Type 2 thyroid allostasis in the residents of Yakutia
A. A. Nikanorova,
T. V. Borisova,
V. G. Pshennikova,
S. S. Nakhodkin,
S. A. Fedorova,
N. A. Barashkov https://doi.org/10.25789/YMJ.2024.86.19
Abstract
Type 2 thyroid allostasis is a dynamic stress response to changes in thyroid homeostasis that may occur in response to chronic exposure to cold. It is believed that, under these conditions, type 2 allostatic reactions can increase the basal metabolic rate to maintain priority thermogenic mechanisms in the body. For the first time, this work assesses the allostatic response of the thyroid gland among residents of the central region Yakutia with the most extreme climate (from -47°С to -11°С) using a mathematical model called SPINA. The SPINA model reflects the total activity of peripheral deiodinase enzymes (SPINA-GD), as well as the secretory capacity of the thyroid (SPINA-GT). The results showed that the SPINA-GT parameter was within normal limits for all individuals in the study. However, the SPINA-GD parameter was also within normal limits in 30% of those examined, with an increased SPINA-GD value found in 70% of the individuals examined. It was revealed that individuals with elevated SPINA-GD had higher free triiodothyronine (fT3) levels (6.79±0.62 pmol/L) and lower free thyroxine (fT4) levels (13.82±1.51 pmol/L) than those with normal SPINA-GD (fT3=5.96±0.48 pmol/L; fT4=15.37±0.98 pmol/L; p<0.001). This indicates an increased rate of T4 deiodination to T3 in 70% of the most individuals, and the reason for this is likely due to type 2 thyroid allostasis in response to cold stress. Using the SPINA parameters for the first time allows us to identify changes in hypothalamus-pituitary-thyroid axis homeostasis during the winter-spring season among 70% of surveyed residents of Eastern Siberia.
About the Authors
A. A. Nikanorova
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Nikanorova Alyona Anatolyevna – junior researcher
T. V. Borisova
M.K. Ammosov NEFU Institute of Natural Sciences
Russian Federation
Russian Federation
Borisova Tuyara Valeryevna – graduate student
V. G. Pshennikova
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Pshennikova Vera Gennadievna – PhD in Biology, visiting research fellow, lab. Director
S. S. Nakhodkin
M.K. Ammosov NEFU Institute of Natural Sciences
Russian Federation
Russian Federation
Nakhodkin Sergey Sergeevich – researcher
S. A. Fedorova
M.K. Ammosov NEFU Institute of Natural Sciences
Russian Federation
Russian Federation
Fedorova Sardaana Arkadyevna – Doctor of Biology, Head of the laboratory
N. A. Barashkov
Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Barashkov Nikolay Alekseevich – PhD in Biology, visiting research fellow, lab. Director
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Review
For citations:
Nikanorova A.A., Borisova T.V., Pshennikova V.G., Nakhodkin S.S., Fedorova S.A., Barashkov N.A. Type 2 thyroid allostasis in the residents of Yakutia. Yakut Medical Journal. 2024;(2):80-84. https://doi.org/10.25789/YMJ.2024.86.19
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