ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2019.66.09ymj-913Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHРоль дефицита содержания циркулирующих лейкоцитов в сохранении иммунного статуса у людей в условиях жизни на архипелаге ШпицбергенThe role of deficiency of the content of circulating leukocytes in the conservation of immune status in people in life conditions on the Spitsbergen archipelagoСамодоваА. В.SamodovaA. V.

Самодова Анна Васильевна ‒ к.б.н., в.н.с., зав.лаб.

Samodova Anna Vasilyevna, candidate of Biological Sciences, head of the laboratory of regulatory mechanisms of immunity of the Institute of Physiology of Natural Adaptations

Office phone: (8182) 21-04-58

Arkhangelsk

annapoletaeva2008@yandex.ruДобродееваЛ. К.DobrodeevaL. K.

Добродеева Лилия Константиновна ‒д.м.н., проф., гл.н.с., директор Института

Dobrodeeva Liliya Konstantinovna, doctor of Medical Sciences, Professor, Honored Worker of Science, Chief Researcher of the Laboratory of Regulatory Mechanisms of Immunity, Director of the Institute of Physiology of Natural Adaptations

Office phone: (8182)652992

Arkhangelsk

Институт физиологии природных адаптаций ФИЦКИА РАН им. акад. Н.П. ЛавероваРоссияFederal State Budgetary Institution of Science Federal Research Center for Integrated Study of the Arctic named after Academician N.P. Laverov, Russian Academy of Sciences, Institute of the Physiology of Natural AdaptationsRussian Federation201922082025023235Copyright © Самодова А.В., Добродеева Л.К., 20252025Самодова А.В., Добродеева Л.К.Samodova A.V., Dobrodeeva L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/913

С целью установления роли дефицита содержания циркулирующих лейкоцитов в сохранении иммунного статуса у людей в условиях жизни на архипелаге Шпицберген обследованы трудоспособные жители пос. Баренцбург. Установлено, что у трудоспособного населения, проживающего в условиях арх. Шпицберген, регистрируется снижение содержания циркулирующих нейтрофилов и моноцитов, которое ассоциировано с резким увеличением активности и интенсивности фагоцитоза. На фоне нейтропении и монопении наблюдается дефицит содержания зрелых Т-лимфоцитов, активированных Т-клеток с рецептором к трансферрину и Т-хелперов. На фоне недостаточности Т-клеточного звена повышены уровни содержания ирисина, Nt-pro-BNP и эндотелина-1.

With aim of the study to establish the role of the deficiency in the content of circulating leukocytes in preserving the immune status of people in the conditions of life on the Spitsbergen archipelago we surveyed able-bodied residents of the village of Barentsburg Arch. Svalbard. The decrease in the content of circulating neutrophils and monocytes is associated with a sharp increase in the activity and intensity of phagocytosis. On the background of neutropenia and monopenia, there is a deficiency in the content of mature T-lymphocytes, activated T-cells with a receptor for transferrin and T-helper cells. Against the background of T-cell deficiency, the levels of irisin, Nt-pro-BNP and endothelin-1 are increased.

