to cadmium content in freshwater fish organism is very scarce. Meanwhile these data are not only of theoretical but also practical importance, since the toxicity of cadmium is independent of the form of its compounds. Excess of cadmium concentration in Yakutia freshwater fish makes 1-2 of MPC, more often in polluted basins, localizing in fish gills and liver.

This article presents the results of studies assessing the distribution of toxic elements (heavy metals) in the organs and tissues of cattle. So as a special role in human nutrition belongs to the micronutrients involved in the metabolism of the body and often defining health state. It was revealed that the concentration of lead, cadmium, mercury and arsenic in the body of surveyed animals was distributed in descending order: kidney> liver> muscle tissue, and did not exceed the MAC (maximum allowable concentration).

In article the literature review on adaptation of children to process of school training is presented including criteria and clinic-functional features of adaptable processes in children, ways of forecasting of a current of adaptation of children to training at school are described, features of cerebral blood circulation and a vegetative homeostasis at children of younger school age are resulted.

The detailed analysis of expertise of the damage of acromioclavicular joint (ACJ), knee joint, and ankle joint was done. The main mistakes in the formulation of diagnosis were revealed, the ways of their elimination were defined, and the data in the literature with the description of the main characteristics of the diagnosis of the ligaments damage of the specified localizations were researched. The analysis of the defects in the medical records done by doctors-traumatologists in formulation and confirmation of diagnosis of patients with damaged ligaments of ACJ, knee and ankle joints for the determining of the injury severity showed the following: there was no uniform approach (algorithm) to the documentation of injuries by the clinical doctors and no standards in their description and researching of capsular ligament joints. All this requires more closely interaction between forensic service and practical health care institutions in the elaboration of appropriate standards for evaluation of patients with this pathology.

Investigations exactly shows that the most suitable condition for cultivating M. bovis is anaerobic, other types of bacteria need aerobic conditions which is reached by various kind of tubes. A rich growth of pathogenic bacterium is observed on the 16th day, atypical ones start growing in a week.

The article presents the results of long-term monitoring studies on dietary nutrition and dietary habits of different population groups and the analysis of the control of the conformity of the quality and safety of food products, according to the legislation of the Russian Federation, the legislation of the Customs Union and the standardized methods used in population-based epidemiological studies. The authors justify necessity of optimizing the structure of the population nutrition and improving the quality of food and the level of its security. They consider the complex of the factors influencing the increasing interest of the food industry to ensure the safety of their products.

We carried out comparative analysis of interpulmonary lymph nodes affected by tuberculosis with non-affected as presented on computed tomography scans. Diagnostic criteria of primary tuberculosis in children and adolescents were established. We also provide results of study of tuberculous changes in lymph nodes depending on age group.