The aim of the study was to search for associations of the rs 1137100 polymorphic marker of the LEPR gene with the lipid spectrum, metabolic syndrome and its components in the indigenous inhabitants of Yakutia. The study involved 227 representatives of the Yakut nationality, permanently residing in the village of Berdigestyah, Gorny region of Yakutia. A statistically significant relationship was established between allelic variant A, AA / AG genotypes of the LEPR gene with hypoalphacholesterolemia. No association with metabolic syndrome or its components was found.

The hypothesis tested that the level of D-dimer, measured in the first 96 hours from the beginning of hospitalization, has a predictive value in relation to mortality in patients with acute ischemic stroke in the acute and early recovery periods.
It was found that the level of D-dimer ≥ 5 VGN is a predictor of an unfavorable outcome in the examined group, which may require a change in the tactics of using anticoagulants, for example, therapeutic doses of anticoagulants, rather than prophylactic ones.

The ethnic (Evens, Yakuts and Russians) and age-related (elderly and senile) features of atherosclerotic cerebrovascular damage in patients with chronic cerebral ischemia were studied. The study revealed that the most pronounced atherosclerotic changes in the extracranial arteries were observed in the Russians, followed by Yakuts, while the Evens are the last ones in atherosclerotic lesions of the cerebral vascular structure.

The purpose of this study was to create an in vivo model of ovarian cancer allowing control of the dynamics of tumor growth and adequate data on its size. As a model Balb/c Nude mouse lines were used. Removal of the mouse ovary with an implanted tumor fragment under the skin made it easier to visualize and to control the dynamics of xenograft growth.

The relationship between the content of transferrin and erythrocytes and the functional activity of leukocytes of peripheral venous blood in residents of the European North of the Russian Federation have been studied. It was found that in 49.21% of the examined individuals the content of transferrin increases against the background of a decrease in the level of the number of cells with a membrane receptor for transferrin (CD71 +), which reflects the known competing relationships of the receptor, the level of its shedding and substrate (transport). An increase in transferrin content is associated with an increase in the concentration of circulating IgG immune complexes in 44.21% of cases. With an increase in the concentration of transferrin in the blood in 27.95%, the content of platelets decreases and in 24.08% - the concentration of hemoglobin, mainly in men with increasing age. In 8.06% of the examined individuals, an increase in the level of transferrin is interrelated with an increase in the concentration of reagins. In 5.12% of cases, an increase in the transferrin content is associated with the activation of cell-mediated cytotoxicity, which is mainly supported by the pro-inflammatory cytokine IL-6. The relationship between the increase in transport protein and IL-10 concentration has not been established.

The clinical of essential tremor, in addition to motor symptoms, includes a wide range of non-motor manifestations, which includes cognitive disorders, psychiatric and other disorders. This article presents the results of a study of the cognitive status in patients with essential tremor using the 3 CT scale. As a result of the study, it was shown that patients with essential tremor are characterized by lower indicators of semantic and phonetic speech activity, spontaneous and delayed recognition without differences between subgroups (family and sporadic forms, variants of classical ET and ET-plus). Thus, in patients with essential tremors cognitive disorders of the dysregulatory profile are diagnosed.

The survey contains an analysis of current research on the treatment of acute respiratory viral infections (ARVI) using immunomodulatory drugs available on the Russian market, and the rationality of the use of this type of medicine from the standpoint of evidence-based medicine.

The article presents an individualized method of regional lymphotropic therapy (RLTT) in combination with photophoresis in the complex treatment of newly diagnosed destructive pulmonary tuberculosis with multidrug-resistant mycobacterium tuberculosis (MDR MBT). The technique was developed for the treatment of patients with a low degree of resistance (1 μg / ml) of MBT to isoniazid in patients with a weak and medium type of drug inactivation. As a result of applying this methodology, an increase in the effectiveness of the treatment is noted within the period of up to 6 months.

The paper presents data on the treatment of distal metaepiphysis of the forearm bones (beam in the "typical place") and their consequences in persons of gerontological profile. A retrospective analysis of 500 medical records of elderly and senile patients with fractures of the radius in the "typical place", who asked for emergency medical care. Also it included clinical materials of the treatment of 57 patients with developed neuroishemic disorders after a fracture of this localization. A significant amount of clinical materials revealed the main errors and complications in the treatment of fractures of this localization in this category of patients. The reasons of their occurrence and ways of treatment are analyzed.