моноцитызрелые Т-лимфоцитыТ-хелперыактивированные Т-лимфоцитыфагоцитоз нейтрофиловирисинмозговой натрийуретический пептид (Nt-pro-BNP)эндотелин-1monocytesmature T-lymphocytesT-helpersactivated T-lymphocytesneutrophil phagocytosisirisinbrain natriuretic peptide (Nt-pro-BNP)endothelin-1Работа выполнена в рамках программы фундаментальных научных исследований по теме лаборатории регуляторных механизмов иммунитета Института физиологии природных адаптаций «Роль внеклеточного пула молекул адгезии и коротких пептидов в формировании и исходе адаптивных реакций человека на изменение светового режима» (№ АААА-А17-117033010123-0).The work was performed in the framework of the program of fundamental scientific research on the laboratory of regulatory mechanisms of immunity of the Institute of Physiology of Natural Adaptations "The role of the extracellular pool of adhesion molecules and short peptides in the formation and outcome of human adaptive responses to changes in the light mode" (No. AAAA-A17-117033010123-0).ReferencesБеседин А.В. Особенности функциональной активности фагоцитов при воздействии магнитных полей различного происхождения /А.В. Беседин, В.П. Калуцкий // Вестник уральской академич. науки. Тематич. выпуск по аллергологии и иммунологии. – 2009. – №2/1. – С. 20 – 21.Besedin A.V. Features of the functional activity of phagocytes when exposed to magnetic fields of various origin / А.В. Besedin, V.P. Kalutsky // Bulletin of the Ural academic science. Thematic issue on allergology and immunology. - 2009. - №2 / 1. - p. 20 - 21.Добродеева Л.К. Взаимосвязь уровней содержания мозгового натрийуретического пептида в крови и активности иммунных реакций у людей / Л.К. Добродеева, А.В. Самодова, О.Е. Карякина // Физиология человека. – 2016. – Т. 42, № 6. – С. 106–115. DOI: 10.7868/S0131164616050052.Dobrodeeva L.K. The relationship between the levels of brain natriuretic peptide in the blood and the activity of immune reactions in humans / LK. Dobrodeeva, A.V. Samodova, O.E. Karjakina // Human Physiology. - 2016. - V. 42, № 6. - P. 106–115.Константинова Н.А. Иммунные комплексы и повреждение тканей / Н.А. Константинова. – М.: Медицина, 1996. – 256 с.Konstantinova N.A. Immune complexes and tissue damage / N.A. Konstantinova. - M.: Medicine, 1996. - 256 p.Парахонский А.П. Циркулирующие иммунные комплексы на поздних стадиях сахарного диабета / А.П. Парахонский // Современные наукоемкие технологии. – 2006. – № 1. – С. 79.Parahonsky A.P. Circulating immune complexes in the late stages of diabetes mellitus / А.P. Parakhonsky // Modern high technologies. - 2006. - № 1. - p. 79.Ambrus C.M. Regulation of the leukocyte level / C.M. Ambrus, I.L. Ambrus // Ann. N.Y. Acad. Sci. – 1959. – V. 77. – P. 445-479.Ambrus C.M. Regulation of the leukocyte level / C.M. Ambrus, I.L. Ambrus // Ann. N.Y. Acad. Sci. – 1959. – V. 77. – P. 445-479.Boyum A. Separation of leukocytes from blood and bone marrow / A. Boym // S. Cand. And Clin. Lab. Invest. – 1968. – V. 21. – P. 97.Boyum A. Separation of leukocytes from blood and bone marrow / A. Boym // S. Cand. And Clin. Lab. Invest. – 1968. – V. 21. – P. 97.Buckton K.E. Lymphocyte survival in nen treated with X-rays for ankylosing spondylitis / K.E. Buckton, W.M. Brown, P.G. Smith // Nature. – 1967. – V. 214. – P. 470–473.Buckton K.E. Lymphocyte survival in nen treated with X-rays for ankylosing spondylitis / K.E. Buckton, W.M. Brown, P.G. Smith // Nature. – 1967. – V. 214. – P. 470–473.Dalmasso A.P. Interleukin-4 induced up-regulation of endothelial cell claudin-5 through activation of FoxOI: Role in protection from complement-mediated injury / A.P. Dalmasso, D. Goldish, B. Benson // J. Biol. Chem. – 2014. – V. 289, № 2. – P. 838.Dalmasso A.P. Interleukin-4 induced up-regulation of endothelial cell claudin-5 through activation of FoxOI: Role in protection from complement-mediated injury / A.P. Dalmasso, D. Goldish, B. Benson // J. Biol. Chem. – 2014. – V. 289, № 2. – P. 838.Emanule E. Serum irisin, precocious myocardial infarction, and healthy exceptional longevity / E. Emanule, P. Minoretti, H. Pareja-Galeno // Am. J. Med. – 2014. – V. 127, № 9.– P. 888-890.Emanule E. Serum irisin, precocious myocardial infarction, and healthy exceptional longevity / E. Emanule, P. Minoretti, H. Pareja-Galeno // Am. J. Med. – 2014. – V. 127, № 9.– P. 888-890.Hall C. Essential biochemistry and physiology of NT-pro-BNP / C. Hall // Eur. J. of. Heart. Fail. – 2004. – V. 3.– P. 257.Hall C. Essential biochemistry and physiology of NT-pro-BNP / C. Hall // Eur. J. of. Heart. Fail. – 2004. – V. 3.– P. 257.Mahmoud F.F. Involvement if B cells in pathogenesis of nonarthritic psoriasis in a kuwati population / F.F. Mahmoud, K.A. Al-Salen, S.A. Al-Habi // FASEB J. – 1997. – V. 11, № 3. – P.118.Mahmoud F.F. Involvement if B cells in pathogenesis of nonarthritic psoriasis in a kuwati population / F.F. Mahmoud, K.A. Al-Salen, S.A. Al-Habi // FASEB J. – 1997. – V. 11, № 3. – P.118.Mazur-Bialy A.I. New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes. Implication for exercise in obesity / A.I. Mazur-Bialy, J. Bilski, E. Pochec // Journal of Physiology and Pharmacology. – 2017. – V. 68, № 2.– P. 243-251.Mazur-Bialy A.I. New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes. Implication for exercise in obesity / A.I. Mazur-Bialy, J. Bilski, E. Pochec // Journal of Physiology and Pharmacology. – 2017. – V. 68, № 2.– P. 243-251.Meuret G. Monocyte kinetic studies in normal and disease states / G. Meuret, G. Hoffman // Brit.J. Hematol. – 1973. – V. 24. – P. 275–279.Meuret G. Monocyte kinetic studies in normal and disease states / G. Meuret, G. Hoffman // Brit.J. Hematol. – 1973. – V. 24. – P. 275–279.Teufel A. Frcp1 and Frcp 2, two novel fibronectin type III repeat containing genes / Teufel A. // Gene. – 2002. – V. 297, № 1/ 2. – P. 79–83.Teufel A. Frcp1 and Frcp 2, two novel fibronectin type III repeat containing genes / Teufel A. // Gene. – 2002. – V. 297, № 1/ 2. – P. 79–83.The Cytokine. Handbook. London, 1992.The Cytokine. Handbook. London, 1992.Yanagasawa M. A novel potent vasoconstrictor peptide produced by vascular endothelial cells / M. Yanagasawa // Nature. – 1988. – V. 332. – P. 411-415.Yanagasawa M. A novel potent vasoconstrictor peptide produced by vascular endothelial cells / M. Yanagasawa // Nature. – 1988. – V. 332. – P. 411-415.Yao Y. Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity / Y. Yao, Z. Scheng., Y. Li // Hum. Gen. Ther. – 2012. – V. 23, № 8. – P. 859.Yao Y. Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity / Y. Yao, Z. Scheng., Y. Li // Hum. Gen. Ther. – 2012. – V. 23, № 8. – P. 859.

The authors declare that there are no conflicts of interest present.