The analysis of the resistance of heterozygous carriers of the С.-23+1G>A mutation in GJB2 gene to diarrhea
https://doi.org/10.25789/YMJ.2018.63.04
Abstract
In this paper, we present the results of an analysis of the resistance of heterozygous carriers of the с.-23+1G>A mutation in GJB2 gene to diarrhea in Yakutia. It was shown that in individuals with c.-23 + 1G> A mutation in the heterozygous state, cases of diarrhea for the last year were registered less frequently (p < 0.05) than in individuals without mutation. The research results support evidence that heterozygous carriers of GJB2 gene mutations may have increased resistance to gastrointestinal diseases, in particular to diarrhea.
Supporting agencies: We thank all participants of this study. The study was supported by the Ministry of Education and Science of the Russian Federation №6.1766.2017, Project NEFU M.K. Ammosov “Genetic features of the population of Yakutia: the structure of the gene pool, adaptation to cold, psychogenetic characteristics, the prevalence of certain hereditary and infectious diseases”. Research of the YSC CMP “The study of the genetic structure and the load of hereditary diseases of the Sakha Republic (Yakutia) populations”. Programs of Bioresource collections of the FASO Russia “Genome of Yakutia” (BRK: 0556-2017-0003) and Russian Foundation of Basic Research (#17-29-06016-ofi_m, #18-54-16004_ NCNIL_a, #18-015-00212_А, #18-013- 00738_А, #18-05-60035_Arctica).
About the Authors
A. V. Solovyev
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University M.K. Ammosov”
Russian Federation
Russian Federation
Solovyev Aisen Vasilievich - Junior researcher, Laboratory of Molecular Biology Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 46
Phone: 8-(914) 300-42-65
N. A. Barashkov
Federal State Budgetary Scientific Institution “Yakutsk Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Barashkov Nikolai Alekseevich - Candidate of Biological Sciences, Head of laboratory of Molecular genetics
677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4
Phone: 8-(4112) 32-19-81
K. E. Savvinova
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University. M.K. Ammosov”
Russian Federation
Russian Federation
Savvinova Kiunniai Egorovna – Student, Department of Biology, Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 48
Phone: 8-(4112) 49-68-42
N. N. Gotovtsev
Federal State Budgetary Scientific Institution “Yakut Science Center of Complex Medical Problems”
Russian Federation
Russian Federation
Gotovtsev Nyurgun Naumovich - Scientific Researcher, Laboratory of Molecular Genetics
677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4
Phone: 8-(914)106- 20-15
F. M. Teryutin
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University M.K. Ammosov”
Russian Federation
Russian Federation
Terutin Fedor Mikhailovich - Candidate of Medicine Sciences, Senior Researcher of Laboratory of Molecular Biology Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 46
V. G. Pshennikova
Federal State Budgetary Scientific Institution “Yakutsk Scientific Center for Complex Medical Problems”, postgraduate student of NEFU
Russian Federation
Russian Federation
Pshennikova Vera Gennadievna - Scientific Researcher, Laboratory of Molecular Genetics
677010, Sakha Republic, Yakutsk, Sergelyakhskoye Shosse, 4
Phone: 8-(4112) 32- 19-81
G. P. Romanov
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University M.K. Ammosov”
Russian Federation
Russian Federation
Romanov Georgii Prokopievich - Engineer, Laboratory of Molecular Biology Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 46
A. M. Rafailov
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University. M.K. Ammosov “
Russian Federation
Russian Federation
Rafailov Adum Mikhailovich - Candidate of Biological Sciences, Associate Professor of Department of Biology, Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 48
Phone: 8-(4112) 49-68-42
N. N. Sazonov
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University. M.K. Ammosov “
Russian Federation
Russian Federation
Sazonov Nikolay Nikitich - Doctor of Biological Sciences, Professor of Department of Biology, Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 48
Phone: 8-(4112) 49-68-42
L. U. Dzhemileva
Federal State Budgetary Institute of Science Institute of Biochemistry and Genetics; Ufa Federal Research Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
Dzhemileva Lilya Useinovna - Doctor of Medicine Sciences, Senior Researcher of Laboratory of Human Molecular Genetics
450054, Yakutsk, Prospect of October 71
Phone: 8-(3472) 35-60-88
O. L. Posukh
The Federal Research Center Institute of Cytology And Genetics The Siberian Branch of The Russian Academy of Sciences
Russian Federation
Russian Federation
Posukh Olga Leonidovna - Candidate of Biological Sciences, Senior Researcher of Laboratory of Human Molecular Genetics
630090, Novosibirsk, Lavrentiev avenue, 10
Phone: 8-(383)363- 49-44
E. K. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
Khusnutdinova Elza Kamilevna - Doctor of biological sciences, Professor, Director
450054, Ufa, Prospect of October, 71
Phone: 8-(3472) 35-60-88
S. A. Fedorova
Federal State Autonomous Educational Institution of Higher Education “North-Eastern Federal University M.K. Ammosov”
Russian Federation
Russian Federation
Fedorova Sardana Arkadievna - Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences
677010, Sakha Republic, Yakutsk, Kulakovsky st. 46
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Review
For citations:
Solovyev A.V., Barashkov N.A., Savvinova K.E., Gotovtsev N.N., Teryutin F.M., Pshennikova V.G., Romanov G.P., Rafailov A.M., Sazonov N.N., Dzhemileva L.U., Posukh O.L., Khusnutdinova E.K., Fedorova S.A. The analysis of the resistance of heterozygous carriers of the С.-23+1G>A mutation in GJB2 gene to diarrhea. Yakut Medical Journal. 2018;(3):15-17. https://doi.org/10.25789/YMJ.2018.63.04
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