Определение биохимических маркеров измененного метаболизма печени у белых крыс, подвергшихся воздействию рентгеновских лучей

В статье представлены сведения о проведенном исследовании по изучению изменений уровня ферментов и свободных продуктов перекисного окисления липидов при нарушении метаболизма в печени экспериментальных животных, подвергшихся рентгеновскому облучению. Исследование проведено на 42 интактных белых крысах, которые были разделены на три группы. В первую группу (контрольную) вошли 6 белых крыс. Во вторую группу вошли 18 интактных белых крыс, подвергшихся рентгеновскому облучению. В третьей группе через 10 суток после прекращения рентгеновского облучения (18 животных) измеряли уровень печеночных ферментов в крови. В крови (сыворотке) подопытных животных определяли уровни перекисноe окислениe липидов (ПОЛ), малонового диальдегида (МДА), диеновых конъюгатов (ДК), перекиси водорода (H₂O₂), креатинфосфокиназы (КФК), щелочной фосфатазы (ЩФ), лактатдегидрогеназы (ЛДГ), гамма-глутамилтрансферазы (ГГТ), аспартатаминотрансферазы (АСТ) и аланинаминотрансферазы (АЛТ).

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