The pandemic of the new coronavirus infection COVID-19 (COVID-19) has had a significant impact on public health, including the reproductive health of women. There is little information on the impact of COVID-19, carried in the pregravidar period, on the course of pregnancy. The medical and social profile, somatic and reproductive health parameters of pregnant women who underwent COVID-19 at the pregravidar stage 6-12 months before pregnancy have not been studied. However, this information may be of significant importance for a preventive approach to the tactics of patient management at the stage of preparation for pregnancy and during gestation.

The aim of the study was to investigate the characteristics of changes in the indicators of the lipid peroxidation (LPO) system and antioxidant defense (AOР) in blood plasma and erythrocytes in adolescents with tension-type headache (TH). 104 individuals (boys and girls) aged 12-17 years were examined, including 64 adolescents with TH (main group) and 40 without TH (comparison group). The content of LPO-AOP system parameters was determined using spectrophotometric detection methods. The obtained data were processed in the Statistiсa 12 program. Results: adolescents with TH had higher plasma MDA levels and lower plasma and erythrocyte SOD activity. A large number of individuals with high plasma MDA concentrations and low plasma and erythrocyte SOD activity were found in adolescents with a history of TH episodes. Statistically significant intragroup differences were revealed for most parameters of the LPO-AOP between their gradations: “normal level” and the level “above normal” and/or “below normal”. Considering the significant role of the imbalance of the LPO-AOР system parameters in the development of oxidative stress, the increase in MDA and decrease in SOD activity that we have identified are ambiguous in terms of their interpretation: on the one hand, they can be regarded as metabolic markers of the presence of TH, on the other hand, their role as predictors of the development of this pathology is highly probable. This assumption can be confirmed or rejected by the results of further studies.

The 5-HTTLPR polymorphism of the SLC6A4 gene plays a key role in the regulation of serotonergic transmission and may influence susceptibility to anxiety and depressive disorders. This study presents a comparative analysis of the distribution of genotypes and alleles of this polymorphism in representatives of the Russian (n = 250) and Yakut (n = 260) ethnic groups. A significantly higher prevalence of the S allele (77.7%) and the homozygous SS genotype (63.8%) was observed in the Yakut population compared to the Russian group (44.8% and 20.8%, respectively; p < 0.001). The Russian sample was characterized by a higher frequency of the L allele and the SL genotype. The identified differences reflect the high frequency of the S allele characteristic of the Indigenous peoples of Siberia and underscore the ethnic specificity of genetic factors involved in psycho-emotional regulation.

The level of tumor markers was assessed in working-age residents of the Aldan district who consume untreated and filtered water. The average level of tumor markers varied within the normal range. Residents of the city of Aldan who consume unpurified water have shown an increase in the average level of cancer embryonic antigen and carbohydrate antigen Ca19-9 compared to other groups. This group also has a high proportion of individuals with elevated levels of carbohydrate antigen Ca15-3, cancer embryonic antigen, and among women, carbohydrate antigen CA-125. Among individuals who consume filtered water, there is a high proportion of individuals with elevated levels of alpha-fetoprotein, which is more commonly found among residents of the city of Tommot, indicating a need for more in-depth study.

In the article, a genetic study of biological samples from uterine cavity aspirate was performed in patients with serous ovarian carcinoma in order to identify gene mutations characteristic of ovarian tumor lesions. It has been proven that the aspiration from the uterine cavity contains diagnostically significant numbers of cells or fragments of ovarian cancer cells necessary for molecular genetic analysis and detection of mutations in the TP53, FAT3, CSMD3, BRAF, and KRAS genes. Mutations of the BRCA1/2 genes are rare. The detection of TP53, FAT3, CSMD3, BRAF, and KRAS gene mutations in uterine aspirate cells requires an active diagnostic search for the detection of ovarian serous carcinoma.

The article presents information about a study conducted to study changes in the level of enzymes and free products of lipid peroxidation in metabolic disorders in the liver of experimental animals exposed to X-ray radiation. The study was conducted on 42 intact white rats, which were divided into three groups. The first group (control) included 6 white rats. The second group included 18 intact white rats exposed to X-rays. In the third group, 10 days after the cessation of X-ray irradiation (18 animals), the level of liver enzymes in the blood was measured. Levels of lipid peroxidation (POL), malondialdehyde (MDA), diene conjugates (DC), hydrogen peroxide (H₂O₂), creatine phosphokinase (CK), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST) were determined in the blood of experimental animals and alanine aminotransferase (ALT).

