Priorities of pathological morbidity structure of the population in places of compact residing of native small in numbers people of Republic Sakha (Yakutia) are ascertained. Authentically significant distinctions in prevalence of pathology of digestive organs, respiratory organs and osteomuscular system in Dolgans, Evenks and Evens are established. The revealed ethnic distinctions substantially have been caused by socially hygienic conditions of life in areas of residing of native people of the North.

The prevalence of emotional and behavior disturbances in children, living in the North of Sakha Republic (Yakutia) is presented. We characterized a group of schoolchildren with neural psychic disorders. We marked that schoolchildren of early ages showed disturbances in the processes of adaptation to school, reflected in poor school performance, regular absence from school, no respect from classmates. In adolescents complex of the problems and school deadaptation signs are growing.

In healthy children of the indigenous and non-indigenous population of Evenkia from 1 to 3 years the structural and functional properties of erythrocyte membranes with definition of lipid profile, levels of lipo-soluble vitamins (retinol and alpha-tocopherol) were studied. Physical and chemical properties of erythrocyte membranes: indices of mobility of molecules in the surface and in the hydrocarbon regions, the level of structured water and the degree of optical lability were established. By the method of pair correlation relationships it was found that liposoluble vitamins (retinol and alpha-tocopherol) displayed ambiguous functional properties to the molecular structure of erythrocyte membranes in children of different ethnicity.

Authors studied catamnesis of 894 deliveries of Yakutsk teen-mothers and anamnesis of their newborn infants, born in 2006- 2009. They compared somatic and obstetric health of teen-mothers and mothers of optimal fertile age, state of infants’ health in early neonatal period. Complications of pregnancy, delivery and pathological state of infant’s health born by teenage mothers are higher than older mothers have.

In our research we have tried by means of complex clinical-functional and angiographic inspections to ascertain factors of unfavorable CAD course in the remote 7-year period.

Arterial hypertension (АH) course in 242 patients of elderly and senile age with femoral proximal fracture is studied. It is found out that femoral proximal fracture in patients of elderly and senile age is accompanied by AH destabilization and increases risk of development of cardiovascular complications.

In work results of interleukin-6,-18 and interferon - γ (INFγ) investigation in blood serum and liquor of patients with Viliuisk encephalomyelitis (VE) and multiple sclerosis (MS) and other neurologic diseases are presented. Statistically significant distinctions in level of interleukin-18 (IL-18) and INFγ in liquor of VE and MS patients are revealed. It is shown that VE patients are characterized by IL-18 raised level in cerebrospinal fluid (CSF), and MS patients - INFγ in CSF and blood serum. The association of INFγ raised level in liquor with revealing intrathecal synthesis IgG in MS patients is ascertained.

Analysis of six SNP in the muscle protein kinase (DMPK) gene, responsible for development of myotonic dystrophy (DM) was done. Six populations of Northern Eurasia (N = 778) and DM patients of the indigenous Yakut population (N = 87) were investigated. Population-genetical characterization of the studied loci, allele and haplotype frequencies comparison were performed and coupling disequilibrium structure was analyzed. Haplotypes associated with the disease were found, significant differences for the studied loci among Ket, Buryat, Russian and Khanty populations were revealed, haplotype blocks of coupling disequilibrium in the investigated samples were shown.

Effect of antiepileptic preparation depakin on the lipid peroxide oxidation and glutathione system of rats and possibility of combined use of sodium valproate and antioxidant – immunocal were studied. Depakin injection causes a decreased antioxidant protection and oxidative stress development. Immunocal contributing to the intracellular glutathione synthesis has a protective influence.

Epidemiological research in the field of oncological pediatry has huge importance for understanding the reasons of development and prevalence of CNS tumors in Republic of Belarus and other countries. Also incidence rate for gender and sex patterns, children’s CNS tumor rate in Belarus are studied. Results of relative epidemiological risk are calculated.

