The purpose of this work is to study the relationship of the gene SLC6A3 rs27072 with nicotine addiction in the smoking population living in Yakutia. In total, we examined 100 people (men and women aged 20 to 70 years). The status of smoking was revealed at the questionnaire. Smoking cigarettes, like many other addictives, has a genetic component. The SLC6A3 gene is an important candidate for predisposition to nicotine addiction. Analysis of the polymorphism association of SLC6A3 rs27072 with nicotine addiction testified the absence of statistically significant differences between carriers of different genotypes, not only in the study group as a whole, but also separately in men and women. Probably, this is due to the small sampling and difficulties in determining the status of smoking using only questionnaires.

The article presents the results of the estimation of the subpopulation composition of lymphocytes in 66 patients with chronic toxic liver damage and anemia of a chronic disease on the background of the transferred infiltrative pulmonary tuberculosis. The use of a combination of sirepar and sodium nucleate in the treatment of such patients contributes to the elimination of the clinical phenomena of the combined pathology, and along with the improvement or complete normalization of the clinical indices in the patients examined, normalization of the cellular immunity parameters was noted, which gives grounds for recommendations on the use of the proposed combination of drugs in the complex treatment.

Cytological analysis of cervix inflammatory diseases was conducted on women aged 18 to 88. The results of the analysis showed a high incidence of disease in the age groups 18-29. In the middle age group (30-44 and 45-59 years), balancing of genital infections is noted and the first effects of infection with viral infections appear (dysplasias of varying severity and background changes in the epithelium). In women in the older age group, mainly inflammatory processes (atrophic colpitis) were observed, which is associated with the intense influence of sex hormones. Generally, long-term preservation of viral HPV is associated with high-oncogenic risk types of HPV infection (mainly HPV 16). Remote causes of viral infection were found rarely (2.9%) on menopause, but it has the important prognostic value, which can predict the risk of cervical pathology development. Inflammation processes (senile vaginitis) are found in the old age group of women (20,9%), which is due to the intensive influence of sex hormones (estrogens). At this period the lack of estrogen harms the main protective properties of the stratified squamous epithelium. As a result, the number of lactobacilli is decreased or completely disappeared by the cause of conditionally pathogenic and pathogenic flora overgrowth.

Thus, infectious-inflammatory diseases of the female genital organs caused by various pathogens, sexually transmitted diseases, or nonspecific microflora, represent a serious medical and social problem.

Glutathione is very important in cells protecting, however, its high concentration in tumor cells can increase their survival by raising resistance to chemotherapeutic drugs and free radical oxidation. The effectiveness of chemotherapy treatment often depends on the individual genetic characteristics of the patient, his sensitivity to pharmaceutical drugs. According to scarce existing research it is indicated that tolerability of chemotherapy among Asians is lower compared to Caucasians. In this regard, we decided to evaluate the influence of ethnicity on the indicators of the glutathione system in patients with lung cancer and persons not suffering from oncopathology.

We examined 50 people with lung cancer, admitted to the Yakut Republican Oncology Center. The control group was selected based on age, gender and ethnicity and included 50 people. The main criterion for selection in the control group was the absence of cancer. The concentration of reduced glutathione, TBA-active products, activity of glutathione reductase, glutathione-S-transferase, glutathione peroxidase were determined by the spectrophotometric method.

The results of our study showed that the concentration of reduced glutathione (Yakuts by 70.7, Russians by 52.4%), the activity of glutathione peroxidase (Yakuts by 34.4, Russians by 18.6%) in the body of patients had been decreasing. The activity of glutathione reductase in the body of patients with lung cancer decreased in Yakuts by 10.5%, while in Russians it increased by 13.0%.

The results of our research testify to the depletion of the glutathione system in the group of cancer patients of the Yakut ethnicity, which is probably the reason for the severe tolerance of chemotherapy.

Red blood cells (RBC) morphology of deceased from various causes (injury, hypothermia) was examined in this study by using scanning electron microscopy. The obtained data shows that the appearance of certain forms of cadaveric erythrocytes depends on the causes of death. Therefore, when death is caused by stabbing and gunshots RBC take acanthocyte forms and in cases of fatal hypothermia RBC take echinocyte forms. The results of an experiment carried out in vitro, at small negative temperatures,show the appearance of acanthocytes in observed blood samples. Based on theobtained data and on the ability of echinocyte to return to normal form, it can be concluded that the probability of restoring the vital activity of the frozen organismsare possible.

