The paper presents the results of sociological, clinical and laboratory tests and instrumental surveys of adolescents with Helicobacter pyloriassociated disorders of the upper digestive tract. At the study of psycho-emotional and social characteristics of these patients we found that they had significantly low scores on all parameters of emotional, social and physical functioning (emotional status and the possibility to do their daily social responsibilities significantly worsened, adolescents coped with high physical activity, passing over one quarter, carrying heavy things significantly worse) due to severe pain present at exacerbation of chronic gastroduodenal pathology. On a background of anti H. pylori and symptomatic treatment we found increase of quality of life indexes on all scales of functioning.

We studied by gas-liquid chromatography the fatty acid composition of phosphatidylcholine and lysophosphatidylcholine of erythrocyte membranes of women who had in III trimester of pregnancy acute herpes virus infection. The increase of saturated and decrease of unsaturated fatty acids of phospholipids membranes at a high titer of IgG antibodies to herpes simplex virus were revealed.

Article is devoted to an actual problem of pediatrics – acute poisonings at children. Authors carry out the analysis of reports of admittingdiagnostic department Pediatric Centre RH N1-NCM from 2006 for 2010. The increase in number of cases of acute poisonings at children of all age is revealed, at teenagers - increase of figures of statistics of alcoholic poisonings, by narcotic substances and cases of suicide attempts is noted. All receptions of hospitals should be provided by sets of antipillboxes for rendering of the urgent help to children with the most frequent kinds of poisonings.

Survey of young people with dysfunction of the autonomic nervous system revealed the presence of pathogenetically significant changes in the major regulatory systems of adolescents: high frequency of mental health problems, complex sub-clinical abnormalities in the immune, endocrine, reproductive systems involving a high level of endogenous intoxication at the cellular and organism level, disruption of the trace element metabolism and large strength of compensatory mechanisms. The project of the program of health monitoring of the mentioned group is developed.

The present study analyzes the data of the National monitoring of congenital malformations for 2000-2009 and for the first time the frequency, structure of malformations of the urogenital system of newborns and aborted fetuses in Yakutia are determined. The estimation of the level of effectiveness of the prevention of congenital malformations is given.

The outcomes of treatment of the neonates with perforative peritonitis for 20 years from 1992 to 2011 in the Pediatric Center RH№1-NCM MH RS (Y) are studied. The use of peritoneal drainage in the complex of measures of preoperative preparation of a patient allowed lengthening the time of preparation from 1.5 - 2 hours to 8 - 12 hours. In this case, there was the possibility of a more appropriate correction of fluid and electrolyte metabolic disorder, urine output restoration, reducing signs of infection and toxic shock, which helps to prevent serious complications of general peritonitis as multiple-organ-failure syndrome and disseminated intravascular coagulation syndrome. Over the study period neonatal mortality with perforative peritonitis decreased from 75% to 21%.

The role of regulatory T-lymphocytes (Тreg-cells) in development of atherosclerotic damage of vascular wall is the subject of research of world leading laboratories. Тreg cells have been identified in atherosclerotic plaques of human carotid and coronary arteries. Males (n=16) aged, at the average, 61,5 ± 9,3 admitted to the intensive care unit diagnosed with unstable stenocardia and conditionally healthy males (n=8) at the similar age were included in the study. The results of the comparative analysis revealed that patients with unstable stenocardia showed a significant increase of Тreg cells (CD4+CD25+FoxP3+), and a tendency towards a decrease of Т helpers (CD4+). The increase of Тreg cells is likely to suppress a further activity of the atherosclerotic process through suppressed proliferation and activity of T-helpers The negative correlative link between Тreg cells (CD4+CD25+FoxP3+) and Т-helpers (CD4+), as well as a positive link between Тreg cells (CD4+CD25+FoxP3+) and ХС-ЛПНП have been identified.

The analysis of published data on the key aspects of the pathogenesis of cardiac arrhythmias and blockades in patients with bronchial asthma (BA) suggests that vegetative regulation of heart rate decreases with increasing of BA severity. Among the main aspects of the pathogenesis of cardiac arrhythmias and blockades in BA patients one can name the following: hypoxemia, reduction of the vascular bed, pulmonary hypertension and right heart overload, hypercatecholaminemia, and also blood gas content changing and acid-base balance.

