The article presents information about children treated in Pediatric center of National medical center of Republic Sakha (Yakutia) from 2001 to 2010 and analysis of the morbidity levels. For this period raised number of children with oncology diseases, endocrinology problems, diseases of nervous system, genitourinary problems is detected. Results of analysis confirm that for this period raised morbidity rate of the some diseases is marked. The qualified specialized medical care in settlements becomes more accessible.

We examined 970 teenagers and made hormonal analysis (hypophisis-suprarenal system, hypophisis-thyroid system). The date conform that the parameters depend on age, sex, ethnicity of the children and ecological condition of the region.

In clause the problem of influence of the new form of the combined hormonal oral contraceptive klayra on the psychological and somatic status of women of reproductive age is revealsed.

The article presents the analysis of results of patients treatment with acute coronary syndrome at a pre-hospital stage has been made: the group of patients received ТLТ and not received was compared. Positive dynamics in group with ТLТ on electrocardiography attributes was found at 63 %, to clinical attributes at 84 % of the patients; in distinction from patients who did not received ТLТ: positive electrocardiography dynamics in 38%, clinical dynamics in 59%. ТLТ technique is effective and safe and can be spent by any emergency brigade.

The condition of hemostasis and fibrinolis systems is studied in patients with erosive and ulcerous changes of gastroduodenal zone. The sequential treatment is validated in this category of patients, including erosions and ulcers of gastroduodenal zone epithelisation and decrease of thrombinemia. It is marked that the stress is non reliable significant factor for filamentous fibrin strands increase in patients with cardiac pathology in period of preparation for the heart surgery with cardiopulmonary bypass.

It is revealed, that intragastral acidity level is prominently higher in non-native patients with ischemic heart disease in comparison with native patients. Scheme of first choice treatment must be 4-component eradicational therapy.

The epidemiologic evidence of infections complications in patients with hematologic malignancies of Khanty-Mansiysk’ and Ulyanovsk’ regions is analyzed in the article.

A comprehensive analysis revealed a high level of needs in orthopedic dental care of elderly and senile patients of the region. The influence of social and hygienic factors on the need for medical assistance was ascertained.

The high prevalence of congenital heart diseases in adults in the conditions of the Far North is a regional feature. In connection with the abovesaid, a comparative analysis of 258 adult patients and 344 children patients was carried out in terms of clinical progression, intracardial circulatory dynamics and diagnostics of septile defects. Progression features of the given pathology in North were found out.

Perspective analysis of the treatment results of patients of elderly and senile age with the acute cholecystitis complicated by choledocholithiasis and obstructive jaundice has been done. Therapeutic approach was minimally invasive methods of surgical treatment. The decrease of postoperative complications and level of the postoperative lethality has been observed due to advanced therapeutic approach.

We analyzed the mortality of the population of Yakutia for the period from 1960 up to 2010. Change in mortality rate is affected by changes in the quаntity and age structure of population, conditioned by migration processes, and also socio-economical living condition. During this period there was a change in the rank structure of mortality. Forecast of population mortality rate of Yakutia depends on the pace of economic development and well-being of Russian citizens.

We have analysed the results of examination and treatment of 168 patients with atherosclerosis affection in the domain of bifurcation of the carotids and inner one. On this basis of instrumental examination methods for all patients were made open and endovascular carotid’s reconstructions. The good results of the surgical interferences on the carotids and low percentage of the perioperative complications show advantage of the surgical correction as an instrument of prophylaxes and treatment of the cerebral circulation’s ischemic maladies.

The results of complex examination of patients’ native and non-native nationality of Yakutia with diseases of the cardiovascular system for definition for the determination of atherosclerotic coronary artery lesions using tomography techniques (CT of the heart) were analyzed. It was revealed that the degree of calcification of the coronary arteries has no significant differences between native and non-native patients with CHD.
The inclusion of CT coronary heart disease in the algorithm of outpatient examination patients with suspected coronary artery disease will reduce the number of invasive angiography, and provides important prognostic information to clinicians.