The quality of life (QOL) of patients after radical surgery for oral cavity and oropharyngeal cancer has been studied as an important factor in determining the treatment effectiveness of speech rehabilitation technique using the OnkoSpeech v4.0 computer software. To assess QOL, the EORTC QLQ-30 (version 3.0) and QLQ-H&N35 questionnaires were used.

The use of OnkoSpeech v4.0 demonstrated higher efficiency of speech rehabilitation and improvement of patients' quality of life compared to the standard technique. The data obtained highlight the potential of integrating digital technologies into speech rehabilitation of cancer patients, which can be recommended for further implementation in clinical practice.

The article presents information about a scientific study conducted to study changes in the course of pregnancy and its outcomes after administration of cyclophosphamide and doxorubicin to female white rats for therapeutic purposes. Women taking antitumor drugs from the cytostatic group may become pregnant during treatment. Given the conflicting opinions about the effect of these drugs on pregnant women and the fetus, it was determined how the therapeutic use of cyclophosphamide and doxorubicin, which are representatives of the cytostatic group, individually and in combination, depending on the dose, affects the onset, course of pregnancy and fetal development in the prenatal and early postnatal periods. Since cytostatics, when used together, cause a sharp decrease in the amount of sex hormones, no pregnancies have been observed against the background of their use. The results of our studies show that compared with the use of a dose of 2.5 mg/ kg of doxorubicin and a dose of 10 mg/ kg of cyclophosphamide, cyclophosphamide has a stronger effective, teratogenic effect.

Among the 200 adolescents aged 12 to 17 years examined, iron deficiency anemia was detected in 28% and latent iron deficiency in 30%. The presence of anemia was confirmed by laboratory indicators. Risk factors for the development of iron deficiency anemia in girls were heavy and prolonged menstruation, fasting, refusal to eat meat, intense physical activity, gastritis and colitis, and in boys pubertal growth spurt, intense physical activity, refusal to eat meat.

The article presents a study on the effectiveness of the immunomodulatory and anti-inflammatory properties of juice from wheat sprouts growing in the extreme climatic conditions of the Far North. Based on clinical and immunological analyses of 27 volunteers from Sakha women aged 40 to 60 years who took whitegrass for 24 days in a volume of 20 ml, positive changes were obtained: there is a significant increase in lymphocytes and monocytes, which indicates the activation of immune mechanisms while maintaining homeostasis. In 29,6% of the participants, elevated ESR levels returned to normal after taking the juice, which shows the anti-inflammatory effect of witgrass. Restoration of leukocyte and granulocyte levels in 14.8% of participants with reduced levels indicates support for hematopoiesis and immunological balance. A moderate increase in IgA, IgM, and IgG antibodies after juice intake causes a strengthening of humoral immunity and the interaction of various parts of the defense system. The results obtained are consistent with the literature data and open up opportunities for further study of the biological properties of juice from the sprouts of local wheat varieties growing in the extreme climatic conditions of Yakutia, its potential for use in complex therapy of immune disorders and for the development of effective natural remedies for the treatment and prevention of many diseases in the North.

The aim of the study has been to investigate the possibilities of conducting and evaluating the performance of diagnostic statistical methods of ICG fluorescence for sentinel lymph node biopsy in breast cancer in the Republic of Sakha (Yakutia). The study included 223 patients diagnosed with cT1-3N0M0 , occurring in the period from 2022 to 2023. Surgical treatment for the mammary gland with sentinel lymph node biopsy using the ICG fluorescence method. As a result of the study, metastases in the lymph nodes were detected in 44 (19.73%) cases out of 223. It has been established that the use of the method of sentinel lymph node biopsy in breast cancer using ICG fluorescence of the gland allows for large-scale surgical treatment of the initial form of mammary gland cancer.

Nowadays, the prevalence of inflammatory periodontal diseases in the population remains at a high level. Meanwhile, periodontal diseases are chronic foci of oral infection, which often cause the development of focal-related diseases. In addition, tooth loss due to complications of chronic periodontitis leads to dysfunction of the dental alveolar system and mandibular joint. In this regard, the study of these aspects is an urgent general medical problem, including clinical dentistry. Thus, a comprehensive study of chronic periodontitis was carried out in the population living in the North, and on the basis of the obtained results, a method for splinting teeth in periodontitis was developed. To carry out the developed method in periodontological practice, a double silicone cast of the upper and/or lower jaw is first taken with further personalized planning of the splinter apparatus on a plaster model of the jaws, further, a splinting structure for immobilisation of movable teeth is made from colourless plastic and titanium woven wire, and the ready combined splint is additionally fixed from lingual or palatal sides of teeth with light hardening composite material on upper and/or lower jaw; splinting is performed with duration from 1 to 3 months. Depending on the complexity of the clinical situation, patchwork operations are performed to reduce the size of the periodontal pockets and create conditions for the formation of a new tight attachment of the gum to the teeth, followed by orthopedic treatment. The results of clinical-functional analysis of developed method application in complex treatment of chronic periodontitis of moderate severity confirm its clinical efficiency.

