A comprehensive immunological examination of children of different age groups with Epstein-Barr-viral infectious mononucleosis was carried out in order to identify the prognostic value of the cytokine dynamics.
It was revealed that changes in the cytokine profile in 3-6 years old children can be considered as a factor explaining the frequent reactivation of EBV in preschool children. A complex immunological response in 12–17 years old children can be considered the most favorable response to the EBV elimination. The immune response of 7-11 years old children was in an intermediate position.

The association of leptin circulating in blood with gastritis clinical morphological signs in schoolchildren with normal and excessive body mass index was under study.
It was revealed that in children with excessive body mass the gastritis and associated pathologic processes in gastric mucosa are being formed and developed under the conditions of hyperleptinemia, because the level of leptin secretion into blood substantially depends on the volume of fat tissue in an organism. Leptin involvement and the strengthening of its regulating role, which is determined in children with normal body mass with dyspeptic symptoms, are balanced under the conditions of the increase of fat tissue quantity in an organism.

The results of a study of a number of hemodynamic parameters – microcirculation and PO₂ oxygen tension – in the skin of the abdomen in rats using laser Doppler flowmetry and transcutaneous oximeter are presented. Animals of the experimental group daily for 30 days were tired by forced running. It was established that in animals of the experimental group the level of intracutaneous oxygen tension was lower than in control ones. At a systematic running load, the microcirculation index in the skin of the animal’s abdomen increased up to 10 days from the experiment start. Then, by the 30th day, the microcirculation rate slowed down. But in all dimensions during the experiment, it was faster than in control animals. The inverse dependence of PO₂ on the microcirculation rate was revealed at measuring the level of intracutaneous oxygen tension, which was expressed by lowering the level of intracutaneous PO₂ in all cases of increasing the rate of intracutaneous microcirculation.

The article reports the study of schizophrenia patients with the help of magnetic resonance imaging, anthropometry, PANSS psychometric evaluation, registering basic clinical signs with hereditary burden, duration of disorder and the main symptoms. The study shows that cysts and dyscirculatory foci are observed more often at negative disorders than at a positive domain. It may be connected with disontogenesis impact on severity of schizophrenia. There were also found the association between hyperstenic somatotype, increasing of big brain hemispheres subarachnoid areas and gynecomorphy with the expansion of the cerebellum subarachnoid space.

The antioxidant activity of the dry extract from the complex plant remedy has been studied in model systems in vitro. It has been established that the plant remedy under study inhibits the oxidation of the biological substrate preventing from the destruction of β-carotene and yolk lipoproteids, making membrane stabilizing effect at peroxide and osmotic hemolysis of erythrocytes. The complex remedy manifests the radical binding activity for 2.2-diphenyl-1– picrylhydrazyl (DPPH˙), superoxide anion-radical, nitrogen oxide, also for Fe²⁺. The marked antioxidant activity of the tested remedy is due to the complex of biologically active substances (flavonoids, tannins, polyphenolic compounds, phenol carbonic acids, ecdysteroids, etc.) contained in its components.

The article is devoted to a comprehensive study of the physical development and physique of freestyle wrestlers, as well as functional parameters of the body. The indicators of cardiovascular system dynamics of indicators of adaptive potential and coefficient of endurance of athletes in different seasons of the year are studied.

The article presents the first experience of human heart transplantation in the Far Eastern Federal District. The clinical case and the surgical technique of the stages of orthotopic heart transplantation are described. A brief overview of the current state of heart transplantation and discussion are presented.

The article is devoted to the study of the results in the surgical treatment of patients with renal neoplasms using a new method of kidney resection, which has its own technical features.
Their essence lies in the temporary superselective embolization of the renal artery, which allows turning off the affected part of the kidney from the circulation. Embolization allows minimizing the blood loss that occurs as well as preserving blood flow in the unaffected areas of the kidney, thereby protecting the remaining part of the kidney from ischemia. As a result, the postoperative period proceeds with a more rapid recovery of kidney function.

In order to increase the effectiveness of treatment of patients with disseminated forms of gastrointestinal stromal tumors, work was done to optimize targeted therapy with imatinib based on monitoring its active metabolites in patients’ blood, and an algorithm for individualizing therapy was developed and applied in practice, depending on the obtained laboratory data and the results of physical examination.

A comparison of cytological results obtained by the method of liquid-based (LBC), implemented in practice on the basis of the laboratory of pathology, histology and cytology of the Clinic of MI M.K. Ammosov NEFU, and the traditional method is done.
It has been confirmed that the diagnostic value of the liquid-based cytology method in the diagnosis of cervical pathology is generally higher compared with TM. It is recommended to supplement the cytological study with a molecular method for the detection of human papillomavirus (HPV testing), which will improve diagnosis and subsequent treatment.

The article reflects the experience of autoplasma donation in pregnant women with threat of by massive bleeding in the period from 2016 to 2018. Analysis of the statistics of massive bleeding according to the diagnosis is presented. According to the analysis pathologies of pregnancy, related with the greatest risk of massive bleeding were identified. We also optimized the management of autoplasma donation in these groups of pregnant women.

