The analysis of all deaths (17 693) of able-bodied population of Yakutsk and RS (Y) for 2005-2008 was held. The dynamics of mortality shows a slight improvement of public health of working-age population in Yakutsk. During this period levels of total mortality in Yakutsk and in the republic have a tendency to decrease by reducing the number of deaths from external causes and diseases of the circulatory system. Significant differences in mortality among men and women, increase in mortality from malignant neoplasms were revealed. The results can be taken into account at planning and developing programs to reduce mortality of able-bodied population of Yakutsk.

We examined 213 Yakuts with the 2 type diabetes mellitus living in rural areas of the Republic Sakha (Yakutia). It is revealed that the 2 type diabetes mellitus more often develops in persons after 50 years, mainly in female during meno- and postmenopause.
For the majority of patients with the 2 type diabetes mellitus, signs of increased risk of vascular complications are characteristic. Diabetic complications in Yakuts with the 2 type diabetes develop in the period from 3,6 to 4,5 years - diabetic retinopathy is rapidly developing (an average of 3.6 yearsc .

Objective: characterization and comparative analysis of the physical development of children of the indigenous population of the Tyva Republic. The study involved 276 boys and 305 girls aged 8 to 11 years, attending national schools of Kyzyl. A comparative analysis of somatometric indicators (body length and weight) of Tuvinian children with children of the indigenous population of Mongolia and Chukotka was held. It was revealed that a significant proportion of junior Tuvinian schoolchildren had disharmonious development options, mainly due to overweight. Indicators of Tuvinian physical development have more similarities with somatometric parameters of children in Mongolia than in Chukotka.

In article efficiency and safety of application of a preparation Fluimucil-antibiotic by an inhalation way at treatment of acute respiratory diseases in children in out-patient conditions is considered. Results of research have shown that inhalation therapy by Fluimucil-antibiotic is an effective method of respiratory diseases treatment at children in out-patient conditions which considerably reduces the treatment period.

A retrospective analysis of anesthetic interventions in children with MRI- and X-ray CT-studies according to the medical records of inpatients and anesthetization registers for 1999 - 2008 was done.
Techniques and drugs for sedation were analyzed; complications and the organization of anesthesia for this type of research were examined.
It was revealed that quite a number of complications of sedation require strict compliance with the selection and monitoring of patients on MRI- and X-ray CT- researches.

In the article the indexes of lipid exchange are studied at new-borns at presence of preeclampsia at mothers. It is proved, that new-borns of this group have the indexes of lipid spectrum higher, than new-borns from mothers with the uncomplicated pregnancy. However at new-borns of Russian nationality dislipidemiya is more expressed on a background of preeclampsia at mothers, then at new-born of the Buryat nationality. Possibly, it testifies to stability of metabolism of lipids for the representatives of Mongol race due to the historically folded terms of life and feed.

Holter monitoring was made in 77 patients with complicated course of hypertension in combination with coronary heart disease in the acute period of ischemic stroke and in a year after disease. In the course of year most of the patients did not accept drug treatment or they were treated not regularly.

On the basis of research it was revealed that our interactive educational program for patients with moderate chronic obstructive pulmonary disease (COPD) affects the majority of indicators of the general QL and all indicators of a specific QL. The most expressed positive dynamics of the quality of life is observed after the first month of training in COPD-school on a scale “role of emotional problems” and “mental health” at the study of general QL, and by the indicators responsible for the psychosocial aspects at the specific QL study.

Results of epidemiological research of prevalence of an epilepsy among the population senior 14 years of a city of Yakutsk Republic Sakha (Yakutia) are resulted. The conducted research has allowed to receive a complex clinical-epidemiological picture of an epilepsy among republic urban population. Prevalence of an epilepsy here was slightly more low, than among agricultural population. Observable distinctions of prevalence of an epilepsy at men and women have not reached authentic values. The analysis of current therapy has shown low efficiency of the received treatment, insufficient use of modern antiepileptic drug.

Combatants - Internal Affairs officers, accomplished their duty in particular conditions were under study.
Somato-neurological, psychophysiological examination using psychometric scales, laboratory tests of blood and urine tests and instrumental investigations (under indications: transcranial dopplerography, ultrasound scanning, brain MRI) were conducted.
It was revealed that individuals with normal psycho-physiological health indicators better adapted to the specific (extreme) conditions of their duty than those with the primary changes in health status, who got those or other neurological (psycho-vegetative) and psychosomatic disorders, requiring the timely detection and correction.