CT is currently a basic and priority method in X-ray diagnosis of primary tuberculosis. To analyze the CT-based semiotics of primary tuberculosis, we studied X-ray data of children and adolescents who had tuberculosis of intrathoracic lymph nodes or various stages of primary tuberculosis complex, treated in “Phthisiatry” Research-Practice Center. The study findings showed that a complicated clinical progression of the primary tuberculosis complex occurred more often in adolescents and infants, and manifested itself as a bronchopulmonary lesion accompanied by a generalization of the process involving other organs and systems. In preschool and junior school age, an unfavorable tuberculosis progression is a rare exclusion and occurs predominantly in the form of a lymphogenous seeding.

The paper represents the results of QOL studies of men. The analysis showed that the level of the physical component of QoL in men of the industrial zone was higher than that of men of agricultural and arctic zones.

Preliminary results of the new operation concerning modified deep scleroectomy with microshunting testify to its efficiency in surgical treatment of primary open-angle glaucoma and closed angle glaucoma as well.

169 acyclic sportsmen aged 18 to 28 years were unter study. Analysis of red blood revealed in more than 20% of surveyed signs of iron deficiency, hypochromic mild iron deficiency anemia was detected in 6.25% wrestlers, and 14.05% boxers.

One of the urgent tendencies of perfection of medical education is the development of connections between different discipline, which can be supplied with the new federal state educational standard, formation on the basis of modular and competent of the approaches of the integrated programs of specialities, which would be not the simple sum of the programs of subjects, as now, but would make a single unit. Essence of postgraduate education essentially varies which should be maximum flexible and have a modular type of training.

In Russia to the start of XXI century big national projects begun: the priority national project «Health», the health care system modernization. The basis problems of the health care system ares low density of the specialists providing (93,8%), non-satisfaction conditions of the rural hospitals (88,5%), and the population on the rural territory need to drugs and drug-store (72,4%). The majority of the rural population wants to take health care on the living places.

The computer express diagnostics of level of adaptation to physical activities spent on a hardware-software complex «Omega-S» of 100 qualified sportsmen and of 100 young sportsmen of Yakutia. By the results of the spent researches аn adaptable potential at qualified sportsmen in 2 times above than at juniors.

This work is based on analysis of case histories of individuals with mixed infections (HIV + parenteral hepatitis viruses) in comparison with mono HIV and parenteral hepatitis viruses, given the epidemiological evaluation of risk factors are potentially able to influence the formation of associated forms. The leading role of age, sex and intravenous drug use, is demonstrated.

Research was carried out in order to evaluate the possibility of using R.Gudman’s standardized screening questionnaire «Strength and difficulties» (for adolescents aged from 11 to 16 years) in the course of every day practice by specialists in psychic health in schools of Saha Republic (Yakutia). Evaluation of psychic health in adolescents revealed neuro-psychic disturbances in 19.3% of schoolchildren of border-line level. This coincides with indices of disturbance prevalence, obtained by M.Rutter test (scale В2 – for teachers). The highest intensity of disturbances was marked in schoolchildren of the 5th and 9th Forms. The majority of the children, who have problems with psychic health, mark that the difficulties, which they faced, upset them or pain them, create barrier to friendly relations and study or impede their lives at home. This group of children needs timely psychological or medical assistance.

Standard system of epidemiological surveillance in Altai krai is added with multilevel component, defined by regional and municipal levels and object sub-levels. On basis of the multi-level system of epidemiological surveillance over vaccine-preventable diseases, following adapted components were developed: “BARS” Web-monitoring of public health; adoption of automated system of immunization control (ACS immunization).
Within the framework of epidemiological surveillance a system of organizing vaccination of infectious diseases (regional model) is created in Altai Krai.

Actual problem of influence of high colour of drinking water after its primary disinfection by the use of chlorine-containing compounds on population health of Mirny is submitted. Statistical data indicate that there is proved dependence of Mirny population health which manifests in carcinogenic effect and pregnancy failure on high indices of residual colour of drinking water and content of water chlorination by-products. It is shown that the primary chlorination method for the purpose of drinking water colour reduction is inadmissible.

In view of the toxicological role of arsenic, the distribution of its mineral compounds in the environment of Yakutia is examined. The distribution of arsenic was studied in various components of the Yakutia’s environment, including the atmosphere, snow cover, surface water and groundwater, and soils. The need for control of human exposure to arsenic compounds is substantiated.

