The article reports results of study of the cytoflavin effect in doses of 50 mg / kg and 100 mg / kg on the antioxidant status of rats at chronic cold exposure. It was established that the studied preparation prevented from stress-induced activity of lipid peroxidation in serum of the animals, exposed to cold. The effect is expressed in less formation of peroxidation products and in the prolonged conservation of a high level of antioxidant system components activity. During the comparative pharmacological analysis it was established that cytoflavin produced a direct antioxidant effect according to a dose during cold exposure on the organism of the experimental animals.

Growth of registration of CD, including CHD, in recent years, and a tendency to increase in difficult CHD and the critical CHD demanding the high-tech cardiac help in the period of a neonatality and at infancy in the Russian Federation, the leading role of CHD when forming invalidization among children, formed the basis for carrying out the comparative analysis of frequency and structure of congenital heart diseases and large vessels among newborn children in RS (Y) in 2002-2004 and 2011-2013. Research was conducted on the basis of the Perinatal Center State Budgetary Institution RS (Y) RH№1 NCM among live-born newborns. CHD were registered according to the nomenclature headings Q20-Q28 (ICD10). The indicator of frequency was made on 1.000, the live born. According to research growth of frequency of CHD is observed among newborns in comparison with 2002-2004 by 4.7 times.

32 patients with acne were surveyed to study changes in total protein oxidative modification of blood. Along with the generally accepted clinical and laboratory findings in patients electrophoresis of serum proteins by the severity of oxidative stress on the content of carbonyl derivatives (in spontaneous oxidative modification of proteins) was determined.

It is proved that the treatment of acne patients with systemic retinoids is accompanied by oxidative modification of serum proteins. The consequence of these processes can be aggravating oxidative stress and increased body harmful effects caused by free radicals in tissues.

Considering not sufficient study of the effects of systemic retinoid therapy, the treatment of acne should be strictly controlled, and in the selection of the dosage form should be dominated by the principles of more bioavailability and maximum effective dosage.

We studied functional state of arterial wall endothelium in elderly patients after splenectomy due to trauma of spleen in close post-operational period. Data showed that antithrombotic features of endothelium has changed heterogeneously, i.e. intensification of fibrinolytic activity due to low thromboresistance of endothelium, which is accompanied by reduced tissue plasminogen activator (tPA) in vascular wall and reduced secretion of it to bloodstream. This data suggests that certain biologically active substances are secreted by spleen, which facilitates release of tPA from endothelium, which in turn can lead to intravascular thrombus formation in these group of patients.

The review presents clinical polymorphism of Vilyui encephalomyelitis, variability and characteristics of the disease, when it is accompanied by the syndrome of amyotrophic lateral sclerosis. Diagnostic criteria and work-up in the differential diagnosis of Vilyui encephalomyelitis and classic amyotrophic lateral sclerosis are described.

We compared long-term results for coronary artery bypass grafting in 195 patients with associated diabetes, 108 (55%) patients underwent coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and 87 (45%) patients underwent off – pump coronary artery bypass grafting (off – pump CABG). Mean follow-up was 56 ±11 months. (≈4.6 years). Fiveyear survival and the "freedom" of recurrent angina pectoris in patients with diabetes who underwent CABG with CPB and off – pump CABG comparable. We have not received significant differences when compared to the five-year incidence of the myocardial infarction and re-revascularization between the groups. The benefits observed in patients after off – pump CABG, when comparing the frequency of "large" cardiovascular complications between the two groups.

The paper presents the analysis of long-term results of treatment of patients with fractures of the proximal humerus - the study of one of the most actual and controversial issues in traumatology. It is revealed that patients with fractures of the proximal humerus in 23% of cases have a reduction in bone density and a high risk of getting re-fractures in the next 10 years. Surgical treatment in up to 85% of cases has a positive long-term outcome.

Objective: Comparative study of effectiveness of different dressings for application on transplanted split perforated autodermotransplants.

Material and methods: Clinical and laboratory evaluation of autodermoplasty made in 108 patients with deep lesions.

Results: It was revealed that good engraftment and epithelialization of autodermotransplants largely depended on the preparation of recipient bed and creation of optimal conditions for healing through use of dressings, rather than on any additional manipulations. Complications in the form of festering wounds with lysis of the transplanted autodermotransplants most often occurred in application of dressings containing no antibiotics.

Conclusion: Rational treatment tactic of burn wounds after autodermoplasty is proposed.

The purpose of the work: to evaluate the clinical efficacy of preparation Wobenzym inclusion in the complex therapy of pneumonia in previously vaccinated with pneumococcal vaccine "Pneumo-23" and unvaccinated patients.

