A retrospective analysis of the 12, 2 thousand deaths due to malignant neoplasms of Yakutia population for the period 2001-2010 is represented. The share of MN is 14, 8% (in Russia -13, 8%) of all deaths in the republic and in significance they are in the third place after cardiovascular pathology. In the dynamics mortality tends to decrease. Republic loses 20, 2 thousand person-years of life, including 8, 4 thousand - of working age.

The analysis of the dynamics, the nature of trends of mortality among working-age population of the Republic of Sakha (Yakutia) for the period 2000–2008 years was made and the prediction up to 2015 year was composed.

An inspection, examination and treatment of 2273 children of both sexes aged from 1 month to 17 years of Mirny region in Yakutia were done. The high level of pathology of the urinary system in children and adolescents has been diagnosed. It was found out that children with congenital anomalies and malformations of the urinary system were at risk for the development of chronic pyelonephritis in the future, and so they required special medical control and preventive measures.

Native and non-native adolescents of the Sakha (Yakutia) Republic and Khabarovsk were surveyed. The features of the phenotypic characteristics of peripheral blood lymphocytes in the young indigenous of Yakutia were revealed. The revealed regional features of the immune status of Sakha (Yakutia) Republic adolescents are considered as adaptive, aimed at compensation of the effects of climatic, technological and emotional environmental factors.

Сhildren with FAS from Republic Sakha Yakutia were detailed by means of 4-digit Diagnostic Code, routine and age-dependent developmental neurological assessment, brain ultrasonography, magnetic resonance imaging (MRI). The FAS rate varies from 0,88 to 2,10 per1000 live births. Peculiarities of dysmorhial and structural cerebral abnormalities depending on ethnicity of the child are identified. Decrease of palpebral fissure lenght could be an early indicator of mental retardation

Investigation of influence of comorbid disease on outcomes in patients with acute coronary syndrome with ST segment elevation (ACSeST) was conducted. Comorbidity was recorded in 88% of patients. The most common comorbidities are the aggravation of chronic cholecystopancreatitis, erosive and ulcerative lesions of the upper gastrointestinal tract, chronic colitis. Statistical analysis showed a significant increase in the incidence of death in ACSeST patients with exacerbation of chronic pyelonephritis and with erosive and ulcerative lesions of the upper gastrointestinal tract.

The medical histories of regular and contract service military men with community-acquired pneumonia treated in the pulmonary department of Branch № 1 FSI «321 OVKG,» the Health Ministry in Novosibirsk in 2003-2005 were analyzed. Seasonal incidence of pneumonia in soldiers was found out: those in active service more often had pneumonia in winter and summer seasons of the year (January, May, June and July), the contract – more often in the winter and autumn (January, September and October).

The paper gives the data of a study of HLA-antigens in 31 aborigens, 1600 donors, 85 patients with psoriasis. In aborigines (the Ulch) low frequency of HLA antigen A1 and tendency for increase of HLA B13 were found. Indices of HLA B-17 were the same as in the control group. In patients with psoriasis high frequency of antigens HLA A-1, HLA B-13, HLA B-17 and low frequency of antigens HLA A-28, B-7, Cw-3, Cw-4 was determined. This can point out the absence of genetic susceptibility for psoriasis in the Ulch.

The high incidence of parenteral viral hepatitis B, C and D markers is determined in patients with hepatocellular carcinoma (HCC). The data on higher rates of progression of HCC among patients with hepatitis B, C and D in comparison with patients with liver cancer in the absence of markers of hepatitis viruses are obtained. HCC with the greatest frequency occurred in HCV-infection with genotype Ib, HBV-infection – genotype D and HDV-infection – genotype I.

The purpose of examination consisted in interrelation revealing between prescription of disease and the content of hormones in a blood of boys with epilepsy. Examination of hormones in bloods of children at duration of disease till 2 years, from 2 till 6 years and over 6 years was spent in age subgroups in which the content of hormones reliably differed irrespectively prescription of disease. Findings of investigation testify, that dependence of a level of hormones in a blood of boys with epilepsy from prescription of disease has the complex character and is or individual for some hormones, or the general for several hormones.

The analysis of anamnestic, clinical-dynamic characteristics, demographical, social-adaptive peculiarities of paranoid schizophrenia patients with criminal and law-obedient behavior in later life on the basis of their long-term catamnesis examining is represented. System analysis (taking into account the dynamics of the leading syndrome, personal and situational characteristics) of remote catamnesis of the specified contingent was carried out. Several connections between trends in the course of the disease, personality, environment and behavior were revealed. In particular, the role of the tendency to weakening or to the stop of the progredience with stabilization of condition and reduction of psychopathological symptoms and the tendency to preserve the activity and progredience of schizophrenic process. The obtained results of the research may contribute to perfecting the prognostic criteria of the disease dynamics and prophylactic treatment of extremely dangerous offences.