We studied an efficacy of whole-blood method of tumor necrosis factor-alpha (TNF-alpha) induction in the presence of Mycobacterium tuberculosis antigens (tuberculin PPD and a mixture of specific recombinant ESAT-6 and CFP-10 antigens), for differential diagnosis of active tubercular infection. A customized test system with immunoenzyme assay was developed, to quantify TNF-alpha in plasma samples. Based on findings of blood sample investigations in 46 adolescents with tubercular infection (latent infection) and active pulmonary tuberculosis, the study demonstrated the possibility of differentiation between active and latent tubercular infection, using ESAT-6 and CFP-10 antigens as TNF-alpha inducers.

Diagnostic capability of N-acetyltransferase in prognosing the extent of possible adhesions in the abdominal cavity in the early postoperative period is presented. It was established that in the postoperative period the level of N-acetyltransferase was increased in the urine of patients compared with the preoperative period. The difference between levels of enzyme in patients where operative treatment was accompanied by the greatest injury is especially expressed.

We have used the improved estimation card of physiological condition severity for the objective evaluation of physiological condition severity of patients with acute cholecystitis complicated by choledocholithiasis and obstructive jaundice. This card has 39 risk factors, each of which corresponds to certain points. The patients are subdivided into 4 categories by physiological condition severity by points summing of factors of operational risk. The algorithm of treatment was developed for each category of physiological condition severity and the predicted outcome depending on the form of acute cholecystitis. The improved medical tactics showed the decrease of postoperative complications to 16,5 % and postoperative lethality rate to 4,7 %.

Nosocomial infections are the main reasons of death rates in intensive care unit and intensive therapy of surgical profile. The growth of pathogen resistance causes treatment complications. Therefore, reconsider of antibiotics formulary should be done taking into an account clinical and bacteriological estimation of effectiveness and creating plans of antibacterial preparations at Republics Hospital № 2 –Center of Urgent Medical Aid.

The indices of morbidity, mortality and lethality from acute myocardial infarction in population of Yakutsk in the age group of 25 – 64 years in dependence of gender and national identity in the period 2004-2006 are investigated.
It is revealed that morbidity, mortality and lethality from acute myocardial infarction with ageing become higher, males suffer this disease significantly more often than females (p< 0,001). Morbidity and mortality from MI are significantly higher in the non-indigenous males than in the indigenous ones throughout all the period of investigation. In the females of young age group there are no significant distinctions in the MI morbidity, in the senior age groups the tendency to morbidity increasing among non-indigenous women is noted.

According to inspection of patients elder 60 on the basis of Neurologic branch of the Geriatric Center RH#3 MH RS (Y) high prevalence of depression of minor and average degree in the persons of advanced age suffering from cerebrovascular diseases is revealed.

The article reflects principles of surgical treatment of keeled chest in the Tomsk Region. It describes an operative approach depending on the deformity kind. The work provides analysis of surgical treatment of 26 patients. There were presented main stages of new technique, which supplement the “classical” kind of surgical intervention. It was noted that using titanium nickelide plates with the shape memory to correct keeled chest in children and adolescents is the method of choice and brings good clinical results.

The results of endoscopic ultrasound artificial esophagus formed from the left half of the colon are presented. The data on the structure of endosonographic coloanastomos are obtained. Three types of blood supply to the graft and esophagocoloanastomos (trunk, loose, and mixed) are marked out. It is proved that the main type of blood supply is prognostically significant at a stenosis of the anastomosis.

The paper focuses on the substantiation of application of uniform generalizing criterion for a complex estimation of epidemiological situation and (or) population health state on example of epidemiological situation on tuberculosis in Republic Sakha (Yakutia) for 19 years (1990 – 2008). It is shown that in spite of multidirectional dynamics of analyzed certain statistical indices, generalized quantitative estimation of the epidemiological situation.

Medico-sociological research of the population, received specialized rheumatologic medical care in hospitals of Yakutsk is conducted. Distinctions in respondents’ answers about conditions of rheumatologic care by rendering type (out-patient and in-patient care) are revealed. Results of sociological study testify to incomplete satisfaction of the population with quality and availability of the specialized rheumatologic care because of organizational aspects in its rendering.