Arterial hypertension is one of the major independent risk factors for complications of cardiovascular diseases, stroke, myocardial infarction, acute and chronic heart failure. In the structure of cardiovascular diseases arterial hypertension occupies the first position in disability and mortality of the working population. In recent years, this contributes to the growth of psycho-emotional stress, anxiety and depression. Periods of sharp changes heliometeofactors also combined with an increase in the proportion of individuals with complications of hypertension. Thus, in the period of magnetic storms, there was an increase in gamma radiation power (within the regional norm), an increase in the degree of psycho-emotional stress and a change in the concentration of electrolytes in the blood of both healthy and persons with cardiovascular disease. The aim of the study was to establish the relationship between the dynamics of γ-background of the environment during magnetic storms and the content of potassium and sodium in red blood cells in patients with hypertension with different temperament and anxiety, taking options for antihypertensive therapy: targeted and not targeted (empirical) on the blockade of psychosomatic characteristics of patients, as well as to determine the most effective treatment option. The prevailing temperament – choleric, sanguine, phlegmatic and melancholy – was determined using the psychological test of John Eysenck and A. Belov, the presence and severity of depression – Je. Ahmetzhanov psychological tests. Potassium and sodium content in erythrocytes was determined by ion-selective method. The gamma background of the medium was measured using the dosimeter «Master».

It was found that the decrease in the activity of the sympathetic Department of the autonomic nervous system and the hypothalamic-pituitaryadrenal system (cortisol), and the increase in the activity of the renin-angiotensin-aldosterone system (aldosterone) in the temperamental series of choleric – sanguine – phlegmatic – melancholy was combined with a decrease in the level of oxygen utilization by tissues and potassium content in erythrocytes and an increase in sodium content in both healthy and patients. Compared with the empirical version of antihypertensive therapy, against the background of a targeted treatment option, the period of return of the values of the studied parameters, the level of oxygen utilization by tissues, the content of potassium and sodium in erythrocytes, as well as the degree of reaction of the body (according to the correlation analysis) were practically the same as in healthy individuals of the corresponding temperament, which indicates in favor of a higher efficiency of the treatment option targeted at the relief of psychosomatic features of the patient.

The article analyzes the psycho-emotional state of persons with cardiovascular disease, depending on gender and the socio-hygienic factors. The study analyzed the results of 140 people with cardiological diagnosis of various etiologies in terms of situational and personal anxiety, depression, hostility, and aggressiveness. The psychodiagnostic examination included Beck Depression Inventory, State-Trait Anxiety Inventory, and BussDurkee Hostility Scale. Among the surveyed there were 68 women (mean age = 43.7 years) and 72 men (47 years). The analysis showed that at the age of 41 to 50 years we found the highest indicators of situational and personal anxiety, and aggression. Significant depressive symptoms are more often noted between the ages of 31 and 40 years. Among women we’ve found significantly higher rates of anxiety and depression. There were no significant differences in indicators of hostility and aggression. A combination of high hostility and low aggressiveness is noted, which indicates a tendency to contain and suppress aggressive manifestations and may be a predictor of psychosomatic pathology. The main social risk factors in cardiovascular pathology affecting the psycho-emotional state of the subjects include the level of education, dissatisfaction with the state of health, financial situation, nutrition, lack of proper diet and sleep disorders in the nature of their aggression.

At present, treatment of inflammatory-destructive diseases of the oral cavity is still a relevant problem. Despite the fact that any dentist disposes a wide range of medical preparations, it is difficult to choose one with the least amount of complications. While managing elderly patients with dental problems the goal is not only to facilitate healing of the oral mucosa, but also to prevent the recurrence of pathology. Injections of platelet autoplasma may be useful in treatment of inflammatory-destructive diseases of the maxillofacial region. Injections of platelet autoplasma for inflammatory-destructive diseases of the oral mucosa, effect of synergism of this method in combination with other therapeutic means justify the need for further study of this issue. In this work, in order to study the regenerative potential, the simulated wound defect in the oral cavity of 30 dogs was treated experimentally. Regeneration control, treatment and supervision lasted 14 days alongside with application of various pharmacotherapeutical methods. To exclude additional factors which might affect the final result of the experiment associated with individual physiological features, study of experimental local treatment methods was carried out within one body: traditional methods of treatment; application of Tysol composition with L-arginine; injections of platelet autoplasma were included in the treatment plan as well as a combined method of treatment. Platelet autoplasma injections combined with Tizol applications with L – arginine was proved to help restore and heal the oral mucosa much faster comparing to other treatment methods.

The aim of our research was in defining hepatoprotective properties of new complex plant supplement on a rat model of D-galactosamine hepatitis. The new complex drug supplement is a dry extract consisting of Hypecoum erectus L., Hedysarum dauricum, Glycyrhhiza uralensis Fisch., Calendula officinalis and Scutellaria baicalensis. Intensity of the main pathogenetic syndromes was evaluated by biochemical tests, lipid peroxidation grade and morphological research. The use for the complex extract resulted in correction of functional state of the liver, inhibition of cytolysis and cholestasis, delay of LPO and enhancing synthetic function of liver manifested in albumin and fibrinogen increase.

