The purpose of research. Studying of features of a coronary atherosclerosis and revealing leading atherogenous lipid infringements in native and non-native men of Yakutia.
Material and methods. 407 men in the age of from 30 till 69 years are surveyed. 201 men of Yakut and Russian nationality with the verified coronary atherosclerosis according to selective coronaroangiography (SСАG) have made the basic groups. Groups of comparison - 206 men of Yakut and Russian nationality without IHD signs. The program of inspection included obligatory sections: clinic – anamnestic data, double measurement of arterial pressure, anthropometrics, electro – and echocardiographies, SCAG, definition of levels of the total cholesterol (TC), cholesterol of lipoproteins of high and low density and triglycerides (TG).
Results of research. In men with a coronary atherosclerosis in comparison with persons without IHD potentially atherogenous infringements of blood lipid structure: increased levels of TC, LPLD (р < 0,01), TG and decreased level of LPHD (р< 0,001) are noted. In men - Russians with a coronary atherosclerosis more expressed lipid infringements and defeats of coronary arteries (CА) in comparison with men -Yakuts are revealed.

Summary. The estimation of efficiency of a preparation equator (amplodipin 5mg. + lizinopril 10mg.) on dynamics of hemodynamic, morphometric and metabolic parameters in aboriginals of Yakutsk with an arterial hypertension is lead. It is proved, that the equator normalizes variability of a daily rhythm of arterial pressure, promotes regression of a left ventricular hypertrophy and reduces coefficient of compliance of an arterial wall. It has metabolically neutral action and it can be applied in persons with dyslipidemias and infringement of tolerance to glucose.

Summary. Changes of a glutathione level and activity of enzymes of its metabolism: glutathioneperoxidase, glutathionetranspherase and glutathionereductase in patients of a gerontologic age with a chronic cerebral ischemia (dyscirculatory encephalopathy) are presented. The characteristic of changes depending on a degree of disease heaviness is given.

The analysis of results of treatment of 42 patients after a low frontal resection with forma-tion of the intestinal tank is lead. Inspection was held in control terms with application of scales SF-36 and Wexner score. In terms in 1 - 3 months after operation main complaints of patients with again generated “ampoule” of rectum were incontinence of liquid feces and gas - 61,9 % that de-manded change of a life way. In terms about 6 up to 12 months after operation only 14,3 % of pa-tients have been forced «to change a way of life», that is caused first of all «by inclusion in work» of a tank, that was generated instead of the removed ampoule of rectum. The analysis of scale SF 36 and the nearest terms after operation has shown growth of life quality first of all due to PF (physical functioning), BP (body pain) and what is very important SF (social functioning). All this testifies to social rehabilitation and labour rehabilitation of the patient, and high enough degree of life quality in the nearest and remote terms after operation of a low frontal resection of rectum with formation of an ampullary tank.

The purpose of research. Studying of structure of morbidity on taking medical advice at the teenagers living in various medical-geographical zones of Republics Sakha (Yakutia).
Materials and methods. The material of retrospective studying of out-patient cards of 2385 children in the age of from 15 till 17 years surveyed in Children’s consultative department of the Pediatric centre of Republican hospital of №1-National centre of medicine for 2005-2007 is presented.
Results. Statistically significant distinctions in morbidity structures depending on sex and residence of the surveyed children are established.
The conclusion. The state of health of teenagers is substantially defined by a complex of specific conditions of the inhabitancy inherent for each medical-geographical zones of RS (Y).

In the given work, the risk factors influencing for terms of rehabilitation actions at children with congenital hiatuses of upper lip and palate in region of Yakutia are studied and revealed. For this purpose, the analysis of a clinical and archival material was done. In total 132 case records of children of various age with a congenital pathology of the face and facial skeleton have been analyzed. At the analysis, a type of the hiatuses, had and concomitant somatic diseases, laboratory analyses data were taken into account. Therefore, at 95,24 % of children infections of respiratory and ENT-organs were marked and revealed. Presence of concomitant pathologies at children with congenital pathologies was proved with changes of parameters of analyses of biological substances. It dictates necessity of optimization of the actions directed on the prevention of development of inflammatory complications of ENT- organs and oral cavity, with carrying out and introduction in region of Yakutia of surgical regenerative actions in early terms.

The purpose of research. Studying of interrelation of lipid exchange parameters with a functional condition of liver at viral hepatitises.
Material and methods. 100 patients with parenchymatous defeats of liver of viral etiology are investigated. Research of activity of enzymes, protein’s levels, urea, lipid exchange parameters is lead on the automatic biochemical analyzer “Cobas Mira plus” of firm “La Roche”.
Results. Participation of liver in initiation and modulation of system inflammatory reaction at liver parenchymatous defeats of viral etiology displaces balance of biochemical mechanisms in it that causes, first of all, infringement of a lipid exchange. The conclusion. Infringements of a lipid exchange in the surveyed patients with various forms of a viral hepatitis are caused by decrease in hepatocytes’ synthetic function and depend on reserve opportunities of liver.

