The article reflects the problem of nasal bleeding in patients with chronic hepatitis C. The purpose of the study was to determine the presence of the HCV virus fragments in nasal mucosa, changes in the local T-cell immunity, detection of morphological changes of the nasal mucosa in chronic viral hepatits C. The result revealed the presence of HCV nonstructural protein NS3, local activation of T-cell immunity and metaplasia of the epithelium of the nasal mucosa.

The aim of our study was to evaluate the relationship of hyperglycemia and postoperative hospital complications after coronary artery bypass surgery in diabetic patients. The study included 482 patients who underwent coronary artery bypass surgery (CABG) in the period from 2003 to 2008 in the Bakoulev Center for Cardiovascular Surgery. In our study, DM is not associated with an increased risk of major cardiovascular events (death, stroke, myocardial infarction) after CABG. However, the presence of diabetes is associated with an increase in the number of postoperative infectious complications. Hyperglycemia more than 200 mg / dL is a risk factor that increases the risk of postoperative complications such as death, stroke, acute renal failure, arrhythmias and infectious complications.

The authors present a retrospective analysis of archival materials of bacteriological laboratories and case histories of patients with surgical infections, hospitalized in the «Municipal Clinical Hospital», Blagoveshchensk and Amur Regional Clinical Hospital from 1985 to 2014.
Microbiological investigation of the material from the surgical and urological patients identified etiologic role mainly of Gram-negative bacteria in patients with surgical sepsis. The role of microbial associations (E. coli with Staphylococcus aureus, Staphylococcus epidermidis and with bacteria of the genus Proteus) went up and the share of Pseudomonas aeruginosa and Candida fungi increased. The authors concluded a preferred application for empirical antimicrobial therapy of surgical sepsis with cephalosporin group III–IV generation drugs (ceftazidime, cefepime, cefpirome) and carbapenems (meropenem, imipenem, doripenem) after analysis of antibioticogramms.

In the City children’s surdology center we examined children with confirmed hearing disorder to identify the factors influencing the psychomotor development of children with hearing deprivation. We revealed that more than half of the children with sensor neural hearing loss had other disorders of the nervous system, and among them problems with balance function prevailed; among development disorders speech delay prevailed naturally, comparing to other deviations; total developmental retardation by the sum of all subscales was detected in one third of the cases. This observation of children with hearing deprivation shows a variety of neurological conditions and irregularities of different functions’ development, and this material may become the basis for individual programs of medical-social help for these children.

Differentiation (Grade) was installed and updated in 358 cases of renal clear cell carcinoma by morphological and immunohistochemical methods. Reaction table of cytokeratin antibodies (СК 5\6, 7,8,10\13, 17,18,19,20) was compiled for each Grade of renal cell carcinoma with control of normal renal tissue.

The authors of the paper analyzed medical histories of teenage patients with pulmonary tuberculosis who were being treated in the Child care department of the State Budget Institution of the Republic of Sakha (Yakutia), scientific and practical center “Phthisiatry”. Most adolescents were infected with Mycobacterium tuberculosis in the early and pre-school age, received preventive treatment, but later under the influence of factors, most often in young men in their teen’s age tubercular process developed. Treatment analysis showed that at the optimal treatment in patients releasing sensitive strains of Mycobacterium tuberculosis, there was an accelerated clinical and radiographic dynamics and less pronounced residual changes in the lung tissue than in patients with multidrug-resistant Mycobacterium tuberculosis, which led to cheaper treatment courses and reduced hospitalization period.

The article presents the results of the surveyed children aged 3-15 years according to the program of computer – dispensary complex ACPEPACPME.
It was revealed that a preliminary assessment of the probability of detection of disease and its profiling dispensary examinations using a computer complex ACPEP-ACPME should reduce costs through targeted allocation of health care resources in the Republic of Sakha (Yakutia).

The article dwells on the study of the control organization in the form of planned inspections of compliance with the rules of licensing of pharmaceutical activity in the Republic Sakha (Yakutia) in 2012-2014. The role of licensing control as necessary element of state control in the field of medicines is defined. We studied and classified detected during scheduled inspections violations by type of work and services, which constitute pharmaceutical activity. We also substantiate the necessity of making all types of works and services, which constitute pharmaceutical activity, in the standing order, defining the procedure for the frequency of scheduled inspections in the field of healthcare, including pharmacy organizations.

