Clinico-Epidemiological and Molecular Genetic Study of Lumbar-Limb forms of Progressive Muscular Dystrophy in the Republic of Dagestan
Abstract
For the first time in the Republic of Dagestan (RD) a comprehensive clinical - epidemiological and molecular - genetic research of limb girdle forms of progressive muscular dystrophies (LGPMD) was conducted. LG forms of PMD: 2A type, 2B type and distal type Miyoshi were identified. The prevalence of LGPMD in RD populations was determined. LGPMD clinical polymorphism in patients living in the mountain, foothill and lowland regions of RD was studied and practical diagnostic algorithm for neurologists was made. Mutation which causes the development of LLPMD family forms was identified.
About the Authors
R. M. Magomedova
State educational institution of higher professional education "Dagestan State Medical Academy" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Magomedova Raisat Magomedovna - senior laboratory of the Department of nervous diseases, neurosurgery and medical genetics
Republic of Dagestan, 367000, Makhachkala, st. Lenin House 1
G. R. Mutovin
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Mutovin Gennadiy Romanovich – MD, Professor of the Department of neurology, neurosurgery and medical genetics
Moscow, st.Ostrovityanova, 1
P. G. Akhmedova
State educational institution of higher professional education "Dagestan State Medical Academy" of the Ministry of Health of the Russian Federation, the Republic of Dagestan
Russian Federation
Russian Federation
Akhmedova Patimat Guseynovna – assistant of the Department of nervous diseases, neurosurgery and medical genetics
367000 , Makhachkala, st. Lenin House 1
R. A. Zinchenko
Research Center for Medical Genetics of RAMS; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Zinchenko Rena Abulfazovna – MD, Professor, head of Laboratory of Genetic Epidemiology Research Center for Medical Genetics of RAMS; professor Department of Molecular Genetics and Cytogenetics Pirogov Russian National Research Medical University
115478 , Moscow, st. Moskvoreche , 1
Z. R. Umakhanova
State educational institution of higher professional education "Dagestan State Medical Academy" of the Ministry of Health of the Russian Federation, the Republic of Dagestan
Russian Federation
Russian Federation
Umakhanova Zoya Rashidovna – CMS, docent, head of the Department of neurology
367000 , Makhachkala, st. Lenin House 1
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Review
For citations:
Magomedova R.M., Mutovin G.R., Akhmedova P.G., Zinchenko R.A., Umakhanova Z.R. Clinico-Epidemiological and Molecular Genetic Study of Lumbar-Limb forms of Progressive Muscular Dystrophy in the Republic of Dagestan. Yakut Medical Journal. 2014;(2):23-24.
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