The article presents the results of mathematical analysis of height and weight of 58,188 children living in the Republic Sakha (Yakutia). Necessity of developing of regional standards of height, weight for children of Sakha and small in numbers people of the North is proved scientifi cally.

Microbial flora spectrum characteristics in 75 children with different forms of repeated chronic bronchitis is investigated. Microbiological examination showed, that the prevalent etiologically significant microorganisms of bronchial secretion were Staphylococcus aureus, Klebsiella pneumoniaе.

In order to study the molecular organization of erythrocyte membranes of umbilical cord blood of newborns by the method of fluorescence sensing erythrocytes of umbilical cord blood of 37 newborns from mothers with iron deficiency anemia (IDA) (main group) and 34 newborns from mothers with normal hemoglobin (control group) were investigated. It was revealed that for the state of erythrocyte membranes in neonates at the iron deficiency anemia in pregnant women the transformation of its protein component and a decrease in calcium-accumulating function is characteristic. The authors assume that the conformation of the protein component of erythrocyte membrane may be due to changes caused by deficient erythropoiesis of fetus at the anemia in pregnant women, which affects the major functions of erythrocyte membrane.

The data on 25 children with the diagnosis Langergans cell histiocytosis (GCH) have been presented for the period from 1998 to 2008. Monosystem GCH was diagnosed among 18 children (72%), multisystem type 7 children (28%). The bon system suffers more in monosystem type of GCH. Polysystem GCH can be observed in children of early age. The state of disease and prognosis depend from involving the risky organs to pathological process. The prognosis is favourable in monosystem form, but in multisystem GCH the efficiency of treatment was not enough.

We examned 2597 children in Nackchivan Autonomic Republic for determine normal size of kidney. Children were of different age. They have not any kidney anomalies by history and ultrasound examination. Kidney length, width, thickness of kidney and type of pelvis were determined during examination.

The clinical and immunocorrective efficacy of the immunotherapeutic drug Affinoleukin (AFL) in the complex treatment of pulmonary tuberculosis in adolescents is investigated. At the immunological study in patients treated with AFL a specific increase in antigen-induced production of interferongamma (IFN-g) in samples of whole blood in vitro was determined; at the immunophenotyping – increase in the percentage of circulating gammadelta T-lymphocytes and a decrease in the subpopulation proportion of IFN-g - producing gamma-delta T-lymphocytes, including antigen-induced ones in vitro was noted. It is assumed that AFL increases the migration of effector gamma-delta cells in the foci of tuberculosis inflammation.

Analysis of results of conservative and surgical treatment of 123 patients before not infected phase of pancreatic necrosis, in view of a complex estimation of intensity of infringement peroxidation processes, and conditions antoxidation systems is carried out.
Increase of value of a role of independent inflammation predictors in a complex estimation of the forecast of disease and probability of complication after the carried out operative intervention at acute destructive pancreatitis is marked.

The article presents mortality data of the female population of Yakutia from malignant tumors of the female genital organs. Retrospective analysis is based on the data bank of 925 cases of death from MT of cervix, uterus and ovaries in the RS (Y) for the period from 1993 to 2007.

Patients senior 60 years with cerebrovascular diseases have been surveyed. The arterial hypertension (AH) has been diagnosed for the majority of them. The mean level of systolic arterial pressure (AP) has made 147, 5, diastolic - 87, 6 mm. hg. It was revealed, that in persons of advanced age with cerebrovascular diseases of Yakutsk AP high levels and AH high prevalence, exceeding values in regions of Russian Federation, are registered.

Research of the glycosominoglycans content in a placenta of lying-in women is executed. It is established, that in process of increase of herpesvirus infection aggression it is reduced.

It’s found out that during different phases of rats’s pregnancy there is the considerable reconstruction of blood vessels of mesometrium and hemodynamics of womb. Blood vessels are the index of going histogenetic processes. The parameters of cellular elements and vessels along the uterine side of mesometrium and veins of the first and second orders situated in this zone change more actively, which is necessary to take into consideration in modeling different processes in the experiments.

Trasological characteristic of traumatic body parts of cattle is given; the mechanism of traumatic exposure in cases of aggression of the animal is defined; injury complex is systematized. Morphological pattern of characteristic external damages is described.