The article describes different effectiveness of endometrial evaluation methods among women with pregnancy termination on the background of chronic pyelonephritis and anemia, their coMPLementarity in the allocation of chronic endometritis types – a proven cause of early reproductive losses. Clear connection is obvious between the lack of pregravid preparation on the background of chronic extra-genital diseases and high CE frequency, the diagnosis and the treatment of which at the pre-grading stage seem to be the best tactics for the prevention of various degrees of the «fetal-endometrial» interaction disorders.

The authors report their study on the antiulcerous effect of a new multicomponent plant extract derived from the following species of medicinal plant materials: leaves of Plantago major L., grass of Gnaphalium uliginosum L., rhizomes and roots of a Inula helenium L., flowers of Matricaria chamomilla L., roots of Glycyrrhiza glabra L., grass of Polygonum aviculare L., grass of Urtica dioica L., fruits of Sorbus aucuparia L. in the ratio 3:3:3:2:2:1:1:1, in experiments on Wistar line rats. The findings of the research confirm the expressed antiulcerous effect of the plant extract which is comparable to the effects of befunginum and ranitidine. The coMPLex of biologically active substances contained in the extract promotes УдК 615;615.2435;616.33;616.34 DOI 10.25789/YMJ.2019.65.14 the acceleration of the ulcer healing due to its versatile influence on the main pathogenesis mechanisms of the given pathology.

To study microcirculatory changes in patients with erosive ulcerous form of red flat lichen, a comparative analysis of the parameters of the microcirculatory link and amplitude-frequency spectrum was carried out. Microcirculation was studied with the help of laser Doppler flowmetry (LDF). It was revealed that at the inflammatory-destructive lesion of the oral mucosa, there are an increase in the parameters of microcirculation against the background of a decrease in the average fluctuation in perfusion and a decrease in the vasomotor activity of the vessels. The amplitudefrequency spectrum showed a decrease in the amplitude of low-frequency flaws and an increase in the amplitude of the pulse and respiratory waves. Having high sensitivity to changes in the microhemodynamic situation in the vascular bed, the use of LDF makes it possible to evaluate the state of functioning of control mechanisms and is a valid method of application in gerontostomatological practice.

A survey of 3 and 6 years children of the Khabarovsk Territory revealed a high prevalence of dental caries. The density of Streptococcus mutans contamination of the dental plaque from the four surfaces of the teeth, the mucous membrane of the tongue and saliva by the microbiological method using Dentocult SM Strip Mutans was determined. There was revealed a high contamination of dental plaque from the lingual surface of the tooth and the interdental space, the smallest - saliva. A microscopic examination of the native scraping from the root of the tongue revealed signs of chronic dehydration of the oral mucous membrane and its direct strong correlation with the CFR index. Microcrystallization was also evaluated. Additional innovative microbiological and microscopic methods personify the approach to the diagnosis, prevention and treatment of caries in children of early and preschool age, have prognostic value and allow taking into account regional features.

The prevalence of smoking among adolescent children in Yakutsk was studied. There was revealed widespread tobacco smoking among schoolchildren of Yakutsk. Girls smoke more often than boys. Teens began to smoke regularly at 13. The proportion of children with smoking experience by the age of 15–17 is 2.6 times higher than that of the group of children aged 13–14, which indicates the steady development of tobacco dependence in adolescents of this age.

The morbidity rate for 2007-2016 years (in the age aspect – since 1992) in the Central Economic Zone of the Sakha (Yakutia) Republic was analyzed. Wherein the general and primary morbidity, both of the entire population and in the age aspect, was considered in the adult and children (0-14 years) population. According to the medical-demographic indicators and morbidity data, the most alarming situation is in Kobyai district, therefore, appropriate management decisions are needed from both the municipality and the Republic’s Ministry of Health.

The knowledge obtained during long-term monitoring studies makes it possible to make a long-term forecast of possible environmental changes under conditions of climate change and anthropogenic impact. The obtained results can be used in planning programs for the socio-economic development of the Vilyui region of the Sakha Republic (Yakutia) and certain administrative districts and municipalities of the republic, in developing projects for the integrated development of mineral deposits, the use of agricultural land, and environmental protection measures. Research materials should be used in the monitoring of the health status of the population and the environment by supervisory authorities.

A summary of the fauna of the parasites of the Lena and Vilyui rivers, which are of sanitary and hygienic interest, have been exposed to a multifactorial technogenic load over a long period of time. These studies broaden the understanding of the adaptive capabilities of fish parasites that are dangerous to human health when inhabited in a polluted environment and contribute to the further development of ecological toxicology and parasitology.

The article considers the opportunity to get a qualitative picture of the oxygen concentration in the winter atmospheric air of northern cities in terms of the redox potential of snow cover. Lower snowcover Eh values within the city suggest oxygen depletion in the air. Estimation of anthropogenic pollution based on negative redox potential anomalies in snowcover provides an additional means of assessing the winter air quality in the urban areas.

