Potential and Perspectives of a-CGH Method in Clinical Practice
Abstract
The identification of chromosomal abnormalities is an important component of clinical genetics. Currently, the methods of classical cytogenetics cannot meet the increasing demands of clinical medicine. The development of fluorescence in situ hybridization techniques (FISH, CGH) has made possible the identification of submicroscopic chromosome aberrations. Progress of the technology has led to the emergence of new high-tech method - comparative genomic hybridization on microarrays (array-CGH, a-CGH). This method is used in many areas of clinical genetics, reproductive medicine and oncology. Besides practical applications, a-CGH is used in fundamental medicine, particularly to study the causes of congenital malformations and undifferentiated intellectual disability, as well as fundamental oncology.
Supporting agencies: The study is supported by RFBR grant № 14-04-32047 mol_a.
About the Authors
N. A. Skryabin
Institute of Medical Genetics SB RAMS
Russian Federation
Russian Federation
Skryabin Nikolai - PhD, researcher
Tomsk
A. A. Kashevarova
Institute of Medical Genetics SB RAMS
Russian Federation
Russian Federation
Kashevarova Anna - PhD, researcher
Tomsk
I. N. Lebedev
Institute of Medical Genetics SB RAMS
Russian Federation
Russian Federation
Lebedev Igor - Ph.D., Head. labs.
Tomsk
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Review
For citations:
Skryabin N.A., Kashevarova A.A., Lebedev I.N. Potential and Perspectives of a-CGH Method in Clinical Practice. Yakut Medical Journal. 2014;(2):51-52.
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