Association of IL-6 gene polymorphism with arterial hypertension and its risk factors in indigenous peoples of Yakutia
https://doi.org/10.25789/YMJ.2020.70.20
Abstract
A case-control study was conducted in Kolymskoye and Andryushkino of Nizhnekolymsky district of Yakutia to determine the association of IL-6 gene polymorphism with arterial hypertension (AH) and risk factors. The relationship with AH and its risk factors for IL-6 gene polymorphism was obtained, namely, the influence of the G allele of the polymorphic locus C-174G and the C allele of the polymorphic locus C-572G on metabolic factors of atherogenesis. Hypertensive patients - carriers of the G allele of the C-174G polymorphic locus of the IL-6 gene, both in the homozygous and heterozygous versions, showed the highest average systolic blood pressure, a high incidence of abdominal obesity, lipid and carbohydrate metabolism disorders. The study of the polymorphic locus C-572G of the IL-6 gene in patients with hypertension showed the highest incidence of abdominal obesity, lipid and carbohydrate metabolism disorders in carriers of the C allele.
Keywords
About the Authors
S. I. Sofronova
Yakut science centre of complex medical problems
Russian Federation
Russian Federation
Sofronova Sargylana Ivanovna – PHD, researcher
89841094825
677000, The Republic of Sakha (Yakutia),Yakutsk, Sergelyakhskoe shosse, 4
A. N. Romanova
Yakut science centre of complex medical problems
Russian Federation
Russian Federation
Romanova Anna Nikolaevna – MD, director
8(4112)32-19-81
677000, The Republic of Sakha (Yakutia),Yakutsk, Sergelyakhskoe shosse, 4
M. P. Kirillina
Yakut science centre of complex medical problems
Russian Federation
Russian Federation
Kirillina Marya Petrovna – PHD, researcher
677000, The Republic of Sakha (Yakutia),Yakutsk, Sergelyakhskoe shosse, 4
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For citations:
Sofronova S.I., Romanova A.N., Kirillina M.P. Association of IL-6 gene polymorphism with arterial hypertension and its risk factors in indigenous peoples of Yakutia. Yakut Medical Journal. 2020;(2):65-68. https://doi.org/10.25789/YMJ.2020.70.20
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