Retrospective analysis of malignant tumor morbidity of Yakutian population during the period of 2001-2010 has been conducted. First decade is characterized by existence of positive tendency in general oncologic disease dynamics, clearly marked by sex-age and territorial conditionality. By 2015 predicted level will be in 1.2 times higher than initial rates in 2001.

Quality of life in present-day conditions is one of the indicators of the adolescents’ health. In order to assess the quality of the RS (Y) adolescents’ life 883 adolescents living in Yakutsk and in 6 northern areas of the republic were under questionnaire.

Article represents the results of the test of 708 children in early and senior school ages for presence of Chlamydia contamination of mucosa of upper respiratory tract. Chlamydia verification was carried out by direct immune fluorescence technique. We show identified Chlamydia types structure depending on age and gender. We show comparative evaluation of ENT-morbidity in children with and without recognized Chlamydia infection.

In a result of the analysis of the clinical finding of rheumatism among children and adolescents of the Republic Sakha (Yakutia) it was revealed that the patients with sub-acute and latent onset predominated. Ultimately, erased clinical course of rheumatism led to late diagnosis and inadequate therapy and was the reason for the formation of heart defects.

We analyzed a content of the antioxidant vitamins A, E and C in blood serum and supply of vitamins in the daily diet of patients with chronic gastritis aged 30 to 50 years, depending on the degree of H. pylori contamination in the gastric mucosa. It was revealed that increasing of the contamination degree of gastric mucosa with H. pylori in patients with chronic gastritis led to the polyhypovitaminosis development.

The study included 24 children between the ages 12 and 16 years, patients with chronic hepatitis B with the 2 stage and the 3 stage of the chronic process. in which a liver biopsy determined for the activity of NAD/F/-dependent enzymes and parameters of lipid profile. We found that the increase in chronic stage of infection was accompanied by a decrease in liver cells of cholesterol and phospholipids, lipid shift toward the formation of triacylglycerides, decreased activity of NADPH-dependent enzyme and decrease of the synthetic potential of cell metabolism and their proliferative capacity, a reduction in the protection of cells from peroxidation processes lipid reduction in their ATP production by inhibiting the reactions of the Krebs cycle and glycolysis.

This article analyzes the prevalence and intensity of dental caries in children and adolescents with varying degrees of mental retardation, the justification of the need for personalized prevention and treatment of dental disease in these patients. In the study, the prevalence of dental caries in the surveyed contingent defined as high. With increasing of severity of mental retardation increased the number of children with dental caries.

This article presents clinical and genetic characteristics of Charcot-Marie-Tooth type 1A disease. By molecular genetic analysis the authors revealed 43 patients, accounting for 38% of all types of CMT. Prevalence of the disease was 4.5 per 100000 of population. Using fragment analysis method with dinucleotide STR-markers (D17S2218, D17S2223, D17S2229) they examined 98 DNA samples of patients with CMT and a sample of healthy individuals of Yakut ethnic group (n = 100). By markers D17S2218 and D17S2229 the authors revealed a high heterozygosity (to 76%), i.e. these markers are informative in the Yakut population and can be used to identify duplication.

The article presents the analysis of newborns with tumoral and cystous neoplasms of various localization, observed in surgical department of the Pediatric center RH№1-NCM MH RS (Y) from 1999 for 2012. The majority of tumors, diagnosed prenatally, are not malignant. Malignant neoplasms were revealed in 18% of the newborns.

The study of the origin, development, distribution and completion of Vilyusk encephalomyelitis (VEM) epidemics on the territory of Sakha-Yakutia shows the course of a unique epidemic process of completely distinctive neuroinfection, plagues of residents mostly of the one ethnic group.The mechanisms of persistence of still not isolated infectious agent and the features of an immunity of the affected population remain a mystery, but gave rise to the clinical polymorphism and a broad clinical continuum of the disease. These circumstances contributed to the introduction of clinical and epidemiological monitoring of heterogenic risk groups of patients in the foci of disease characterized by different degree of reliability of VEM diagnosis, that allows to express some polar points of view on the nature and pathogenesis of VEM. Consideration of these hypotheses in the key common understanding of the epidemic process VEM should allow to find out the important questions of comorbidity and predispose to disease of the certain immune-genetic disorders.

