The retrospective analysis of a state of the oncological help in RS (Y) for 1995-2007 testifies to presence of set of the problems, major of which are upgrading of annual routine examinations and enriching of the YROH material resources which are not meeting modern requirements of today.

For the purpose of studying of reproductive health of the North children complex investigation of 1205 children and teenagers of indigenous population in northern.

Studying of stress effect in the late prenatal ontogeny on morphometrical indexes of development of brain, adrenals and gonads of rats at 40- day age, subjected to stress influence by immobilization in the conditions of the high illumination in the narrow plastic cases limiting their motility is made.
Changes of both gravimetric and morphometric indexes of neocortex and hippocampus, and also adrenals and gonads at posterity of female rat subjected to stress influence are established.

To reveal the condition of a mineral exchange, the estimation of 22 chemical elements in hair of 102 not pregnant women, 50 pregnant and their newborn, living in Yakutsk was carried out. Масrо- and microelement structure of pregnant women hair was more changed especially there were authentically low levels of cuprum, phosphorus, iodine. Accumulation of microelements in a newborn organism is connected with the phenomenon of “superstorage”, thus essential microelements are not accumulated.

Revealing of clinic-electrophysiological features of various forms of epilepsy at children on the basis of analysis of results of the complex diagnostic study including clinic-anamnestic, neuro-visualization and electrophysiological data, video-EEG monitoring and development of tests for their differential diagnostics was under study. Complex diagnostic study with video-EEG monitoring has allowed to establish epilepsy at all children, and inaccurate directional diagnosis has appeared in 22, 08 % of cases, and in most cases (71, 78 %) it was defined.

The article discusses one of the abortion consequences, namely chronic autoimmune endometritis resulting in sterility and a number of various pathological processes in the uterus and other reproductive organs. The authors make an attempt to evaluate efficiency of the therapeutic and preventive measures package aimed at the reproductive health rehabilitation in 13 teenage girls and 53 reproductive-age women after first pregnancy artificial abortions.

The article is devoted to the actual problem - pathology of the upper gastrointestinal tract in adolescents of 10-17 years, living in the Republic Sakha (Yakutia).

The functional reserves of cardiorespiratory system are investigated in different ethnic groups of Yakutia. At research of human gustatory sensitivity ethnic dependence of gustatory senses is established.

Results of one-stage researches of unorganized Yamal residents at the age of 20-59 years are presented. Influence of chemical elements on an index of body weight in the conditions of high latitudes is presented. The chemical elements influencing formation of overweight and adiposity are defined.

Objective research of patients with ischemic heart disease younger 45 years is held to study the features of the disease activity and possibility of IHD surgical treatment in patients of young age.
It is revealed that in IHD patients younger 45 years males dominate with increase in level of atherogenous lipids and triglycerides level, in particular, in comparison with patients of the senior age groups. At ischemic remodelling for IHD patients of young age a characteristic feature is a tendency to dilatation of the left ventricle cavity and decrease in the general contractile ability of myocardium. The endovascular technique of a straigz.

Revealed genotype *H/*H of polymorphyc variant Y111H(ADIPOQ) of adiponectine gene is a marker of high risk of diabetic retinopathy in type2 diabetes mellitus for ethnic group of the Yakuts.
The obtained results will assist duly prognosis and /or revealing of risk group of diabetic retinopathy among the Yakuts and will help to define the treatment tactics for patients predisposed to diabetic retinopathy with the use of individual complex of prophylactic and treatment activities.

The authors have studied I/D polymorphism of ACE gene and CETP D442G gene in group of senior patients with coronary heart disease in regard to nationality, age, sex and coronary heart disease clinical manifestations. Having analyzed ACE I/D gene polymorphism the authors found out the association of genotype II with old myocardial infarction (OMI) (Q-negative), left ventricle hypertrophy (LVH) ( with Sokolov-Lyon sign), sick sinus syndrome (SSS) and with a high angina functional class (AFC).

The aim of the study was to explore heart remodelling in patients with pulmonary tuberculosis associated with chronic obstructive bronchitis. A Doppler echocardiography technique was used. Anatomical characteristics and velocity rates for right and left ventricles were calculated. Our data showed that all patients had right ventricular dilatation, right atrial dilatation, increased mean pulmonary artery pressure, reduced left-ventricular systolic function, increased myocardial stress, and pseudonormal filling type.