The features of the clinical course of alcoholic liver disease in various ethnic groups were studied in comparison with chronic alcohol-viral and viral hepatitis B.

All patients underwent clinical and laboratory examination.

It was revealed that in indigenous patients chronic alcoholic hepatitis was formed in a shorter time, as evidenced by the high frequency of their detection in the age groups up to 20 and from 20 to 29 years and was characterized by more pronounced clinical manifestations.

The main distinguishing features of alcoholic liver damage, regardless of the presence or absence of CVH infection, are hepatomegaly, the prevalence of pronounced extrahepatic manifestations, increased activity of AlAT in combination with GGT, and immunological changes.

We have studied the cytoarchitectonics of mucous-associated diffuse lymphoid tissue (MALT - mucosa-associated lymphoid tissue) of the larynx in persons who died from hypothermia. The material was collected in the summer (June, July, and August) and winter (December, January, and February) seasons of the year with the support from the State Budget Institution of the Bureau of Forensic Medical Examination of the Sakha (Yakutia) Republic. Death caused by low natural temperature occurred most often at ambient air temperatures ranging from -34°C to -40°C, less often at -31°C to -33°C. As one of the most frequent factors contributing to the onset of death from hypothermia is alcohol intoxication, for comparative characteristics of the morphology of lymphoid tissue, we also investigated the group of persons who died from general hypothermia with underlying alcohol intoxication.

Significant changes in the cellular composition of the mucous-associated diffuse lymphoid tissue of the larynx were revealed: a decrease in Tand B- lymphocytes and plasma cells and an increase in the number of destructively altered cells and macrophages.

Aseptic necrosis of the femoral head (ANFH) is one of current problems in orthopedics today. The arthroscopy of a hip joint in ANFH is a modern way of minimal-invasive surgery. We use the following staged means of arthroscopy: capsulotomy and synovectomy, debridement and sanation of a joint, revision of degenerative and dystrophic changes, resection of the affected cartilage, microfracturing, removal of free microscopic and macroscopic fragments of cartilage. The quality of life in operated patients before and after was estimated on Harris Hip Score (HHS). Arthroscopy of the hip joint has shown the positive clinical results and indeed improves quality of life in patients. It is necessary to revise more deeply all possibilities of arthroscopic surgery of the hip joint, to estimate all results, to improve treatment methods and to achieve long remission of a disease.

On the basis of the orthopedic department of the KGBUZ Regional Clinical Hospital No. 2 in Khabarovsk, an analysis of the frequency of occurrence of aseptic necrosis of the femoral head, its various diagnostic methods, conservative and operative treatment, and the pathological picture of the disease among the adult population in various age categories was made. The obtained positive results of treatment indicate the need for further study of the problem in order to achieve a long lasting remission, and possibly a complete recovery of the patient. 

Aim. To identify the peculiarities of surgical treatment of APIDST.

Material and methods. The analysis of treatment of 302 men with APIDST in the department of purulent surgery of the 301 Military Clinical Hospital of Khabarovsk from 1987 to 2013 was carried out.

Results. Surgical emergency procedures were performed in 40 (13.2%) patients with APIDST before admission to the hospital and in 262 (86.8%) patients with APIDST immediately after admission to the hospital. Necrectomy was performed in 6 (2.0%) patients with APIDST before admission to the hospital and in 118 (39.1%) patients with APIDST immediately after admission at the hospital. The signs of anaerobic infection were found during the surgical procedures in 260 (86.1%) patients. During hospitalization 2 or more surgical procedures were required in 188 (62.3%) patients with APIDST due to the progression of the disease.

Conclusions. In case of substantiated suspicion of APIDST surgical intervention should be based on the main principles of surgical treatment of anaerobic infections regardless of the duration of the disease. It is recommended to start the procedures with a small diagnostic incision through the site of introduction of the initiating substrate with a mandatory revision of the subfascial space and performing radical necrectomy.

In this paper we present for the first time the results of the audiological and clinical-genealogical research of the population of settlements Batagai-Alyta and Kustur of the Eveno-Bytantaisky National District (ulus) of the Sakha Republic (Yakutia) for studying the postlingual form of deafness of unknown etiology, which we for the first time have identified earlier in 3 Evens. As a result of an audiological examination of 72 people, 10 patients from 6 nuclear families who met the criteria of postlingual form of hearing loss were found. The segregation analysis carried out in these families confirmed the autosomal recessive type of inheritance of this form of postlingual hearing loss. The distant relationship of the examined patients with postlingual hearing loss living in two villages of the Eveno-Bytantaisky National District of the Sakha Republic can indicate to the role of the founder effect in the local prevalence of this pathology. The results of present study and obtained expedition material will be the basis for further research of the molecular genetic etiology of this form of deafness and the discovering of mechanisms of its accumulation in this region of Yakutia.

