ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.86.19ymj-289Research ArticleТОЧКА ЗРЕНИЯPOINT OF VIEWАллостаз щитовидной железы 2 типа у жителей ЯкутииType 2 thyroid allostasis in the residents of Yakutiahttps://orcid.org/0000-0002-7129-6633НиканороваА. А.NikanorovaA. A.

Никанорова Алена Афанасьевна – м.н.с.

Якутск

Nikanorova Alyona Anatolyevna – junior researcher

nikanorova.alena@mail.ruhttps://orcid.org/0000-0002-6984-7934БорисоваТ. В.BorisovaT. V.

Борисова Туяра Валерьевна – аспирант

Borisova Tuyara Valeryevna – graduate student

borisovatv96@gmail.comhttps://orcid.org/0000-0001-6866-9462ПшенниковаВ. Г.PshennikovaV. G.

Пшенникова Вера Геннадиевна – к.б.н., в.н.с.-руковод. лаб.

Якутск

Pshennikova Vera Gennadievna – PhD in Biology, visiting research fellow, lab. Director

pshennikovavera@mail.ruhttps://orcid.org/0000-0002-6917-5760НаходкинС. С.NakhodkinS. S.

Находкин Сергей Сергеевич – н.с.

Nakhodkin Sergey Sergeevich – researcher

sergnahod@mail.ruhttps://orcid.org/0000-0002-6952-3868ФедороваС. А.FedorovaS. A.

Федорова Сардана Аркадьевна – д.б.н., гл.н.с. ИЕН СВФУ им. М.К. Аммосова, с.н.с. ЯНЦ КМП

Fedorova Sardaana Arkadyevna – Doctor of Biology, Head of the laboratory

sardaanafedorova@mail.ruhttps://orcid.org/0000-0002-6984-7934БарашковН. А.BarashkovN. A.

Барашков Николай Алексеевич – к.б.н., в.н.с.-руковод. лаб.

Якутск

Barashkov Nikolay Alekseevich – PhD in Biology, visiting research fellow, lab. Director

barashkov2004@mail.ruЯНЦ КМПРоссияYakut Science Centre of Complex Medical ProblemsRussian FederationИнститут естественных наук СВФУ им. М.К. АммосоваРоссияM.K. Ammosov NEFU Institute of Natural SciencesRussian FederationИнститут естественных наук СВФУ им. М.К. Аммосова; ЯНЦ КМПРоссияM.K. Ammosov NEFU Institute of Natural SciencesRussian Federation202406022025028084Copyright © Никанорова А.А., Борисова Т.В., Пшенникова В.Г., Находкин С.С., Федорова С.А., Барашков Н.А., 20252025Никанорова А.А., Борисова Т.В., Пшенникова В.Г., Находкин С.С., Федорова С.А., Барашков Н.А.Nikanorova A.A., Borisova T.V., Pshennikova V.G., Nakhodkin S.S., Fedorova S.A., Barashkov N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/289

В настоящей работе у жителей Якутии с помощью математической модели SPINA в зимне-весенний период при отрицательных температурах атмосферного воздуха (от -47 до -11°С) проведена оценка аллостатической реакции щитовидной железы. Изменение гомеостаза оси гипоталамус-гипофиз-щитовидной железы (аллостаз 2 типа) при низких температурах атмосферного воздуха выявлено у 70% обследованных лиц, проживающих в экстремально холодных климатических условиях Центральной Якутии.

Type 2 thyroid allostasis is a dynamic stress response to changes in thyroid homeostasis that may occur in response to chronic exposure to cold. It is believed that, under these conditions, type 2 allostatic reactions can increase the basal metabolic rate to maintain priority thermogenic mechanisms in the body. For the first time, this work assesses the allostatic response of the thyroid gland among residents of the central region Yakutia with the most extreme climate (from -47°С to -11°С) using a mathematical model called SPINA. The SPINA model reflects the total activity of peripheral deiodinase enzymes (SPINA-GD), as well as the secretory capacity of the thyroid (SPINA-GT). The results showed that the SPINA-GT parameter was within normal limits for all individuals in the study. However, the SPINA-GD parameter was also within normal limits in 30% of those examined, with an increased SPINA-GD value found in 70% of the individuals examined. It was revealed that individuals with elevated SPINA-GD had higher free triiodothyronine (fT3) levels (6.79±0.62 pmol/L) and lower free thyroxine (fT4) levels (13.82±1.51 pmol/L) than those with normal SPINA-GD (fT3=5.96±0.48 pmol/L; fT4=15.37±0.98 pmol/L; p<0.001). This indicates an increased rate of T4 deiodination to T3 in 70% of the most individuals, and the reason for this is likely due to type 2 thyroid allostasis in response to cold stress. Using the SPINA parameters for the first time allows us to identify changes in hypothalamus-pituitary-thyroid axis homeostasis during the winter-spring season among 70% of surveyed residents of Eastern Siberia.

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The authors declare that there are no conflicts of interest present.