ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-1814Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHВзаимосвязь воспалительных маркеров с метаболическим синдромом и коронарным атеросклерозом на примере жителей Якутии: этнические и гендерные особенностиThe relationship of inflammatory markers with the metabolic syndrome and coronary atherosclerosis at the example of Yakutia residents: ethnic and gender featuresРомановаА. Н.RomanovaA. N.

Романова Анна Николаевна – д.м.н., гл.н.с.

doctor of medical sciences, chief researcher of Department of epidemiology of chronic non-communicable diseases

677010, Sergelyakhskoe highway, 4km, Yakutsk

ranik@mail.ruВоеводаМ. И.VoevodaM. I.

Воевода Михаил Иванович – д.м.н., проф., чл.-кор. РАМН, директор

corresponding member of RAMS, doctor of medical sciences, professor, director

630089, Boris Bogatkov str., 175/1 Novosibirsk

ГольдероваА. С.GolderovaA. S.

Гольдерова Айталина Семеновна – к.м.н., гл. н.с.

candidate of medical sciences, chief researcher of department of adaptation mechanisms investigation

677010, Sergelyakhskoe highway, 4km, Yakutsk

ЯНЦ КМП СО РАМНРоссияYakut Scientific Centre of complex medical problems SB RAMSRussian FederationНИИ терапии СО РАМНРоссияInstitute for Internal Medicine SB RAMSRussian Federation201302102025033943Copyright © Романова А.Н., Воевода М.И., Гольдерова А.С., 20252025Романова А.Н., Воевода М.И., Гольдерова А.С.Romanova A.N., Voevoda M.I., Golderova A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1814

Изучена взаимосвязь воспалительных маркеров (ИЛ-6, ИЛ-8, ФНО-α, ИНФ-γ и СРБ) с метаболическим синдромом и коронарным атеросклерозом у жителей Якутии в зависимости от этнической и гендерной принадлежности. Проанализированы результаты обследования мужчин и женщин в возрасте 45-64 лет с верифицированным коронарным атеросклерозом и без клинических проявлений ИБС. Результатами исследования было показано, что у больных с метаболическим синдромом, осложненным коронарным атеросклерозом, по сравнению с лицами без клинических проявлений ИБС были выше уровни всех изучаемых маркеров воспаления. Получены значимые этнические и гендерные отличия. У некоренного населения Якутии был выше уровень ИЛ-6 в отличие от коренных жителей, также его уровень был выше у женщин, чем у мужчин. У коренных мужчин с коронарным атеросклерозом был выше уровень ИНФ-γ по сравнению с некоренными жителями.

The relationship of inflammatory markers (IL-6, IL-8, FNO-α, INF-γ and C–reactive protein) with metabolic syndrome and coronary atherosclerosis among inhabitants of Yakutia depending on ethnicity and gender was studied. The results of the survey of men and women at the age of 45-64 years with verified coronary atherosclerosis and without clinical signs of coronary heart disease are analyzed. The results of the research showed that in patients with metabolic syndrome complicated by coronary atherosclerosis in comparison with persons without clinical signs of coronary heart disease the levels of all studied inflammatory markers were higher. The significant ethnicity and gender differences are received. Ethnicity differences were characterized by elevated of IL-6 levels among non-native people of Yakutia unlike native population. Gender differences were characterized by the increase of IL-6 levels in women, than in men. In native men with coronary atherosclerosis the INF-γ level in comparison with non-native was higher.

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The authors declare that there are no conflicts of interest present.