The contents of interleukine - 6 (IL-6), the tumor necrosis factor - α (TNF- α), C- reactive protein (СRP) and procalcitonin (PCT) in blood serum of 50 patients with extra-hospital pneumonia in various clinical-morphological groups is investigated. Authentic increase of IL-6, СRP and PCT levels in 2-3 times in comparison with parameters in practically healthy persons is revealed. Sharp increase of PCT, CRP is recorded at connection of infectious complications at the extra-hospital pneumonia.

In article results of research of maintenance IL-1 α, TNF α, α1 -АТ and α2 -МГ with calculation of factor which allows to estimate a current of inflammatory process at an extrahospital pneumonia are shown. Use of the given parametre presumes to bring necessary correction in treatment of the given group of patients in due time.

In order to assess lipid peroxidation in patients with chronic gastritis, depending on the degree of Helicobacter pylori (HP) infection, 158 patients with chronic gastritis Yakuts in age from 30 to 50 years are examined.
It was revealed that the peroxidation final product – malonic dialdehyde (MDA) in the serum of infected patients increased depending on the degree of HP infection. Indicators of antioxidant protection significantly lowered activity of superoxide dismutase (SOD) in the patients with chronic gastritis associated with HP, as compared with uninfected patients (p 0,05) concentration was marked.
These data suggest that the biochemical mechanisms of inflammation at the HP infection are associated with activation of prooxidant processes.

Changes of a glutathione level and activity of enzymes of its metabolism: glutathioneperoxidase, glutathionetranspherase and glutathionereductase in patients of the senior age group with a chronic ischemia of a brain and a type 2 diabetes mellitus before pharmacological correction mildronate are presented.

Features of morphometric parameters of the thyroid gland (TG) in fetuses and newborns were identified. The material was the TG of 120 fetuses and newborns of different terms of intrauterine growth - from 22 to 40 weeks. The increase in thyroid volume in 33,3% of fetuses and newborns above normal values was established. High rates of desquamative and transitional types in full-term infants show delayed morphological differentiation of the thyroid in locus of iodine deficiency. Often the cause of hypothyroidism expressed signs in thyroid tissue is a longterm effect of damaging factor, what is the cause of death, but the deficiency of iodine, which is characteristic for the region.

The article presents the indices of prevalence and structure in chronic othorhinolaryngologic pathology in urban native and alien people of Khakasia Republic. The authors examined 2607 subjects by random. The results of cross-section research revealed high prevalence of the pathology in Ear-Nose-Throat-organs in urban population of the republic irrespective of ethnic belonging. Comparative analysis of prevalence indices corresponding to the Europoids and the Khakass determined the range of ethnic peculiarities in epidemiology of chronic diseases of ear, nose and throat.

The review presents data on the infl uence of polymorphic variants of genes NORD2/CARD15, DLG5, TLR4 on the disease progressing, age of manifestation, frequency of complications, and the length of the infl ammatory process along the intestine at the infl ammatory bowel disease.

The paper presents a description of monitoring, which includes socio-hygienic survey of respondents, their complete medical examination, the results of which are formed in a single database. A software product is designed for medical and social monitoring of the working population.

The results of implementation in the Republic Sakha (Yakutia) of the new approaches in the organization of sanatorium for children from risk groups for tuberculosis are presented.
The efficiency of organizational and methodological work carried by Republican Children’s Tuberculosis Sanatorium after T. P.Dmitrieva with district children’s tuberculosis sanatoria is analyzed. Results of the work to strengthen the sanatorium’s material base, training and retraining of medical personnel and teachers, educators, the rational use of sanatorium beds are shown. The positive impact of new approaches to management of tuberculosis care for children in specialized sanatoria in the incidence of tuberculosis among children in the Republic of Sakha (Yakutia) is established.

With the purpose of studying of individual adaptation of children living in various regions of Siberia, 208 pupils of 7-15 years of Krasnoyarsk and Evenkia are surveyed. By the method of microfluoremetery with use of a fluorescent probe of chloride tetracycline reactance of erythrocyte membranes of children to exogenic bioregulators of vegetative nervous system is studied. The revealed different variants of reactance of cellular membranes on bioregulators in children of various regions of Siberia have universal character. It is shown, that adaptive activity is individual and is accompanied by increase of activity of strategic mechanisms of regulation homeostatic functions in children of non-indigenous population of Evenkia while in children of indigenous population of Evenkia and Krasnoyarsk their low functional activity is observed.