The Ushnitsky-Chakhov device was developed for conducting mandibular anesthesia using a Gow-Gates method. Individual anatomical and topographic features of the mandible branch were obtained, that influence on precise determination of the target point and depth of immersion of a needle. Traumatic damage to the maxillary artery, tissues of the mandible and temporal joints, the mandible vascular-nervous sheave and the lateral wing muscle are excluded or minimized.

The prevalence and structure of recurrent cephalalgias in adolescents with different types of online behavior have been studied. More pronounced association of recurrent cephalalgias (especially frequent episodes) in adolescents with disadaptive online behaviors (pathological and non-adaptive use of the Internet) illustrates the adverse impact of the computer and the Internet. It also justifies the need for a personalized approach to these adolescent populations in order to prevent them from developing chronic psychosomatic pathologies.

The dynamics of the incidence of pertussis among the total population of the Irkutsk region for the period from 2000 to 2019 was analysed and the assessment of the adherence of parents and doctors of Irkutsk to vaccination of pertussis was carried out.
In the course of the descriptive retrospective epidemiological study, a voluntary anonymous survey of parents and doctors of various specialties was conducted to study the level of awareness and attitudes towards cocoon-vaccination against pertussis. Also the long-term dynamics of the incidence of pertussis among the total population of different age groups was analysed.
Despite the growing incidence of pertussis infection among parents and doctors in Irkutsk, there is a low level of awareness of the need for revaccination at school age, especially in relation to cocoon vaccination.

The occurrence of secondary cases of VEM in previously unaffected populations indicates that VEM is a transmissible disease with a mode of transmission characteristic of chronic infections.
Reduce patient-to-patient contact in the acute and subacute periods of VEM with the surrounding population through prolonged hospitalization of patients in specialized medical institutions and improvement of social and hygienic living conditions in Yakut villages led to a slow decline in the incidence in the 1980s and 1990s and its complete disappearance in the 2000s. No new cases of VEM have been reported since 2012.

The article presents the dynamics of HIV infection incidence, mortality and disability from HIV infection in the region with a higher level of its prevalence among the population. It is shown that these indicators exceed the all-Russian ones. HIV infection significantly causes the prevalence of population mortality. Among the adult population, for the first time recognized as disabled due to HIV infection, the working age is predominant. To stabilize the situation, additional measures are required for optimizing prevention and epidemiological monitoring programs.

To justify the use of regional standards for the physical development of children living in the Republic of Sakha (Yakutia) on the basis of their ethnic predisposition the data were analysed obtained during preventive examinations in 2019-2020 in the territory of the republic. The evaluation of the physical development of children aged 3 months up to 17 years was conducted as well as the comparative analysis of the compliance of centile tables CDC, WHO and regional normative scales of physical development. It was found that the regional compliance standards most adequately reflect indicators of the physical development of children in the studied populations.

The results of studying the prevalence of East Asian and Western variants of the cagA gene among Helicobacter pylori strains in Yakutia are presented. In the studied sample of Helicobacter pylori (H. pylori) DNA samples isolated from biopsies of patients with gastroduodenal diseases, western variants of the cagA gene (Western cagA) are prevailing, while East Asian variants of the cagA gene (East Asian cagA) were not found. The rest of the samples do not belong to either the Western (Western cagA) or the East Asian (East Asian cagA) variant of the cagA gene, which may indicate the presence of specific local variants of the cagA gene among H. pylori strains circulating in Yakutia.

The study was conducted to identify the relationship between adverse perinatal outcomes and coronavirus pneumonia. As the material individual cards of pregnant and postpartum women aged 18-49 years with confirmed coronavirus infection (COVID-19) were used.
A relationship has been established between coronavirus pneumonia and the frequency increase of abdominal delivery and premature birth.

The study is devoted to the differences in the incidence and mortality of cervical cancer (cervical cancer) and mortality from it in the period from 2008 to 2019 among the republics, territories and regions located in Siberia, and Russia as a whole. Considering its results, state formations, which are characterized by a multiethnic population - the Kemerovo Region, the Republic of Buryatia and the Trans-Baikal Territory, are acutely, and the Republic of Tuva is in critical need of preventive measures in relation to the incidence of cervical cancer and mortality, including vaccine prophylaxis.

