The hereditary methemogemoglobinemia I type is autosomal-recessive disease, endemic for Sakha (Yakutia) Republic. In this article methemogemoglobinemia registry data of Advisory polyclinic of Pediatric Center RH#1-NSM (Yakutsk) are presented.

150 women of the native nationality and their new-born children were examined with the aim of discovering of the factors of cerebral ischemia risk in new-born children in the Republic Tyva. Analysis of the statistic meaning of the distinctions of the qualitative signs was made with the help of the criterion x2 with Yeits correction. The index of ratio of the chances with 95% confidence interval was used for risk calculation. The revealed signs of pre-natal hypoxia during pregnancy increase a risk of acute ischemia of brain in 4,85 times in period of new-borning. Risk of the ischemic injury of central nervous system of a new- born child increases in 2,92 times at the presence of the urogenital infection in a mother and twice - at the presence of anemia in a pregnant woman and a threat of misbirth.

This study investigated metabolic processes in the indigenous population of Sakha Republic (Yakutia) using the results of two cross-sectional studies (conducted in 2003 and 2009). Studied anthropometric and metabolic parameters in 320 Yakut adults over 18 years old (171 females, 149 males). Measured BMR was compared to predicted BMR based on norms for lower latitude populations. Measured BMR of both males (1677 ± 24 vs. 1542 ± 12 kcal/day; P< 0.001) was substantially elevated (percentage of deviation was 9,4 and 8,5%, respectively) compared to predictions on fat-free mass. No significant age-related differences in BMR were detected after adjustment for body composition and year of study. Comparison the samples 2003 and 2009 indicated that BMR level is relatively lower in a group studied in 2009. This study is another confirmation of the increased level of metabolism among representatives of the northern populations (Yakuts).

Metabolic disorders at 185 women with DH are studied. The results are comparable with similar at women without endocrinal disorders. At women with DH the increase in an index of body mass, abdominal type of obesity is marked. Against barrenness menstrual cycle disorders, lowering of progesterone level in the 2 phase of the menstrual cycle are revealed. At every fourth surveyed glucose tolerance disorders, insulin resistance and LPVP decrease are marked. Timely diagnostics and correction of metabolic disorders will allow to improve the reproductive prognosis.

By results of research it is shown that atherosclerotic lesion of coronary arteries, first of all, is connected with metabolic syndrome, arterial hypertension and dislipidemia are one of leading components of metabolic syndrome in the surveyed ethnic groups.

In the article results of a relative assessment IHD patients’ biochemical indexes depending on body mass index (BMI) are presented.

An incidence of fetal alcohol syndrome (FAS) in maternity, child hospitals and orphanages of St.Petersburg and Republic Sakha Yakutia was investigated. 39 children with FAS from St.Petersburg and 39 ones from Republic Sakha Yakutia were detailed evaluated by means of the standard neurological assessment, Developmental Scales, anthropometry, The 4-Digit Diagnostic Code and MRI and Cranial Ultrasound. Evenian and sakha children demonstrated significant decrease of palpebral fissure length compared with the europeoid babies up to 3 years old. Sakha children had most often ptosis, epicanthus and dilatation of subarachnoidal spaces than St.Petersburg babies neglected to ethnic features. There were not differences between babies’ subgroups in Physical and Neurodevelopment.

We carried out the retrospective study of history cases of inpatients of the MI «Yakutsk clinical hospital» cardiological unit during 2006-2009. The obtained data testify to available distinctions of myocardium infarction with Q on the electrocardiogram in the natives and non-natives. The prevalence of Q positive myocardium infarction was higher in men as compared with women in both ethnic groups for all period of the survey. The increase of myocardium infarction was marked in both groups irrespective of nationality. The frequency of myocardium infarction in the native population was lower in comparison with the non-natives. During the last years the rejuvenation of myocardium infarction has been noted in the natives of Yakutsk.

In a work basis direct and mean-term (1 year) clinical-angiographic results of percutaneous transluminal coronary angioplasty (PTCA) and stenting of coronary arteries (CА) in 86 IHD patients, residents of Yakutia are put. The factors affecting on unfavorable IHD clinical course after CA stenting, appearance of coronary stents restenosis are studied. The assessment of efficacy of application of usual metal stents and drug-eluting stents at CA stenting is given.

