Purpose. To develop the optimized technique of the prevention of development of local tuberculosis in children infected with drug-resistant strains of tuberculosis mycobacteria (TMB).
Materials and methods. Object of research were statistical accounting data for 2002-2004 of the Republican antitubercular clinic, children at the age of 2 to 14 years who were divided into 2 groups: 1-st (basic): 80 children, received ХП (preventive treatment) in the strengthened condition. They were divided into 2 subgroups: 1-st A - 40 children from contacts with patients allocating DR strains of TMB. 1-st B - 40 children from contacts with patients allocating TMB with medicinal sensitivity, 2-nd (control): 40 children who received chemoprophylaxis by a standard technique.
Results. The frequency of children’s infecting with DR strains of TMB and degree of risk of development of tuberculosis in the given category of children were determined. For the first time clinic laboratory displays and features of reaction of the immune system of children infected with DR strains of TMB were revealed. New data on uniformity of infringements of immunologic reactance in children, infected with DR strains of TMB and children suffering from drug-resistant tuberculosis was obtained. Application of preventive treatment in the strengthened condition in a complex with immunocorrector lycopid for the prevention of disease was proved. The scheme of differential diagnostics of infecting with drug-resistant and sensitive strains of TMB was developed. The symtomatology of immunobiologic infringements in children infected with DR strains of TMB was determined. The technique of its correction was developed.
Conclusion. The technique of preventive treatment appeared more effective in comparison with the standard scheme of chemoprophylaxis and as the result of it can be the decrease of tuberculoses sensitivity of all parameters, the essential increase of an annual gain of weight and body height parameters, the decrease in frequency of sharp respiratory infections, the normalization of parameters of the immune status and absence of tuberculosis morbidity.

Purpose. Studying of premorbid background and clinical current for the first time diagnosed hysteromyoma in young women (till 30 years).
Materials and methods. Examination was spent on the basis of the Center of science of medicine and the Prenatal Center of the Sakha Republic (Yakutia) of Yakutsk. In our research prospectively and retrospectively the inspections of 101 patients with hysteromyoma (in diameter from 1 up to 9 sm), being under our supervision from 2004 to 2006, were included.
Results. A hysteromyoma is more often diagnosed after 25 years. Between a regular sexual life and the first childbirth passes not less than 9.3 years. A leading symptom of infringement of menstrual period was hyperpolymenorrhea 55.5 %, with the subsequent development of hypochromic anemia. From accompanying gynecologic diseases it is necessary to allocate hyperplasia of endometrium, cyst and ovarian cystoma. Chronic extragenital diseases and their combination (2-3 in each patient) are probable. Promotes a somatic mutation of cells.
Conclusion. The given pathology in young women develops more often on a background of numerous diseases and absence of duly realization of reproductive function.

Purpose. Studying insemination, morphological pictures and conditions of local immune reaction of mucous membrane of stomach and duodenum in patients with various degree of severity of current of ulcer of stomach.
Materials and methods. Inspection of 100 workers of «Yakutugol’” company, suffering from ulcer of stomach and (or) duodenum, was carried out. They underwent endoscopy examination with target biopsy and detection Нр in biopsy material. Insemination Нр was defined before carrying out of treatment, control examination was carried out in 1 month after antichelicobacterial therapy.
Results. Severe treatment of ulcer of stomach was accompanied by the development of relapses (12.0 %), increase of levels IL-4 and α-PNO in 2 times and more expressed character of changes of mucous membrane. Full eradication was more often in patients with mild and an average degree of current of ulcer of stomach (78.0 %).
Conclusion. Detection of level of IL-4 and α-PNO is an accessible and effective method of detecting the condition of local immune reaction of mucous membrane of stomach and duodenum.

Purpose. Development and introduction in practice a new poorly invasive method of operative intervention in a fracture of neck of radial bone and epiphyseal fracture of head of radial bone, excluding traumatism of an elbow joints.
Materials and methods. Experience of diagnostics, treatment and studying of outcomes is put in a basis of research in 30 patients at the age of from 5 to 16 years with diagnoses: the closed fracture of neck of radial bone with displacement of head, epiphyseal fracture of head of radial bone with displacement.
Conclusion. During performance of this operation there is an opportunity of the most exact replacement of fragments. Unlike transarticulary fixings of head our technique allows not to take root into a cavity of an elbow joint. For performance of the presented operation special preparation of the surgeon and toolkit is not required.

Purpose To reveal the features of atherosclerotic process in the common and internal carotic arteries in indigenous and nonindigenous population of Yakutsk.
Materials and methods. Using visually planimetric and histomorphometric methods we examined 247 complete sets of the internal and common carotic arteries. And intracerebral arteries either.
Results. Atherosclerosis in carotic arteries presents essentially more poorly in indigenous population, than in non-indigenous. Severity of atherosclerotic process in both ethnic groups was essentially more in the common carotic artery, than in the internal. When the arteries of the basis of the brain were examined by histomorphometric method, we found out more expressed changes in non-indigenous population, than in the Yakuts. These changes are connected with hyperplasia, sclerosis of intima and media, increased tortuosity of internal elastic membrane.
Conclusion. The Yakut population has the smaller frequencies and area and the slow development of towering atherosclerotic defeats, whereas non-indigenous population has the early, frequent and more intensive development of an atherosclerosis in common and internal carotic arteries.