Research of the surgical treatment results of patients with single- and multiple valve heart defects has shown that risk factors of patients with specified defects equally influence surgery outcome. Рresence of two or more risk factors significantly increases the risk of hospital lethality.

Аrticle presents the results of experimental studies of biological adhesive developed by the swimming bladder of sturgeon. Glue composition were investigated by IR-and UV-spectroscopy, adhesive properties in tying two strips of leather was investigated by measurement of tensile strength. Glue structure was investigated by light and atomic force microscopes. Results are obtained planimetric studies of experimental model of cutaneous wounds in laboratory animals using the developed tissue adhesive. The covering of a wound biological film with drug excipients shows good adhesion on the wound surface, the lack of irritation, as well as a stimulating effect on the healing process of skin wounds.

Osteochondrosisis is one of the most frequent diseases of the musculoskeletal system. The conservative therapy has short period effect, because it doesn’t remove the cause of the discogenic compression. The usage of laser puncture intervertebral discs reconstruction with simultaneous sequester vaporization method at the treatment of complicated forms of lumbo-sacral dorsopathies was investigated. It was revealed that the application of the method in most cases lead to the pain decrease, extension syndrome disappearance, radicular sensory disorders and motorical radiculer prolapses disappearance. In 92, 9% of cases the total disappearance of orthopedic violations was noticed.

In article results of research of cognitive functions of the patients, with different variants of a cerebrovascular pathology (CVP) are reflected, depending on residing region. At comparison of research results of cognitive functions of CVP patients it was revealed that the patients more often had distresses connected with memory, attention and concentration disorders, herewith the patients of the Arctic zone who had the good ecological situation, had these disorders on rare occasions. In comparative-group ratio moderate prevalence of the specified distresses was marked in the inhabitants of Viljuisky region, which was known by the bad ecological situation.

Heavy metal content in meat of Yakut young horse was under study.
It was revealed that concentrations of Zn, Cu, Fe and Mn in the investigated samples of meat didn't exceed maximum concentration limit (San 2.3.2.560-96.) and corresponded to hygienic requirements. In the investigated samples of meat pesticides were not noted. Estimations of amino acid and vitamin content of horse meat from Ojmjakonsky region testify to rather high food value in the studied samples.
Thus background indicators of meat toxic elements depend on such conditions of animal husbandry as local, natural, climatic, fodder, ecological and territorial.

Based on recent and new data on respiratory Chlamydiosis, the present article represents scientific rationale for urgency of working out the complex of measures and main tendencies for improving the organization of medical care for the patients with upper respiratory tract diseases, associated with Chlamydia infection.

Republic of Sakha (Yakutia) is unfavorable territory for the chronic viral hepatitis and their adverse outcomes. The role of blood-contact viral hepatitis in the development of primary liver cancer is proved.

In the article the literature data on the results of virological, immunological and clinical studies of combined forms of HIV and hepatitis B and C. The necessity

In Sakha Republic (Yakutia) for the study period from 2004 to 2011, trends in epidemiologic process based on key indicators prove that epidemiological situation for (tuberculosis) TB in the region is tensed. We observed growth in incidence of TB cases presenting with destructions in lung tissue and bacillary-positive state, persisting trend towards increase in TB cases caused by MDR MTB, high proportion of deaths during the first year of outpatient follow-up for TB, and low coverage of the population with fluorographic mass examinations. The quality of anti-TB measures conducted by local health institutions varies between different socio-geographical zones of the republic. The study proved the need for better organized control of TB that would take into account differences in socio-geographic conditions, medical economics, technical resources, and staff availability in the regions of the republic, within the ongoing context of modernization of anti-TB service.

Phthisiologists working in the field of therapy for pulmonary tuberculosis and development of new treatment methods started their scientific and practical work in the 1950s. The first two stages of the work became history by now; the 2000s were the beginning of the third stage – the quest for contemporary methods to treat and overcome M.tuberculosis drug resistance. Thesis works and patents for inventions give eloquent illustration of the close interconnection between science and practice.

Multidrug-resistant tuberculosis without prior treatment (primary MDR-TB) is a major problem in the Russian Federation, and also in Eastern Siberia and Far East. Mycobacterium tuberculosis isolates from patients with primary TB at two referral sites in Irkutsk oblast and the Sakha Republic (Yakutia) were tested for conventional susceptibility and genotyped using MIRU-12. Outcomes from primary MDR-TB were compared between sites. Phylogenetic reconstruction was used to determined basic epidemic genotypes with MDR. Primary MDR-TB was common in both regions and phylogenetic patterns; drug-resistance and outcomes carried regionally distinct differences, emphasizing the need for locally informed diagnosis and treatment strategies.

