Authors present results of neuron-specific enolase (NSE) determination in neonates with hypoxic-ischemic brain disorders. Examination showed correlation of NSE serum level and severity of brain disorders and the gestational age in neonates. As well as high probability of infectiousinflammatory diseases in newborns with a high level of NSE.

The frequency of calls to emergency medical care and hospitalization in children with exacerbation of allergic diseases based on allegrocentre with day care hospital of a large industrial area of Saint-Petersburg is analyzed.

In this article the authors present results of the anthropometric examination of the 11 675 children up to 3 years, belonging to different ethnic groups living in the Republic of Sakha Yakutia. The Sakha – 7197, Russian – 3915, the North small in number people – 563. The height of these children is different but the Russian children have a higher height than the Sakha and a small in number people of North. The weight of the small in number people of North is higher than the Sakha and Russian on this period of life.

We have carried out a study of actual diet among 240 children with pathology of organs of sight in the conditions of a preschool institution in Yakutsk. The received data on menu-apportionment point out the lack of fish, dairy produce (milk, sour dairy produce, curd, cheese), fresh fruit, low content of calcium, magnesium and vitamin E. The results of the study can substantiate the necessity to correct the nutrition of children with pathology of organs of sight in a preschool institution.

The article presents the results of molecular genetic typing and studying of resistance to antibiotics of Pseudomonas aeruginosa nosocomial strains, isolated from the clinical samples of the patients in period of 2010-2011. Clonal spread of multidrug-resistant (XDR) metal-beta-lactamaseproducing P.aeruginosa strains ST235 (VIM-2) were revealed.

The cellular composition of the oxidation-state of metabolic function and cytokine-producing activity of cells of bronchoalveolar (BAL) fluid of patients to clarify the mechanisms that determine the severity of the clinical course of bronchial asthma (BA) was studiedю
The increased number of neutrophils in BAL fluid of patients with asthma as the worsening of the disease was marked. Also it was found that with the worsening of the severity of BAL fluid cells of asthmatic patients secrete more Th2 cytokines profile. The authors substantiated the fact that these changes in the functional state of pulmonary cells are the basis of the mechanisms that determine the severity of the clinical course of asthma.

A high spread of dyspepsia symptoms have been revealed among elderly population in Yakusk. Reliable differences of dyspepsia symptoms have been noted according to sexual and ethnic indications.

In given article the comparative characteristic of application of two kinds of neiroaxials blockade is resulted: symmetric spinal and unilateral spinal anaesthesia at operations on a ground floor of a belly cavity at patients of the senior age groups. It is proved that at use of unilateral spinal anaesthesia stability of indicators of haemodynamics, smaller requirement in infusion therapy and sympathetic support is marked.

The paper carried ethological study of the structure of non-verbal behavior of patients with paranoid schizophrenia in relation to the evolutionary strategy of human behavior. A relationship between the clinical types of defect states, behaviors, according to the four evolutionary models of human behavior (egoistic, altruistic, cooperative, agonist) is ascertained.

By methods of microscope research cytoarchitectonics of mucous membrane’s diffuse lymphatic tissue of larynx of the deceased from common hypothermia and alcohol intoxication was under study. It was revealed that some changes in cellular composition of mucous membrane’s diffuse lymphatic tissue of larynx at mortally hypothermia – decreasing of T- and B- lymphocytes and plasmacytes and increasing of the number of destructively changed ctlls and macrophages, that let us confirm in suppression of local immunity of the deceased from natural low temperature in the territory of the Republic of Sakha (Yakutia).

In this research studying of interrelation of the quantitative value and calcium volume in a wall of coronary vessels as, possible risk factor of a failure of cardiac methods of treatment of an ischemic heart disease is carried out.

The article presents the clinical observations of episodes of loss of consciousness among aviation professionals representing a threat to safety. Results of complex examination showed features of clinical manifestations, the results of instrumental findings identified the predominant etiologic factors provoking paroxysms of loss of consciousness.

DNA sequencing of 51 exons and exon-intron junctions in COL1A1 gene in patients with osteogenesis imperfecta from Yakutia was performed. Two different mutations: mutations shifting the reading frame c.3540_3541insC (p.Gly1181AlafsX38) are identified in a patient of Yakut ethnicity and splicing site mutation c.4005 +1 G> T in patient of Russian ethnic origin. Mutation c.3540_3541insC (p.Gly1181AlafsX38) hasn’t been described early. Mutations lead to a clinical 1 type of osteogenesis imperfecta, identified in heterozygous state and are unique to each family.

