Vasoactive proteolytic systems are involved in the regulation of various physiological systems and the development of many pathological states. In this work we investigated the activity of kallikrein, kallikreinogen, angiotensin-converting enzyme, α1-proteinase inhibitor, α2-macroglobulin in infants with chronic secondary pyelonephritis. In chronic secondary pyelonephritis, no matter what type of congenital renal disease, there is activation of vasoactive proteolytic systems that may have diagnostic and prognostic significance.

Anthropometric survey of young men in Central Siberia has revealed uneven distribution of somatotype on sexual differentiation mainly with domination of gynecomorphous somatotype and asthenia, with a gradual leveling of age indicators. It was found that in adolescence the process of physical and sexual maturation is not completed.

The review of results of the spent researches and now existing representations about etiology and pathogenesis of juvenile idiopathic scoliosis (JIS) in children and teenagers is given. Neuro-anatomic interrelations and a role of system dysfunction in JIS pathogenesis are discussed. Modern theories of development, major factors of risk of development and progressing of juvenile idiopathic scoliosis in children, its basic components are reflected. Importance of continuation of JIS researches at molecular-biochemical level, necessity of allocation of specific parameters - development markers of idiopathic scoliosis for perfection of approaches to diagnostics, forecasting of current features, prevention and treatment of the disease in children is underlined.

74 healthy adolescents and 142 patients with the pubertal period hypothalamic syndrome were examined. The indexes of protein, lipid and carbohydrate metabolic processes, hormone state, psychological peculiarities, quality of life, physical development peculiarities and reproductive function formation were investigated. Detected clinical and laboratory changes represent the early debut of the metabolic syndrome (MS) in the adolescents with hypothalamic syndrome (HS). The polymorphism of metabolic and endocrine disorders in the adolescents with HS reflects the high risk of early atherosclerosis and diabetes mellitus type 2 developments, progression of poly-endocrine pathology, resulting in reproductive disabilities.

The analysis of clinical-endoscopic manifestations of lesion of stomach and duodenum mucosa at thyroid gland dysfunctions in the various ethnic groups, living in Republic Sakha (Yakutia) is carried out.

Our research presents the immunological characteristics of 88 patients with chronic gastritis type B, indigenous (Yakuts), age range 30-50 years. In research the dependence of the levels of immunoglobulins and cytokines on the degree of Helicobacter pylori contamination in the blood serum of patients with chronic gastritis is revealed.

60 men with metabolic syndrome in combination with paroxizmal atrial fibrillation were investigated to estimate the influence of simvastatin (simvastol) on the parameters of matrix metalloproteinase-9 and its antagonist – tissue inhibitor of matrix metalloproteinase-1. In all patients the serum level of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1was studied by immunoassay method. The significant decrease of matrix metalloproteinase-9 activity (P=0,043) and increase of the tissue inhibitor of matrix metalloproteinase-1 activity (P=0,018) after simvastol therapy were revealed. Thus, the addition of simvastatin (simvastol) to usual therapy in patients with metabolic syndrome in combination with paroxizmal atrial fibrillation is useful with the pathogenetic position.

It is noticed in article that with ropivacain use on the operation beginning the highest level of proinflammatory IL-1β in a combination with the lowest IL-2 is marked, that has defined pronounced imbalance of interleukin production. For a moment of the most traumatic manipulations on the background of ropivacain application decrease in synthesis of proinflammatory IL-1β and strengthening of immunoregulatory IL-2 secretion were observed. Ropivacain provides immunopreserving influence.

High association of gene LPL, Int8 SNP (rs320) with 2 type diabetes let us possible to make out proposition about mechanism and role of LPL in 2 type diabetes developing.

The microbiological research of peritoneal exudates of 147 patients with general peritonitis (GP) to study the structure and antibiotics resistance of aerobic causative agents of GP for the optimization of empirical antibacterial therapy was performed.

