The article analyzes the infant mortality rate of the Sakha Republic (Yakutia) in the period of implementation of major projects in the health field from 2000 to 2015. It is noted that according to official health statistics, the infant mortality rate in the Republic Sakha (Yakutia) steadily decreases.

Improving the availability and quality of specialized and high-tech medical care to children and adolescent is one of the priority tasks of state policy in the sphere of health care [1-3]. Pediatric center “Republican hospital №1-National center of medicine” (Director, PhD Lyudmila Alekseevna Nikolaeva) is the country’s only medical institution providing specialized, highly skilled and high-tech medical care for child and adolescent population. The article presents data of hospitalized morbidity of children and adolescents of the Republic of Sakha (Yakutia) on applications to a Pediatric Centre for a 15 year period.

Since the late 80-ies of XX century, due to the expansion of laboratory capacity genetics, amount of new genetic disease has increased significantly. Clarification of the etiopathogenesis of the disease is of great importance to address the issue of disease prognosis, therapy and prognosis of the most important thing for parents about the possibility of the birth of their healthy baby. Therefore, caution is so important neonatologist, a thorough history and careful examination of the patient. The article is devoted and little-known wide range of medical problems - diagnosis and treatment of a rare genetic condition Prader-Willi syndrome in newborns admitted to the neonatal pathology and premature babies Perinatal Center №1 “RH №1-NCM” in the period from 2013 2016. We present our 4 cases of laboratory-confirmed Prader-Willi syndrome. On the first stage of nursing infants were suspected neurological conditions with muscular hypotonia, inhibition of unconditioned reflexes, ie, Neonatologist missed. The syndrome has characteristic symptoms, on the basis of which a neonatologist, pediatrician, neurologist, geneticist may be suspected in the newborn disease Prader-Willi. Flaccid syndrome child who manifested suppression of consciousness, faint, brief cry, difficulty in feeding, the oppression of the majority of congenital reflexes, diffuse muscle hypotonia, decreased spontaneous motor activity. The characteristic phenotype: light skin and hair, dolihotsefalicheskaya head shape, narrow high forehead, microgeny, gothic sky, bird-like face, palpebral boys, girls, almondshaped eyes cryptorchidism boys, girls hypoplasia of the clitoris and the labia minora. The diagnosis was confirmed in all newborns tsitogenetichkim molecular analysis (nuc ish del (15) (q11.2q11.2) (SNRPN) [200]) and found a deletion in a gene SNRPN 100% of the interphase nuclei.

The article is devoted to an actual problem of infectology and pediatrics. The introduction into laboratory practice of molecular biology techniques for detecting infectious agents significantly increased the understanding of the characteristics of chronic hepatitis B course (CHB). It was shown that DNA virus with a low copy number continues to be determined in serum and liver tissue in patients with some level of HBsAg nedektiruemym both acute and chronic infection, or even after antiviral therapy. In recent years, it has been convincingly proved the existence of HBsAg-negative forms of chronic hepatitis B, which has led to the emergence of the concept of latent HBV infection, which is characterized by the presence of the virus in the body at undetectable levels of HBsAg. This reduction in the formation of HBsAg to undetectable levels during the development of chronic infection is a very common and well-described phenomenon. This is a special group of patients, who often escape the attention of doctors, since screening is carried out only by HbsAg. With such an important development of CHB, and often the only serological marker of infection the patient is the presence of anti-HVcor IgG.

In the present study we compared the clinical and laboratory data of children and adolescents with HBsAg-negative and HBsAg-positive chronic viral hepatitis (CVH). The study did not reveal fundamental differences in epidemiological, clinical laboratory data in patients with latent chronic hepatitis B, in comparison with the manifest forms of the disease. It is found that these patients suffer from chronic liver disease not less than HbsAg (+) patients. Introduction of а-НВсor to the screening will allow actively identify these patients and to carry out a full range of medical and dispensary activities.

The article is devoted to an actual problem of infectology and pediatrics. The introduction into laboratory practice of molecular biology techniques for detecting infectious agents significantly increased the understanding of the characteristics of chronic hepatitis B course (CHB). It was shown that DNA virus with a low copy number continues to be determined in serum and liver tissue in patients with some level of HBsAg nedektiruemym both acute and chronic infection, or even after antiviral therapy. In recent years, it has been convincingly proved the existence of HBsAg-negative forms of chronic hepatitis B, which has led to the emergence of the concept of latent HBV infection, which is characterized by the presence of the virus in the body at undetectable levels of HBsAg. This reduction in the formation of HBsAg to undetectable levels during the development of chronic infection is a very common and well-described phenomenon. This is a special group of patients, who often escape the attention of doctors, since screening is carried out only by HbsAg. With such an important development of CHB, and often the only serological marker of infection the patient is the presence of anti-HVcor IgG.

