ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2018.61.01ymj-1015Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHИсследование роли полиморфных вариантов генов интерлейкинов в развитии астмы в якутской популяцииResearch of the role of polymorphic options of interleukins genes in development of asthma in the Yakut populationСоловьеваН. А.SolovyovaN. A.

Соловьева Наталья Алексеевна – к.м.н., вед.н.с.,-руковод.лаб.

Solovyova Natalya Alekseevna - candidate of medical sciences, the leading researcher - the head of laboratory of population genetics of department of molecular genetics

8-924- 171-34-89, 677010, Yakutsk, Sergelyakhskoye Highway 4

onata608@yandex.ruКуртановХ. А.KurtanovKh. A.

Куртанов Харитон Алексеевич – к.м.н., гл.н.с.-руковод. отдела

Kurtanov Khariton Alekseyevich - candidate of medical sciences, the chief researcher – head of department of molecular genetics

Yakutsk 

ПавловаН. И.PavlovaN. I.

Павлова Надежда Ивановна – к.б.н., вед.н.с.- руковод.лаб

Pavlova Nadezhda Ivanovna - сandidate of biology sciences, the leading researcher - the head of laboratory of hereditary pathology of department of molecular genetics

Yakutsk 

СизыхЕ. Ю.SizykhE. Yu.

Сизых Елена Юрьевна – м.н.с., врач высшей квалиф. категории, зав. поликлиникой больницы

Sizykh Elena Yurevna - junior researcher of laboratory of population genetics of department of molecular genetics, the doctor of the highest qualification category, the manager policlinic

Yakutsk 

МихайловаУ. Н.MikhaylovaM. N.

Михайлова Ульяна Никитична – м.н.с., врач-ординатор больницы

Mikhaylova Ulyana Nikitichna - junior researcher of laboratory of population genetics of department of molecular genetics, attending physician of therapeutic office

Yakutsk 

Янц КМПРоссияFGBNU “The Yakut scientific center of complex medical problems”Russian Federation20182608202501810Copyright © Соловьева Н.А., Куртанов Х.А., Павлова Н.И., Сизых Е.Ю., Михайлова У.Н., 20252025Соловьева Н.А., Куртанов Х.А., Павлова Н.И., Сизых Е.Ю., Михайлова У.Н.Solovyova N.A., Kurtanov K.A., Pavlova N.I., Sizykh E.Y., Mikhaylova M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1015

Целью настоящей работы явилось исследование полиморфных локусов генов интерлейкинов IL4 (C589T, G/C3’UTR), IL4R (Q551R, I50V), IL5 (C703T), IL5RA (G80A), IL9 (T113M) у больных астмой и в контрольной группе индивидов. В результате проведенного анализа нами показано, что маркерами повышенного риска развития астмы у детей-якутов являются С аллель и генотип СС (G/C 3’UTR) гена IL4, аллель Т и генотип ТТ (С589Т) гена IL4, аллель R (Q551R) гена IL4RA, аллель I(I50V) гена IL4RA, аллель M (T113M) гена IL9. Таким образом, в данном исследовании впервые показана ассоциация полиморфных вариантов генов IL4, IL4RA, IL9 с развитием астмы в якутской популяции.

The purpose of this study was to investigate the polymorphic loci of interleukins genes IL4 (C589T, G/C3’UTR), IL4R (Q551R, I50V), IL5 (C703T), IL5RA (G80A), IL9 (T113M) in patients with asthma and in the control group of individuals. As a result of the analysis, we showed that the markers of an increased risk of developing asthma in the children-Yakuts are the C allele and the CC genotype (G/C 3’UTR) of the IL4 gene, the T allele and the genotype TT (C589T) of the IL4 gene, the allele of the R (Q551R) gene IL4RA, allele I (I50V) of IL4RA gene, allele M (T113M) of IL9 gene. Thus, this study for the first time shows the association of polymorphic variants of IL4, IL4RA, IL9 genes with the development of asthma in the Yakut population.

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The authors declare that there are no conflicts of interest present.