We represent the results of the study of apparently healthy men, the overweight northerners. We observed increased fibrosis, combined with local regulation system activation, which was manifested as an increase in the content of matrix metalloproteinases (MMP-1 and MMP-9) and tissue inhibitors of matrix metalloproteinases (TIMP-1 and TIMP-4). The revealed correlations between forms of hydroxyproline and cardiovascular risk factors indicate the relationship of collagen metabolism and atherogenesis.

We surveyed the men of Yakutia indigenous population (n = 150) living in rural and urban areas. The shift of lipid metabolism in the direction of dyslipidemia was observed in men in Central Yakutia, while among urban residents the signs of disadaptation were more marked. The men who lived in the north of Yakutia, there was no deviation from the norm. We revealed the correlation of lipid metabolism index (atherogenic index) with metabolic equilibrium index (De Ritis Ratio) that allows recommending the use of De Ritis Ratio for the formation of groups at risk of cardiovascular pathology and timely implementation of preventive measures.

Biomedical research of the indigenous Arctic population of the Republic Sakha (Yakutia) for 1994 and 2013 showed reduction in the proportion of people with normal cholesterol level and increase of proportion of the individuals with borderline high and high cholesterol. There has been growth of triglyceride level as well. High cholesterol is not always accompanied by a shift towards the atherogenic changes, in 75% of men and 76% of women increased cholesterol level can be considered as a consequence of the process of adaptation to changing conditions of life. The imbalance in lipid profile was identified also in people with normal cholesterol level, which is indicating the need for a mandatory determination of lipid fractions, regardless of its level. The tension of regulatory mechanisms of metabolism of proteins and carbohydrates, associated with atherogenic changes in lipid profile requires assessment of all risk factors and mandatory correction of the diet.

We studied the indices of relative microviscosity of the erythrocyte membranes in the two groups of inhabitants of the village Sumburgh Yamalo-Nenets Autonomous District: indigenous (tundra and forest Nenets) and non – indigenous arrived from central Russia. We revealed a significant increase in microviscosity of lipid-lipid interactions in the native women aged 46-55 years (p<0.05) compared with the non – indigenous ones. Increased membrane microviscosity may obstruct erythrocytes passage through microcapillary channel and lead to the development of the northern hypoxia.

Russia occupies one of the first places in the world by the level of children’s and adolescents suicides. In Russia itself, in the number of suicides the northern regions are in the leading position, where mainly small in number people live. The problem of suicide among indigenous people is typical not only for Russia but also for other countries in the Arctic zone, including highly-developed countries, such as Canada and the United States. Suicide worldwide is predominantly «male» phenomenon. An important reason for suicidal behavior is a weakening of the institution of the family – «paternity crisis». The lowest suicide rate is observed in the regions of North and South Caucasus countries, due, apparently, to the development of folk pedagogy of the Caucasus, where the fathers mainly bring up boys.
Thus, an important task in the prevention of youth suicide in the Russian Federation is a gender education, which implies the return of interest in the origins of folk pedagogy and strengthening the institution of paternity.

To study the prevalence of metabolic syndrome (MS) risk factors and the structure of morbidity in women - M.K. Ammosov NEFU workers during perimenopause we questioned and examined 50 women aged 43-70 under the annual medical examination of the NEFU employees.
The most common pathologies in the examined women break down as follows: arterial hypertension, mammary glands pathology (mastopathy), endocrine system pathology, gynecological disorders. More than 50% of the surveyed women have signs of type 2 metabolic diabetes and cardiovascular diseases. In particular, 51.9% of the women had arterial hypertension.

We studied the correlation of the comorbidity severity and pathological meteosensitivity of the North residents with arterial hypertension (AH), assessed certain psychophysiological and biorhythmological factors determining this interrelation.
The obtained data indicate that hypertension in the non-indigenous reisedents of the North is developing against the background of the presence of a pronounced degree of comorbidity. We determined the correlation of comorbidity severity at the hypertension in the North with meteosensitivity level, which is an important risk factor for hypertension in extreme environmental conditions.