One of the priority trends in the improvement of the epidemiological situation in our country is increasing the efficiency of treatment and clinical follow-up of tuber-cular patients. Efficiency analysis of the 6-year-clinical follow-up of tubercular patients showed a complex of medical and organizational shortcomings requiring emergency measures for their elimination.

The study carried out on elderly and senile aged population of Yakutsk, including long-livers, testifies to imbalanced diet on fatty and carbohydrate components, as well as energy value in different ethnic and sex age-groups.

In Yakutia a number of projects, including working out of the Elkonsky deposit which will lead to some ecological-technological risks, to ecologicalsocial and medical-ecological consequences is formed and realized. Level of a natural radiating background in settlements of Aldan area as a whole doesn't exceed the established specifications, but a little above republic values. At ranging on structure of diseases on the first place are registered illnesses of nervous system, on the second – illnesses of digestive organs, on the third – illnesses of respiratory organs, on the fourth – congenital developmental anomalies, on the fifth – illnesses of endocrine system.

In article the review of complications of endodontic treatment is presented. The original classification based on allocation of stages of treatment, and also epidemiology of the most widespread complications is resulted. The clinic of typical failures is in detail described at performance of each stage, the basic methods of their treatment and prevention are characterized.

In this article consider classification and clinical features of Charcot-Marie-Tooth disease depending on the affection gene and inheritance type are presented.

The article presents current data on the synthesis of steroid hormones during pregnancy. Particular attention is paid to cortisol, since it is a key hormone in the implementation of responses to ensure homeostasis. Showing modern and informative methods of diagnosis of hormone levels in newborns.

The article deals with the material on the study of an alien medicinal species – Ural licorice in the environment of Yakutia. The herb exhibits a slower phenorhythm and ontogenetic rate of development in the introduction. In general the species manifested itself as sustained, winterhardy and producing mature seeds. It can successfully propagate itself by a vegetative way or by seeds

The carcinoma in situ is a noninvasive form of the mammary gland cancer presented by malignant cells localized in the epithelium and not penetrating the basement membrane, but potentially, capable of invasion. The latest developments in the molecular genetics, discovery of oncogenes and tumor growth suppressing genes confirm the opinion that the carcinoma in situ is an early phase of the genuine breast cancer. These neoplacms possess various biological properties and differ in the risk of progressing into invasive cancer and treatment practices.

A rare case of the generalized myasthenia form’s debut in a she-patient with intrapulmonary thymoma is presented.

Results of treatment of patients with endothelial - epithelial dystrophy of the cornea by intrastromal implantation of amniotic membrane. The method can cut corneal syndrome, reduce the risk of disease recurrence.

Experience of application of a primary plasticity of a mammary gland is presented at a cancer. One-stage reconstruction of a mammary gland after a mastectomy represents an effective method of rehabilitation of women and has a number of advantages: psychological, esthetic and practical. The choice of a method of reconstruction depends on an oncological situation, constitutional features of the patient, and also own wishes. However carrying out possibility preservation of organs and reconstructively-plastic operations directly depends on a stage of disease and should be carried out under strict indications.

The microflora of wounds in children with burn injury was studied. This microflora is represented different etiology. Gram-negative bacteria isolated in 52.3%, Gram-positive - in 42.3% and Candida albicans - 5.4% of the studies. Pseudomonas aeruginosa is predominated among the gramnegative organisms (16,6%), Staphylococcus aureus (18.5%) and Enterococcus spp. (22,7% of pathogens)- from Gram-positive. Staphylococcus aureus resistance to penicillin, erythromycin and lincomycin (the level of resistance was respectively 97.2, 55.0, 52.5 and 42.9%). Pseudomonas aeruginosa resistant to ampicillin (86.4% of isolates), sulfamethoxazole (80.4%), tobramycin (58.6%), cefoperazone (57.9%) and ciprofloxacin (51.9%)

The analysis of treatment of 12 patients with severe cold injury, which was complicated with the development of the multiple organ dysfunction, was conducted. The method of hemodiafiltration was used in intensive care, which effectively reduced the level of endotoxemia, improved the function of the respiratory system and achieved a positive clinical effect.