In given article personal experience of surgical treatment of recurrent and big ingvinalis hernias is resulted. Authors offer a technique of intraperitoneales plastics mesh polipropilen by an artificial limb ingvinalis the channel from access on “Nyhus”, and also the experimental substantiation of a way of an arrangement endoprotesis is given at plastic of hernial defect. It is proved, that the most active current of reparative processes is observed at subapponevrotic and subperitoneal endoprotesis arrangement.

The variability of polymorphic variants of three interleukine genes (rs1143634 in the gene IL1B, rs3212227 in IL12B gene and rs2234663 in the gene IL1RN) in Yakuts is characterized. Associations of studied polymorphic variants with pulmonary tuberculosis in Yakuts are not revealed. A comparison of allele and genotype frequencies between groups of TB patients and between control groups of three ethnoses (Russians, Tuvinians and Yakuts) of Siberia is held. It was shown that the differences between the samples of patients from different ethnic groups were of different nature (variability of allele frequencies and genotypes) than at comparing population samples. These differences in the level of differentiation between groups of patients and control of different ethnicities suggest the existence of racial specificity of the frequency distribution of alleles and genotypes of the investigated genes-candidates of susceptibility to tuberculosis.

We studied a condition of immunity at patients with malignant tumours of maxillofacial area. Decrease of data of cellular immunity at patients with malignant tumours of maxillofacial area is revealed. Decrease of only IgG concentration at persons with wide-spread tumoral process is established at studying of humoral immunity.

We analyzed the statistical material containing more than 19 thousand death cases from malignant tumors of the RS (Y) population for the period 1991-2007. Concept of the levels of mortality from MT in the country was obtained by using intensive and standardized parameters.
Results of the study. In Yakutia for the 1991 - 2007 marked tendency to decrease mortality from all forms of carcinomas has led to the fact that the ac By 2012 the prognosed levels of mortality from colorectal cancers will be essentially significant for the initial values.

Analysis, which main purpose was to explain the magnitude of the effect of some the most socially significant factors on the dynamics of the breast cancer morbidity in the RS (Y), is done.

Case reports of patients with arterial aneurysms over 5 years, as well as case reports and transaction records of patients operated by the method of endovazal occlusion of the aneurysm are studied.
It was revealed that the basic epidemiological characteristics generally correlate with the data of world and domestic literature. Prevailation of women - Yakuts of working age among patients is characteristic. Results of surgical treatment, carried out in our region, are good.

Prevalence and clinical-morphological manifestations of gastroduodenal pathology in 1503 schoolchildren of indigenous and non-indigenous population of Evenkia aged 7-16 years were under study. It was found that nearly half of the surveyed children had dyspeptic complaints, the prevalence of which was higher among indigenous schoolchildren. Erosive-ulcerative lesions of gastroduodenal zone, on the contrary, more often were diagnosed in non-indigenous schoolchildren. Besides there is a poor quality of medical care for children with gastroduodenal pathology, first of all, low and delayed diagnosis and treatment.

The paper reveals the importance and role of the doctrine of a sober lifestyle as the main direction of preventive medicine in the modern world.

The morbidity of the Yakut State University students on reference to a doctor and data of medical examinations, questioning of students to describe the lifestyle and health of students was investigated. Medical - social study found out that the incidence of students living in the dormitory was higher than that of the students living in apartments, especially in the age of 20 - 22 years. According to medical examination data, on the contrary, the incidence was higher in students living in apartments than living in a student hostel. The study showed that in order to improve the health of students it’s necessary to improve the quality of food, increase the rest time, take sanatorium therapy, play sports, improve housing conditions.

The object of study is the effect of mineral water “Abalahskaya” at chronic gastritis. Methods for water treatment of chronic gastritis with different secretory function of the gastric mucosa are worked out and clinical tests to assess their effectiveness are held.
The effectiveness of treatment of patients with chronic gastritis is defined by a pronounced anti-inflammatory and normalizing effect of water on the motor-evacuatory function of the gastrointestinal tract and the universal property of the impact of mineral water “Abalahskaya” on the secretory function of gastric mucosa.