An analysis of the body mass index (BMI) revealed the ethnic, gender, age differences among the groups of hospital patients with coronary heart disease (CHD) aged over 60. Significantly higher value of BMI was identified in non-indigenous patients compared to Yakut group that was respective to the obesity of p <0,001. Maximum values of BMI were established in the older group aged between 60 and 74 years. The decrease in BMI can be observed with the age in the senile age group and more clearer dependency on age in the indigenous group. When comparing the BMI among the age groups: older, senile age and long-livers, the lower value of BMI was noted among long-livers (p <0,001). The obesity was identified significantly more often among women.

The purpose of the study is the serological and molecular-biological monitoring of the latitude of viral hepatitis B, C, D and E in the Republic of Sakha (Yakutia).

Materials and methods. Used official statistics and annual reports. The analysis of the incidence of acute and chronic viral hepatitis B and C, hepatitis carriers for the period from 1999 to 2016, as well as serological and molecular biological monitoring of the latitude of viral hepatitis B, C, D and E in the Republic of Sakha (Yakutia).

Results and discussion. In the dynamics of the incidence of AVG B, the carriage of VGV and VG C in Yakutia, there is no existence of any of their own laws that are not inherent in many regions of Russia. In general, based on the level and dynamics of the incidence of chronic viral hepatitis In the country, it is possible to characterize the overall epidemiological situation as unfavorable, even despite a noticeable decrease in the incidence. The unstable undulating nature of the incidence and their increase in recent years indicate the persistence of epidemiological tension with respect to viral hepatitis B. A distinctive feature of the structure of chronic viral hepatitis in the Republic of Sakha (Yakutia) is the high incidence of chronic viral hepatitis B and the steady growth of chronic viral hepatitis C. The infection of the population of the Republic with hepatitis B and C viruses can be determined as high. This situation, given the high frequency and severity of the adverse effects of HBV, HCV infections, as well as the endemicity of HDV infection, poses a threat to public health. According to the results of serological, molecular biological studies, a high incidence and infection rate of the population of the republic with all known hepatitis viruses was stated. An increased circulation of hepatitis E virus, previously considered a tropical infection, was also detected in the Arctic zone of Russia.

Conclusion. In general, an epidemiological analysis of the incidence of acute and chronic viral hepatitis showed that in the Republic of Sakha (Yakutia) a highly endemic area with respect to viral hepatitis C, B, D and E, and such a tense epidemiological situation requires urgent appropriate measures. Studies of the genetic heterogeneity of the identified hepatitis viruses and the pathogenetic mechanisms of the development of the disease among the indigenous people of the Russian North are also required.

Progressive muscle atrophy (PMA) is a rare disease of the motor neuron disease group (MND), which is characterized by selective lesions of the anterior horns of the spinal cord.

Objective: to study the features of the course of sporadic and family form of PMA over the period from 1986 to 2016.

Materials and methods: in 2006, a personalized register was introduced, which included patients with MND (amyotrophic lateral sclerosis, progressive muscular atrophy, progressive bulbar paralysis, primary lateral sclerosis). Since 1986 till 2006 patients were introduced after a retrospective study. The study included 15 patients with sporadic form and 5 patients from the same family. For the described study, patients with PMA were divided into 2 groups: 1 group included sporadic cases of progressive muscle atrophy (n=16), 2 group consisted of sick family members of a family case of 2 women and 2 men (n=4). Clinical examination of patients included assessment of somatic and neurological status in the onset of the disease and its further development, age of onset and duration of course.

Research methods: needle electromyography (EMG), Amyotrophic lateral Sclerosis Functional Rating Scale (ALSFRS) [9], spirography (LNG), forced vital capacity (FVC), magnetic resonance imaging (MRI), computed tomography (CT) of brain and spinal cord. In 9 cases, direct DNA diagnosis was carried out to exclude Kennedy’s Bulbo-spinal amyotrophy.

Results: Our study revealed a moderate rate of progression in sporadic cases and a slow rate of progression in the family form of PMA. In our study, the duration of PMA was significantly higher in the family form and was 140±37.8 and 53.6±30.3 months in sporadic cases (p =0.003). In the family form of the disease, an earlier age of debut was observed than in sporadic PMA and in men the disease began earlier than in women.

This article demonstrates the advantages of pharmacological medical termination of missed abortion. It presents an analysis of women’s experiences of pharmacological and surgical terminal of missed abortion based on material from the Department of Gynecology №1of the SBI RS (Ya) “Yakutsk City Clinical Hospital (YCCH)”. The study included only patients with normal hemostatic system parameters. Patients with MA who have contraindications to the use of Mifepristone and Misoprostol were also not included in the group. The comparison group included 69 patients with MA, who underwent a surgical method of emptying the uterine cavity by vacuum aspiration. All patients were under observation in the gynecological department of the YCCH. To establish the diagnosis of MA a female pelvic ultrasound scan was performed using a vaginal sensor. The ultrasound control diagnosis was performed on the 14th day after taking Misoprostol and the vacuum aspiration. The complications and treatment options are presented.