Research objective was to estimate the uric acid levels in patients with the verified coronary atherosclerosis and persons without clinical signs of IHD, and also the frequency of the association of hyperuricemia with coronary atherosclerosis depending on ethnic and gender origin on the example of Yakutia population. Results of the survey of men and women at the age of 45-64 years of native and non-native population with the verified coronary atherosclerosis according to selective coronaroangiography, and also of persons without clinical signs of IHD, were analyzed. The results of the research showed that the uric acid levels were significantly higher in patients with the verified coronary atherosclerosis (excepting of women of non-native nationality) in comparison with persons without clinical signs of IHD and higher in representatives of non-native nationality, than in the native population of Yakutia.

A genetic characteristics of virus C hepatitis in the Republic Sakha (Yakutia) is presented. Genotyping of virus C hepatitis was carried out in the laboratory of the Central Research Institute of Epidemiology of the Federal Service of Supervision in the Sphere of Protection of the Rights and Well-being of Consumers (Rospotrebnadzor) of the Russian Federation (Moscow) with application of PCR-test-system. This test-system allows identification of 4 genotypes of virus C hepatitis: 1a, 1b, 2a, 3a. During 2007-2010 163 samples of viral RNA of the chronic hepatitis C patients from the Republic Sakha (Yakutia) were genotyped.

The analysis of clinical–endoscopic manifestations of symptoms of functional dyspepsia in different ethnic groups, living in Republic Sakha (Yakutia) is carried out. At the analysis of clinical symptoms of functional dyspepsia patients with postprandial distress syndrome and epigastric pain syndrome are revealed. Clinical manifestation and course of chronic gastritis with functional dyspepsia in the Republic Sakha (Yakutia) have a number of distinctive features: among the surveyed epigastric pain syndrome occurs in patients of indigenous and non-indigenous population the intensity of pain in the indigenous is much lower than that of non-indigenous. Postprandial distress syndrome was diagnosed in 71, 9% of indigenous patients and 28, 1% of the nonindigenous. At endoscopy in all patients with functional dyspepsia chronic gastritis is diagnosed. The native inhabitants more frequently have mixed gastritis (54, 5%), the non-natives – superficial gastritis (66, 7%). At the epigastric pain syndrome continuous acid production and hyperacidity are detected more often in the non-indigenous (41, 4%) than in the indigenous population (9, 8%). At the postprandial distress syndrome in the indigenous normacidity is more common (45, 3%), in the non-indigenous – hyperacidity (14, 1%). At the syndrome of epigastric pain more effective was the prescription of anti-H. pylori and antisecretory drugs, and at postprandial distress syndrome – prokinetics, at the revealed hyperacidity therapy should be supplement with antisecretory agents.

A high frequency of symptoms of gastroesophageal reflux disease and irritable bowel syndrome in the elderly population of Yakutsk is noted. The differences in the frequency of GERD and IBS according to ethnicity and gender are revealed.

Modern herniology presents innovational field of surgery. Among the causes of hernia development the disturbance of collagen metabolism plays a great role, and leads to heterogeneous maturation of the connective tissue and disorder of its structural characteristics. Investigation of the collagen contents of the connective tissue with the help of polarization microscopy reveals Collagen Type I to Type III ratio in skin and aponeurosis in patients with and without hernia disease. Presented investigation makes prognosis and prophylactics of hernia disease possible in early postoperational period.

Overproduction of hepcidin in the liver is considered to be due to the effect of high levels of proinflammatory cytokines. Interleukin-6 is known to play a key role in the development of anemia in patients with juvenile rheumatoid arthritis. During the study of patients with juvenile rheumatoid arthritis treated with biological disease-modifying drugs (tocilizumab and golimumab), direct relations between the level of hemoglobin and hepcidin were not found. Most probable, anemia in rheumatoid arthritis is multifactorial and involves violation of iron metabolism in the organism and the negative effects of proinflammatory cytokines on erythropoiesis. Severe anemia can be associated with iron deficiency or with the macrophage activation syndrome in children with juvenile rheumatoid arthritis.