The method of research. The study included 157 patients with pneumonia, men, soldiers performing military service at the age of 18 to 22 years (19.2 ± 0.19), admitted to the pulmonology department of the military hospital in the period from 2007 to 2010. Depending on the treatment, all patients included in the study were divided into four groups randomly. The 1st main group (MG, n = 46) included patients previously vaccinated with pneumococcal vaccine and treated with standard therapy; in the 2-nd (MGSET) - vaccinated patients (n = 44), who were prescribed in addition Wobenzym; in the third group - the comparative (СG, n = 34) - patients previously non-vaccinated and treated with standard therapy, and the 4th (СGSET) - unvaccinated patients, but additionally treated with medication Wobenzym (n = 33).

Results. It is shown that the inclusion of the preparation Wobenzym in the complex therapy of pneumonia contributed to a more rapid regression of all clinical manifestations of pneumonia and reducing the probability of formation of residual radiological changes of lung tissue. It is found that the inclusion of systemic enzyme therapy drugs in the complex treatment of pneumonia is pathogenetically substantiated.

The algorithms of actions for the definition of the condition severity and choice of the medical-diagnostic measures in the patients with the biliary sepsis are presented. We take into account the traumatic factor of the operation, the kind of narcosis (endotracheal, local anesthesia) and severity level of the initial condition of the patients. We suggest using this program of the actions in the form of the computer program for the diagnostics of the severity level of a condition of the septic patients, creation of the database and electron archives of results of treatment, and also continuous monitoring of the condition of the patients.

The paper presents the study of indicators of medical-demographic, social-hygienic, physical and dental status of 755 indigenous women of the Taimyr Dolgan-Nenets Municipal District of the Krasnoyarsk region.

Patients belong to socially vulnerable groups (low income and education level, remoteness of residence area, lack of adequate medical care), in connection with which there are big problems with health in general and in particular with the dental one. There is no permanent dental care in small settlements of North of Krasnoyarsk region, no dispensary registration and dental treatment of pregnant indigenous women of the North. Permanent dispensary dental care of indigenous women of the North of Krasnoyarsk region is a compulsory condition to improve the dental health of women and their progeny.

The article presents an analysis of the diagnostic and treatment and rehabilitation of children suffering from tuberculosis and children with latent TB infection who were in the Republican Children’s tuberculosis sanatorium named after T.P.Dmitrieva for 2011-2013.

We studied the content and distribution of lead compounds in the Republic freshwater fish in the Rivers Amga (Amginskiy District), Vilyui and lakes of Vilyuisk population, Chroma riv. lower reaches, the Indigirka riv. (Allaikhovsky District) and Kolyma (Srednekolymsky District) in 1996-2011. Studies indicated insignificant level of lead in the tissues and organs as herbivorous and carnivorous fish. Exceeding was detected in some of fish where industrial mining was taking place.

On the basis of analyzing the views of scientists and experts, and on the basis of their data, the authors express their point of view on the desirability of providing the Arctic (North) medicine as an independent field of theoretical knowledge and practical activity like, for example, tropical medicine.

The paper analyzes the demographic situation in the Arctic, a region with indigenous northern peoples on the example of the Sakha Republic (Yakutia). The problems of the modern social and economic situation of the indigenous peoples of the North connected with the development of the traditional Northern branches are considered. Measures on improvements of the state policy towards the indigenous numerically small people of the North are proposed.

The paper presents the analysis of application of the indicator of the dental pathology development risk, according to the recommendations of the European Commission and the program of joint actions on monitoring of dental health “Daily intake of food and drinks" in pension age persons, living in the "Social house №1 of Khabarovsk veterans ", Khabarovsk. As the study showed the indicator interpretation was not resultative, which was expressed in the assessing index of the CFE (caries, filling, extracted teeth) and the number of surviving functioning teeth not more 8. 86±1. 59 on each subject.

The paper deals with the topical issue of the drug’s interactions with components of commonly used food and remedies of traditional medicine (folk medicine). Similar studies are needed for a personalized approach to the treatment. In particular, the effect of traditional and new food, plants, which are used in traditional medicine, the characteristics of the person's lifestyle on the activity of enzymes of the family of cytochrome P-450 involved in the metabolism of drugs and actively studied in pharmacogenetic studies has been shown. Presented problematics is the basis for a thorough gathering of the medical history referring to the ways of life (food, bad habits) of the patient in the appointment of appropriate therapy.

This article reviews data on manufacturing children’s foods derived from animal raw materials supplied by local farms of Sakha Republic.