We present results of an analysis of chronic diseases of the central nervous system in children and adolescents in the region of Mirny in Yakutia. The pathology of the nervous system of the underlying disease was 34.8%. A high percentage of CNS pathology in children from an early age indicates that it is a consequence of undergoing intrauterine hypoxia on the background of the pathological course of pregnancy.

The article presents the data of endoscopic examination of patients of the Medical unit the Health Ministry of Internal Affairs of the RF in the RS (Y) with a diagnosis gastroesophageal reflux disease and its complicated forms. We compared the chromoezophagoscopy data with the results of histological examination of biopsy samples. We analyzed risk factors frequency of patients with a verified diagnosis Barrett’s esophagus.

The article reviews physical development of teenagers living in extreme climate conditions. The influence of various factors on physical development leads to phenotypical changes. The environment influences much on the children’s organism as due to genetic plasticity and lability it is more acquisitive to unfavorable factors. Researches in the North where residing conditions are severe enough, considering extreme factors, such as long period of low temperatures, sharp day differences of atmospheric pressure, polar night, deficiency of solar radiation, etc., have revealed delay of terms of the beginning of growth activity, a great speed of transit of separate stages of the organism development, the accelerated maturing and early biological maturity which is explained as a phenotype approaching to the special ecological conditions.

We have compared the association of parameters of insulin resistance and visceral fat dysfunction with the main and additional components of metabolic syndrome in men who permanently reside in West Yakutia industrial region and work in mining company. There was a close connection between insulin resistance and analyzed main and additional components of metabolic syndrome. However, we have found no association between the dysfunction of visceral fat tissue and disorders of carbohydrate metabolism, which is the principal component of metabolic syndrome. Cardiometabolic risk assessment using the criteria of visceral fat dysfunction can therefore result in underestimated contribution of carbohydrate metabolism disorder to cardiometabolic risk. Thus, insulin resistance criteria are more informative in population studies of metabolic syndrome epidemiology and pathogenesis than the criterion of visceral fat tissue dysfunction.

We estimated main indices of lipid metabolism and hormonal status in blood serum obtained from indigenous inhabitants (tundra Nenetses) of Samburg village and non-indigenous population (mostly Russians) who arrived from other regions. The study revealed an increased concentration of insulin in all groups and a lower level of cortisol and thyroxin (women) in non-indigenous population. Hypertriglyceridemia and hypercholesterolemia as well as a high atherogenic index were found in the representatives of non-indigenous male population. A high level of insulin, an increased content of atherogenic fractions of lipoproteins, and a decrease in HDL content at a low activity of the thyroid gland and adrenal cortex are likely to result in the development of metabolic syndrome, especially in the representatives of non-indigenous population.

We studied peripheral blood parameters of population of the northern (Anabarskij) and central (Megino-Kangalasskij) regions (uluses) of Yakutia. We revealed significant differences in the hemogram. More than 50% of the residents of the Megino-Kangalasskij ulus have increased red blood cell count and hemoglobin concentration, which is not typical for the indigenous people, especially for women. The Anabarskij ulus residents have absolute and relative monocytosis probably associated with food and the environment. The blood count is more harmonious in the population of the Anabarskij ulus.

We studied a state of pro- and antioxidant balance in the athletes - freestyle wrestlers of Yakutia, aged from 18 up to 29 years. It is revealed that the CAOP/LPO characterizing pro-antioxidant balance depends on a season. The lowest CAOP/LPO values are noted during the winter period that is caused by the prooxidant processes connected with increase of Thiobarbituric acid reactive substances (TBARS) concentration. The intensification the CAOP/LPO in spring time is connected with activation compensatory adaptation reactions from antioxidant protection (increase of activity of SOD and CAT).

The article presents research data of 12-lead electrocardiography at rest (Rest ECG) and Holter ECG monitoring of athletes. Daily assessment of cardiac rhythm and conduction disturbances showed that the cardiac rhythm disorders by type of frequent supraventricular arrhythmia (up to 17 560/day) and frequent ventricular arrythmia (up to 22 450/day most frequently encountered in endurance-athletes (aerobic exercises), whereas the athletes training speed-strength (dynamic loads) had conduction disturbances by type of the second-degree AV block, Mobitz Type 1 (with a maximum duration of pauses up to 3 seconds). However, changes in Holter ECG and EchoCG have not been revealed in athletes with Brugada-like changes, but they are still under close control.

