Spinocerebellar ataxia type 1 and treatment perspective
Abstract
Yakutia is an adverse region in the epidemiology of the autosomal dominant form of spinocerebellar ataxia type 1 (SCA1). Over the past 21 years, the number of carriers of the SCA1 mutation in the Republic Sakha (Yakutia) has reached 46 cases per 100,000 people of the Yakut population and is the highest in the world. Currently, there are no known effective methods of pathogenetic treatment. In general, symptomatic treatment of clinical manifestations of SCA1 is practiced. The article briefly describes the main results obtained to date in the world, on the disclosure of the molecular mechanism of the pathogenesis of SCA1 and ways to find promising means for the treatment of this disease.
About the Authors
V. I. Osakovsky
Спиноцеребеллярная атаксия НИИ здоровья СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
T. M. Sivtseva
Спиноцеребеллярная атаксия НИИ здоровья СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
T. K. Davydova
Спиноцеребеллярная атаксия НИИ здоровья СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
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Review
For citations:
Osakovsky V.I., Sivtseva T.M., Davydova T.K. Spinocerebellar ataxia type 1 and treatment perspective. Yakut Medical Journal. 2017;(4):51-52.
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