Including of selenium-containing preparations into the complex treatment of patients with community-acquired pneumonia allows to normalize.

Based on analysis of features seen in development variants of different types of tuberculomas in 302 patients living in the Extreme North, differential approach to surgical treatment has been formulated. Thus clinically and morphologically grounded treatment approach to patients taking into account variants of development of tuberculomas clinical-anatomic types promotes to make not only the adequate schema of chemotherapy, but also to apply surgical interventions in early terms of clinical follow-up. Implemented to medical practice, this differential approach to chemotherapy and surgical treatment of patients with pulmonary tuberculomas based on main features in development variants and clinical course of tuberculomas remarkably decreases the probability of tuberculosis relapse.

Our investigation was influenced by the absence of common view on endovascular treatment tactics of patients with large and giant cerebral arteriovascular malformations. Using principles of staged AVM obliteration based on angioarchitectonics and modern technological advances, we managed to increase surgical efficacy by less number of stages and to increase good results in patients with AVM of IV-V grades according to Spetzler-Martin.

Results of surgical treatment of patients with complicated colon cancer, operated urgently, are analyzed. Thanks to a mathematical model of the for.

Clinical-dynamic, social-adaptive characteristics of schizophrenia patients with law-abiding and criminal behavior in later life were analyzed on the basis of examining their long-term catamnesis; comparative system analysis (taking into account the dynamics of the leading syndrome, personal and situational characteristics) of remote catamnesis of the specified contingent was carried out. Two opposing trends in the course of the disease were revealed: the tendency to weakening or to the stop of the progredience with stabilization of condition and reduction of psychopathological symptoms and the tendency to preservation the activity and progredience of schizophrenic process. The obtained results of the research mЧ.

The patients with different diagnoses who were directed to the Holter ECG monitoring by the doctors – cardiologists were examined.
During the Holter ECG monitoring the heart rate turbulence was registered among the patients with cardiovascular diseases and 2 type diabetes. It was registered more often among men, non-indigenous residents of Yakutia.

The analysis of the primary medical documentation and the questioning data of women with breast cancer is carried out. It is found out that patients with a disease incipient stage (I-IIA) regularly passed professional surveys and consultations of the gynecologist. With augmentation of a cancer stage (IIB-IIIA) the quantity of women, to whom preventive examinations were not made or were made formally, increases.

Anatomic peculiarities of extrahepatic bile ducts were examined on 50 cadavers who died from different diseases at age between 40 to 60 years without pathologies in abdominal cavity. In most cases (98%) bifurcation and lobar hepatic bile ducts located out of hepatic tissue with length domination in left side, that allows to conduct reconstructive operations of injures and strictures of extrhepatic bile ducts.

For a decade (1997-2007), morphogenesis features of different types of tuberculomas were studied in 125 non-aboriginal patients living in the environmental conditions of the Extreme North. The study showed that morphogenesis of tuberculoma in non-aboriginal patients started more often as a result of specific alterations following lymphohematogenous tuberculosis (72.9 ± 3.2%; р < 0.01). Interestingly, tuberculous alterations in the lungs developed amid unaltered lung tissue. As a rule, formation of tuberculomas in patients from non-aboriginal population is not associated with the development of marked fibrosis of lung tissue. These distinctive features of tuberculoma formation were determined by predomination of the processes of healing and alveolar epithelium renewal over inflammatory changes, thanks to which a better repair of the structure of lung parenchyma could be attained in the end.

The article is dedicated to analysis of clinical and electroencephalographic results of EEG-based beta-training in the Attention Deficit Disorder treatment. Results of neuropsychological inspection on A.R.Lurija’s method of children with the diagnosis «Attention Deficit Disorder/Hyperactivity» (ADНD) before and after EEG-based beta-training rehabilitation course are presented. The analysis of results allows to say that at the majority of children with ADНD syndrome the primary reason of occurrence of characteristic symptoms is dysfunction of subcortical structures of brain.

Collection, preprocessing and use of biological samples cause many organizational problems, which are successfully resolved with help of biobanks. Among the components of successful work of biobank is a practical, functional and reliable database for storage of information. In the paper, principals and problems of database development for biobanks are considered, taking as example the biobank of the Institute of Medical genetics SB RAMS.

