Studying features of resistаncy of low - density lipoprotein (LDL) to oxidation in men with a coronary atherosclerosis is lead. Significant distinctions in a condition of prooxidant potential of LDL in patients with coronary atherosclerosis in comparison with persons without IHD are revealed.

The purpose of research. Estimation of adult population health state in places of compact residing of Republic Sakha (Yakutia) native small in numbers people.
Materials and methods. In forwarding conditions 375 persons in the age of 17 to 86 years, living in villages Zhigansk and Kustatyam of Zhigansk region, Kuptsu and Ezhantsu of Ust-Maj region of RS (Y) were screened.
Results. Priorities of pathological affection structure of the population are certained. Authentically significant distinctions in prevalence of pathology of urinogenital system, respiratory system, osteal-muscular and endocrine systems, infectious diseases among surveyed population of Zhigansk and Ust-Maj regions are established. Correlation dependence of a pathological affection level from way of life, floor space security, incomes level and educational level of the population is revealed.

The purpose of research. Estimation of protein metabolism some sides in inhabitants of Yakutia depending on ethnicity.
During complex medical and biologic expeditions 1719 inhabitants of Yakutia of both sexes in the age of 18 - 75 years are surveyed. From them persons of a native nationality 1340, non-natives - 379.
Dependence of the content of proteins and free amino acids from ethnicity which specifies disadaptation attributes in the natives is revealed, and for the non-natives it is an adaptation price to conditions of the North. Revealing of protein metabolism parameters metabolic deviations will allow to find out prepathological changes.

The analysis of systolic arterial pressure (SAP) variability in healthy people and AP patients is lead. It is revealed, that AP patients have more often lower relative values of a low-frequency component of a spectrum (%LF), reflecting baroreflex activity. On the basis of the received data the criterion of an estimation of AP development risk is worked out.

In the data of erythropoietin function researches in parturient women at a various degree of work herpes infection manifestation during pregnancy are given. Direct dependence between aggressiveness of a herpes virus, serum erythropoietin parameters, maturity of erythroidal cells and quantity of circulating in blood of morphofunctional forms is fixed.

We studied the conduction anesthesia efficiency with use of the auxiliary device for carrying out of local anesthesia by Gow-Gates method. Clinical efficiency of lower socket nerve blockade, due to simplicity and convenience of its use is proved. Positive properties of the developed device allow recommending to doctors-stomatologists to use it widely in practical activities.

The purpose of the present work was studying of clinical-endoscopic manifestations of gastroesophageal reflux disease (GERD), chronic gastritis (ChG) with dyspepsia, ulcerative disease of the stomach (UDS) in various ethnic groups of patients.
371 patients have been included in research, from them 183 – of the Asian ethnicity (1st group) and 188 – European (2nd group). Esophagog astroduodenoscopy was carried out to patients with taking biopsy materials from esophagus lower third, body and antral portion of a stomach. For research on Helicobacter pylori histological, immunological and biochemical methods were used.
Conclusion. In clinical manifestations and current of GERD, ChG and UDS Asian and European ethnic groups have a number of distinctive features. In patients of the Asian group intensity of a painful syndrome is essentially lower, frequency of atrophic changes of a mucous membrane of stomach is considerably higher, than in the European. At morphological research in the 1-st group the light degree of activity and a low degree of НР-seeding of a mucous membrane of stomach also prevailed.

Measurement results of esophagus and stomach motility in various disorders of gastro-intestinal tract among different groups of patients have been presented. 47 stationary patients with gastro-intestinal tract diseases at the age 21 to 50 have been examined in Republican Hospital N1- National Medical Centre.
The obtained data show that differences of esophagus and stomach motility depend on pathology of gastro-intestinal tract.

The authors show the results of 24 patients who have been treated according to the suggested methods of forming an areflux jejunostomy. The methods allowed in short time to restore the metabolic status means by stabilization of the anabolic processes, normalization indicators of the proteinogram and immune status. Also it allowed to keep the stomach for further esophagogastroplastic and had no negative appearances such as secreting aggressive intestinal contents on the front abdominal wall.

With the purpose of finding out of major factors of liver cancer development risk the componental analysis of primary liver cancer mortality increase, correlation analysis between primary liver cancer and chronic virus hepatitises B and C, their virus carriers in regional conditions of the North are lead.