In order to study the treatment results and evaluate the effectiveness of the method of in-direct lymphotropic therapy (ILTT) in the treatment of patients with pneumonia a comparative analysis in groups of patients with pneumonia treated with antibiotics by the ILTT method (n = 44) and patients received antibiotics intramuscularly (n – 46) was done.
In the patients who underwent ILTT, there was acceleration of the dynamics of clinical and laboratory data, significantly faster signs of intoxication and other indicators of clinical course of pneumonia cut short, in 2 - 3 days earlier and other objective signs of disease were stopped than in patients receiving antibacterial therapy intramuscularly. X-ray resolution of pneumo-nia in patients who underwent ILTT, occurred significantly faster, and length of hospital stay was significantly shorter than similar indicators of patients who received antibiotics therapy intramuscularly. ILTT application allowed lowering a course dose of antibiotic in two.

The results of immunological study of 58 patients with juvenile idiopathic arthritis are given. It was found out that in all forms of the disease substantial changes of cytokine status in serum and synovial fluid were observed, the degree of severity depends on the variant and the activity of the inflammatory process. Study of cellular immunity was held to a differentiated approach to the choice of therapy, as well as the efficiency of the drugs varied depending on the variant of the disease. The greatest efficiency in the treatment of polyarticular and oligoarticular spreading form was observed in remicade, combination therapy with sandimmun-neoral and methotrexate is preferable to use at oligoarticular persistent form of juvenile idiopathic arthritis.

The paper represents the results of studying 44 households with family members having upper respiratory tract diseases, associated with Chlamydia infection. Control group included 43 households with ENT family members, who didn’t show Chlamydia. Diagnostics was provided by using the complex of laboratory methods (direct immune fluorescent and immune enzyme analysis, polymerase-chain reaction). The presence of one patient with respiratory chlamydiosis in a household results in infecting other family-members with Chlamydia.

Effect of metabolites of fungi Trichoderma harzianum on the number of gram-positive and gram-negative microorganisms: Bacillus subtilis, Micrococcus luteus, Salmonella moskow, S. typhimurium was studied by the method of holes. Antibiotic activity of metabolites of the fungus T. charzianum against M. luteus, S. moskow is shown. These metabolites are perspective as producers of new antibiotic drugs.

The clinical and etiological characteristics of discirculatory encephalopathy (DE) depending on residing region have been studied. The analysis of risk factors has shown that the leading reasons of vascular lesion of brain at all patients were the atherosclerosis and arterial hypertension, thus at patients of I group at whom old traditions of food and quieter, traditional way of life have remained, these risk factors were present less often. Clinical symptoms of discirculatory encephalopathy, as well as numerous subjective and clinical displays, have been most expressed at patients of the basic group, inhabitants of ecologically adverse Vilyuskiy region.

The results of superovulation stimulation in 30 native women of the North (the main group) and in 27 non-native women (the comparison group) with tubal-peritoneal infertility are presented. In the main group the ovarian response to gonadotropin stimulation is diminished, the number of preovular follicles and oocytes are less than in the comparison group, the embryos development in vitro is slowed and the pregnancy rate in the program of In Vitro Fertilization (IVF) is almost 3 times lower. The use of superovulation stimulation protocols with GnRH-A in the main group increases the effectiveness of IVF in three times.

This article reflects stages of treatment of funnel chest in the Tomsk Region from 1977 to 2009. The work provides analysis of surgical treatment of 78 patients, including 16 children treated by G.A. Bairov’s method, 20 children were operated using suspension splint with damping arrangement, 42 patients were operated by author’s method by means of thoracoplasty with the following fixation of costosternal complex using previously chilled titanium nickelide plates, which have thermodynamic properties. There were also presented main stages of new technique, which supplement the “classical” kind of surgical intervention.
It was noted that using titanium nickelide plates with the shape memory to correct funnel chest in children and adolescents is the method of choice and brings good clinical results.