Cerebrorenal relationships between the early signs of cerebral atherosclerosis and the level of the calculated glomerular filtration rate (GFR) with account of the influence of risk factors (RF) of cerebrovascular diseases in elderly and senile patients of the Republic Sakha (Yakutia), suffering from chronic brain ischemia (CBI) depending on the region of residence were under study.

The results of surgical treatment of patients with combined chest and abdominal injuries are analyzed. The use of Computer Assisted Surgery technology has significantly increased the accuracy of diagnosis, and the introduction of minimally invasive techniques has shown to be indispensable in cases of severe trauma.

This article illustrates surgical treatment results analysis of patients with the combined disease of coronary and carotid arteries. The patients underwent a multi-step or a single-step surgery. On the basis of received results, a strategy of surgical tactics has been offered on how to treat this category of patients.

The increase of morbidity and invalidization frequency of patients with the breast cancer stipulate a necessity to find of the new diagnostic ways and prognostic markers with the aim for early diagnostic, optimization and individual way of therapy that will allow to improve the quality of life, patients physical and social rehabilitation. The results of histological research of operational materials from women of different age groups with the breast cancer with the subsequent immunohistochemistry (IHC) definition expression of mutation suppressor gene p53 are analyzed. Obtained data testify that IHC-research expression of mutation р53 correlates with high histological malignancy degree that proves need of the apoptoziz account in estimation of the malignant potential and defining breast cancer.

The authors made a comparison of the quantitative value and volume of calcium in the wall of the coronary vessels and the results of perfusion scintigraphy in patients of different ethnic groups in Yakutia with coronary artery disease.

Patients aged 57, 8 ± 14, 4 years, with painful form of cholelithiasis were under study. The microbial spectrum of gallbladder bile obtained from the gall bladder intra –operationally - during cholecystectomy and duodenal sounding was analyzed. Statistically significant differences in the frequency of bacteriocholia in patients with cholelithiasis at the duodenal and intrabladder bile sampling were not revealed. In the bile, taken at the duodenal sounding, a statistically significant excess of conditionally pathogenic microorganisms: Streptococcus and Candida fungi groups, represented in the oral cavity, was revealed, which should be considered when interpreting the microbial spectrum of duodenal bile aspirate and addressing the need for antibiotic therapy.

The force of the fixation of nylon, cast metallic and bent metallic klammers to the supporting teeth has been investigated on the model of the dental defect. The stronger fixation to the supporting teeth with the expressed equator of metallic cast and bent klammers in the comparison with elastic nylon klammers has been revealed.

In article the concept about adaptation, adaptation stages is given. Questions of influence of adverse factors of Far North on a state of health of the children’s population of the region, features of a course of adaptation process at children who have moved to a constant residence in new climate-geographical conditions of accommodation are in detail considered.

We investigate the influence of the Yakut kumys on lipid peroxidation and antioxidant system of sportsmen volunteers (freestyle wrestlers) aged 13-16 years during the recovery period in the summer sports camp “Rodnik” of the Republic Sakha (Yakutia). The athletes were divided into two groups: who drank kumys and who did not in the recovery period. The studies showed that on the 11th day of recovery period in the group of athletes who drank kumys by the scheme within 10 days, the concentration of tiobarbiturat - active products in erythrocyte membranes decreased in 1.57 times, while in the group of athletes who did not drink kumys- had remained at a high level. The content of low molecular antioxidants in the second group of sportsmen increased in 1.68 times, which was on 42% higher than in athletes who did not drink kumys. The level of ascorbic acid in the second group increased in 1.59 times, in the first group its content decreased in 8%.
Thus, it was confirmed that the Yakut kumys reception by athletes during the recovery period due to the scheme helped to reduce the intensity of lipid peroxidation and non-enzymatic activation of antioxidant defense, i.e. was the effective method in accelerating the recovery of the body.