As indicated in the extant literature, numerous research groups encounter challenges in creating PDX models of gastric cancer, which is associated with a low level of engraftment of tumor samples. Consequently, in the pursuit of enhancing and refining the conventional implantation technique, we have recognized the significance of the tumor sample collection site. It was hypothesized that cells located on the tumor periphery and forming the invasion front may have a more prjonounced potential for malignant growth and, consequently, the ability to grow as xenografts. To this end, ten gastric tumor samples were obtained from each patient: five from the tumor edges and five more from areas more than 5 mm from the visible tumor edge. All samples were implanted subcutaneously on the right side of Balb/C Nude mice. A subsequent analysis of the results indicated that, upon the collection of biological material concurrжent with the capture of the visible tumor edge, the formation of tumor nodules occurred in three out of five recipient animals. Consequently, the xenotransplantation efficiency in this instance was determined to be 84%. Conversely, when tissue samples were obtained from areas distant from the tumor edge, the formation of tumor nodules in recipient animals was observed in only one procedure out of five. Consequently, the xenotransplantation efficiency was 20%. The histological examination conducted as part of this study revealed that the heterotopic PDXs accurately reproduced the histotype of the corresponding donor tumors, confirming their adenocarcinoma status. We also conducted an IHC study, which demonstrated that the level of Ki-67 expression in the tumor edges forming the invasion front was significantly higher, with an average value of 70 [60; 80]%. Conversely, in samples extracted from non-marginal regions of the same tumor, Ki-67 expression levels were notably lower, with an average of 15% [5; 25%] (p<0.05). The obtained data suggest that the higher proliferative potential characterizing the marginal areas of tumors may contribute to more effective xenotransplantation of such tumor samples compared to samples obtained from areas of the tumor remote from the visible edge and characterized by a lower proliferative potential.

The purpose of the study was to evaluate and compare the observance and understanding of the concept of a healthy lifestyle among students of medical and non-medical specialties of the M.K. Ammosov NEFU. Theoretical, verbal-communicative and statistical research methods were used. The conducted research has shown that modern students generally adhere to the basic principles of a healthy lifestyle. There was a lower proportion of people with bad habits among medical students and a higher number of students who adhere to the principles of healthy eating. At the same time, students of non-medical specialties are 2.48 times more likely to study in sports sections. It has been established that in the group of students of non-medical specialties, there are those who do not perceive a healthy lifestyle as a success factor in various spheres of human activity and consider compliance with the principles of a healthy lifestyle not mandatory. Thus, students studying in medical and non-medical specialties have different attitudes towards the concept of a healthy lifestyle and, therefore, adhere to it in different ways. The results obtained dictate the need to popularize the versatility of a healthy lifestyle as a foundation for the formation of a full-fledged, harmonious personality in all spheres of life.

The article presents the results of a study of the nutritional characteristics of patients with chronic generalized periodontitis. According to the World Health Organization, more than one billion people in the world suffer from severe periodontal diseases. Periodontal pathologies are closely associated with a number of major chronic non-communicable diseases, which determine their high medical and social significance.

A cause-and-effect relationship was revealed between the degree of manifestation of periodontitis symptoms and nutritional factors of patients. It was found that the less essential nutrients in the diet, the more pronounced the clinical signs of periodontal damage become. Increased body weight can be considered as one of the signs of metabolic syndrome involved in the development of periodontitis. Thus, with an increase in body weight, the severity of the clinical course of periodontitis steadily increases, and the revealed dependence is statistically highly significant (p = 0.01). With an increase in the number of proteins, carbohydrates and dietary fiber in the diet, a decrease in the degree of periodontitis is observed. An increase in the number of vitamins (A, B1, C) and a number of macroand microelements (Cu, Zn, K) has the same effect.