The relationship of inflammatory markers (IL-6, IL-8, FNO-α, INF-γ and C–reactive protein) with metabolic syndrome and coronary atherosclerosis among inhabitants of Yakutia depending on ethnicity and gender was studied. The results of the survey of men and women at the age of 45-64 years with verified coronary atherosclerosis and without clinical signs of coronary heart disease are analyzed. The results of the research showed that in patients with metabolic syndrome complicated by coronary atherosclerosis in comparison with persons without clinical signs of coronary heart disease the levels of all studied inflammatory markers were higher. The significant ethnicity and gender differences are received. Ethnicity differences were characterized by elevated of IL-6 levels among non-native people of Yakutia unlike native population. Gender differences were characterized by the increase of IL-6 levels in women, than in men. In native men with coronary atherosclerosis the INF-γ level in comparison with non-native was higher.

To investigate the role of nephrotic proteinuria in the light of reno-cardiac interactions in chronic glomerulonephritis (CGN) at an early stage of the disease patients with CGN: with a daily proteinuria 3.5 g were under study. All patients underwent clinical examination. In patients with nephrotic proteinuria lower concentrations of Hb, red blood cells, platelets, and total protein in the plasma were revealed. Also they had higher total cholesterol, LDL cholesterol, triglycerides and fibrinogen concentration. In patients with proteinuria the authors found linear increase of the heart size compared to patients with proteinuria < 3.5 g per day. Correlation analysis showed a close negative relationship between left ventricular mass, concentration of Hb and platelet counts, as well as the positive correlation between left ventricular mass and the amount of daily proteinuria in the 2nd group. In patients with CGN, presence of nephrotic proteinuria is associated with increased left ventricular mass and left ventricular cavities.

Depression prevents the rehabilitation of patients and also is connected with the low quality of life. We examined 30 patients with post-stroke depression in 1-12 months of the ischemic stroke. Patients took antidepressant fluvoxamine for 6 weeks. Neurological, psychopathological and psychometric investigations in dynamics were carried out. It is established that the preparation is efficient both for treatment of depression and anxiety of patients who had ischemic stroke as well as it facilitates the rise of quality of life of these patients.

Extension of anemia syndrome was searched in elderly patients with systemic osteoporosis complicated by proximal femoral fracture who received expert care at the Center of emergency medical care of Republican hospital №2 of Yakutsk. Anemia syndrome is detected in 70.0±2.4% of patients during hospitalization. Reduction of Hb level in dynamics is 19.5±2.0% of the initial level. Anemia syndrome increases lethality level in the next two years of observation.

The instructions in this message data confirm the feasibility and the need for the use of endoscopic methods of treatment of diseases of the biliary tract and concomitant pathology as preoperative preparation and as a treatment for high operative risk. Endoscopic interventions in 365 of patients with biliary hypertension in the face of severe concomitant pathology were done. The result was a reduction of bilirubin indicators by 65% from the initial level, and in 13% of patients with a high operative risk endoscopic intervention was effective final method of treatment.

The article deals with planning and organizing the process of population-based study of the life quality of the adult population of the Republic Sakha (Yakutia). The logical structure of the study protocol and determination of the volume of the minimal representative sample are described in detail.

The detailed analysis of the call cards and the accompanying ambulance sheets of patients, which were taken to the state hospital No1, Emergency Department, during the period from the September 2012 to the July 2013, was done in this article. It is devoted to the investigation of the patients of trauma profile with injuries of the musculoskeletal system of different localization. The assessment of the quality of the medical care at the pre-hospital stage was based on the following features: the level of the care rendering, the compliance with emergency care standards, accuracy, timeliness, validity, sufficiency, and adequacy. The next stage was to detect the defects in rendering of emergency medical care: organization, diagnostics, and treatment. After that, the assessment of the influence of the different factors on the process and results of medical assistance was done. The timeliness and correctness of diagnosis installing were analyzed.

The article reviews the analysis of the results of endoscopic sclerotherapy (ES) in patients with portal hypertension (PH). the effectiveness of the method in the treatment of varicose veins (VV) of the esophagus in case of bleeding and delayed planned order was assessed. ES VV of esophagus in case of PH is an effective treatment and a good alternative to the “open” surgical interventions.

Study of epidemiological characteristics of smoking in teenage population of the Republic Sakha (Yakutia) gives evidence about rather widespreading and high intensity of smoking among both boys and girls.
Analyzing results received from smoking teenagers we came to the conclusion, that smoking ones have breach of bronchial termeability aсcompanied with noticeable changes of breathing patterns.

Results of the biochemical screening of the I trimester pregnancy in Yakutia women within the Health national project in Yakutia are given. The obtained data confirm high efficiency of definition of biochemical markers and ubtrasonography in the I trimester of pregnancy of formation of group of risk of chromosomal anomalies and they meet the requirements of early identification of pathology of a fetus.