In the present study we compared the clinical and laboratory data of children and adolescents with HBsAg-negative and HBsAg-positive chronic viral hepatitis (CVH). The study did not reveal fundamental differences in epidemiological, clinical laboratory data in patients with latent chronic hepatitis B, in comparison with the manifest forms of the disease. It is found that these patients suffer from chronic liver disease not less than HbsAg (+) patients. Introduction of а-НВсor to the screening will allow actively identify these patients and to carry out a full range of medical and dispensary activities.

The article is devoted to an actual problem of modern medicine - the study of cytomegalovirus infection. A group of children aged 2 to 5 years, often suffering from SARS with low-grade fever of unknown genesis with positive ELISA and PCR for cytomegalovirus (CMV) was examined. It was found that in children with CMV reduction of natural killer cells (CD16 +), T-helper cells (CD4 +), cytotoxic T lymphocytes (CD8 +), increase of IgM, IgG, and the CEC were marked.

The study was conducted on the basis of the Medical Institute NEFU. 44 volunteers from the university students between 18 and 23 years were the object of the study. All surveyed were male. We studied the features of psychophysiological state at forming adaptive reactions of the students M.K. Ammosov NEFU from countries with a hot climate (the main group). The control group consisted of students, representatives of indigenous ethnic groups (Yakuts, Evens). It was revealed that at adaptation to extreme subarctic climate in foreign students there are marked a shift in the balance towards the activation of the sympathetic part of the vegetative nervous system, moderate and high levels of personal anxiety, not accompanied by the perception of the majority of situations as threatening and the development of anxiety. On Harvard step-test graduation index in both groups there were no persons with the assessment of physical performance “excellent”. By indicators of heart rate variability in the main group the activity of stress-limiting systems dominated, whereas in the control – optimal adaptation indicators. It was found that the adaptive possibilities of the body of persons in the control group, estimated by the capacity of slow and fast waves, are characterized by low levels of mobilizing and reduction potential, in the main - a moderate level.

The article is devoted to an actual problem of primary immunodeficiencies. Primary immunodeficiencies are rare diseases, and awareness of this pathological condition is not enough. Itleads to late diagnosis and inadequate treatment of patients suffering from primary immunodeficiency.

Allergic diseases often dominate clinical picture of immunodeficiency states. There is a case’s descriptionof primary immunodeficiency in a child with asthma.

The health of children and adolescents living in regions of the Far North is extremely actual. In these regions there is a clear effect on the body unmanageable climatic-geographical and social factors that contribute to the formation of various diseases. Organization of rational nutrition is the most important area in the health of the younger generation. We conducted a study of children and adolescents living in the Aldan district the RS (Ya), which included a comprehensive, in-depth examination of the health status of children, the determination of the elemental composition in biological substrates and questionnaire on nutrition. We diagnosed in children and adolescents more often diseases of the respiratory tract, gastrointestinal disorders and low vision. It was revealed that inadequate provision of macro - and micronutrients may lead to the development of various pathologies. Nutrition of children and adolescents is moderately rational; in addition to natural products they consume unhealthy foods. According to the results we gave practical recommendations.

In the article the issue of compliance to medication treatment of patients with previous Q - positive myocardial infarction within one year after discharge from the hospital is considered. 113 persons were included in the research. The control was conducted after 6 and 12 months. Lower compliance to treatment was noted concerning all groups: β-adrenergic blockers, APF/ARA inhibitors, double antithrombocytic therapy, with a greater proportion of reducing statins (50 %).

The authors investigated the level of steroid and gonadotropin-releasing hormones in women of older reproductive age to identify early markers predicting uterine fibroids. We have recognized Ulipristal acetate («Esmiya», Hungary) as the most effective drug for the conservative treatment of uterine fibroids. An in-depth study of the clinical and laboratory, including hormonal parameters will improve the tactics of directing patients, develop indications and contraindications for the use of the drug, increase their efficiency, develop an algorithm for the treatment of patients with a diagnosis uterine fibroids.

The women with uterine fibroids and in the nearest 12-24 months’ myomectomy were examined. The comparative evaluation of the effectiveness of preconception care in the prevention of complications of pregnancy in women after myomectomy is presented.

The article reports the analysis of the results of examination and treatment of patients with lung and liver echinococcosis. According to the analysis, in most cases we observed lung damage with a significant lack of hydatid cysts in the liver, which is not complying with the all-Russian statistics as a whole. Patients were forwarded to our department from different out- and in-patient facilities. Based on the data of instrumental and laboratory studies, all patients underwent echinococcectomy combined with antiparasitic therapy.