A way of life of family and single students of the Yakut state university according to questioning was under study. Medico-social research has revealed distinctions in a way of life of both family and single students and the factors necessary for strengthening and preservation of health of students.

Level and structure of acute enteric infections morbidity in industrial and agricultural areas of Republic of Sakha (Yakutia) were under study. Correlation communication of high and average force between enteric infections desease of population of industrial and agricultural areas and sanitary-bacteriological condition of objects of surrounding environment is revealed.

The problem of regional anesthesia used in pediatric surgery has been inadequately studied. This investigation was undertaken to develop a balanced regional anesthesia schedule and to analyze its efficiency during orthopedic operations on the lower extremities in 190 children aged 1 to 17 years. Comparative assessment of monitored indices during surgery and a need for postoperative analgesia in the groups of patients demonstrated a reliable intraoperative and effective postoperative analgesia after balanced regional anesthesia.

The purpose of the present research was studying of a condition of cellular and humoral immunity links in patients with acute non-lymphoblast leukemia, using various statistical methods for estimation. It was revealed, that at a stage of attack and remission of acute non-lymphoblast leukemia the T-cellular immunodeficiency developed, at a stage of relapse - the combined immunodeficiency with lesion of Т-and В-systems of immunity. The exhaustion of the NK-cells content which promotes progressing of disease and development of relapse is the feature of acute non-lymphoblast leukemia. Neuronet modeling and the discriminantal analysis have revealed the most significant parameters of the system analysis change of which promote both to occurrence, and progressing of oncological disease.

Microbiological monitoring of perioperative preventive antibiotics efficiency is lead. In the article clinical efficiency of operative treatment in dependence of methods of antibacterial prevention of purulent-septic infections is presented. The level of antibiotic resistance of staphylococcus, enterococci and gramnegative bacteria is studied. Resulted data allow to estimate parameters of antibiotic resistance that essentially helps with a choice of preparations for etiotropic treatment.

In the review condition, problems and prospects of ethnogenomics’ development are considered.

In the survey of the scientific researches there are modern data about prevalence of the аrterial hypertension of children, its association with prothrombotic dysfunctions is presented. Comparative analysis of the data of the scientific researches and frequencies association of variability of the genetic markers of the prothrombotic dysfunctions with genetic markers of the аrterial hypertension is held. Besides, information about the most studied population’s candidate genes of the аrterial hypertension and thrombophilia are introduced.

Investigation objective – study of introduction stability of the medicine herb Leonurus deminutus V. Krecz. Rhythmus of seasonal development (his seminal renewal) study is necessary to achievement of goal. Material of the introduction experiment was introduction population Leonurus deminutus. Observations were carried in nursery and initial cenopopulation simultaneously. Phenological observations were realized. Seminal renewal was defined. Based on introduction stability analyses, we could say that Leonurus deminutus is highly stable in culture and perspective to growth in Central Yakutia species.

The article deals with the data on medicinal application, biology and ecology of Valeriana alternifolia, a subspecies of garden heliotrope Valeriana officinale of a pharmacopoeia type in Yakutia. Annually the species when cultivated produces an yield of ripe seeds and can be grown on the plantations as an industrial plant and in the kitchen gardens. Ontogenetic spectra of the natural coenopopulations in the environmental conditions are described, and explanations on fluctuations in the spectra have been given. Judging by a productivity indicator coenopopulations growing in the flooded plain of the Vilyui River may be taken as initial material and crude drug.

In the article prevalence and clinical variants of a metabolic syndrome among the native population of Yakutia are considered. On an example of type 2 diabetes in representatives of the Yakut population a role of a metabolic syndrome and system inflammatory process in development of a somatic pathology is discussed. Results of genetic researches of polymorphic variants of genes (LPL, IL6, RSTN, ABCC8), causing predisposition of the Yakut population representatives to development of metabolic disturbances, insulin resistance and to disease by type 2 diabetes are presented.

One of the effective approaches, promoting early revealing of breast cancer, is DNA-diagnostics of disease hereditary forms which develop in most cases because of presence of mutations in BRCA-1 and BRCA-2 tumor genes-suppressors. Definition of mutations in genes is objective criterion for formation of groups of the increased risk of development of breast and ovarian cancers with the purpose of prevention and duly diagnostics.