The role of deficiency of the content of circulating leukocytes in the conservation of immune status in people in life conditions on the Spitsbergen archipelago
https://doi.org/10.25789/YMJ.2019.66.09
Abstract
With aim of the study to establish the role of the deficiency in the content of circulating leukocytes in preserving the immune status of people in the conditions of life on the Spitsbergen archipelago we surveyed able-bodied residents of the village of Barentsburg Arch. Svalbard. The decrease in the content of circulating neutrophils and monocytes is associated with a sharp increase in the activity and intensity of phagocytosis. On the background of neutropenia and monopenia, there is a deficiency in the content of mature T-lymphocytes, activated T-cells with a receptor for transferrin and T-helper cells. Against the background of T-cell deficiency, the levels of irisin, Nt-pro-BNP and endothelin-1 are increased.
Keywords
monocytes,
mature T-lymphocytes,
T-helpers,
activated T-lymphocytes,
neutrophil phagocytosis,
irisin,
brain natriuretic peptide (Nt-pro-BNP),
endothelin-1
Supporting agencies: The work was performed in the framework of the program of fundamental scientific research on the laboratory of regulatory mechanisms of immunity of the Institute of Physiology of Natural Adaptations "The role of the extracellular pool of adhesion molecules and short peptides in the formation and outcome of human adaptive responses to changes in the light mode" (No. AAAA-A17-117033010123-0).
About the Authors
A. V. Samodova
Federal State Budgetary Institution of Science Federal Research Center for Integrated Study of the Arctic named after Academician N.P. Laverov, Russian Academy of Sciences, Institute of the Physiology of Natural Adaptations
Russian Federation
Russian Federation
Samodova Anna Vasilyevna, candidate of Biological Sciences, head of the laboratory of regulatory mechanisms of immunity of the Institute of Physiology of Natural Adaptations
Office phone: (8182) 21-04-58
Arkhangelsk
L. K. Dobrodeeva
Federal State Budgetary Institution of Science Federal Research Center for Integrated Study of the Arctic named after Academician N.P. Laverov, Russian Academy of Sciences, Institute of the Physiology of Natural Adaptations
Russian Federation
Russian Federation
Dobrodeeva Liliya Konstantinovna, doctor of Medical Sciences, Professor, Honored Worker of Science, Chief Researcher of the Laboratory of Regulatory Mechanisms of Immunity, Director of the Institute of Physiology of Natural Adaptations
Office phone: (8182)652992
Arkhangelsk
References
1. Besedin A.V. Features of the functional activity of phagocytes when exposed to magnetic fields of various origin / А.В. Besedin, V.P. Kalutsky // Bulletin of the Ural academic science. Thematic issue on allergology and immunology. - 2009. - №2 / 1. - p. 20 - 21.
2. Dobrodeeva L.K. The relationship between the levels of brain natriuretic peptide in the blood and the activity of immune reactions in humans / LK. Dobrodeeva, A.V. Samodova, O.E. Karjakina // Human Physiology. - 2016. - V. 42, № 6. - P. 106–115.
3. Konstantinova N.A. Immune complexes and tissue damage / N.A. Konstantinova. - M.: Medicine, 1996. - 256 p.
4. Parahonsky A.P. Circulating immune complexes in the late stages of diabetes mellitus / А.P. Parakhonsky // Modern high technologies. - 2006. - № 1. - p. 79.
5. Ambrus C.M. Regulation of the leukocyte level / C.M. Ambrus, I.L. Ambrus // Ann. N.Y. Acad. Sci. – 1959. – V. 77. – P. 445-479.
6. Boyum A. Separation of leukocytes from blood and bone marrow / A. Boym // S. Cand. And Clin. Lab. Invest. – 1968. – V. 21. – P. 97.
7. Buckton K.E. Lymphocyte survival in nen treated with X-rays for ankylosing spondylitis / K.E. Buckton, W.M. Brown, P.G. Smith // Nature. – 1967. – V. 214. – P. 470–473.
8. Dalmasso A.P. Interleukin-4 induced up-regulation of endothelial cell claudin-5 through activation of FoxOI: Role in protection from complement-mediated injury / A.P. Dalmasso, D. Goldish, B. Benson // J. Biol. Chem. – 2014. – V. 289, № 2. – P. 838.
9. Emanule E. Serum irisin, precocious myocardial infarction, and healthy exceptional longevity / E. Emanule, P. Minoretti, H. Pareja-Galeno // Am. J. Med. – 2014. – V. 127, № 9.– P. 888-890.
10. Hall C. Essential biochemistry and physiology of NT-pro-BNP / C. Hall // Eur. J. of. Heart. Fail. – 2004. – V. 3.– P. 257.
11. Mahmoud F.F. Involvement if B cells in pathogenesis of nonarthritic psoriasis in a kuwati population / F.F. Mahmoud, K.A. Al-Salen, S.A. Al-Habi // FASEB J. – 1997. – V. 11, № 3. – P.118.
12. Mazur-Bialy A.I. New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes. Implication for exercise in obesity / A.I. Mazur-Bialy, J. Bilski, E. Pochec // Journal of Physiology and Pharmacology. – 2017. – V. 68, № 2.– P. 243-251.
13. Meuret G. Monocyte kinetic studies in normal and disease states / G. Meuret, G. Hoffman // Brit.J. Hematol. – 1973. – V. 24. – P. 275–279.
14. Teufel A. Frcp1 and Frcp 2, two novel fibronectin type III repeat containing genes / Teufel A. // Gene. – 2002. – V. 297, № 1/ 2. – P. 79–83.
15. The Cytokine. Handbook. London, 1992.
16. Yanagasawa M. A novel potent vasoconstrictor peptide produced by vascular endothelial cells / M. Yanagasawa // Nature. – 1988. – V. 332. – P. 411-415.
17. Yao Y. Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity / Y. Yao, Z. Scheng., Y. Li // Hum. Gen. Ther. – 2012. – V. 23, № 8. – P. 859.
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For citations:
Samodova A.V., Dobrodeeva L.K. The role of deficiency of the content of circulating leukocytes in the conservation of immune status in people in life conditions on the Spitsbergen archipelago. Yakut Medical Journal. 2019;(2):32-35. https://doi.org/10.25789/YMJ.2019.66.09
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