The results of the analysis of 1365 cases of kidney cancer of Republic Sskha (Yakutia) population for 1991-2010 are presented. In Yakutia, the incidence of male and female kidney cancer in all age groups had a marked tendency to grow and is prognosed to have in both populations almost threefold increase compared to the original figures.

Efficiency of treatment and quality of life of patients at a gynecologic cancer immediately depend on timely diagnostics and treatment. Authors carry out the analysis of a contingent of patients with the female genitals malignant neoplasms for detailed studying of indicators of survival rate depending on a stage and treatment.

We present an evaluation and analysis of the changes in and territorial features of substance dependence disorders in the Kostroma Region, based on the 1999–2011 statistical materials that describe the structure and levels of primary incidence and prevalence. We determined the specific features of territorial differences in chronic alcoholism and drug addiction indicators. In addition, we determined their connection with disorder risk factors. No dependence was determined for chronic alcoholism levels on drug addiction indicators. For purposeful prevention of substance dependence disorders in specific districts, it is necessary to study specific disorder and relapse risk factors and the organization of narcological aid.

Diagnosis of edematous changes in the breast without clearly identifiable tumor is a challenging task. Differential diagnosis should include cancer and mastitis of various etiologies. The results of breast ultrasound, mammography, computed tomography and magnetic resonance imaging can be uninformative. Thorough examination of regional lymph nodes must be performed: presence of metastases in them, combined with clinical changes in the breast, confirms diffuse breast cancer. Any suspicious areas are subject to a biopsy. Echographic determined asymmetrical thickening of the skin over 3mm pathological evidence of edema.

Analysis of the poll of antiphthisic institutions heads showed some problems of the organization of TB care in terms of national health care reform. The main ones are poor condition of buildings, low staffing levels of tuberculotherapist, insufficient funding, lack of TB beds, low adherence to treatment of patients and incidence of tuberculosis, combined with HIV infection. Also the proposed measures to improve the effectiveness of TB services were studied.

The paper presents data of complex epidemiological analysis of acute intestinal infections in the Republic of Sakha (Yakutia) for the period from 2002 to 2011.

A research objective was an assessment of an expression of superficial markers of lymphocytes in patients with IHD of a various form depending on ethnicity. The received results of the comparative analysis depending on IHD form allow to confirm that destabilization of IHD is characterized by increase of an expression of CD19 + (B-lymphocytes), activation markers of CD25 + (a receptor to IL-2) and CD71 + (a trancferrine receptor), and also molecules of intercellular adhesion of CD54 + (ICAM-1). At unstable angina in persons of native nationality signs of deficiency of the Tcellular link (T-lymphocytes, T-helper), and also significant increase of expression СD11b + (integrine) in comparison with persons of non-native nationality are revealed.

The research aims at studying patterns and regional characteristics of morbidity and incidence of various papillomavirus infection and cervical cancer forms in the Republic of Sakha (Yakutia) in the pre-vaccination period and the first years of vaccination against this pathology. It is established that the studied periods do not show any significant differences or decreasing trend in anogenital (venereal) warts morbidity. The study revealed higher (by 1/6-2 times) incidence of high-risk HPV of type 16 in women, compared with men. There was no decrease in type 16 and 18 HPV incidence in 2008-2011 (the period of introducing low vaccination coverage), compared with the year 2007. There is a trend for increased CC morbidity in women aged 30-44 years.

A long-term laboratory study of drinking water to the level of calcium, magnesium and hardness in the different sources of water: the Lena river, lakes and underground water from wells. It was established that the low calcium and magnesium, as well as the total water hardness were drink detected in lake water. An analysis of statistical data on morbidity, mortality, and the infestation has revealed that people who low-mineralized, soft lake water are more susceptible to diseases of the circulatory system, as evidenced by relatively high coefficient of correlation between mortality from cardiovascular diseases and hardness of drinking water due to the presence of salts magnesium and calcium.

Analyzed literature proves the known fact that the state of women’s reproductive health depends not only on their gynecologic and physical health, but also is characterized by regional specifics and depends on ecological and demographic situation of the region.

In given article the general information on heavy disease – gangrene Fournier's is resulted. In it some epidemiological aspects of disease, etiology are opened, and also clinical cases of successful treatment of the given pathology are resulted. It is shown, that one of etiologyсal factors of gangrene Fournier's is the anaerobic infection. Only the complex treatment including active surgical tactics and adequate volume of conservative actions help to reach good result of treatment.

A case of clinical practice of a patient with diagnosis “idiopathic fibrosing alveolitis” due to the rarity of the disease is presented. The patient is observed for 6 years. Favorable course of the disease.