Neopterin Level In Blood In Patients With Ihd
Abstract
Introduction. Neopterin (NP) concerns to pteridines which represent heterogeneous group of the substances derivative of the guanosinetriphosphate which level raises at activation of macrophages in reply to stimulation of interferon - γ. Increase of neopterin levels is marked in acute coronary syndrome and in the various pathological states, accompanied by infl ammatory-destructive changes.
The purpose of research. To study interrelation of the neopterin content in blood in patients with various forms of ishemic heart disease.
Materials and methods. 110 persons (43 women and 67 men) are included in research in the age of from 35 till 80 years (middle age has made 67,9±7,6 years): 17 patients with myocardial infarction, 38 patients with unstable angina pectoris, 40 patients with angina of exertion, 15 healthy persons. Besides routine clinical researches, in the all NP levels, sVCAM-1, interleukine-6 (IL-6) and C-reactive protein (CRP) by means of highsensitive immunoferment methods were defi ned.
Results. Neopterin levels authentically correlated with CRP content (r=0,42, p=0,01), IL-6 (r=0,36, p=0,03) and sVCAM-1 (r=0,42, p=0,043). Content of NP, sVCAM-1, IL-6 and CRP in blood of healthy persons and in patients with angina of exertion authentically did not differ. In comparison with the patients with angina of exertion, in patients with unstable angina pectoris neopterin levels are higher - 9,3±4,9 nmol/l vs 14,9±8,6 (p<0,05) and CRP - 4,9±3,9 mg/l vs 11,2±10,4 (p <0,05). The conclusion. Neopterin is a marker participating in IHD pathogenesis; its levels in blood correlate with expressiveness of a system infl ammation and are higher in patients with acute coronary syndrome (ACS).
About the Authors
O. P. Shevchenko
ФУВ ГОУ ВПО РГМУ
Russian Federation
Russian Federation
L. V. Harlamova
ФУВ ГОУ ВПО РГМУ
Russian Federation
Russian Federation
D. H. Kushhova
ФУВ ГОУ ВПО РГМУ
Russian Federation
Russian Federation
O. V. Orlova
ФГУ «НИИ трансплантологии и искусственных органов Росмедтехнологий»
Russian Federation
Russian Federation
L. V. Dajbanyrova
МИ ЯГУ
Russian Federation
Russian Federation
A. O. Shevchenko
ФУВ ГОУ ВПО РГМУ
Russian Federation
Russian Federation
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Review
For citations:
Shevchenko O.P., Harlamova L.V., Kushhova D.H., Orlova O.V., Dajbanyrova L.V., Shevchenko A.O. Neopterin Level In Blood In Patients With Ihd. Yakut Medical Journal. 2008;(1):12-15. (In Russ.)
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