The relationship of inflammatory markers with the metabolic syndrome and coronary atherosclerosis at the example of Yakutia residents: ethnic and gender features
Abstract
The relationship of inflammatory markers (IL-6, IL-8, FNO-α, INF-γ and C–reactive protein) with metabolic syndrome and coronary atherosclerosis among inhabitants of Yakutia depending on ethnicity and gender was studied. The results of the survey of men and women at the age of 45-64 years with verified coronary atherosclerosis and without clinical signs of coronary heart disease are analyzed. The results of the research showed that in patients with metabolic syndrome complicated by coronary atherosclerosis in comparison with persons without clinical signs of coronary heart disease the levels of all studied inflammatory markers were higher. The significant ethnicity and gender differences are received. Ethnicity differences were characterized by elevated of IL-6 levels among non-native people of Yakutia unlike native population. Gender differences were characterized by the increase of IL-6 levels in women, than in men. In native men with coronary atherosclerosis the INF-γ level in comparison with non-native was higher.
About the Authors
A. N. Romanova
Yakut Scientific Centre of complex medical problems SB RAMS
Russian Federation
Russian Federation
doctor of medical sciences, chief researcher of Department of epidemiology of chronic non-communicable diseases
677010, Sergelyakhskoe highway, 4km, Yakutsk
M. I. Voevoda
Institute for Internal Medicine SB RAMS
Russian Federation
Russian Federation
corresponding member of RAMS, doctor of medical sciences, professor, director
630089, Boris Bogatkov str., 175/1 Novosibirsk
A. S. Golderova
Yakut Scientific Centre of complex medical problems SB RAMS
Russian Federation
Russian Federation
candidate of medical sciences, chief researcher of department of adaptation mechanisms investigation
677010, Sergelyakhskoe highway, 4km, Yakutsk
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Review
For citations:
Romanova A.N., Voevoda M.I., Golderova A.S. The relationship of inflammatory markers with the metabolic syndrome and coronary atherosclerosis at the example of Yakutia residents: ethnic and gender features. Yakut Medical Journal. 2013;(3):39-43.
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