Immunehistochemical study of apoptosis marker p53 as a prognostic factor for breast cancer
Abstract
The increase of morbidity and invalidization frequency of patients with the breast cancer stipulate a necessity to find of the new diagnostic ways and prognostic markers with the aim for early diagnostic, optimization and individual way of therapy that will allow to improve the quality of life, patients physical and social rehabilitation. The results of histological research of operational materials from women of different age groups with the breast cancer with the subsequent immunohistochemistry (IHC) definition expression of mutation suppressor gene p53 are analyzed. Obtained data testify that IHC-research expression of mutation р53 correlates with high histological malignancy degree that proves need of the apoptoziz account in estimation of the malignant potential and defining breast cancer.
About the Authors
M. P. Kirillina
YSC CMP SB RAMS
Russian Federation
Russian Federation
Kirillina Maria Petrovna - Junior Researcher of Pathomorphology laboratory and study the impact of cold on the human body
Yakutsk
K. S. Loskutova
YSC CMP SB RAMS;
PAO GBU RS (Y) "RH number 1 - NCM"
Russian Federation
Russian Federation
Loskutova Kyunnyay Savvichna – Chief non-staff pathologist of the Republic Sakha (Yakutia) MH, PhD, the Head of Pathomorphology laboratory and study the impact of cold on the human body;
the Head;
physicianpathologist of the highest category
E. L. Lushnikova
Research Institute of Regional Pathology and Pathomorphology SB RAMS
Russian Federation
Russian Federation
Lushnikova Elena Leonidovna - Academy of Natural Sciences, Doctor of Biology, Professor, Head of the Laboratory of Cytology and Cell Biology, Department of Cell Biology and Morphology
Novosibirsk
L. M. Nepomnyashchikh
Institute of Regional Pathology and Pathomorphology SB RAMS
Russian Federation
Russian Federation
Nepomnyashchikh Lev M. - corresponding member of RAMS, MD, Professor, Director
Novosibirsk
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Review
For citations:
Kirillina M.P., Loskutova K.S., Lushnikova E.L., Nepomnyashchikh L.M. Immunehistochemical study of apoptosis marker p53 as a prognostic factor for breast cancer. Yakut Medical Journal. 2013;(2):55-58.
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