Healthy nutrition is a key element that has a significant impact on the general condition of the human body and helps maintain its well-being. Normalization of diet, including a balanced intake of essential nutrients, is a key element in the prevention of periodontal diseases and an important aspect of rehabilitation. The results of this study can be used to develop scientifically based methods aimed at improving the preventive activities of health care workers, including general practitioners, dentists and dental hygienists, increasing the motivation of the population to lead a healthy lifestyle and adhere to the principles of a balanced diet.

The article presents a study on the formation of phases and the severity of symptoms of burnout syndrome among doctors who have completed advanced training programs using simulation technologies. The study involved doctors who participated in advanced training courses at the Educational and Accreditation Center – Medical Simulation Center of the S.P. Botkin Moscow Multidisciplinary Research and Clinical Center in 2024. All phases of burnout syndrome were identified in 71 (50%) of the respondents. Individual symptoms of burnout syndrome were identified in 140 of the 142 study participants; more common were such as "experiencing traumatic circumstances" (83/58.45%), "inadequate selective response" (82/57.74%), "reduction of professional duties" (79/55.63%). Compared with surgeons, anesthesiologists and intensive care physicians were more likely to have all three phases, with symptoms such as "emotional and moral disorientation" being more pronounced (p <0.05). The data obtained on the high incidence of burnout syndrome, the degree of formation of phases and the severity of individual symptoms among doctors studying advanced training cycles using simulation technologies allow us to identify the main areas of preventive work in the future.

The article, devoted to the development of the concept of a unified departmental approach to quality and safety management of medical activities in the Republic of Sakha (Yakutia), discusses the implementation and replication of practical recommendations of the National Institute of Quality of Roszdravnadzor. This can be achieved by creating an integrated quality and safety management system for medical activities in subordinate medical organizations based on the Regional Competence Center for Quality and Safety Management of Medical Activities.

The Regional Competence Center is a key element in the concept of an approach aimed at improving the quality and safety management of medical activities. Its creation makes it possible to consolidate knowledge, resources and forces for the development and implementation of effective tools in the field of quality and medical care, as well as replicate best practices and existing experience.

Based on the depersonalized database of the State Medical and Social Expertise Bureau of the Irkutsk Region, an analysis of primary disability in women due to breast cancer (BC) was conducted. Among the contingent of primary disabled people, women with the second disability group, living in urban areas and over 55 years of age, currently prevail. For 2009-2023, a statistically significant increase in the overall indicators of primary disability due to BC was noted: "gross" by 1.4 times and standardized by 1.3 times. The increase in the average age of disabled women from 53.2 to 58.1 years is associated with both improved medical care and patient survival, and with the aging of the population. Despite the improvement of diagnostics [3], the multidirectional dynamics of the proportion of disability groups 1 and 2 (an increase in the share of group 1 from 14.8 to 18.4% and a statistically significant decrease in the share of group 2 from 57.7 to 48.2%) does not correlate with the data on primary breast cancer incidence by stage, which is explained by legislative changes in detailing the classification and criteria for the implementation of primary examination by medical and social expertise institutions. To prevent severe disability due to breast cancer, it is necessary to take a set of measures: active interdepartmental cooperation of all interested specialists, effective diagnostics of breast cancer, accessibility of medical care, and the development of a regional prevention program.

The article presents a retrospective analysis of statistical data on infant mortality in the subjects of the Far Eastern Federal District (FEFD) in the period 2012–2023.The aim of the study was to study the features of the dynamics of the infant mortality rate (including early neonatal mortality), as well as the indicators of perinatal mortality, stillbirth and fetoinfantile losses in the territories of the Far Eastern Federal District in comparison with the data for the Russian Federation for 2012-2023. In the Far Eastern Federal District, as in Russia as a whole, for several decades there has been a positive trend in reducing mortality in children up to 1 year. This is considered one of the important achievements of the region in the socio-economic and medical spheres. A detailed analysis and comparison of infant mortality rates in certain regions of the country is an important tool that allows you to quickly identify the most disadvantaged regions of the Russian Federation, and then understand in detail the causes of the current situation and its correction. It is concluded that there are areas with a low level of prevention of fetoinfantile losses and significant differences in the medical and social efficiency of the maternity and childhood service are assessed.

We calculated incidence and prevalence rates of circulatory system diseases (CSDs) in the working-age population (WAP) of the Republic of Sakha (Yakutia) and analyzed their dynamics in 2011–2023. We also assessed the statistical significance of differences between the disease rates in Yakutia and the Russian Federation before, during and after the pandemic of the novel coronavirus disease. We observed a statistical increase in the CSD prevalence in Yakutia in 2022–2023 and in the chronicity rate in 2020–2023. The high rate of increase in the latter indicates a more severe course of chronic CSDs during the COVID-19 pandemic and the early post-pandemic period in the WAP.