There was studied the structure of extragenital pathology of pregnant women on the basis of women`s consultation of perinatal center State Inst. MofH RofS(Yakutia) «RH №1-NCM» for the year 2012. The presence of extragenital pathology of pregnant women is a major factor of the high risk of maternal mortality. Most women (90%) have two or more of extragenital pathology simultaneously. In the structure of extragenital pathology of pregnant women the first place take urinary system diseases, 2nd place - diseases of the cardiovascular system, 3rd place - diseases of the hematopoietic system. Diseases of the cardiovascular system are the lead indications for terminate pregnancy. In this work is shown necessity for more effective collaboration of gynecologists, general practitioners and specialists of narrow specialization to identify women who are at high risk of perinatal pathology, the forecasting of carrying pregnancy and timely decision on the prolongation and tactics of waging.

The investigation of the share of risky, dangerous, and possibly dependent drinking among doctors of Yakutsk was done. The interrelation of social and hygienic aspects accompanying risky and hazardous alcohol consumption, and identified risk factors was studied.

Injuries are a major health and social problems of our time, for most countries of the world.
It’s necessary to open Trauma centers, equipped according to the standards of trauma care to reduce mortality from injuries.
A key issue for the development of a specialized trauma care is the development of a network of Trauma centers from level III to I, the timely re-equipment, modernization of medical equipment, developing new modern high-tech diagnostic technologies.
On the basis of the national project “Health” and Modernization of the health of the Russian Federation, the issues of creating trauma centers I, II, III levels in the Republic of Sakha (Yakutia) were considered.
First, it is necessary to organize Trauma centers I level on the bases of Republican Hospital № 2-Center of Emergency Medical Services, Republican Hospital № 1 - National Medical Center and Trauma centers II level are created in Mirny, Neryungri, Nyurba, Maya. In Trauma center of level I are hospitalized victims with combined injuries, including supplies from a place of road accident with injuries of any severity and localization, the victims are transported from Trauma centers II, III levels, and patients for the staging of surgical treatment of consequences of injuries received in accident.

Results of the analysis of medical demography, morbidity, physical inability parameters describing population health of the Far East federal district as a whole in the all-Russian context according to 2009-2010 official statistics are presented.

Results of complex research of the social and hygienic and stomatologic status of the families living in extreme climatic conditions of the North (Yakutsk) more than 10 years are presented. Parameters of social and hygienic, somatic, medico-demographic, stomatologic, orthopedic stomatologic statuses are studied. Population of the surveyed families was characterized of generally young (20-30 years) and an average (30-50 years) age, with existence by generally healthy adult members of the family (61,8 %) and children. At the same time the quantity of dysfunctional families on psychological factors makes 56,9 %. In 39,0 % of families it is noted at least at one member of the family a disease of blood circulation or bone and muscular system. The greatest negotiability to stomatologic offices and clinics is noted concerning tooth prosthetics. Level of hygiene of an oral cavity according to Fedorov–Volodkina at children in all families is good. A hygienic index Bernadsky in Tchizhov’s updating – Novikova for teeth and artificial limbs at adult members of the family – average (from 0,2 to 0,49) for all families. The complex assessment of parameters of the specified statuses as families as a whole, and each member of the family separately, gives the chance to reveal prime problems of health and social security of the families living in extreme climatic conditions of the North, allows to increase quality of rendering them necessary social and medical care.

The main factor for chronic obstructive pulmonary disease (COPD) is smoking. Scientific researches conducted in recent years have established that smoking during index exceeding the number 120 (the number of cigarettes smoked per day multiplied by the number of months in the year, during which time a person smokes) typically develop symptoms of COPD. It is also proved that the COPD risk increases at the age of 40-60 years. Reputable studies have shown that smoking contributes to such social factors as loneliness, unemployment, etc. In Yakutia smoking has long been widespread and with severe climatic factor it is the factor for the development of COPD.

The article presents the analysis of newborns with tumoral and cystous neoplasms of various localization, observed in surgical department of the Pediatric center RH№1-NCM MH RS (Y) from 1999 for 2012. The majority of tumors diagnosed prenatally, are not malignant. Malignant neoplasms were revealed in 18% of the newborns.

In a result of clinical and epidemiological studies on nutrition and health of mothers and children, it was found that the majority of mothers’ diets were profoundly deficient in energy value and all food substances. The interconnection of insufficient supply of maternal dietary with iron, magnesium, calcium, vitamins C, B2 with the development of anemia, preeclampsia, placental insufficiency, intrauterine growth retardation syndrome was proved.