The use of modern molecular genetic methods for the identification of M. tuberculosis isolates made it possible to obtain a detailed characterization of the pathogen population circulating in one of the poorly studied northern territories of Russia. The studied isolates of the M. tuberculosis population circulating in the Republic of Sakha (Yakutia) can be represented by nine main heterogeneous clusters - Beijing, T, S, Ural, Lam, Haarlem, Orphan, Uganda, X. The analysis of the massiveness and growth rate, drug resistance to anti-TB drugs of the main families of tuberculosis pathogen genotypes in newly diagnosed patients with respiratory tuberculosis showed the heterogeneity of the biological properties of M. tuberculosis. There is a connection between the viability of the pathogen and the manifestation of primary drug resistance of the M. tuberculosis population, which is clearly seen in the genotype S. Consequently, the massive growth of mycobacterium tuberculosis indicates the epidemiological danger of patients isolating these strains, especially if it is combined with rapid growth and multidrug resistance.

Evaluation of the proliferative activity and adhesive capacity of cultured in vitro fibroblasts on polylactide films of various thicknesses, depending on the presence of an adhesive factor was carried out.
Adding an adhesive factor AF which contains gelatin to the nutrient medium activates the proliferation of cultured cells. The largest number of attached fibroblasts is noted on the 3rd day with substrates of 100 microns and 150 microns in wells with AF, while in substrates with the thickness of 125 microns - on the 1st and 3rd days of cultivation. Based on supravitally stained samples, it was found that the fibroblast adhesion, depending on the thickness of the polylactide film, showed statistically significant differences between films with the thickness of 125 and 100 microns, as well as a tendency to increase between 125 and 150 microns. Only with the polylactide thickness of 125 microns the number of fibroblasts on the surface of the film is higher than in the well, and with other thicknesses the number of cells in the well is greater than on the polylactide.

An assessment of the mortality rate of the population of Yakutia as a result of exposure to excessively low natural temperatures in 2011-2019 and the level of disability in 2014-2019 has been given. It was revealed that the impact of excessively low natural temperature (cold injury) ranks third in the structure of external causes of death of the population of Yakutia after suicides and homicides. The death rate of the population due to cold injury exceeds the death rate as a result of road traffic accidents (RTA). At the same time, the level of disability due to severe frostbite, which led to injuries, is relatively low.

The cytological study of the cervix was carried out in women aged 18 to 44 years. It was found that the higher rate of background and precancerous diseases of the cervix is noted in women aged 30-44 years. Early diagnosis and treatment of underlying and precancerous diseases of the cervix will contribute to contribute to improving the early diagnosis, monitoring, and prognosis of CU cancer.

The article presents data from the study of seasonal fluctuations in the hormones of the pituitary-thyroid system in children of the Arctic regions of Yakutia. Higher levels of TSH in winter have been established, which should be considered as physiological changes reflecting adaptation to the change of season of the year.

The research involved 364 young men aged 17-21, who are permanent residents in the coastal (Magadan city, n = 217) and continental (the settlement of Susuman, n = 47) climatic zones of Magadan region. Morphofunctional parameters of the microcirculatory bed vessels, as well as thermographic characteristics of different parts of the body were studied. It was found that the residents of Susuman were characterized by smaller arterial diameter and bigger diameters of the venous and transitional sections of the capillaries as compared with those from Magadan. At the same time, significantly higher average temperatures were observed in Magadan subjects through all the analyzed areas of the thermographic picture than it could be seen with examinees from Susuman.

The aim of the study was to evaluate the functional state of kidneys in the group of people with arterial hypertension (n=159), representatives of the indigenous population of the Republic of Sakha (Yakutia). 78% of the examined individuals had signs of decreased kidney function. Most number of these patients had hypertension and additional risk factors that contribute to the development of kidney dysfunction. The surveyed women are characterized by a more unfavorable risk profile for chronic non-communicable diseases, which probably accounts for a higher proportion of women with signs of chronic kidney diseases.

The article presents the results of analysis of heart rate variability in preschool children (3-7 years old) living in the Arctic region of the European part of Russia. A comparative assessment of the state of the cardiovascular system of pre-school children of the indigenous population and newcomers in the Murmansk region showed that there were no pronounced differences between these contrasting groups. The more significant differences are observed in representatives of the newcomers at lower rates of spectral characteristics (TP and HF), which are manifested in children with all four types of vegetative regulation.

The article reviews data based on the current literature on olfactory dysfunction (OD) in patients with COVID-19. Numerous studies have shown that the incidence of olfactory dysfunction in patients with COVID-19 ranges from 33.9 to 68%, with much higher in women. Patients with COVID-19 may experience sudden olfactory dysfunction without any other symptoms. Otolaryngologists should pay attention to the symptom of anosmia on an outpatient basis in order to diagnose COVID-19 as soon as possible. Many questions that are in one way or another related to the loss of smell during coronavirus infection remain unresolved to date.