Aim. The purpose of the research is to study the characteristics of the physical development of 7-8-year-old girls with non-physiological perinatal period.

Materials and methods. 236 girls of 7-8-year-old girls from Kirov (Russia) were divided into groups: group I - control (n = 60, physiological perinatal period), group II (n = 58, late gestational hypertension in the anamnesis), group III (n = 61, placental insufficiency in the anamnesis), group IV (n = 57, maternal anemia in the anamnesis). We measured their physiometric characteristics (heart rate, blood pressure, vital capacity of lungs, flexion muscle strength of the right and left hand, maximum oxygen consumption) and anthropometric ones (length, body weight, chest circumference, its excursion). Then the corresponding indices and coefficients were calculated.

Results. Girls with late gestational hypertension have lower mass-growth index, the Quetelet index and dynamometry indicators; girls with placental insufficiency have higher systolic blood pressure and lower work power; girls with maternal anemia in the anamnesis have low mass-growth index, the Quetelet index and the power of work.

Conclusion. It is shown that the studied perinatal pathologies have a similar remote effect on physical development: gestational hypertension and anemia of a mother during pregnancy affect the mass-growth index and the Quetelet index, placental insufficiency and anemia influence the work power. Thus, we consider these indicators of 7-7-year-old girls (mass-growth index, the Quetelet index and work power) to be the most sensitive to pathologies of the perinatal period.

In Yakutia, the contribution of GJB2 mutations to the etiology of hereditary deafness is 48.8% and is one of the highest in Asia, due to a significant accumulation of the mutation of the splice site c.-23+1G>A in the GJB2 gene due to the founder effect in the Yakut population (“age” of mutation ~ 800 years). The results of scientific research in the field of genetic forms of deafness are actively introduced into practice in the form of various test systems of routine DNA diagnostics. However, the bioethical, social and psychological problems arising from the application of these genetic technologies are less well understood than the molecular genetic aspects of deafness. We conducted a questionnaire and a selection of buccal epithelium of 241 people, whose mean age is 21, in order to analyze their opinion on the potential risk of a deaf child’s birth and conduct genetic testing for the presence of the mutation c.-23+1G>A in the GJB2 gene. The frequency of heterozygous carriage of the mutation c.-23+1G>A of the GJB2 gene among hearing young people (n = 241) in the Yakut population was 10.8%, which is comparable to the previously obtained data. Analysis of data from the questionnaire with genotypes shows that there are no statistically significant differences in the respondents’ responses (p>0.05). As a result of the questionnaire, it is shown that most young hearing people think that deafness can be a hereditary disease (62.6%). Most young people assume the possibility of birth of a deaf child from hearing parents (81.33%), but only 2.49% of respondents agree with this risk. Such an answer can be explained by the protective internals of the psyche, when a person assumes the existence of the same risk of the birth of a deaf child in all people, but denies such a possibility in himself.

The main results of the infectious service were analyzed for the study of its state in the Republic of Sakha (Yakutia) during 2000-2017. Also there were given comparative characteristics with analogical indicators in the Russian Federation. According to results of 2017, the growth of morbidity in 12 infections was recorded in the Republic. Due to persisting unfavorable situation, the problem of realization of medical service to infectious patients demands to take system arrangements on deficit reduction of infectious diseases’ specialists and infectious beds in hospitals; to increase financing of current medical care in the Republic of Sakha (Yakutia).

Background. The analysis of the quality of medical care for children with cancer is based on statistical data. Evaluation of the results is also the basis of the strategy for the development of medical care for this category of patients.

Aim. Analysis of the main indicators characterizing medical care for children with cancer in the Far Eastern Federal District.

Methods. The operative reports for 2017 of the executive authorities in the sphere of health protection of 7/9 (77,8%) subjects of the Russian Federation that are part of the Far Eastern federal districts have been analyzed (The Ministry of Health of the Republic of Sakha (Yakutia) and the Khabarovsk Territory did not provide the data).

Results. The number of children was 790855 (0-17 years), the number of children’s oncological beds was 60 (0.7 for 10 thousand 0-17 years), the average number of days of berth employment in the year was 283.7 days. In 4 (57.1%) subjects of the department of pediatric oncology are absent, in 2 (28,6%) - there are no children’s oncological beds. The number of doctors providing medical care to children with cancer is 13, of them 7 (0.8%, 0.08 for 10 thousand 0 - 17 years) have a certificate of a doctor-pediatric oncologist. In 5 (71.4%) subjects there are no doctors-children oncologists. The incidence of malignant tumors was 15 (per 100,000 0-17 years), the prevalence was 90.1 (per 100,000 0-17 years), the mortality rate was 2.9 (per 100,000 0-17 years), the one-year mortality rate - 7.6%. 5% of patients were actively detected. 52 (43.7%) of primary patients were sent to medical organizations of federal subordination, 8 (6.7%) of primary patients left the territory of the Russian Federation.