Purpose. To estimate the clinical, morphofunctional and prognostic effectiveness by tiotropium bromide (ТB) for the mucociliary insufficiency (MCI) correction in patients with bronchial asthma (BA) combined with chronic obstructive pulmonary disease (COPD).
During 12 weeks 67 patients with BA combined with COPD were treated with the traditional therapy by inhaled corticosteroids accompanied with long-acting β2-agonist. It is revealed that he additional use of TB during 12 weeks of treatment in patients with BA combined with COPD significantly de-creases the functional demonstration of MCI. TB effectiveness for MCI correction can be prognosticated by the initial data of integral MCC p

In the present research it is shown, that precultivated with aminazine immune competent cells change the functional activity. The specified cells after transplantation to syngenic mice-recipients are capable to reduce essentially parameters of horizontal and vertical impellent activity of the last in the test « the open field ». Changes of parameters of motor and research components of rough - research behaviour in animals after transplantation of processed with neuroleptic cells are accompanied by change of expressiveness of reaction of hypersensitivity of the delayed type. The presented results show an opportunity of reception of neuroleptic effect in experimental animals by transplantation immune competent cells preliminary processed by aminazine.

The results of monitoring of congenital malformations of obligatory registration group in Tomsk during nine years are represented in this article. The level and dynamics of prevalence of birth defects were investigated. The frequency of prenatal detected and interrupted congenital malformations was revealed. The efficacy of prenatal diagnostics was estimateds.

The purpose of research: To reveal frequency of painless (silent) ischemia of myocardium in men of Yakutia and to study connection with postinfarctional cardiosclerosis, AH, the 2 type diabetes mellitus, LVH and with expressiveness of coronary arteries atherosclerosis.
Materials and methods. The analysis of HM ECG results in 252 patients with the verified coronary atherosclerosis, including native - 125 men, non-native - 127 men comparable on age is lead.
Results. In the result of research it is established, that among the natives there were authentically more often patients with episodes of painless (silent) ischemia, than with painful one and authentically more often - with myocardial infarction in the anamnesis without previous stenocardia. Authentic connection of myocardium painless ischemia in the representatives of indigenous population with postinfarctional cardiosclerosis and left ventricle hypertrophy, in the representatives of the non-indigenous population - with the 2 type diabetes mellitus and severe multivascular lesion of coronary arteries is revealed.

Results of the analysis of polymorphic variant A46G association of gene В2-adrenoreceptor (ADRB2) with atopic bronchial asthma (BА) are presented. Research is lead in group of 86 unrelated patients with atopic BA, Yakuts by ethnicity, and 195 healthy unrelated Yakuts. The association of replacement 46А> G gene ADRB2 with atopic BA in the Yakut population is not established.

40 patients with small-cell lung cancer were under research (20 patients in YROH, 20 – RONC after N.N. Blohin of Russian Academy of Medical Science) which have received chemotherapy courses by docetaxel (taxoter) 75 мг/м² once a day, cisplatin 75 mg/m² once a day with recurrence of cycles each 3 weeks.
Results of research testify that the chemotherapy docetaxel + cisplatin is an effective method of small-cell lung cancer treatment. More expressed toxicity in the Yakut group is revealed, in this connection expedient continuation of search of new ways of the decision of the given problem is represented.

Epidemiological research was conducted among the working-age population of different socio-territorial zones of the Republic of Sakha (Yakutia). The development of circulatory diseases was found to be significantly affected by such socio-hygienic factors as unemployment, financial unsecurity, living conditions, the presence of harmful behaviors, and food quality. These results will be useful in the planning and design of programs to improve the socio-economic conditions of the inhabitants of the Extreme North.

Results of the analysis of inspection data of 189 children practically healthy children (I-II group of health) are presented. The estimation of sexual development and hormonal status is carried out. In this article only facts which include physiology of reproductive system formation in children of indigenous population of Yakutia are presented.