The purpose of research. Estimation of brain primary tumours morbidity among adult and children’s population of RS (Y) during 2000 - 2004. Materials and methods. The analysis of 366 cases of brain primary tumours fixed in RS (Y) territory during 2000 - 2004. Results. It is revealed, that prevalence of brain primary tumours in RS (Y) territory is at a high level and has made 7,67 on 100.000 of population. City dwellers are sick more often. Peak of morbidity is in age group from 41 till 50 years. Tumours of brain coatings and neuroepithelium row with supratentorial localization among adult population and neuroepithelium tumours with subtentorial localization among the children’s population are most widespread.

The purpose of research. The comparative analysis of serumal immunoglobulins’ level of inhabitants of cities and the settlements of Yakutia located at different geographical latitudes.
Material and methods. Research of the immunoglobulins A, M and G content in blood serum of 417 inhabitants of Subpolar and 438 inhabitants of the Central Yakutia by standard immunological methods was carried.
Results and discussion. The significant interlinking of the raised development of immunoglobulins to high latitudes was established. The direct communication of the strengthened synthesis of immunoglobulins with a national identity (non-indigenous population) and illnesses of nervous system was shown. The revealed features of immunity of northerners associate with conditions of a natural light mode of the North.

The purpose of research was to reveal morphological features of changes in a mucous membrane of the stomach at НР- associated gastritis in children and teenagers living in Republic Sakha (Yakutia).
Material and methods of research. 188 biopsy materials from the antral portion of the stomach in children in the age of from 7 till 17 years with a dyspepsia clinical picture were investigated by endoscopic and histilogic methods (with the use of morphometry), 69 girls and 119 boys from them. In structure of the surveyed indigenous children -131, non - indigenous - 75.
Results. Frequency of the НР - infection in the general structure of the surveyed children and teenagers in the age of 7-17 years has made 58,5 % (р=0,01). On a morphological picture, the prevailing form of gastritises was a chronic superficial gastritis. Chronic gastritises in children of 7-9 years were associated with the second and third degrees of the НР-infection, and in teenagers of 15-17 years with the first degree of the НРinfection and their absence.
The conclusion. At the adult population of Yakutia infection with the НР occurs mainly in the childhood and increases with the years, as the early childhood is the critical period on НР-infection. The chronic infection caused by Helicobacter pylori leads to multifocal or diffusive atrophic gastritis and gastric epithelium metaplasia.

By hemocoagulography method on the reological blood properties analyzer of portable ARP-01 «Mednord» the analysis of hemostasis indicators at 55 women before mastectomy operation concerning a mammary cancer is carried out. The data obtained during research about a condition of hemostasis in patients with mam-mary cancer before operation have shown, that in all patients activization coagulational hemostasis link, shown by increase of structural and shortening of chronometric hemocoagulogramm constants is marked. Hemocoagulography gives the chance in rather short time (m=45,0±4,5 min) to receive sufficient volume of information condition of all links of hemostasis system and fibrinolysis in patients with mammary cancer and there is no need in laboratory services that allows to recommend it as a base method of hemostasis system research in this category of patients.

The purpose of research. Studying of reparation process features in uterus cut area after operation of cesarian section which will allow to define an optimality of healing and to increase percent of women with scar on uterus, delivered through natural patrimonial ways.
Material and methods of research. The complex estimation of reparation process character in uterus cut area in 80 women, delivered by cesarian section is lead.
Results. On the basis of the received data it is possible to construct the forecast of healing process and delivery method in subsequent desired pregnancy.
Conclusion. Obtained data specify great forecasting value of complex estimation of reparation process feature in uterus cut area after cesarian section that will allow to define an optimality of healing and to increase percent of women with scar on uterus, delivered through natural ways.

In practice of medical-genetic consultation of Republic Sakha (Yakutia) the way of diagnostics of oculopharyngeal miodystrophy by means of molecular-genetic research of a mutation in PABN1 gene is introduced. The given method is fast in execution, cheap and exact.

The article presents positive tendencies in the obstetric services in the Republic of Sakha (Yakutia). It also reflects negative social factors, which affect the reproductive health of women living in the Republic. It proposes certain measures to organize prevention services, especially at the primary level.

The acute enteric infection morbidity in RS (Ya) and Yakutsk is characterized by high indices comprising 500 and 1000 cases per 100 000 peoples, being 10 times higher than those for the Russian Federation and 7 times higher then in the Far East Federal District. In Yakutsk the structure of morbidity is as follows: AgEI – 72 %, enteric infections of clear aetiology – 12 %, salmonellosis and dysentery – 8 % each. The study revealed regional peculiarities of the pathogens of acute enteric infections: of 20 species of widespread AEI causing bacteria only 11 are observed in Yakutsk more often. The direct correlation of high and medium significance has been estimated between sickness rates of dysentery, salmonellosis, AgEI for Yakutsk residents and quality of drinking water, food, hygiene and sanitary conditions of living quarters and soils.