The analysis of the basic indexes of health care system of the population in residence of the native small in numbers people of the North of Republic Sakha (Yakutia) for 1990, 1995, 1999-2003 is carried out. The basic tendencies such as decrease of number of medical institutions, feldsher’s-obstetrical stations, bed complement and number of personnel resources are detected.

In article the analysis of payments of the temporary disablement allowances made in the Arctic group of areas of republic for 2005-2009 is presented. Indicators среднедневного the size of the grant, days of payments are presented, to average duration of 1 case on time invalidity.

The estimation of results of additional prophylactic medical examination and efficiency of improving actions of medical workers of municipal authorities of Yakutsk is spent. The measures of improvement spent by results of additional prophylactic medical examination, have authentically led to decrease in indicators of the general, primary disease and disease with temporary disability of medical workers of Yakutsk.

We assessed the efficacy of several disinfectants accepted for use in tuberculosis institutions by activity against M. tuberculosis cultures. Disinfectant test procedure is based on procedures adopted from a well-known method commonly used in disinfectant testing practice, which consists in submerging coarse calico test-objects contaminated with the test-microbes into a disinfectant. Analysis of the study results showed that both museum and clinical test-strains of M.bovis and M.tuberculosis are more pertinent to real tuberculosis causative microorganisms in terms of resistance to disinfectants. The study findings support the feasibility of using a number of various test-strains in the development of national tuberculocidal disinfectant regimens instead of “Mycobacterium B-5” alone.

Morbidity statistic indexes and prophylactic medical examination of children with acute pneumonia in the Republic Sakha (Yakutia) was analyzed. In the group of children with acute pneumonia concomitant pathology, disease current features and treatment efficacy was studied.

The analysis of primary liver cancer morbidity (1658 cases) for 1996-2007 in Republic Sakha is conducted. A retrospective analysis allowed marking more than fourfold exceeding of indexes of primary liver cancer morbidity of Yakutia’s population by comparison to indexes on Russia. The exposed distinctive information on prevalence of morbidity in the different medical geographic areas of republic can be used for development of measures of prophylaxis of this pathology.

Prevalence and intensity of dental caries, paradontium at children of preschool and school age, and also teenagers of Yakutsk educational institutions have been studied. The indicators of necessity and the dental care rendering level are defined on the basis of received data. Ways of the specialized help optimization and the increase of hygiene level at children and the teenagers living under the conditions of the North large units are proved.

In the social status before receipt in a hospital pensioners on age prevailed, the contingent part had disablement owing to somatic diseases. The analysis of structure of physical inability at persons of elderly and senile age (n=136), for the first time addressed for the psychiatric help has shown, that for the first time recognized disablement owing to mental frustration met more often in age categories from 70-79 years and is more senior 80 years, on weight of frustration first group of disablement is defined. In structure of disorders forms a leading place occupied dementia.

The problem of search and selection of new antibiotics of the metabolites of imperfect fungi is particularly relevant in our time. The effect of metabolites of fungi of the genus Trichoderma in a number of gramnegativnyh and grampozitivnyh microorganisms. Showing antibiotic effect studied metabolites.

The maintenance of the element maintenance of calcium and phosphorus in plasma of blood at laboratory animals is investigated at application of the new derivative connections which are being clathrate and conjugate of β-cyclodextrin with acid paraaminobenzoic were used. Positive dynamics of the maintenance of defined elements under influence of the synthesized substances is revealed. The most positive tendency is found out in the skilled group received conjugate of β-cyclodextrin with acid paraaminobenzoic.

A comparison of the data of selective angiography, computed tomography and risk factors in patients with coronary atherosclerosis is carried out. Analysis of risk factors in patients revealed that among indigenous men at less severity of coronary artery atherosclerosis, low values of atherogR .

The work is devoted to the Life and activity of the first doctor from sakha people Prokopi Nesterovich Sokolnikov. P.N.Sokolnikov got fundamental university education in Tomsk imperial and then in Moscow imperial universities. He became the first professionally qualified doctor, first scientist, founder of the prophylactic medicine in Yakutia, avganizer of Churapchinsky region public health, public figure, educator of native people.