Research of the role of polymorphic options of interleukins genes in development of asthma in the Yakut population
https://doi.org/10.25789/YMJ.2018.61.01
Abstract
The purpose of this study was to investigate the polymorphic loci of interleukins genes IL4 (C589T, G/C3’UTR), IL4R (Q551R, I50V), IL5 (C703T), IL5RA (G80A), IL9 (T113M) in patients with asthma and in the control group of individuals. As a result of the analysis, we showed that the markers of an increased risk of developing asthma in the children-Yakuts are the C allele and the CC genotype (G/C 3’UTR) of the IL4 gene, the T allele and the genotype TT (C589T) of the IL4 gene, the allele of the R (Q551R) gene IL4RA, allele I (I50V) of IL4RA gene, allele M (T113M) of IL9 gene. Thus, this study for the first time shows the association of polymorphic variants of IL4, IL4RA, IL9 genes with the development of asthma in the Yakut population.
About the Authors
N. A. Solovyova
FGBNU “The Yakut scientific center of complex medical problems”
Russian Federation
Russian Federation
Solovyova Natalya Alekseevna - candidate of medical sciences, the leading researcher - the head of laboratory of population genetics of department of molecular genetics
8-924- 171-34-89, 677010, Yakutsk, Sergelyakhskoye Highway 4
Kh. A. Kurtanov
FGBNU “The Yakut scientific center of complex medical problems”
Russian Federation
Russian Federation
Kurtanov Khariton Alekseyevich - candidate of medical sciences, the chief researcher – head of department of molecular genetics
Yakutsk
N. I. Pavlova
FGBNU “The Yakut scientific center of complex medical problems”
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna - сandidate of biology sciences, the leading researcher - the head of laboratory of hereditary pathology of department of molecular genetics
Yakutsk
E. Yu. Sizykh
FGBNU “The Yakut scientific center of complex medical problems”
Russian Federation
Russian Federation
Sizykh Elena Yurevna - junior researcher of laboratory of population genetics of department of molecular genetics, the doctor of the highest qualification category, the manager policlinic
Yakutsk
M. N. Mikhaylova
FGBNU “The Yakut scientific center of complex medical problems”
Russian Federation
Russian Federation
Mikhaylova Ulyana Nikitichna - junior researcher of laboratory of population genetics of department of molecular genetics, attending physician of therapeutic office
Yakutsk
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Review
For citations:
Solovyova N.A., Kurtanov Kh.A., Pavlova N.I., Sizykh E.Yu., Mikhaylova M.N. Research of the role of polymorphic options of interleukins genes in development of asthma in the Yakut population. Yakut Medical Journal. 2018;(1):8-10. https://doi.org/10.25789/YMJ.2018.61.01
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