Vliuysky encephalomyelitis: clinical polymorphism, focusing on slowly progredient fatal disease course. Variations of the epidemic process
Abstract
The study of the origin, development, distribution and completion of Vilyusk encephalomyelitis (VEM) epidemics on the territory of Sakha-Yakutia shows the course of a unique epidemic process of completely distinctive neuroinfection, plagues of residents mostly of the one ethnic group.The mechanisms of persistence of still not isolated infectious agent and the features of an immunity of the affected population remain a mystery, but gave rise to the clinical polymorphism and a broad clinical continuum of the disease. These circumstances contributed to the introduction of clinical and epidemiological monitoring of heterogenic risk groups of patients in the foci of disease characterized by different degree of reliability of VEM diagnosis, that allows to express some polar points of view on the nature and pathogenesis of VEM. Consideration of these hypotheses in the key common understanding of the epidemic process VEM should allow to find out the important questions of comorbidity and predispose to disease of the certain immune-genetic disorders.
About the Authors
V. A. Vladimirtsev
Science Research Institute of Health of North-Eastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
F. A. Platonov
Science Research Institute of Health of North-Eastern Federal University named after M.K. Ammosov
Russian Federation
Russian Federation
References
1. Vladimirtsev V.A. The necessity to categorize moderately chronic period of Vilyuisk encephalomyelitis / V.A. Vladimirtsev, A.I. Vladimirtsev, V.P. Alexeev, F.A. Platonov // Topical issues of health of the Rep. of Sakha (Yakutia) population: issues of the sci.-pract. conf. to the 75th anniversary of YRKK and ОМCH MH of RS(Y). - Yakutsk, 1993. - P.116-119.
2. Vladimirtsev V.A. Progressive forms of the Vilyuisk encephalomyelitis and differential diagnosis of the disease // Vlyuisk encephalomyelitis in Yakutia: collection of proceedings / Ed. MD, V.P. Alexeev, c.m.s., K.V. Sukhov - Yakutsk, 1993. - Vol 1. - P.14-19.
3. Vladimirtsev V.A. Analysis of typical and atypical manifestations of the Vilyuisk encephalomyelitis in long-term clinical and epidemiological monitoring of the disease / V.A. Vladimirtsev // The IV-th International sci.- pract. conf. «The problem of the Vilyuisk encephalomyelitis and degenerative diseases of the brain in Yakutia»: abstracts of the reports. - Yakutsk, 2011. - P.17-20.
4. Karavanov A. S. Some results and prospects of studies of the etiology of the Vilyuisk encephalomyelitis / A. S. Karavanov, M.P. Chumakov, N.M. Ralph, E.S. Sarmanova // Epidemiology of neurologic and mental diseases in the YASSR. - Yakutsk, 1985. - P. 30-34.
5. Some clinical and anatomical parallels and issues of differential diagnosis Vilyuisk encephalomyelitis / G.L. Zubri, A.P. Savinov, I.A. Robinson [et al.] // Actual problems of Virology and prophylaxis of viral diseases: abstracts of the 17-th sci. session of the Inst. of poliomyelitis and viral encephalitis AMS of the USSR. – M., 1972. - P.206-209.
6. Osakovski V.L. Immunopathology of the Vilyuisk encephalomyelitis / V.L. Osakovski, T.M. Sivtseva, V.G. Krivoshapkin // Neuroimmunology – 2012. – V. X, No. 3-4, P. 22-27.
7. Cytokine status features of the IgG oligoclons of the patients with Vilyuisk encephalomyelitis and multiple sclerosis / T.M. Sivtseva, R.I. Chemezova, V.L. Osakovski [et al.]// Yakut medical journal - 2011. - № 4. - P. 27-30.
8. Another attempt to verify the hypothesis of viral etiology of the Vilyuisk encephalitis / G.G. Karganova, M.V. Bardina, A.P. Gmil [et al.] / The problem of the Vilyuisk encephalomyelitis and degenerative diseases of the brain in Yakutia: abstracts of the reports of the IV-th Intern. sci.- pract. conf. - Yakutsk, August 24-26, 2011-Yakutsk: Publishing and printing complex NEFU, 2011.-P.30-33.
9. Sarmanova E.S. Virus KPN, isolateted in the study of brain in woman who had died with the diagnosis of Vilyuisk encephalomyelitis / E.S. Sarmanova, V.A. Zaklinskaya, A.S. Karavanov, M.P. Chumakov // Issues of the medical Virology: abstracts of the XVIII sci. session of the Institute of poliomyelitis and viral encephalitis AMS of the USSR.- M., 1975.- P. 379-380.
10. Sarmanova E.S. Study of etiology and spreading pathways of the Vilyuisk encephalitis / E.S. Sarmanova // Abstr. interregional conf. of the medical employees of the Urals, Siberia and the Far East.- Krasnoyarsk, 1955. - P. 65-66.
11. Sarmanova E.S. Immunological examination of the population in endemic foci of the Vilyuisk encephalomyelitis in the Yakut ASSR / E.S. Sarmanova, M.B. Bichkova // Virology issues. - 1965.- №2.- P. 125-126.
Review
For citations:
Vladimirtsev V.A., Platonov F.A. Vliuysky encephalomyelitis: clinical polymorphism, focusing on slowly progredient fatal disease course. Variations of the epidemic process. Yakut Medical Journal. 2013;(3):33-38.
Views:
3
Email this article 