Study of reindeer milk from different farms revealed that it might serve as a substitute for human milk after certain processing. This is mainly due to its high nutritional value and technological features.

This is also true for horse milk. It contents is significantly different from cow milk but close to human milk.

Considering close similarity of fat from young species of Yakut horse to milk fat in contents of middle-chain fatty acids, it may be viewed as an additive for adjustment of fat contents.

We studied the content and distribution of lead compounds in the Republic freshwater fish in the Rivers Amga (Amginskiy District), Vilyui and lakes of Vilyuisk population, Chroma riv. lower reaches, the Indigirka riv. (Allaikhovsky District) and Kolyma (Srednekolymsky District) in 1996-2011. Studies indicated insignificant level of lead in the tissues and organs as herbivorous and carnivorous fish. Exceeding was detected in some of fish where industrial mining was taking place.

The article considers the problem of increasing the number of depressed patients worldwide. The main reason for this phenomenon is the phenomenon of “alienation”. The author lists three main types of alienation. The main problem in Russian psychiatry is the stigma - hanging shameful labels on people seeking help from a psychiatrist or psychotherapist. Social measures to combat depression and anhedonia are considered.

Review is devoted to the description of the world’s approaches of using graphene oxide as a nanostructured quencher for DNA diagnostics of SNPs. The unique properties of graphene oxide with respect to DNA and detailed options for its use as a replacement for molecular quenchers in classical test systems are described. The potential for adaptation of existing approaches for the laboratory DNA-diagnostic is considered.

Here a review of modern approaches to outpatient psychiatry care is represented and dynamics of problems and achievements in remodeling the “psychiatric hospital - branch of psychiatric hospital (psychoneurologic dispensary)” are analyzed. In particular, the dynamics of shifting psychiatry care from hospitals to their branches (psychoneurologic dispensaries), combined with the decrease in bedspace during the last 7-8 years is shown.

The positive sides and perspectives of therapy and rehabilitation of mental patients in day patient facilities and by using patronage in modern conditions are described. The arguments supporting feasibility and advisability of giving priority to the outpatient psychiatry services during the last decades (pathomorphism of psychic disorders, implementing new generations of medicines, developing the methods of social-activating rehabilitation) are analyzed. Also the concept, according to which in case of spending as little time in psychiatric hospital as possible the self-conscience of mental patient changes less, which provides higher chances for one to see oneself as a full-fledged member of society, is reflected. Consequently, therapy and rehabilitation in case of outpatient care get a social motivation, which increases their efficiency.

Several modern approaches to psychiatry care are represented in historical aspect of succession of Old Russian territorial (local) psychiatry.

We report a patient with chronic herpes infection, which manifested as parainfectious limbic encephalitis (PILE) and sensory-predominant chronic inflammatory demyelinating polyneuropathy (SP-CIDP). It is demonstrated that persisting herpes infection associated with immunodeficiency can facilitate two pathological processes: direct viral damage of limbic structures and autoimmune damage to myeline sheath of peripheral and cranial nerves. Description of the case includes clinical presentation and diagnosis of SP-CIDP and PILE. CIDP is an autoimmune disorder, characterized by damage of myelin sheath of peripheral and cranial nerves. It is thought that CIDP accounts for 20-50% cases of undiagnosed polyneuropathy. The contribution of Herpesviridae family to development of CIDP is a matter of debate. PILE associated with Herpesviridae infection is one of the most common forms of chronic herpetic encephalitis, characterized by abnormalities in function of limbic system (hippocampus and amygdala), with protracted course of disease and frequent exacerbations. Parainfectious limbic encephalitis is caused by direct viral damage to limbic structures.

We suggest a new diagnostic algorithm of SP-CIDP, which includes nerve conduction study, stabilometry with use of EU standard Rhomberg’s test, computerized pallesthesiometry (CP) of distal parts of upper and lower extremities, computerized thermosensometry (CTS) for evaluation of thermoception and pain threshold for cold and hot stimuli. This algorithm can be used in the setting of outpatient clinic by neurologists and general practitioners. The diagnostic methods utilized in this algorithm, such as CP and CTS, are safe, simple, and non-invasive and may have broad application.

This article focuses on the actual problem of modern pediatrics - dysfunctional disorders of the biliary tract in children. It was revealed that dysfunctional disorders are more marked in children early switched to artificial feeding, underwent an intestinal infection and treated with antibiotics to two years. The authors studied the clinical efficacy of the drug hofitol in children with dysfunctional disorders of the biliary tract. It is found out that the use of the drug hofitol reduces pain and helps to normalize stool for 3-4 days of therapy.