An observational, analytical, cross-sectional study was conducted to assess the prevalence of iodine deficiency among children living in the Arctic and southern zones of the Far Eastern Federal District (FEFD). Iodine status was assessed by determining the concentration of ioduria using the arsenite-cerium method. The study revealed that only 26.1% of children living in the Far North had normal iodine levels in their bodies. Mild, moderate, and severe iodine deficiency was diagnosed in 34.0%, 30.3%, and 9.6% of those examined, respectively. The incidence of low iodine status in children in the Far North was 2.6 times higher than in the southern zone (80.9% and 61.8%, respectively, OR = 2.611, 95% CI 1.339-5.090), with a significant prevalence of moderate iodine deficiency (37.5% and 17.7%, respectively, p = 0.005). Interviews with parents of the examined children revealed that only 20.0% of Far East families use iodized salt daily, which is categorically insufficient to eliminate iodine deficiency.

The article is devoted to the hygienic assessment of working conditions and their impact on the health of employees of a mining enterprise engaged in the extraction and processing of copper-zinc ore located in the Southern Urals. The relevance of the study is due to the need for a detailed study of the hygienic situation in all divisions of a mining enterprise in order to assess the levels of occupational risk of damage to the health of employees and timely preventive measures aimed at minimizing it. Priority harmful production factors have been identified in the workplaces of various departments: during underground ore mining, noise, vibration, lack of natural light, unfavorable microclimate, severity, and labor intensity; during transportation of extracted ore, vibro-acoustic factors, severity, and labor intensity; during ore processing, noise.

Climatic fluctuations and the ethnic heterogeneity of the population can shift the standards of intrauterine growth; however, their combined effect has been little studied. Air temperature, day length, and pregnancy season, in combination with the mother's ethnicity, modify fetal biometry and newborn weight. A retrospective cohort analysis included 1,812 singleton pregnancies completed between 2018 and 2024. Fetal biometric parameters (BPD, OFD, HC, AC, FL) were measured according to unified ultrasound screening protocols. Climatic data by trimester (mean temperature, number of sunny days, photoperiod duration) were obtained from Roshydromet. Ethnic groups: Russians, Tatars, Mari, Udmurts. Two-way ANOVA and multilevel linear modeling adjusted for gestational age were used. The third trimester of pregnancy, occurring in the spring–summer period (+4°C above annual average), was associated with a 3.1% increase in abdominal circumference (p < 0.01) and an increase in newborn weight by 112 g. The ethnic factor manifested from week 24: Finno-Ugric groups showed a significant reduction in femur length (–2.4 mm) with a simultaneous increase in AC (+6.5 mm). In the newborn weight model, climatic predictors explained 18% of the variance, ethnicity 7%, and their interaction 4%. Furthermore, accounting for these factors improved the accuracy of the Estimated Fetal Weight prediction model by 9% compared to the standard Hadlock formula. Climatic conditions and ethnocultural background form independent and interdependent trajectories of intrauterine growth, cumulatively accounting for about one-third of the variance in birth weight. These data substantiate the need for seasonal and ethnic adjustments when assessing fetal biometry.

In this work, an assessment of the health risk to the population of Ufa associated with chemical contamination of food products with heavy metals was carried out. The study revealed specific patterns of accumulation of toxic elements in different groups of products: dairy prod-ucts demonstrate elevated concentrations of Pb, Cd and Ni; meat products – Hg; fruit and vege-table products – As. An excess of the permissible level of non-carcinogenic risk for arsenic (HQ = 1.143) was revealed, indicating a potential danger to the nervous and cardiovascular systems. The total carcinogenic risk is at an acceptable level (1.39×10-5), with the main contribution of cadmi-um (52%) and arsenic (43%).

The data obtained emphasize the need for priority control of As and Cd content in food products, development of targeted preventive measures, and optimization of the food monitoring system.

The study is devoted to studying the level of awareness of residents of the Republic of Sakha (Yakutia) about dementia. 328 residents of Yakutia (81,7% women, 18,3% men) were involved in this survey. It was found that the population of Yakutia has basic knowledge about dementia, however significant gaps in understanding of nature, symptoms, age characteristics and disease prevention are preserved. The findings revealed that 68,0% of respondents were able to distinguish between dementia and Alzheimer’s disease, However, even among medical professionals, 13,8% mistakenly regarded dementia as a natural part of aging. A high level of self-stigma was revealed: 46% of participants would prefer to hide the diagnosis if it concerned them personally. The data highlight the high social relevance of dementia, not only as a clinical condition but also as one that elicits emotional and behavioral responses within society. These findings can serve as a foundation for developing research methodologies aimed at investigating dementia-related stigma, involving both individuals with dementia and their caregivers.

