The hypothesis of the development of diabetic retinopathy in the Yakuts at type 2 diabetes mellitus
Abstract
The authors reported the results of the examination of patients with diabetic retinopathy (DR) at type 2 diabetes mellitus (DM), ethnic Yakuts, permanently residing in the areas of the Leno-Amga interfluve to the third generation, registered in the state register of the SD of the RS (Ya). It is assumed that the development of DR at type 2 diabetes in ethnic Yakuts is due to the fact that the genetic (internal) factors involved in the metabolism of lipids and carbohydrates, the inflammatory process and oxidative stress, under the influence of environmental risk factors and hormonal expression in a certain age period, mainly in meno- and andropause, cause metabolic disorders and oxidative stress with an energy deficit in cells with active cleavage of ATP. Further chronic course of the inflammatory process and generalized oxidative stress lead to atherogenic damage of the vascular wall, causing pathological changes inherent to DR.
About the Authors
L. L. Yavlovskaya
Якутская республиканская офтальмологическая больница МЗ Республики Саха (Якутия)
Russian Federation
Russian Federation
Lubov Leonidovna Yavlovskaya - Ophthalmological clinic of Republic Sakha (Yakutia) Healthcare Ministry
E. K. Khusnutdinova
Institute of biochemistry and genetics of Ufa Scientific Centre of Russian Academy of Sciences
Russian Federation
Russian Federation
Elsa Kamilevna Khusnutdinova - Corresponding Member of Academy of Sciences of Republic Bashkorcostan, Doctor of Biological Sciences, Professor, Head of the Department
R. I. Shatilova
GOU VPO “V.F.Voino-YasenetskyKrasoyarsk State Medical University” of Ministry of Health of Russian Federation
Russian Federation
Russian Federation
Rimma Ivanovna Shatilova-Doctor of Medical Sciences,Professor of Ophthalmological Department
V. I. Lazarenko
GOU VPO “V.F.Voino-YasenetskyKrasoyarsk State Medical University” of Ministry of Health of Russian Federation
Russian Federation
Russian Federation
Victor Ivanovich Lazarenko-Doctor of Medical Sciences, Professor of Ophthalmological Department
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Review
For citations:
Yavlovskaya L.L., Khusnutdinova E.K., Shatilova R.I., Lazarenko V.I. The hypothesis of the development of diabetic retinopathy in the Yakuts at type 2 diabetes mellitus. Yakut Medical Journal. 2017;(3):69-72.
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