Preservation and strengthening of population health in conditions of the North is the priority strategic mission of the President and the Government of the Republic of Sakha (Yakutia), medical science, practical public health services and innovative development of the region, and ensuring of qualitative health-improving feeding – national safety and improvement of quality of life of population.
Unified data base on actual feeding of various groups of population of the republic in 12 years dynamics was made by the researchers of the Institute of Health of North-east Federal University named after M.K. Ammosov; the results of clinical-epidemiological studies of health disorders and diseases caused by unsatisfactory feeding and actual food habits were received.
Correlation of insufficient feeding with development of complications during pregnancy, pathology of fetus and child health disorders was proved. Dependence of frequency of respiratory infections, atopic status upon duration of breast feeding of infant and also correlation of irondeficient and osteopenic status in children and teenagers with insufficient intake of various nutrients including essential as calcium and iron were revealed. There was shown clear interrelation of breast feeding duration with educational level of mothers.
Results of long-term investigations carried out by Research Institute of Health, NEFU after M.K. Ammosov were used as basis for acceptance of the project of the Concept of State Policy in the Field of Healthy Feeding of the Population of the Republic of Sakha (Yakutia) in 2001 with the plan of basic activities up to 2005, for development of mechanisms of optimization of feeding of population of the republic, development of various normative-legal documents, scientific-methodical recommendations and educational-methodical complexes, and also for development of the project «Bases of State Policy in the Field of Healthy Feeding of Population of the Republic Sakha (Yakutia) for the period till 2025» that was approved on plenary session of inter-regional scientific-practical conference «Feeding – Basis of Healthy Way of Life and Health of Population in Conditions of the North» held on 4-5 April, 2012.
Results of scientific activity promote development of technology and manufacture of functional food stuffs from local raw products and also development of innovative activity aimed to preservation and strengthening of health of population in conditions of the North.

Epidemiological indicators of glaucoma in the Republic Sakha (Yakutia) are analyzed. The prevalence and structure of glaucoma depending on the demographic and climatic conditions of the republic for 10 years (2001-2010) are examined.

Basing on the retrospective analysis, the article presents the dynamics of the main causes of mortality of the population inhabiting different regions of the Sakha Republic (Yakutia) in the period 1991-2010. It reveals the periods of the mortality rate variations, as well as the trend changes in the main classes of mortality causes in the rural, industrial and Arctic groups of the republic’s regions. It also emphasizes the importance of keeping record of the population loss peculiarities.

The findings are presented stressing the need for timely diagnosis of candidiasis in patients with pulmonary tuberculosis, confirming the association between the presence of nonspecific flora in smear-positive tuberculosis patients and increased number of unfavorable outcomes of anti-tuberculosis therapy, and the association between the risk of development of drug-resistance in M.tuberculosis and microbial concurrence of M.tuberculosis and yeast-fungi.

In the treatment of children and adolescents aged 3 to 18 years with uncomplicated compression fractures of bodies of thoracic and lumbar vertebrae was used specially designed extension body cast. The use of a corset in clinical practice eliminates the burden on anterior vertebral bodies, helps to be engaged in physical therapy, to receive physiotherapy.

The main tasks of health protection are: rising of effectiveness medical-diagnostics processes on base of improvement of medical and information technologies; improvement of statistic analyses and morbidity forecasting; rising of quality of prophylactic measures among population; using effective methods of planning of medical institutions budget. In this work the optimization scheme of children prophylactic system by using automated system of survey and organization of away medical works were presented.

Results of ultrasonic research of hepatic hemodynamics at diseases of a hepatopancreasbiliary zone (HPBZ) in 152 patients are presented. The reliable increase in arterial inflow on A. hepatica communis system, than venous, is proved; especially in the indigenous, at early stages of chronic biliary pancreatitis, postcholecystectomy syndrome and chronic calculous cholecystitis. Further there is qualitatively new sign - delay of venous return of blood that is the cause of increase of volume sizes of blood circulation of a liver and a sign of the compensatory and adaptive mechanism. In the indigenous the qualitative characteristics of hepatic blood circulation at early stages of a disease is higher, than in the non-indigenous by 7-8%.

The paper presents the study of the composition of erythrocytes membranes lipids of saturated fatty acids of the umbilical cord of newborns from mothers who have had gestational exacerbation of herpes viral infection. It was revealed that the studied composition of those born from mothers who have had acute herpes virus infection with antibody titer IgG to herpes simplex virus type 1 as 1:12800, was characterized by an increase in the concentration of myristic, pentadecanoic, palmitic, margaric and stearic fatty acids.