Conclusion. Low morbidity and mortality are attributable to defects in the account and the lack of reliable follow-up data. It is advisable to introduce electronic accounting systems. For reliable estimation of the level of provision of the population with children’s cancer beds and the percentage of patients sent for treatment in medical organizations of federal subordination, audit of patients’ illnesses is necessary. Deficiency of children’s oncologists and a low percentage of patients identified should be eliminated by reforming the training of medical personnel.

The Republic of Sakha (Yakutia) belongs to Arctic territories. Hard social and economic conditions cause broad development of helicobacter infection in the republic. A comparative analysis of detectability of Helicobacter pylori CagA strain among adults and children with chronic gastritis since 2012 to 2016 according to Republic hospital №1 - National center of medicine (RH №1-NCM) revealed a distinct decrease in these indexes among adults and children with chronic gastritis. Thus it demands its further identification and treatment for prevention of stomach diseases of oncological risk group. This article presents research data of detectability of Helicobacter pylori among adults and children for 6 years in RH №1- NCM clinical-immunological laboratory by method of enzyme immunoassay on antibodies to antigen Cag A Helicobacter pylori. The blood serum of patients from the National center of medicine was the material for this research.

15868 patients were examined, 6993 of them were revealed Helicobacter pylori Cag A that made 44,1%. The detectability for the research period decreased from 49,6% to 40%. 3827 adults out of 8272 patients were revealed Нр (+) Cag A that made 46,3%, and detectability decreased from 52% to 42% for this period. Among 7596 sick children a decrease in detectability of Нр (+)CagA was from 47,4% to 39,1%. Thus, a comparative analysis of detectability of Нр (+)CagA for the reporting period proved a distinct decrease in indexes among adults and children with chronic gastritis.

Serological diagnostic methods for diagnosing the pathology of the upper digestive tract are of great importance for mass medical examinations. They allow diagnosing the disease in the early (asymptomatic) stage.

There is a tendency to reduce the rates of Helicobacter pylori infection among patients with chronic gastritis, which requires further identification, treatment and prevention among the population.

The purpose of research is to study the quality of medical and social care and the attitude of the population towards HIV-infected people in Yakutsk in the Republic of Sakha (Yakutia). The main methods of research are the analysis of normative and legal acts and statistical data, a sociological questioning. A study of the opinion of HIV-positive people about their satisfaction with the quality of medical and social services, living standards and social status showed that 90% of patients receive the necessary medical care and often attend the AIDS Center. The results of the research showed that the majority of HIV-infected people in Yakutsk, young people aged 19 to 29, contracted sexual intercourse, which in turn indicates that there are still many young people who are poorly informed about the threat HIV infection and other STDs. Survey of HIV-infected and medical workers of the State Bank of the Yakut Republican Center for AIDS Prevention and Control revealed that in our republic a sufficiently effective and qualified medical and social work is carried out, providing crucial help to HIV-infected people, but not enough social assistance is provided. It has been found that the society is generally benevolent towards HIV - infected patients and is ready to provide some form of support to a person living with HIV, regardless of whether they know him or not. However, the responses also showed that HIV-positive status appears as an extremely strong social label, significantly worsening the attitudes of others around it. It was noted the need to open a sanatorium-type rehabilitation center for HIV-infected people.

Indicators of morbidity of adult population according to out-patient office of Hospital of the Yakut Science Center of Complex Medical Problems (Yakutsk) during 2015-2017 are presented in article. The characteristic of dynamics and structure of cases of the general and primary incidence is given. Decrease in level of the general incidence for all analyzed period is established. In structure of the general incidence of adult population the prevalence of diseases of respiratory organs and the blood circulatory system is revealed. The analysis of dynamics of indicators of primary incidence has shown the stable growth of her level with prevalence a case of diseases of respiratory organs. The obtained data on the dynamics and distribution patterns of diseases have served as the basis for selecting the directions of molecular genetic research, the search for associations of genetic markers of the system of cytokines responsible for the development and maintenance in the body of chronic systemic inflammation, the genes B2 - adrenoreceptor and genes of cold receptors involved in the hereditary predisposition to hyperreactivity of the respiratory and the cardiovascular system in response to the effects of low temperatures.

The article provides a retrospective analysis of child mortality in the Republic of Sakha (Yakutia) for the period 2006-2015. According to the analysis, there is an evolution of child mortality rates, a steady trend towards a decrease in child mortality rates for many groups of diseases, the presence of gender differences in the structure of child mortality, high child mortality rates in the Arctic regions of the Republic of Sakha (Yakutia).