The aim of the research is to investigate the indices of heart rate turbulence among indigenous and non- indigenous residents of Yakutia.
The patients with different diagnoses who were directed to the Holter ECG monitoring at the department of functional diagnosis by the doctors of cardiology clinical advisory department of RH № 1-NCM were examined.
The pathological values of HRT were registered more often among non-indigenous residents of Yakutia, in the older age group and patients with a strong family history. Abnormal values were parameter of TO.

Epidemiological indexes of prevalence of cerebral stroke are studied. Gender and ethnic features of cerebral stroke prevalence according to population screening of Yakutsk residents at the age of 60 years and elder are shown.

Results of genetic research on row of gene-candidates determining predisposition to multiple sclerosis disease are given. For the first time it is shown that disease has reliable association with reception gene CD40 and cytokine gene TNF-α.

This article presents data on chronic viral hepatitis of children with oncohematological diseases. There were evaluated clinical and laboratory data of 11 children with chronic viral hepatitis B and C, among which 10 patients were with monoinfection and 1 was with mixedhepatitis B + C. It also presents results of treatment of chronic viral hepatitis with interferon-alpha in children with hematologic malignancies.

In the article there was firstly described evaluation of risk factors of viral hepatitis B (HBV) contamination in Far North area among indigenous rural population. There were studied transmission routs and multiple-factor risk of hepatitis B (HBV) contamination. There was found out under multiple-factor risk analysis associated connection with the following risk factors: chronic disease, family contact, alcohol abuse and male sex.

Dependence of gastroduodenal ulcers revealing in patients of the indigenous and non-indigenous nationalities taking non-steroidal antiinflammatory drugs (NSAIDs on risk factors of NSAIDs – gastropathy was estimated. It is revealed that the risk of development of ulcers in patients of the indigenous nationality increases at taking of non-selective NSAIDs, aspirin and cardiovascular pathology. Smoking and taking of glucocorticoids do not increase risk of development of ulcers in patients of non-indigenous nationality.

In the ethnic group of the Yakuts polymorphic variants of resistine rs34861192 (-639G/A), rs1862513 (-420C/G),rs3219177 (156C/T) and rs3745367 (298G/A) are not for sure associated with diabetic retinopathy in 2 type sugar diabetes which is the evidence of their secondary role in the development of retinal diabetic lesion.

The results of kidney medulla morphological study from rats with ethylenglycol oxalate nephrolithiasis model are analyzed. Characteristics mitochondrial superoxide dismutase and malone dialdehyde expression during ethylenglycol oxalate nephrolithiasis modeling are evaluated. Registered morphological signs of oxidative damage activation and antioxidant enzyme attenuation in renal tissues.

On a basis of conducted researches high level of prevalence of dental diseases including defects of tooth alignments of the persons of Sakha Republic of elderly and senile age is revealed. Thus, the considerable part of dentures, which are in the inspected people’s mouth, needs to be changed. In combination with pathological processes of bodies and mouth tissues it defines their requirement for the dental help.

100 women of the active reproductive age with tubal-peritoneal infertility and 30 women of the same age without fertile malfunction were examined. Assessment of ovarian reserve was performed on the content of Follicle-Stimulating Hormone (FSH), Inhibin B, Anti Muller Hormone (AMH) in the blood serum, according to the data of echoscopy of ovaries and Doppler studies of stromal vessels. It was found, that, in patients with infertility of tubal-peritoneal genesis, ovarian reserve is diminished. Parameters of ovarian reserve reflect the functional state of women’s ovaries and the most reliable marker of ovarian reserve is the level of AMH.

Results of operative treatment of 290 women with cervical cancer, carried out as a stage of the com-bined treatment, depending on a process stage are analyzed. It is revealed that 3 year’s and more sur-vival rate compounds 70, 7 % of women. Efficacy of treatment and life quality directly depend from timely diagnostics and the program of the treatment based on clearly determined principles.

Laryngeal cancer incidence among population of the Tomsk region was analyzed. Out of the total cancer cases registered in the Tomsk region in 1994-2008. Laryngeal cancer occurred 19 times more frequently in males than in females, the incidence rate showed a tendency to increase in females. Laryngeal cancer incidence rates were increased among rural population while, among urban population, the rates showed a stable trend. Scientific estimates for 2018 in the Tomsk region predict 9.3 new cases per 100,000 males and 0.8 cases per 100,000 females.

