A study of the polymorphism RS9939609 of the FTO gene and RS738409 of the PNPLA3 gene as risk factors for the development of NAFLD in the Yakut population of type 2 diabetes mellitus
https://doi.org/10.25789/YMJ.2018.63.05
Abstract
In order to study the distribution frequency of the polymorphism alleles rs9939609 of the FTO gene and polymorphism rs738409 of the PNPLA3 gene among the Yakuts, DNA samples of type 2 diabetes patients and healthy volunteers were tested.
The study of the distribution frequency of the polymorphism alleles rs9939609 of the FTO gene and polymorphism rs738409 of the PNPLA3 gene in both groups showed no significant differences. Analysis of the distribution frequency of alleles and genotypes of the polymorphic variant of the FTO gene (rs9939609) in the group of patients with type 2 diabetes and healthy revealed a predominance of the T allele and a homozygous genotype of TT, except for a group of practically healthy men, which despite the prevalence of the T allele was characterized by the highest level of the heterozygous genotype AT. At analyzing the distribution frequency of the alleles and genotypes of the polymorphic version of the PNPLA3 gene (rs738409), the allele G and the homozygous genotype GG prevailed in both groups. In the studied men of both groups the G allele significantly prevailed over the C allele (p <0.05).
About the Authors
N. I. Pavlova
FGBOU VO Yakutsk State Agricultural Academy
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna – PhD (Biology), leading researcher, head of the laboratory of hereditary pathology; doctor laboratory assistant of the Scientific Clinical Diagnostic Laboratory
N. A. Solovyeva
FGBOU VO Yakutsk State Agricultural Academy
Russian Federation
Russian Federation
Soloveva Natalia Alekseevna – PhD, senior researcher, laboratoriy of population genetics
A. T. Dyakonova
FGBOU VO Yakutsk State Agricultural Academy
Russian Federation
Russian Federation
Dyakonova Alexandra Timofeevna - Jr. researcher, laboratory of hereditary pathology
N. P. Filippova
FGBOU VO Yakutsk State Agricultural Academy
Russian Federation
Russian Federation
Filippova Natalia Pavlovna - PhD (Biology), associate professor, scientific researcher, laboratory of population genetics
V. V. Dodokhov
TOS ATF FGBOU VO; Yakutsk State Agricultural Academy
Russian Federation
Russian Federation
Dodokhov Vladimir Vladimirovich - PhD (Biology), senior researcher, laboratory of hereditary pathology; Senior Lecturer of the Department
phone: 89248760599
M. A. Varlamova
FGBOU VO Yakutsk State Agricultural Academy
Russian Federation
Russian Federation
Varlamova Marina Alekseevna - researcher, laboratory of hereditary pathology
Kh. A. Kurtanov
FGBOU VO Yakutsk State Agricultural Academy
Russian Federation
Russian Federation
Kurtanov Khariton Alekseevich - PhD, Chief Scientific Officer - Head of the Department of Molecular Genetics
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Review
For citations:
Pavlova N.I., Solovyeva N.A., Dyakonova A.T., Filippova N.P., Dodokhov V.V., Varlamova M.A., Kurtanov Kh.A. A study of the polymorphism RS9939609 of the FTO gene and RS738409 of the PNPLA3 gene as risk factors for the development of NAFLD in the Yakut population of type 2 diabetes mellitus. Yakut Medical Journal. 2018;(3):18-21. https://doi.org/10.25789/YMJ.2018.63.05
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