Estimation of state and effectiveness of medical equipment using in the Health Care Institutions of Sakha Republic over the period from 2005 to 2009 years is presented. Changes of indicator of the medical equipment’s state in dynamic was revealed: increase of balance cost and wear of medical equipment; wear of medical equipment; reduction of coefficient of replenishment and coefficient of increase of medical equipment; increase of indicator of doctor’s fund – capability by medical equipment; increase of coefficient of use medical equipment.

The article presents analysis of temporary disability payments realized in the Republic Sakha (Yakutia) rural regions for 2005-2009. It includes figures on the average daily benefit amount, duration of payment in days, average duration of one temporary disability case.

Influence of smoking on frequency and expressiveness of bronchial passage disorders in the geronts of Yakutsk depending on ethnicity is studied and shown.

A conjugate retrospective analysis of a long-term study of the HIV, hepatitis B and C morbidity dynamics in the Republic Sakha (Yakutia) having the general (hemocontact) mechanism of transfer in comparison with the determinants that are presumably able to affect its pattern is presented in the article. The leading significance of antiepidemic measures in health facilities and current trends in the prevalence of drug addiction in the population is shown. The difference in the mechanism of formation of above mentioned infections’ morbidity in Yakutia as compared to other regions of Russia is revealed.

In article tactics of rendering medical aid to the anthrax patient is submitted. The brief characteristic of organizational actions is given at treatment of 7 patients with this especially dangerous infection. On a clinical example anthrax rare complication as a gastric bleeding is shown. Endoscopic picture of plural ulcer defects in a stomach differs that on periphery of ulcer inflammatory infiltration shaft is absent, and ulcer surfaces are covered with necrotic scab. Tactics of anthrax patient treatment complicated with a bleeding is shown.

It is shown that the health of the North population, formed on the background of extremely harsh natural conditions, has a distinct specificity. In this case, one of the main determinants of population health state factors are extremely low winter temperatures, dropping down to the extreme values, truncated to a month spring and autumn transition periods with sharp fluctuations of air temperatures and strong winds, as well as the complete absence of solar or short-term light with a low degree of insolation in the long cold period lasting from September to March (polar night) and long days and bright “white” nights during the summer. The causes of diseases, occurred in the largest northern region - Yakutia as a result of the impact of natural and man-made factors are adduced; the ways of health and environmental situation improving are projected.

The review includes modern scientific data on organism adaptation response under the Extreme North Ecology and level of their potential in native and non-native population. There have been summarized the results of the research in pathophysical processes in organism and factors, which determine their nascency under extreme conditions of the North. There are scientific opinions on associations of pathophysical disturbances with the formation and specifics of the prevalence of different forms of somatic pathology in adults and children in natives and non-natives of the northern regions.

Creating and maintenance of functioning of system of the register of patients with essential arterial hypertension (EAH) from children’s and teenage age becomes rather actual. EAG register in children and teenagers of Irkutsk allows defining gender and age structure of children with EAH, disease tendencies, indicators of frequency of occurrence of the given disease, the indicators characterizing hereditary predisposition. The register gives the chance to establish in what medical institution the given patients are observed, where and when they undergo inspection and treatment, to estimate a regularity and the characteristic of medicinal therapy, and also to establish the list of children with EAH, reached 18 years, who should be included in system of AH monitoring at their transfer to adult network.

The medical records of the hypertensive patients treated at the Krasnoyarsk regional hospital for war veterans have been analyzed in order to study the pharmacoepidemiology of elderly and old patients’ hypertensive disease and its conformity with the latest recommendations. It has been found out that the treatment of hypertensive patients in the Krasnoyarsk regional hospital for war veterans meets the present-day recommendations. The study shows that basic classes of antihypertensive agents prescribed by the physicians of the Krasnoyarsk regional hospital for war veterans are the angiotensin - converting enzyme inhibitors (55,44% of the cases), diuretics (17,99%), calcium antagonists (9,11%). The proportion of combined antihypertensive agents prescribed to patients with HD is 100%.