The state of the primary disability of the adult population of the Irkutsk region due to HIV, mental disorders, injuries, eye diseases, etc. was studied. The region is among the top ten disadvantaged RF entities according to these indicators every year. The first place was occupied by malignant neoplasms in the structure of the causes of primary disability. Strong correlation links were found between 9 separate indicators of primary disability of adults and socio-economic indicators.

The article presents a historical insight on the first medical and environmental research in the Republic, what tasks were solved and what results were obtained in a survey of the population of the Vilyui group of uluses. Medical and environmental research is nowadays of great importance, especially in light of the last precedent on the River Ireliah in summer, 2018.

An assessment of the association of the clinical manifestations of reflux disease with lipid-metabolic parameters in individuals of the Yakut nationality was carried out. The study revealed the contribution of components of metabolic syndrome, in particular abdominal obesity, arterial hypertension and triglycerides, to the development of dyspeptic symptoms, such as bloating, heaviness in the epigastrium, esophageal (belching) and out-of-esophageal manifestations (night cough) of reflux disease.

In order to find effective methods and modes of ice-houses’ sanitation for food storage in permafrost conditions, their microbiota has been studied. It has been established that the use of electrochemically activated solutions of anolyte in combination with peracetic acid effectively disinfect the ice surfaces contaminated with pathogens of intestinal, coccal, and spore infections.

The main genes of hemostasis system are presented in article: FGB, FII, FV, FVII, FXIII, ITGA2, ITGB3, MTHFR, PAI-1 and also genes, concerning the system of hemostasis. The role of polymorphisms of these genes in formation of pathological states as thromboses and thrombophilia is described, also the polymorphisms of genes of hemostasis having protective effect are considered.

The paper presents a review, which demonstrates current understanding of the molecular biology of chronic myeloproliferative diseases.

The review is devoted to the study of brown adipose tissue in adults in the light of renewed scientific interest and the growing body of evidence that renewal and activation of this tissue can cause energy expenditure and play a significant role in the treatment of metabolic diseases in the future.

The article presents statistical data of the incidence of osteosarcoma in children, the classification of osteosarcoma, a description of the main localizations, as well as a detailed description of existing treatment protocols, including personalized therapy. Literary data are described in detail – the results of treatment of children with osteosarcoma using different courses of chemotherapy, as well as new approaches to treatment, including personalized therapy. It is noted that the results of treatment of children with primary metastatic osteosarcoma, relapse and refractory course of the disease remain unsatisfactory.

In the Soviet years, the idea was formed, that Yakutia was one of the centers of longevity in the country. Based on the study of archival materials and census data, it was established that this statement was erroneous. The reasons for spreading this false statement are shown. As an illustrative example, the church and statistical documents of the Oymyakonsky and Suntarsky uluses were considered as areas of Yakutia, where the so-called longevity phenomenon was most pronounced. The age of specific residents of Oymyakonsky district from the family list for 1928 was compared with the lists compiled from 1942 to 1946, as a result of which it was established that in most cases the villagers provided overestimated information about their age.

The article describes a clinical case of a hematotoxic adverse reaction in a patient against the background of ongoing anti-tuberculosis chemotherapy. It has been established that the appearance of anemia of mixed genesis with thrombocytopenia in a patient is associated with the intake of PASK. On the background of the replacement therapy with blood components and the cancellation of anti-TB drugs, blood counts returned to normal.

The article reports the clinical case of rare localization of extrapulmonary tuberculosis -abdominal tuberculosis in incurable stage.

A clinical case of eczema is presented for a representative of one of the smallest peoples of the North – the Selkup. The disease is associated with professional activity – the collection of wild plants.

The article reports the study of psychoemotional state and condition of autonomic nervous system of Yakutsk adolescents. It was revealed that the teenagers were mainly extroverts or potential extroverts. Hyperthymic, affective-exalted, emotive and cyclothymic types of accentuations prevail among them. The majority of adolescents have an average level of social adaptation and vegetative resistance. Low social adaptation and low vegetative stability are most often observed in young men. Obtained results showed that the imbalance of autonomic nervous system is present in adolescents of both sexes. Sympaticotonia, functional tension and overstrain, an increased response of the cardiovascular system to an orthostatic test, excessive, inadequate and paradoxical vegetative maintenance are characteristics of adolescents.

Vilyui encephalomyelitis (VEM) is a degenerative disease of the central nervous system, in the acute form manifested by meningoencephalitis that tends to develop into a prolonged chronically progressive panencephalitis, finally leading to death. Despite 60 years of experience in the study of Vilyui encephalomyelitis, the cause of the disease has not been clarified to date. Since 2010 on the territory of Yakutia, no new cases of VEM with classical clinical manifestations have been registered. We have developed a new hypothesis about anthropozoonosis nature of the disease based on the analysis of a sudden stop incidence of VEM. The purpose of this paper is to provide a scientific basis for this hypothesis. We have analyzed the extensive data of clinical observations of patients according to archival data stored in the former NEFU Scientific-Research Institute of Health, as well as a review of scientific publications on VEM over the past 30 years.