The article presents an analysis of demographic and health indicators of the obstetrics service in the Sakha Republic (Yakutia) in the light of the development of optimal schemes of pregnancy and childbirth routing. Problems, similar to the problems of our northern region, are very relevant and marked in all countries of the circumpolar region; in recent years they are discussed at the international level within the circumpolar congress.

The results of investigation describe high prevalence of common dental diseases among the residents of industrial areas of the Republic of Sakha (Yakutia).

In order to compare the hormonal status of young athletes of the Republic Sakha (Yakutia) youths aged 16-17, professional sportsmen and those, not involved in sports, were investigated.
The authors came to conclusion that in 56.3% of the studied athletes catabolic metabolism prevailed, including 12.3 percent of them in a state of overtraining. Athletes had higher levels of cortisol and testosterone than the non-athletes. With increasing degree of reactive anxiety cortisol and testosterone levels significantly increased. Most athletes belonged to the stress-resistant types of people.

This article presents a study of the doctor in charge opinion about the availability and quality of medical care for cardiovascular diseases in the institutions of the Far East Region which is based on sociological research in 2013-2015. The local level of care had the largest share of negative assessments; the federal level received the maximum number of satisfaction rate. More than a third of physicians indicate the difficulties in patient diagnostics, almost half of the respondents recommend developing of preventive direction. Problems of patient rehabilitation and territorial remoteness were undeservedly forgotten. The majority of respondents feels the need for additional information of the cardiovascular system diseases diagnostics and treatment, as well as endorses the idea of the appointment of advanced cardiology courses. Few respondents approve the new system of continuous education.

Among the most important problems of modern practice of obstetrics, one of the most acute problems is premature birth. After all prematurity is the leading cause of perinatal morbidity, mortality and disability of children. The article presents an overview of current research done in the world to outline the causes of premature birth.

This article deals with the clinical case of early congenital syphilis in the 1 month child, admitted to the Oncology Department of the Pediatric center of Republican hospital №1 – National Center of Medicine and the Children’s City Hospital №2. Complaints on admission to the hospital were rashes all over the body, yellowness of the skin, general weakness. The child was diagnosed with a congenital mixed infection: early syphilis, cytomegalovirus, herpes, chlamydia, mikoplazma.
The patient was examined by specialists: a neurologist, a hematologist and dermatologist. Dermatologist recommended treatment with penicillin in a dose 100 thousand kg/day, divided into 6 injections over 28 days. In addition, neocytotect intravenously in age dose according to the scheme, immunovenin within 3 days. Also there was conducted hemocomponent substitutional, symptomatic therapy and albumin. On the background of such treatment the child’s condition has improved, he has no longer a temperature, put on weight.

The article reports the clinical case of severe acute meningoencephalitis out of the epidemic. We identified serological titer of 1:128 influenza A (H1N1) 09 in the patient with severe acute meningoencephalitis out of the epidemic, which had been reducing from 1:32 to negative in the period of reconvalescence. Taking into the consideration a pandemic situation of influenza A (H1N1) 09 currently it is recommended organization of dispensary observation of patients with viral neuroinfections of any etiology in the Sakha Republic to identify progressive forms of torpid encephalopathy, due to the unpredictable potential effects of the viral interference, not only in the former, unstable foci of Vilyui encephalomyelitis, but also outside of them.

The authors report their morphometric study data on comparative analysis of linear longitudinal, transverse and girth sizes of the lower limbs and definition of proportionality laws of their structure at various forms in the Saratov region girls of 17 - 20 years. They determined the basic variants of the anatomical configuration of the free lower limbs; indices of limbs’ proportions depending on their form; indexes of lower limb proportions to the total length of the body depending on their form; the incidence of various forms of lower limbs at their endo-, meso-and ectomorphic types.

The analysis of the carried-out hemotransfusion in coloproctological department of multidisciplinary clinic has shown stable need for the following components of blood: erythrocyte containing environment and fresh frozen plasma. Development tendencies are transfusion of quarantine freshfrozen plasma, the erythrocyte containing environment which was exposed to leukofiltration.

The article is devoted to an actual problem of modern pediatrics - children, frequently having acute respiratory viral infections. The analysis of the detection of IgG, IgM to the Ebshtein-Barr (EBV) virus, Cytomegalovirus, HSV, Mycoplasma pneumonia and to the Chlamidia pneumonia in the group of children, frequently having acute respiratory viral infections, is done. In the studied group compared with healthy children an increased antibody titer is revealed.