Prognostic value of the high level of interleukin-18 is directly stimulating production of interferon-γ in the acute period of serious influenza pH1N1 was established.

Showing the effect of smoking on the formation of CBs in persons 60 years and older in a population of Yakutsk.

The purpose of research were the substantiation of the diagnosis and correction or change of treatment of children with the epileptic and not epileptic paroxysms, directed in St.-PbSPMA for refinement of the diagnosis, the form of an epilepsy and selection of adequate treatment. As a result of complex diagnostic study of sick children with conducting video-EEG of monitoring it is established, that more than a half of children had the diagnosis epileptic paroxysms. Correction of treatment made after refinement of the diagnosis. As a result on clinical data efficacy of treatment of children with an epilepsy has increased. We were noted martempering of cognitive functions at children with not epileptic paroxysms.

The purpose of research was comparison of parameters of the contents of hormones in blood of boys with different forms of epilepsy. Significant differences in contents of hormones were revealed in group of children with idiopathic and symptomatic generalized epilepsies. Findings of investigation testify that the most expressed changes in contents of hormones in blood were revealed in boys of all ages with symptomatic temporal form of epilepsy. Obtained data confirm necessity of research and evaluation of hormonal status at children with epilepsy for prevention and correction of possible endocrine disturbances.

Use of a method of the component analysis and materials of the statistical reporting of department of medical statistics of the Yakut republican oncological clinic for 1995-2005 have allowed to de-fine that the increase of total number of patients with CRC happened mostly for the account of “change of number and age structure of the population», than «from risk to fall ill». In men de-crease is marked at the expense of reduction «from risk to fall ill» than from «change of number and age structure of the population». In women the general increase of number of the CRC dis-eased is bound both to growth of influence of risk factors, and with number and age structure changes.

The estimation of actual feeding was made by method of individual interviewing of respondents according to standards of WHO international program on the integrated prevention of noninfectious diseases − CINDI. Insufficient consumption of meat, fish, milk and dairy products, vegetables, fruit is revealed that leads to deficiency of the main macro- and micronurtrients.

The problem of gestosis pregnant – one of the most urgent in modern obstetrics, as gestosis is the most common and serious complications of pregnancy. The article presents the results of clinical and laboratory examination of women whose pregnancy was complicated by gestosis of different severity.

This article is an example of a successful surgery for cicatricial stricture choledochal in conditions of central district hospitals.

The number of diagnostic and therapeutic procedures done outside of the operating room and the intensive care unit has increased substantially in recent years. In parallel, the management of acute pain and anxiety in children undergoing therapeutic and diagnostic procedures has developed considerably in the past two decades. The primary goal of procedural sedation and analgesia is the safe and efficacious control of emotional distress and pain. The availability of non-invasive monitoring, short-acting opioids and sedatives has broadened the possibilities of sedation and analgesia in children in diverse settings. While most of these procedures themselves pose little risk to the child, the administration of sedation or analgesia may add substantial risk to the patient. This new guidelines the current status of sedation and analgesia for invasive and noninvasive procedures in children providing an evidencebased approach to several topics of importance, including patient assessment, personnel requirements, equipment, monitoring, and drugs.

On the basis of integrated clinical-laboratory methods of research on the use of dietary supplements “Epsorin” in the surgical stage of dental implants first developed recommendations for its use. The scheme allows you to select the optimal dosage of dietary supplements, which eliminates an overdose of this tool and promotes more rapid relief of swelling, redness and pain in eriimplantation zone. It has been established to investigatet he in formative indicators of AOD / LPO.

The authores gives classification of VE and examples of clinical cases of spastic-paretic and demented-paretic forms of VE. At present some changes in severity of VE development in patients are revealed. Lately clinical manifestations of VE have changed a little to ease. Primary chronic forms of VE without acute phase are found out.

This article presents intraoperational factors of 116 patients with generalized peritonitis underwent planned relaparatomies at the surgical department of Republics Center of Urgent Medical Aid in Republic Sakha (Yakutia) 2003-2006. A comparative analysis of single and multiple planned relaparatomies in 116 patients with using statistics methods for creating a scoring system of individual prognosis of planned relaparatomies has been presented.