Results of a preclinical trial on studying of influence of the standard complex therapy and complex therapy with use of a local irrigation of a wound sodium hypochlorite on the course of superficial experimental phlegmons are presented in article. During the research assessment of a morphological picture of a postoperative wound for 3, 7 and 10 days is made. At a combination of complex therapy to a local irrigation of a postoperative wound sodium hypochlorite solution pathomorphologic signs of an acute purulent inflammation became less expressed, with formation of a proliferative infiltrate in an interstition of a hypodermic musculation and faster retrogress of inflammatory process.

We studied the influence of CYP2C19 gene polymorphism on the development of in-stent restenosis after transdermal coronary intervention in patients with acute coronary syndrome. The obtained data have revealed a gene almost in the half of patients with restenosis in coronary artery, it being responsible for the reduction of clopidogrel metabolism.

In this paper we describe the method of isolation, maintaining and storage of human primary skin fibroblasts to treat damaged skin. The described method is fast, simple and reproducible.

In the present work results of influence of antioxidants (emoxypin and mexydol) on formation of adhesions in an abdominal cavity at experimental animals in comparative aspect after modelling of adhesive illness are presented. It is established that in the groups received specified preparations authentic decrease of formation of adhesions is marked with optimization of antioxidant system. The quantity of remezotelizated cells on deserosaled sites of peritoneum in comparison with control group increases.

In the paper the etiology, possible pathogenesis, symptomatology and treatment of neuritis of the second branch of trigeminal nerve, emerged as a traumatic damage result or in the postoperative period, are described. The authors proposed the complex treatment of this pathology. The carried out observations justified its effectiveness.

The authors reported data on temperature changes in the stomach and on the wrists of the two swimmers during swim across the Bering Strait in conditions of extremely low water temperature (3 ° C to 6 ° C), as well as in the preliminary swim across the river Lena in more favorable conditions.

The continuous measurement of the body of the swimmers’ temperature was done using a thermologger iBDL DS1922L, which, having a small size and a non-volatile memory can be placed directly inside of the object. The minimum temperature in the stomachs of swimmers during swim across the Bering Strait was fixed at 27 ° C. Measurement of body temperature in extreme environmental conditions can help to study the limit of an organism and to fight with the effects of hypothermia.

The article describes some clinical data on influence of low temperatures on organism of dogs in an experiment.

The article presents a review of the literature on the effects on human of space and helio-geophysical factors.

The literature review is based on the analysis of sources, covering pathomorphology of colorectal cancer. Topical issues were highlighted for further study of this problem.

The authors report assessment of dietary intake, physical development and health of students of the Far Eastern state University. The cause-and-effect relationship between physical activity, diet, lifestyle, and the specifics of their training are revealed. It is established that the nutrition of students is unbalanced and deficient in energy value, content of basic nutrients, vitamin and mineral composition. We determined that vitamin and mineral supplements took less than half of girls and boys. The actual energy of the involved in sports students match 4 group work intensity according to the physiological norms. Malnutrition (underweight) among boys, girls, and the low level of physical performance are revealed. The greatest contribution to the status of actual nutrition and physical health of students makes the average monthly income. The influence of this factor is the most pronounced in the group of students with average wealth. The peculiarities of food consumption and physical development can serve as a basis for developing specific recommendations for the prevention of various diseases among students.

During clinical inspection of 117 men, aged from 25 up to 55 years, which are aircrew of civil aviation of the Russian Federation, the frequency of occurrence and feature of clinical course of parodontitis is studied. It is established that with a satisfactory individual hygiene of an oral cavity, the frequency of occurrence of gingivitis, periodontitis and parodontosis by the aircrew is respectively, 47,5%, 29,2% and 2,5%. 26,7% of pilots needed dental treatment, but the USP index about 56,3% corresponded the normal stomatologic treatment of an aircrew. It is emphased that during planned profound surveys or medical and flight examination of an aircrew of civil aviation, it is necessary to make a prophylaxes of early loss of natural teeth, to tap the persons having clinical signs of diseases of parodont by studying the parodontal status and refer them to the prevention facilities for performing specialized treatment.

The presented clinical case is probable case of the Creutzfeldt-Jakob Disease (CJD) from the region of distribution of the Vilyui encephalomyelitis (VEM) in Yakutia. The disease occurs in the form of rapidly progressive, fatal meningo-encephalitis, with positive identification of oligo bands of IgG in the cerebrospinal fluid and meningeal symptoms, but with CJD characteristic MRI neuroimage changes. Such cases, even being single and possibly not related to prion diseases, should cause the attention of the scientific and medical community and require thorough investigation and further study.

This article describes a clinical example of successfully carried out an endovascular local thrombolysis at a massive pulmonary embolism. The carried-out local thrombolysis therapy has surpassed all expected effects of treatment.