ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.70.20ymj-689Research ArticleАРКТИЧЕСКАЯ МЕДИЦИНАARCTIC MEDICINEАссоциация полиморфизма гена IL-6 с артериальной гипертензией и ее факторами риска у коренных малочисленных народов ЯкутииAssociation of IL-6 gene polymorphism with arterial hypertension and its risk factors in indigenous peoples of Yakutiahttps://orcid.org/0000-0003-0010-9850СофроноваС. И.SofronovaS. I.

Софронова Саргылана Ивановна – к.м.н., гл.н.с.-руковод. Отдела

Sofronova Sargylana Ivanovna – PHD, researcher

89841094825

677000, The Republic of Sakha (Yakutia),Yakutsk, Sergelyakhskoe shosse, 4

sara2208@mail.ruhttps://orcid.org/0000-0002-4817-5315РомановаА. Н.RomanovaA. N.

Романова Анна Николаевна – д.м.н., директор

Romanova Anna Nikolaevna – MD, director

8(4112)32-19-81

677000, The Republic of Sakha (Yakutia),Yakutsk, Sergelyakhskoe shosse, 4

ranik@mail.ruКириллинаМ. П.KirillinaM. P.

Кириллина Мария Петровна – к.б.н., в.н.с.-руковод. лаб., зав. лаб. Клиники

Kirillina Marya Petrovna – PHD, researcher

677000, The Republic of Sakha (Yakutia),Yakutsk, Sergelyakhskoe shosse, 4

kirillinamp@mail.ruЯНЦ КМПРоссияYakut science centre of complex medical problemsRussian FederationМИ СВФУ им. М.К. АммосоваРоссияYakut science centre of complex medical problemsRussian Federation202017052025026568Copyright © Софронова С.И., Романова А.Н., Кириллина М.П., 20252025Софронова С.И., Романова А.Н., Кириллина М.П.Sofronova S.I., Romanova A.N., Kirillina M.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/689

Для определения ассоциации полиморфизма гена IL-6 с артериальной гипертензией (АГ) и факторами риска проведено исследование «случай-контроль» в селах Колымское и Андрюшкино Нижнеколымского района Якутии. Выявлена взаимосвязь с АГ и ее факторами риска полиморфизма гена IL-6, а именно определено влияние G аллеля полиморфного локуса C-174G и C аллеля полиморфного локуса C-572G на метаболические факторы атерогенеза. У гипертоников-носителей аллеля G полиморфного локуса C-174G гена IL-6 как в гомозиготном, так и в гетерозиготном варианте отмечены наиболее высокое среднее систолическое АД, высокая частота абдоминального ожирения, нарушений липидного и углеводного обменов. Исследование полиморфного локуса C-572G гена IL-6 у лиц с АГ показало наиболее высокую частоту абдоминального ожирения, нарушений липидного и углеводного обменов у носителей C аллеля.

A case-control study was conducted in Kolymskoye and Andryushkino of Nizhnekolymsky district of Yakutia to determine the association of IL-6 gene polymorphism with arterial hypertension (AH) and risk factors. The relationship with AH and its risk factors for IL-6 gene polymorphism was obtained, namely, the influence of the G allele of the polymorphic locus C-174G and the C allele of the polymorphic locus C-572G on metabolic factors of atherogenesis. Hypertensive patients - carriers of the G allele of the C-174G polymorphic locus of the IL-6 gene, both in the homozygous and heterozygous versions, showed the highest average systolic blood pressure, a high incidence of abdominal obesity, lipid and carbohydrate metabolism disorders. The study of the polymorphic locus C-572G of the IL-6 gene in patients with hypertension showed the highest incidence of abdominal obesity, lipid and carbohydrate metabolism disorders in carriers of the C allele.

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The authors declare that there are no conflicts of interest present.