We assessed the effectiveness of bioremediation of oil-contaminated territories as the basis of a sys-tem of measures to improve the environment of human habitation in Northern Siberia. We collected soil and water samples on the territory of the activities of oil companies in the South of the Yamalo-Nenets Autonomous area before and after cleaning with the association of microorganisms capable of decomposing oil and oil products. It is shown that treatment of oil-contaminated and petroleum sites with preparations on the basis of oil destructor microorganisms leads to decrease of oil products on average 56,64±18,82%.

We’ve analyzed the impact of anthropogenic, technogenic stresses of the environmental and socio-economic factors on the malignancies morbidity of people living in the harsh conditions of the Arctic.

We’ve done a monitoring of the dynamic changes in the cardiovascular system under the influence of specific physical parameters of space weather. It was revealed that the test people organisms react with changes in the T-wave symmetry on each change in the geomagnetic storminess. The existence of coincident peaks of ECG data changes with geomagnetic parameters at the two observing stations proves the impact of the changes in geomagnetic storminess on the human cardiovascular system. The contrasting of the research results and the 2009 experiment results allows to assume that the different reactions of the human cardiovascular system may be related to the different phases of the 11-year solar cycle.

We researched the actual nutrition among persons of the indigenous nationality of Yakutia. By our study we proved imbalance of the actual nutrition by macro - and micronutrients. Besides we revealed increase in a share of fats (10%) and carbohydrates (12%) in a daily diet.

In order to study the prevalence of risk factors for acid diseases in the adult population according to the residence area in the Republic Sakha (Yakutia) we surveyed men and women aged 45-70 years living in the Arctic and Central Yakutia. Prevalence of symptoms of acid disorders was 53%, more often in the living in the Arctic. We revealed the high prevalence of chronic atrophic gastritis, Helicobacterpylori infection and poor dental health. Some risk factors for these disorders are modifiable, allowing to plan in their relation therapeutic and prophylactic measures.

The article reports an analysis of hydro-chemical parameters of water in comparison to the MPC for fishery and drinking water use. Due to a comprehensive assessment in 2010 the water of river Kolyma was characterized as the 3rd class category «A» «polluted». Typical contaminants were phenols, copper and zinc compounds.

This study was provided to characterize the localization of intracerebral hematomas, associated with anticoagulant therapy, in patients with warfarin-associated and spontaneous hypertensive intracerebral hematomas. It is found that warfarin-associated hematoma is characterized by a common site in the cerebellum compared with hypertensive intracerebral hematomas.

We have done the research of the volunteers with temporomandibular joint dysfunction syndrome (TMD) in the period from 2014 till 2015 years with an aim of receiving information about the parameters of chewing. As the result of this work was identified temporal and graphical parameters of the chewing moves, which is characterized for subjects with TMD.

The article presents the results of morpho- and organometry of mammary glands in the indigenous and non-indigenous women of Yakutia in age from 20 to 40 years. The study revealed that topo- and organometric breast indices had asymmetry of nipple-areola complex, the size of the base of the breast, skin and glandular fold along breast poles. We defined asymmetry of mammary glands forms in women of indigenous and nonindigenous nationality at different age periods. We also revealed the highest frequency of the asymmetric structure of the chest carcass and level asymmetry of submammary fold in the indigenous women. These topometric breast indicators in indigenous and non-indigenous women may be used as quantitative age morphological markers to choose breast implant and tactics of surgical correction.

We made the comparative assessment of efficiency of praziquantel and complexes of albendazole with arabinogalactan (ABZ-AG) on Opisthorchis felineus on model of experimental opisthorchiasis. The experiments were carried out on five groups of golden hamsters Mesocricetus auratus infected with O. felineus and receiving various doses of praziquantel and complexes of albendazole with arabinogalactan. The group of the animals infected with O. felineus who weren’t receiving anti-helminthes has been used as control. The obtained data indicate that efficiency of ABZ-AG complexes is similar to therapeutic efficiency of praziquantel. Thus, results of this study confirm a possibility of the development of drugs for treatment of opisthorchiasis on the basis of intermolecular ABZAG. Besides, as praziquantel and albendazole possess different mechanisms of action on helminths, it is possible to assume that combinatory action of a praziquantel and ABZ-AG complexes be more effective on O. felineu s than individual effects of these drugs.