The purpose of research - the description of componental structure of body of girls Yakuts of pubertal age of the RS (Y) central region.
Anthropometrical inspection of 125 girls of pubertal age, Yakuts, living in the RS (Y) central region is lead. Somatotypical diagnostics was spent by R.N. Dorohov, V.G. Petruhin’s technique [2].
The characteristic of componental structure of body of girls Yakuts of the RS (Y) central region in ontogenesis pubertal period is revealed. It is established, that in the given age ethno-territorial group persons with microcorpulent, micromesoost and micromesomuscle types of a componental level of variation dominate. Small prevalence or full absence of extreme types of a componental level of variation is revealed.

In work adaptive opportunities of primary classes children and their health condition are studied. Today the problem of adaptation is one of the most actual. Adaptation as continuous process has multilevel and dynamic character. Mechanisms of adaptable potential are genetically fixed on individual and populational level, but their realization depends on environment and training.

The maintenance of heavy metals, mainly of mercury, in the ground atmosphere of Blagoveshensk, in the air of premises, in ground of rural pastures, city ground, superficial waters of the rivers Amur and Zeya, in potable water was determined. It is established, that there were associations of other heavy metals simultaneously with mercury. However dependence of separate kinds of primary nonspecific bronchopulmonary pathology in children from intensity and character of emissions in the environment of the Amur area of the polluting substances containing toxic metals, or pollution of environment with mercury containing pesticides or technogenic losses at gold mining is not revealed.

In article the comparative analysis of acute infections of respiratory illnesses, acute intestinal infections, virus hepatitises and meningococcal infection morbidity in Yakutsk, RS (Y) and the Russian Federation is lead. Direct correlation dependence between vaccination parameters and some controlled infections morbidity is shown.

The effect of the first year infant feeding character on disease debut, prevalence and course type of atopic dermatitis (AD) in conditions of Yakutia is studied.
The correlation of infant feeding character with disease debut and AD course severity was determined.

For the study of harmless influence of small dozes of alcohol for pregnant women and fetus 20 women have been divided in two groups for comparison: 1) not using, 2) moderately taking alcoholic drinks. In both groups state of health, a social status, macro-and microelemental structure of blood have been studied. Researches were spent in the first and third trimester of pregnancy. The comparative analysis has shown that socially uncomfortable women have more changed parameters and the tendency to presence of bad habits (smoking, the use of alcohol). Мacro- and microelemental structure in blood in pregnant women of the 2nd group has been subjected to change in a greater degree; especially there were authentically low Zn and Cu levels. These changes have been revealed in the period close to conception and in the first trimester of pregnancy.

Investigation of a carbohydrate metabolism in 106 pregnant women with neurometabolic-endocrinal syndrome (NMES) depending on degree of adiposity and in 40 newborn girls in arterial umbilical blood is carried. Results are compared with similar in pregnant women without endocrinal pathologies. In mothers with NMES the glucose and insulin maintenance are higher, than without endocrinal pathologies. The glucose maintenance in an umbilical blood was in direct correlation dependence with the maintenance in blood of mother and in return – with the insulin maintenance. Newborns with transitory hypoglycemia and Caro index lower 0,33 make risk group on development of metabolic disorders.

The purpose of research: studying of reproductive health of children of Republic Tyva indigenous population. The analysis of gynecologic morbidity of children and teenagers for the period from 1997 for 2007 according to statistical reports is lead. For the characteristic of sexual development of girls - Tyvas in the age of 10 to 18 years M.V. Maksimova mark estimation and J. Tanner phenotypic estimation were used. Factors which can negatively influence realization of reproductive function are revealed: a high level of gynecologic diseases and menstrual dysfunctions, a delay of formation of secondary sexual attributes.

In work the medical-social reasons of occurrence of deviations in somatic development and health state in the senior preschool children with speech disorders are studied; main risk factors of the researched from the moment of home nursing in a polyclinic after birth and till 6 years are revealed. Influence of a condition of speech activity and health of children during transition from preschool education to training in an elementary school is certained.

We estimated the efficiency of plasmaferesis in 8 children with Gullain-Barre Syndrome on dynamics of neurologic semiology, electroneuromyography datas, durations of stay in a hospital. 5 children by the end of term of hospitalization had full restoration of function because of using treatment by plasmaferesis in a phase of progressing. It is proved, that application of plasmaferesis in a phase of progressing of illness promotes earlier indemnification of the broken functions, reduces terms of treatment in a hospital.