Considering the higher level of general (1247,2 per 10 thousand adult population) and primary (165,3 per 10 thousand adult population) glaucoma in RS (Y), we have conducted the statistical research of results obtained while inspecting invalids due to eye illnesses in RS (Y) and its regions.
The analysis of inability due to glaucoma in RS (Y) in 2001-2010 has revealed the leading position of glaucoma in the structure of blindness and weak eyesight in nosology of PI due to eye illnesses, the increase of IM of general inability of the population and IM of primary inability due to glaucoma on 7,2 % and 25 % accordingly, the decrease in amount of invalids I and II groups from FRI due to glaucoma and the increase in number of persons with III group, the highest parameters estimated in the arctic region.
The analysis of the basic markers of inability due to glaucoma in RS (Y) in 2001-2010 has shown the necessity of adequate monitoring of glaucoma patients, especially in the remote arctic areas of the republic for what the reorganization of ophthalmologic service in RS (Y) is necessary.

The structure and prevalence of dental and jaw anomalies and deformation were studied in children aged 6-13 living in extremely continental climate in Zabalkalye. High prevalence of dental and jaw anomalies was revealed, with distal occlusion and maxillary deformation being wide spread. Main etiologic factors contributing to prognathic occlusion development were determined.

The analysis of the literary data testifies, that chronic obstructive pulmonary disease (COPD) leads to deterioration of all life quality components of the person. Restrictions for normal life of patients accrue with illness weighting. At the same time there is other data relative to influence of illness gravity on life quality. Appreciable variability of life quality indicators within one severity level was shown too. The literary data about sex influence on life quality are inconsistent. There are too little researches about life quality of patients with different severity level of COPD and its dynamics in illness development. Only individual researches contain the data about influence of long basic therapy on life quality of patients with COPD.

In the review methods of prenatal diagnostics of congenital and genetic diseases are represented. Questions of prenatal screening of pregnant women as a means of decreasing child mortality and disability in Russia are discussed. The authors tell how to increase the effectiveness of prenatal diagnostics service in prevention of genetic pathology.

In this study conventional culture test for tuberculosis was comparatively analyzed against automated BACTEC MGIT–960 test system, the latter showed high effectiveness.

The analysis of changes of a symmetry coefficient of a T-wave of the electrocardiogram during two types of geomagnetic storms is carried out. It is shown that the growth of the parameter characterizing a state of a human cardiovascular system coincides with the beginning of a storm. Maximum values are reached on the third day after the beginning of a storm – at the recovery phase. More clearly this dependence may be observed for the recurrent storms.

In this article authors carry out a comparative analysis of results of hybrid treatment of combination of the acquired heart diseases (AHD) and the ischemic heart disease (IHD) by a two-stage method (2-staged hybrid) in 48 patients and single-stage correction in the conditions of artificial blood circulation (ABC) in 21 patients. Authors draw conclusions that, when treating combination of AHD and IHD, hybrid operations have obvious advantages over single-stage operations of heart valve replacement and coronary artery bypass graft (CABG). It is indicated that there is a need in organizing specially equipped “hybrid” operating rooms for carrying out operations by the One-stop hybrid method.

In the article the results of research of the fundus of patients suffering from dyscirculatory encephalopathy depending on region of residence and ethnicity by direct ophthalmoscopy are given. They revealed more expressed changes in the status of the fundus of the representatives of the non-indigenous population and patients living in ecologically unfavorable region.

Analysis of complicated forms of pediatric primary tuberculosis is presented, based on x-ray findings of 45 patients, treated in the ‘Phthisiatry’ Research & Practice Center, Sakha Republic (Yakutia). The study revealed that clinical x-ray pattern of primary tuberculosis complex correlated with age factor. We observed that due to age-specific host responsiveness differences, a complicated clinical progression of primary tuberculosis complex occurred more often in adolescents and infants, and manifested as bronchopulmonary involvement with generalization of the process spreading to other organs and systems. In preschool and junior school age, an unfavorable tuberculosis progression was far rarer exclusion and manifested predominantly as lymphogenous seeding.

Systemic thrombolytic therapy can significantly reduce the degree of neurological deficit and improve outcome in patients with ischemic stroke. The effectiveness of this method was illustrated by the presented clinical report of systemic thrombolysis in ischemic stroke patient in Regional Vascular Centre, Yakutsk. The “dramatic” decrease of focal symptoms (NIHSS score 2 points) occurred after thrombolysis in 44-old-year patient had initial severe neurological deficits (hemiplegia, hypoesthesia, dysarthria, gaze paresis (NIHSS score 15 points)). This led to the full recovery of lost function and to the independence of the patient’s daily life. Thus, systemic thrombolytic therapy can significantly reduce the degree of neurological deficit and improve outcome in patients with ischemic stroke.