Our work presents treatment results of the keloid scars appeared after the trauma and operations of auricles. Thus authors offered the complex program of therapy of the keloid scars taking into account the sizes and duration of their existence with an individual approach for each case. Preoperative local medication preparation of abnormal site growth of cicatricial tissue in the auricles and anti-relapsing treatment in the postoperative period was carried out for this purpose. Preoperative preparation includes infiltration of 2,0-4,0 ml of 0,5% lidocaine in tissues around the keloid and through one puncture injection by a syringe of 10-40 mg/ml of Kenalog (Diprospan) where the preparation dose always depended on the size of the keloid scar. The quantity of injections reached 5 times depending on efficiency of influence of these medications. The following stage when the keloid didn’t decrease any more after the corticosteroids influence – surgical excision of scar was planned. In the postoperative period the anti-relapsing treatment has been continued including 10-15 times of phonophoresis in the postoperative scar area with the use of Contractubex ointment or 3000 ME gel of Longidaza. Such tactics of complex therapy is characterized by lack of its recurrence and favorable esthetic type of the scar.

Compared to separate laparoscopic myomectomy, its combination with uterine arteries (UA) occlusion reduces the duration of the intervention, intraoperative blood loss and adverse clinical symptoms among 93,7% of women. It also has low myoma growth recurrence rate (during 12 months’ observation period – just 3.0%). High therapeutic effectiveness of UA laparoscopic occlusion consists of good knowledge of the basics of angiology, having manipulative skills, adequate perioperative management and complex rehabilitation after surgery.

The paper reports the analysis of the primary morbidity of the population of the Republic Sakha (Yakutia) in 2013-14 on the basis of Russian Ministry of Health statistical reports. High levels of primary morbidity in 2013-2014 were observed in such class of diseases as diseases of the nervous system, the eye and adnexa, respiratory and digestive system, skin and subcutaneous tissue; diseases of the blood and blood-forming organs, musculoskeletal system and connective tissue of the urogenital system were above average level. It also turns out that from the 113 species of the considered pathologies high and higher than average incidence rates in the country are found in 69 species, low and below average levels – in 19.

The analysis of the revealed violations during routine checks in the pharmacy organizations of the Republic of Sakha (Yakutia) for the 2012- 2014 showed that one of the violations of the licensing requirements is not compliance with the mandatory minimum assortment. In this regard, the investigation of violations of compliance with the minimum assortment of medicines in pharmacy institutions in the Republic of Sakha (Yakutia) was done.
The assortment and the minimum assortment of medicinal products was classified by the level of demand and speed of treatment. The technique of definition of level of demand and speed of treatment with the obligatory account of the available balances of the pharmaceutical professionals working directly with visitors, will contribute to the continuous maintenance and the determination of the optimal number of mandatory minimum assortment of medicines in pharmacy institutions.

The article presents the results of studies of the biological value of Yakut carp’s proteins by age of Lake Nigili in the Kobyaisky District of the Republic Sakha (Yakutia). It is concluded that the meat of carp under the age of 5 by the protein content significantly inferior to the meat of adult carp. Yet carps in the age of 5 have a high biological value - the amount of the amino-acid score is higher than standard (more than 100%).

The method of analysis of DNA damage («DNA comet», DNA-comet assay, method of gel electrophoresis of individual cells DNA) found its application in clinical practice as a method of monitoring the effectiveness of treatment and the severity of genetoxicologic effect in the development of endogenous intoxication. The literature review data suggest a possible clinical application of the method in determining the level of endogenous intoxication in patients with acute destructive pancreatitis.

The article attracted the attention of doctors to clinical features of diseases similar with Parkinson’s disease for early diagnosis and adequate treatment. We provide our own clinical cases of patients with neurodegenerative diseases (multiple system atrophy, essential tremor) who in the debut were diagnosed with Parkinson’s disease.