For five years we have observed 29 children with various forms of foot gigantism and a various congenital pathology of vessels. 12 patients have been operated. According to our research, surgical correction of feet is recommended to patients at an average and heavy degree of embryonal type of lesion of the main veins as they are characterized by presence of the expressed gigantism. Patients with the heaviest degree and spoiling deformation of foot are amputated.

In the article the disease problem by an arterial hypertension of the children’s population according to domestic official and references is considered. Under this data now there is a tendency to increase of occurrence of the given pathology at children’s age and, thus, the increasing value is got by its preventive maintenance and early revealing. At the present stage of development of domestic public health services it is the important and actual problem.

Results of retrospective research of the social status and morbidity of pregnant women of native nationalities of the Far North of Krasnoyarsk region are presented. Age features of parturient women of indigenous population of the Far North in comparison with the non-indigenous population, their education, the social status, marriage position are revealed. Extragenital and gynecologic morbidity has been studied, approaches to improvement of the North native women’s health are offered.

Long-term researches testify to negative dynamics of environmental pollution parameters of Yakutsk vicinities. The maximal contents of lead in city soils achieves 700-5000 mg/kg what is in 20 and even in 100 times higher than maximum concentration limit, and it is already a level of ecological disaster.

Biotic role of zinc concerning parameters of blood circulation, anthropometry, carbohydrate, fatty and mineral metabolisms in able-bodied, unorganized persons of 20-59 years living in territory of Yamal-Nenets autonomous region was under study.

Circulation of mold fungi in air of rooms in surgical departments of medical institution was established. The technique of definition of efficiency of disinfectants applied against mold fungi, on which 64 experiments are lead, is introduced. Researches have allowed to define optimum concentration of disinfectants, effective against mold fungi, which have been found out in the air environment.

The periods of circulation and stages of microbic microflora formation are studied on an example of a multi-type hospital new building. The bacteriological control was based on defini-tion of the general microbic seeding and definition of sanitary-indicative microorganisms (staphicoccuses, bacteria of group of E.coli, etc.) in an environment of a multi-type hospital. It is revealed, that during five months after commissioning a new building of a multi-type hospital there is a fluctuation of a specific variety of microorganisms. Obtained data allow to reveal the adverse periods of epidemiological conditions in a new multi-type hospital that is perspective for increase of efficiency of sanitary-preventive actions.

Epidemiologic characterization of tuberculosis in the Sakha Republic (Yakutia) over 38 years, on 4 main indicators: incidence, morbidity, sputum smear positivity, and mortality (1970-2007) is presented. In general, the named indicators are shown to have decreased markedly over the study period, owing to those years when the population had experienced a relative social wellbeing. But the last years (1990-2007) are characterized by a strong aggravation of epidemiologic situation.

The materials of research of food allowance, which are recommended for population of the Republic of Sakha and nutritional value of key products, are presented.

Traumatism, which negatively influences all parameters of health due to a high death rate, physical inability, morbidity with temporary disability, reduction of mean life expectancy of the population, became the major social and economic and medical problem of a modern society. It is connected with the fact that there are adverse factors on workplace, outside of workplace, in a daily life which become sources of the increased traumatism. The contents of article covers medical-social aspects of traumatism in Yakutia, thus such factors, as a level of mean per head income of the population and a rate of unemployment, became the basic socio-economic factors of traumatism growth.

The material, covering increased neurosecretory activity of supraoptical and paraventricular hypothalamus nucleuses at the general cooling of rabbits’ organism at temperature-30ºС within 25 days is presented.

In connection with a wide circulation of microorganisms’ strains resistant to antimicrobic preparations many pharmaceuticals reduce or even lose the practical importance. All it demands search of new antimicrobic means.
The purpose of the given work was revealing validity of using of vancomicin, amikacin, meropenem in the departments of intensive therapy and reanimation of the RH №1 – NCM.

This article presents surgical treatment data of 20 biliary sepsis patients (2001 – 2008) with nontumor main biliary duct disease, complicated with acute purulent obturational cholangeitis, by means of one stage rehabilitation method of main biliary duct permeability.

From the end of 90th years in medicine and biology increase of interest to carrying out of the researches directed on revealing of ethnically caused distinctions in anatomy and physiology of separate populations is steadily registered. This interest is consequence of natural development of science. In the review works on studying evolution of the person and populational variability are presented.