Insertion of high-tech methods of medical care, input of pediatric and prenatal centers played a huge role for decreasing child mortality rate. Especially it is up-to-date issue in the conditions of the Arctic region, where children’s destinies are sometimes resolved by long distance and possibility of ambulance aircraft. Sufficiently huge number of child and adolescent mortality in RS (Y), due to external causes, makes social component of loss. Thus, in the modern stage of development of the Republic of Sakha (Yakutia) the peculiarities of child mortality include, at first, huge demographic significance, at the second-dependence on social life conditions. Because child health is a social category, child mortality rate and structure are integral criterions of population life quality rating and the quality of medical care in the region.

221 employees of river transport of Yakutia at the age 20-49 years old were examined simultaneously. Metabolic syndrome (MS) was verified in 7.7% of employees of non-indigenous nationality. One of the most significant risk factor for MS was the age (F = 8.24, p = 0.005), 58.8% of people with MS belong to the age group from 40 to 49 years old. A sign of disadaptation of an organism - metabolic disorder was observed among people with the experience of 10 and more years. The degree of disorder of metabolic processes is mostly noticed among employees of non-indigenous nationality with an experience of residence in Yakutia of 15-20 years. Revealed age, severe arterial hypertension and the degree of dyslipidemia among river transport employees with MS in comparison with the population with MS indicate the acceleration of mechanisms of metabolic disorder in Yakutia.

The article presents a comparative analysis of psycho-emotional peculiarities of persons from polar, sub-polar and middle latitudes, taking part in multiple-latitude monitoring, in relation to a psychological sensitivity to heliogeomagnetic factors. 64 relatively healthy persons, males and females, have been examined using the following tests: State-Trait Anxiety Inventory (STAI) (Ch. Spielberg, U. Khanin), E. Heim Test, Psycho-Geometric Test. Reactive anxiety and integral index of heliogeomagnetic activity (Kр-index) have been determined by a two-month phase of monitoring, other tests have been checked once in the beginning of a phase. Group I consisted of persons with maximum coincidences in Kр-index peaks and in reactive anxiety. Group II consisted of persons with no coincidences. It is found that the volunteers from the group I and II, as in northern (polar and sub-polar) as in middle latitudes, had a number of similarities depending on a psychological sensitivity to heliogeophysical factors (tending to analyze problems, emotional suppression, agreeableness, purpose). The findings of the study allow organizing patient-specific preventive methods for psycho-somatic diseases and neuroticisms in relatively healthy persons taking into consideration their psychological sensitivity to changes in heliogeomagnetic activity, and the latitude of their place of living.

The climatic conditions of the North have been forcing the human body to use additional social and biological means of protection against the adverse effects of environmental factors. It should be noted that, first of all, the cardiorespiratory system undergoes the influence of these abiotic factors. In this regard, the purpose of the research was to study and identify the characteristics of the cardiovascular system in young male residents of Magadan Region who differ in terms of residence in the northeast of Russia. 1632 young male subjects aged 17 to 21 and permanently residing in the city of Magadan, were examined in 2005–2017 using standard methods for determining cardiovascular parameters. Depending on the length of residing in the region all the subjects were divided into 4 groups. They represented three generations as well as migrant Caucasians who were not born in Magadan Region but came there from the central regions of the country. Residents of the northeast of Russia with short periods of residence in the North demonstrated a state of stress in the cardiovascular system manifested by an increase in systolic pressure, total peripheral vascular resistance, heart rate, and a decrease in the blood stroke volume. At the same time, the representatives of the 3rd generation had better functioning of the system. They were significantly lower in blood pressure (both systolic and diastolic) and the heart rate. In addition, the subjects of this group had minimal cardiac output, which indicated a more economical functioning of the cardiovascular system in the conditions of the northeast of Russia.

Aim. To analyze the usage of the fixed-doses combinations for treatment of arterial hypertension in three northern regions of the Far Eastern Federal District.

Material and methods. The pharmacoepidemiological study of realization of antihypertensive drugs in the pharmaceutical organizations of the Magadan region, Kamchatka Krai, the Sakha Republic (Yakutia). The studied period was 2013-2017. Total sales were calculated based on the amount of drugs and defined daily doses, acquired by patients. The range of international nonproprietary names has been divided into therapeutic classes. Further calculation of indicators in group for each combination was carried out. The analysis was performed with usage of Microsoft Office of Excel 2015.