Сurrently the tendency of growth of number of chronic diseases in children by the time they start school, despite the fact that improving the health of children is a leading task of modern medicine, is marked. We assess the health state and health improvement among pre-school children in preschool institutions. Recommendations for the implementation of the main forms of rehabilitation of children are developed. As a result of their introduction in 2009-2011 improvement of physical development indicators of children is noted.

This paper presents review of traditional feeding disorder in the North. The efficiency of the work of schools on prevention of type 2 diabetes mellitus (MD 2) in Yakutia is shown. Recommendations on nutrition of MD 2 patients and list of recommended and excepted foods of therapeutic diet #9 are given. The authors present model menu and the multiplicity of meals for MD patients. The role of physical activity and refusal from harmful habits in treatment and prevention of MD type 2 are shown.

The results of the first stage of comprehensive studies of cultivated microorganisms isolated from the oldest permafrost exposed rocks of “Mammoth Mountain” in Yakutia are presented, and their potential scientific and applied significance is shown.

The analysis of dynamics of morbidity indicators by the given infection in Altay territory during the period from 1986 for 2009 was carried out. The objective was to study development of the acute virus hepatitis B epidemic process.
As a result of the spent analysis it is revealed: morbidity decrease in 2009 to a maximum level of 1996; presence of inverse statistically significant correlation dependence between acute hepatitis B morbidity of the population and coverage by preventive inoculations against the given disease of children till 17 years as well as adults, with more expressed dependence among adult population till 55 years; change of age structure of ill children till 17 years towards decrease in relative density of children of preschool age and increase in a share of children of school age; excess of acute hepatitis B morbidity indicator among city dwellers in relation to agricultural population at equal coverage by preventive inoculations of townsmen and villagers.

Hepatitis B and C markers have been revealed in Viliuisk encephalomyelitis (VE) and dyscirculatory encephalopathy (DE) patients. Anti-HB-cor has been more frequently found in VE and DE patients than in control group. Marker of hepatitis C (a-HCV) has been more frequently found in VE patients than in DE patients and control group.

In view of the toxicological role of nitrogen, the distribution of its mineral compounds in the environment of Yakutia is examined. The distribution of nitrogen compounds – nitrates, nitrites and ammonium – was studied in various components of Yakutia’s environment, including the atmosphere, snow cover, surface water and groundwater. Data on the atmospheric deposition of nitrogen fluxes to the landscapes are presented. The need for control of human exposure to nitrogen compounds is substantiated.

In this article dynamics of prevalence of allergic diseases depending on age of children and ecological living conditions is shown.

The article reflects the data on high prevalence of Chlamydia contamination in upper respiratory tract in different populations (in organized population, both children and adults, in patients with acute and chronic inflammatory diseases of nose, paranasal sinus and nasopharynx). Authors show species structure in identified Chlamydia in accordance with age and gender of the examined subjects.

An assessment of the social status of the population of rural settlement in the city district “Yakutsk” territory is presented.

Literature review of structural and proliferative processes in the gingival epithelium in parodontium status changes is presented.

In article the authors consider a modern level of knowledge of etiology, pathogenesis of the disease Legg-Calve-Perthes (DLCP), a new approach to DLCP diagnosis and treatment in view of knowledge about oxidative stress, antioxidant system, lipid peroxidation.

In article three models of moral medicine from which the “contract” model is recognized most to answer the purposes of medical ethics are briefly compared.

The clinical case of the patient with primary immunodeficiency which was observed with the bronchiectasis is presented.

The analysis of city children’s epileptologist work for 2009 – 2010гг is carried out. The received results of treatment of epilepsy patients: increase in quantity of patients with clinical remission, improvement of their life quality, improvement of continuity of conducting patients allow to confirm necessity and timeliness of the organization of a city epileptologist cabinet.