In article results of studying of clinico-epidemiological features of the acute intestinal infections caused by opportunistic microorganisms, in children of Irkutsk are submitted. Primary affection of children of early age, prevalence of аverage degree of disease, dependence of infection hea.

The paper presents the results of a study of epidemiological characteristics of different forms of acute intestinal infections in the Republic Sakha (Yakutia) in general and in its central regions.

In article the estimation of quality of waters of a river basin of Lena (Republic Sakha (Yakutia)) under the maintenance of mineral oil is given. It is shown that mineral oil concern priority polluting substances of superficial reservoirs of region. Considerable excess of maximum permissible concentration on separate sites of pool of the river of Lena is revealed. The estimation of measures on preservation of water objects from pollution by mineral oil is given. Necessity of perfection of ecological monitoring of superficial reservoir is shown.

The article adduces analysis of nosocomial infection in different health care hospitals according to their profile, a comparison of data on the structure of nosocomial infections in Yakutsk with data on the RS (Y) and the Russian Federation, and also the level of infection of medical workers with viral hepatitis B in Yakutsk and the need for their vaccination is shown.

Populations of northern people, for thousands of years living in extreme conditions, in the result of centuries-old evolution have been formed by natural selection. In the Arctic indigenous people regardless of ethnicity many common features, both in the structure of the body, in a number of physiological characteristics, and in the development of a number of specific pathological processes were revealed. In the process of evolution in the specific nature-climatic conditions of the Far North only the gene complexes that are most appropriate for the inhabi-tancy were supported by selection.

We study the hard tissues of intact permanent teeth in children of school age, extracted on orthodontic indications, in order to identify quantitative and qualitative changes in hard tissues of teeth for their purposeful correction during the preventive measures. Results of the study revealed a decrease in the stability and structural changes in the homogeneity of enamel, which are biological risk factors for dental caries in children of Yakutia.

The main results of the Local Committee on Biomedical Ethics of the YSC CMP SB RAMS are presented. The basic criteria for ethical review of clinical research in the Republic Sakha (Yakutia) are shown.

A “Сosmetic way of suturing of contaminated surgical wound at appendectomy” is worked out and implemented. The analysis of clinical results of hospital treatment and outpatient post-operative treatment using different methods of suturing of surgical wound is carried out. Decrease of purul

Inflammatory complications in the abdominal cavity are the most frequent complications after operations on the gall bladder.The chair of faculty surgery of the Amur State Medical Academy carries out complex scientific work on the problem:”Prophylaхis and prognosis of the complications of the beliferous pathways surgery”. Our investigation is aimed at: working out of rational methods of prognosis of purulent complications after cholecystectomies in elderly and old patients. The authors noted a definite dependens between the degree of disturbance of the immune system and postoperative complications, functional condition of the liver and postoperative purulent complications.

This article presents surgical treatment data of 106 patients with postoperative peritonitis, underwent numerous relaparatomies at the surgical department of Republics Center of Urgent Medical Aid in Republic Sakha (Yakutia) 2006-2008. A comparative analysis of treatment results in 62 p

Studying of morphological changes of bone elements temporomandibular joint by a method of definition of optical density of a bone fabric with use of a computer tomography at patients with a syndrome of painful dysfunction temporomandibular joint is spent. Changes of indicators at investigated basic and control group are revealed.

At present, chronic generalized parodontitis are widely spread demonstrating actuality of correct choice of therapeutic methods. Estimation of efficiency of therapeutic method using medical ozone in patients with chronic generalized parodontitis associated with Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis is described.

The article provides a definition of iatrogenic conditions, the author proposes a model of forensic medical iatrogenic conditions, based on cluster analysis of their development causes, justified by the possibility of its use in forensic medicine

A long-term clinical observation of two monozygotic twin brothers with chronic hepatitis was held. Traditional general clinical laboratory tests and ELISA markers of hepatitis were used.
The disease in unvaccinated twins occurred with an interval of 7 years on the background of close home contact. In both brothers acute hepatitis transformed into the chronic form, with the second one - in the shortest terms. Acute hepatitis in the second brother coincides with the peak of the exacerbation of hepatitis in the first.
In this regard, vaccination of persons at risk in outbreak of viral HBV-infection is very important, as well as studying of the genetic properties of the viral agent and the response of microorganism by the help of molecular-genetic methods.