Results. In a therapeutic class of combinations β-blockers with diuretics or calcium channel blockers the combination atenolol+сhlortalidone remained the leader in three regions. Shares of sales of other international nonproprietary names were insignificant, and did not exceed totally 10%. Valsartan+amlodipin had the greatest indicators of realization in the therapeutic class of аngiotensin II antagonists with calcium channel blockers. Among combinations of аngiotensin II antagonists and diuretics, the combination of losartan+hydrochlorothiazide had more than a half of the acquired defined daily doses. Since 2017 in the Sakha Republic (Yakutia) were more actively used valsartan+hydrochlorothiazide, azilsartan medoxomil+chlortalidone. In a therapeutic class of angiotensin-converting-enzyme inhibitors with calcium channel blockers in the Magadan region and in the Sakha Republic (Yakutia) the leader of the market was the combination of lisinopril+amlodipine, in Kamchatka Krai - perindopril+amlodipine. Acquisition of the drugs containing ramipril and amlodipine has increased in all three regions. In a therapeutic class of combinations of angiotensinconverting-enzyme inhibitor with diuretics, the redistribution of preferences from drugs containing enalapril+hydrochlorothiazide in favor of perindopril+indapamid was observed. The combinations lisinopril+hydrochlorothiazide had the considerable share of sales in the Sakha Republic (Yakutia). Usage of a combination of hydrochlorothiazide+triamterene and drugs of a reserpine is characteristic of the Magadan region and Kamchatka Krai. In the Sakha Republic (Yakutia), in comparison with other explored regions, triple-component drugs are more actively applied.

Conclusions. The greatest part of realization of the defined daily doses of the modern antihypertensive fixed-doses combinations was the share of only seven international nonproprietary names, on condition of presence in the pharmaceutical market of 43 variants. Current situation proves expediency of prescription of the applied schemes of drugs therapy, taking into account the available range of drugs in the pharmaceutical organizations of regions.

A study of the association of insertion-deletion (ID) polymorphism of the ACE gene with arterial hypertension and risk factors of cardiovascular diseases in the indigenous people of the northern territory of Yakutia was conducted. The obtained data show that the representatives of the indigenous population with the ID genotype of the ACE gene are associated with a level of systolic blood pressure, abdominal obesity. Carriers of this genotype of the ACE gene have the greatest chance of developing hypertension, metabolic syndrome. The heterozygous DD genotype is associated with lipid metabolic disorders both in hypertensive patients and persons without hypertension. Therefore, the research confirms influence of the D allele ACE gene polymorphism onto genetic mechanisms of cardiovascular diseases development.

There is still no clear understanding of the human papillomavirus infecting, as well as its eliminating process from the body. It is known that cervical cancer is caused by human papillomavirus in 99 percent of cases, but only in a small number of human papillomavirus infected women leads to develop cervical cancer. At the same time, based on cytological and histological analysis of the women cervical samples, it is currently impossible to establish criteria that would indicate the malignant progression possibility. Blood, as a unique tissue with specific and nonspecific protective adaptive mechanisms, can be a source of crucial information about the human body papillomavirus infecting. The article provides an overview of the research devoted to the human papillomavirus detection in blood and identifies unresolved issues arising from these studies.

The relevance of this article is due to the fact that cardiovascular diseases are currently the leading cause of death and disability worldwide. The leading role in the structure of mortality from cardiovascular diseases belongs to coronary heart disease. Ischemic heart disease (IHD) is a chronic disease that develops with insufficient oxygen supply to the myocardium. The main cause (more than 90% of cases) of insufficient intake of oxygen is the formation of atherosclerotic plaques in the lumen of the coronary arteries, the arteries of the blood supplying the heart muscle (myocardium). One of the main drugs for antiplatelet therapy in cardiology is clopidogrel, the use of which can reduce the incidence of thrombotic complications. Clopidogrel is the most famous member of the thienopyridine group. Clopidogrel remains the main drug for antiplatelet therapy in patients who received stenting of the coronary vessels for acute coronary syndrome. The rationale and design of the observational study aimed at testing the hypothesis that the high frequency of the genetic polymorphism of cytochrome CYP2C19*2 is associated with coronary stent thrombosis is presented.

Indicators of the hospitalized incidence of adult population according to YSC CMP Hospital during 2015-2017 are presented in article. The characteristic of dynamics and structure of the cases demanding performing treatment in stationary conditions is given. Growth of cases of hospitalization of patients with metabolic disorders, including diabetes 2 types and diseases of cardiovascular system is established. The obtained data served as the basis for conducting research and developing molecular genetic methods of diagnosis in relation to this pathology.

The frequency of clinical manifestations in patients with joint damage among the indigenous people of Yakutia (n = 687) was studied. It is revealed that the damage of the joints can begin both in the early childhood (2 years) and in old age (77 years); on average, joint lesion starts at 41-43 years. The most common symptoms of joint damage are pain in the joint and crepitus in the knee joints. Among women, there are more often observed: swelling of the wrist and knee joints, restriction of mobility of the wrist joints and bilateral crepitus at the knee joints; among men, one-sided crepitus at the knee joints. With age increasing, the duration of pain and the frequency of changes in the configuration of the joints at the time of inspection increase.