Analysis of 10-year tuberculosis control activities in the setting of one of rural agricultural regions in extreme north demonstrates that significant successes leading to considerable reduction in epidemiologic indicators for tuberculosis could be achieved by well-organized program regulating multifaceted interaction between municipal institutions, healthcare facilities, agencies and the leading all-republic specialized anti-tuberculosis institution. Improvements in epidemiologic situation are apparent from significantly decreased infection levels and tuberculosis incidence rates among children and adolescents.

Study findings on the effect of thoracoplasty (one of the chief surgical treatments for pulmonary tuberculosis) on respiratory function, central hemodynamics, and immune status are presented. High compensatory capacities of the respiratory system and increased humoral immunity were detected, canceling the need for remedial therapy. Treatment with nitrates and ganglionic blockers was proposed for remedy of hemodynamic abnormalities.

Thoracic surgery specialty had been developed in Russia since the postwar years, but was officially established as a specialty in 1996. Absolute majority of thoracic surgical operations in the USSR were performed in anti-tuberculosis institutions. In Yakutia, thoracic surgery developed in three stages: start-up, assimilation of new techniques, development and introduction of in-house original methods of surgery.

Results of monitoring for complications to BCG vaccine in children in Sakha Republic (Yakutia) are presented. Incidence, structure and nature of complications to vaccines against tuberculosis infection were analyzed; causes of complications were determined. The study established that complications develop most often to BCG vaccine, and rarer to BCG-M vaccine. Lymphadenitis was the prevailing diagnosis in the clinical structure of complications. Severe forms of complications were registered more frequently in children under 3 years of age. Complications in children immunized at pediatric polyclinics or rural first aid posts were mostly due to wrong administration technique. Main causes for complication development were: perinatal pathology, underestimation of counterindications, infectious or virus diseases in postvaccinal period, faults in vaccine administration technique.

We comparatively analyzed the incidence of tuberculosis in the staff of various specialty healthcare organizations, through the case of the Sakha Republic (Yakutia), and monitored clinical M.tuberculosis strains for susceptibility/resitance to disinfectants. Incidence of tuberculosis among the staff of anti-tuberculosis institutions was 3 to 4 times higher (p< 0.05), than in the staff of other healthcare organizations; among them, tuberculosis occurred mostly in registered nursing staff and in nurse assistant staff.
Disinfectants types that played main role in the control of nosocomial transmission of M.tuberculosis were chlorine compounds, and quaternary ammonium compounds (QAC) in combination with aldehydes.

The specifics of conducting antiepidemic work within the foci of tuberculosis infection in the setting of rural extreme northern region are presented. Study of 150 foci of tuberculosis infection showed: remoteness and hard accessibility of rural infection foci to specialized health service delays timely hospitalization of newly identified patients with tuberculosis, complicates examination and isolation of children to sanatoria, and hampers the conduction of antiepidemic measures in new foci of tuberculosis infection by epidemiologists and phthisiologists.

Diagnostic effectiveness of skin test Diaskintest® (DST) and Mantoux test with 2TU PPD-L in children and adolescents was comparatively studied based on evidence from the city of Yakutsk. DST showed high effectiveness in diagnosis of tuberculosis in children and adolescents and allowed detection of high risk groups among the outpatients included to follow-up registries of Tuberculosis Dispensary.

Although the incidence of extrapulmonary forms of tuberculosis in the Sakha Republic (Yakutia) has relatively stabilized, growth in the incidence of osteoarticular tuberculosis can be observed. Total hip replacement is being introduced currently – a new high-tech treatment method to restore the mobility of the diseased hip in patients with tuberculosis of the hip and its sequelae. 17 patients underwent treatment with the new technique, using prostheses by Ceraver and Smith&Nephew.

Analysis of coverage of the Sakha Republic (Yakutia) with the first aid posts is presented, as first aid posts share significant responsibility for providing medical care to patients with tuberculosis and for keeping record on follow-up (dispensary) patients. Number of the foci of tuberculosis infection observed by the local first aid posts has been determined; age-specific, social and epidemiologic description of the tuberculosis infection foci has been done. In conclusion, first aid posts are one of the key healthcare units to follow-up patients with tuberculosis at their place of residence.

The article presents the research of dynamics of suicide in the Russian Federation and Republic Sakha (Yakutia). In the Russian Federation, now there is a pronounced downward trend in suicides, since 1996 year. Reducing mortality from suicide for the Russian Federation as a whole amounted to 35.4%. In Republic Sakha (Yakutia) in recent years the suicide rate is 47-48 per 100 thousand people that is not a steady downward trend. Archaic Pagan beliefs and Archetypes of the “collective unconscious” (K. Jung) as an ethnocultural factor in the origin of the suicides were researched.

The subject of this article is the survey of evolution and factor mechanisms effecting formation of firm dental tissue pathological process of demineralising character. There is a description of clinical and epidemiological features of dental caries and also its connection with organs and systems of the whole organism. Different factors of this pathology from the medical point of view are given here in details.