The review presents current data on the effect of endometrial expression of the homeobox genes HOXA10 and HOXA11 on implantation processes in healthy fertile women and in common gynecological diseases. The features of gene expression, potentially unfavorable for implantation and leading to infertility are described. The variability of receptivity markers expression before and after myomectomy, salpingectomy and the removal of ovarian endometriomas was shown.

The epidemiological and pathogenetic aspects of HDV infection have been studied using the example of the Republic of Sakha (Yakutia). In addition to the genetic characteristics of the virus, the role of interferon genes in the formation of liver fibrosis was noted, due to their binding to the receptors of host cells and their influence on the process of viral reproduction within the cell. The results of clinical studies indicate their predictive effects among Asian populations (Japan, China, Taiwan). Taking into account the above data, the clinical and epidemiological situation for hepatitis D can serve as a subject of studying the impact of the virus genotype and polymorphisms of candidate genes on the formation of HDV-associated hepatocellular carcinoma, as well as probability of achieving a sustainable viral response and / or spontaneous clearance in patients with different rates of progression of the liver disease.

Neuroactive steroids are a class of endogenous steroids synthesized in the nervous tissue and / or capable of having a modulating effect on its functional activity in the brain. The first part of the review is devoted to the little-studied genomic and non-genomic mechanisms of action of pregnenolone, pregnenolone sulfate, and their synthetic analogs, and to the identification of peculiarities of the secretion of pregnenolone and its metabolite in various parts of the central nervous system of rats in the ontogenetic aspect. A number effects of pregnenolone and pregnenolone sulfate are presented, such as modulation of NMDA, GABAA, kainate and AMPA receptors, voltage-dependent Ca2+ channels in vitro and in vivo, etc., an attempt was made to systematize the main effects of neurosteroids depending on the central nervous system.

The aim of the study is to study the possibility of predicting bone fractures by determining the concentration of markers of bone remodeling in patients with rheumatoid arthritis (RA). The diagnostic value of laboratory determination of bone remodeling markers (CrossLaps, P1NP and 25-OH vitamin D in serum) was studied using a characteristic curve (ROC curve). It was found that laboratory determination of type I collagen C-telopeptide for predicting the risk of fractures in RA is of good quality.

A scientific review of the problem of active longevity and prospects for its study in a group of researchers is carried out. At the moment, various components of the issue of active aging are being widely studied. However, most of these issues have not been studied systematically regarding research workers, and there are practically no justified preventive measures, that would normalize functions being already impaired in a particular researcher. The development of the problem of active longevity of research workers will help formulate a set of measures to extend effective professional longevity of research workers and ensure scientific continuity.

Schoolchildren of Siberia (Tyva, Evenkia, Aginsky Buryatsky National District, Krasnoyarsk city) with gastrointestinal complaints were examined. Aim: to study the features of clinical manifestations and indicators of circulating cytokines in gastritis in schoolchildren with familial predisposition to the peptic ulcer disease.
It was found out that in children with familial predisposition, gastritis occurs with the involvement of the systemic level of cytokine regulation (expression of IL-4, IFN-α). Moreover, in children with H. pylori infection, the cytokine regulation of the inflammatory process is specific (TNM-α expression).

The article presents a clinical case of drug-resistant tuberculosis in a teenager. The peculiarity of the clinical case is related to the fact that the teenager was deregistered for local tuberculosis was observed for local tuberculosis, but a year later he was admitted to the antitubercular hospital with widespread tuberculosis of extensively drug resistant mycobacterium tuberculosis (MBT) to 8 antitubercular drugs, with poor tolerance to chemotherapy. All these factors led to a complicated course of tuberculosis and were an indication for surgical treatment, for upper lobectomy with atypical C6 resection of the left lung with decortication. It is important to further improve the organization of anti-tuberculosis measures among patients with drug-resistant forms of tuberculosis. Pediatricians are advised to be alert to children who have contact with people with the drug - resistant form of tuberculosis.

The article presents a clinical observation of a patient with myxoma of the antrum of the stomach with severe concomitant pathology, for which surgical endoscopic treatment was performed. The positive results of the performed treatment indicate the high efficiency of endoscopic submucosal resection of the gastric myxoma.