A literature review was conducted on biomarkers, such as proteins, metabolites and other biological molecules found in biological fluids, as a tool that can improve the understanding of pathophysiological processes in traumatic brain injury (TBI) and contribute to the development of promising therapeutic approaches. The results of the systematic review show that biomarkers have significant potential for clinical application, but further standardization of technologies for their detection and analysis is required. The development of new platforms, such as POC systems using electrochemical biosensors, can provide fast and reliable diagnosis at all stages of TBI treatment. For further in-depth study, it is necessary to combine the efforts of the interdisciplinary research community, which will create personalized treatment strategies and improve long-term outcomes for patients.

This systematic literature review analyzes the environmental factors that affect the course of bronchial asthma. Based on 46 studies, a number of factors have been identified whose impact has been reliably confirmed, including sudden changes in daytime temperatures, vitamin D levels, micronutrient status, persistence of herpes-like viruses, and the specific sensitization spectrum of a particular region.

A comprehensive approach to the diagnosis, prevention, and treatment of bronchial asthma, taking these factors into account, will allow for personalized treatment of individual patients and improve its effectiveness.

The literature review presents the problems of congenital connective tissue disorders, characterized by multifactorial origins, associated with aggressive factors from the external and internal environment, manifesting as various general and local phenotypic traits. Anatomical-topographic changes in congenital collagenopathy of the organs and tissues of the oral cavity negatively impact the functional activity of the entire dental and jaw system, indicating their biological interconnection which correlates with each other. According to the results of the conducted studies, the most common dental and jaw anomalies in children and adolescents with dentofacial abnormalities are distal occlusion, narrowing and deformation of the dental-alveolar arches of the upper and lower jaws, and deep incisor overlap. As of today, the prevalence of dental and jaw anomalies does not show a tendency to decrease, and their combination with DSD in children and adolescents is insufficiently studied, which requires further research aimed at early detection of local phenotypic signs and improvement of socio-medical rehabilitation with an interdisciplinary approach.

Due to the steady increase in the incidence of metabolic syndrome (MetS), studying the ways to reduce the risk of its occurrence is an important task for modern medicine. The aim of the study is to identify the relationship of MetS markers with the levels of specific IgG to various products, as well as to assess the relationship of the content of proinflammatory cytokines and C-reactive protein with MetS. It is shown that for the examined individuals with MetS, more direct correlations are recorded and most often with the glucose level. Many products can provoke postprandial hyperglycemia, which in a practically healthy person will not cause significant disturbances, but with MetS, a failure of glucose and lipid homeostasis in combination with insulin resistance does not allow effective correction of blood glucose levels. Thus, when introducing elimination diets for MetS, it is necessary to take into account the possibility of postprandial hyperglycemia in this group of people, monitor glucose and insulin levels to prevent the development of insulin resistance.

To study the effectiveness and prospects of using telemedicine technologies for monitoring blood pressure (BP) in patients with arterial hypertension (AH) at the primary care level, remote BP monitoring was carried out using a digital platform. The study included 146 patients with uncontrolled BP, who measured BP at least twice a day using automatic monitors with Bluetooth data transfer. Measurement data were received by the remote monitoring system, where they were automatically processed and transmitted to the attending physician’s personal account. During the 10-month follow-up of patients with AH, target BP values below 135/85 mmHg were achieved in 83% of cases. During remote monitoring, therapy adjustments were observed: the number of patients on monotherapy decreased from 22.4% to 8% (p<0.05).

A case report describes a severe hypokalemia (0,6 mmol/L) case with severe secondary hypokalemic generalized muscle weakness, bilateral symmetric calcification in the brain in the patients with chronic tubulointerstitial nephritis.

In our report, we present a case of a 45-year-old female patient with MHL. Before surgery, a differentiated diagnosis included cholangiocarcinoma and focal nodular hyperplasia. Attempts of morphological verification, including ultrasound-guided biopsies, were uninformative. The final diagnosis was established after laparoscopic anatomical liver resection with histological and immunohistochemical examination. This case highlights the importance of a comprehensive approach to the diagnosis of liver tumors in adults and the need to include MHL in the differential diagnosis in the case of atypical clinical and radiological presentation.