32,9 thousand cases of malignant tumors of the population of Yakutia for the period from 1991 to 2007 were under analysis. Nature of the disease has a distinct sex-age and territorial conditioning. According to forecast, by 2012 overall incidence rates will increase among the male population in the 1, 2 times, female - 1, 4 times in comparison with 1991, mainly due to the growth rate of colorectal cancer localization, reproductive organs, skin, thyroid, hemoblastoses.

In article results of monitoring of congenital developmental anomalies of the central nervous system of newborns, children and the aborted fetuses for the 10-years period (2000-2009) in Republic Sakha (Yakutia) are presented. Frequency in regions and dynamics of their prevalence on years is analyzed. The analysis of risk factors is held. Frequencies of congenital defects of the central nervous system of fetus, revealed on early terms and interrupted on medical indications are certained. Estimation of the efficiency of antenatal diagnostics and prevention of defects of the central nervous system is given.

The article analyzes the dynamics of glucose content in newborns from mothers with preeclampsia. It was revealed that immediately after birth in umbilical cord blood the lowest levels of glucose were marked, which rose to the third day. In this case, it was noted that in new-borns of Buryat nationality from mothers with preeclampsia glucose content in blood in dynamics authentically was higher compared with Russian ones. The expressed fluctuations in blood glucose levels are regarded as a violation of the adaptation process.

102 children with diabetes mellitus I type and diabetic polyneuropathy were observed by means of the routine neurological assessment, standard neuropathic scales (NDS, NSS), EMG and Nerve Conduction Velocity in Out-patient Child Diabetes Center. It demonstrated the development of neuropathy after 3 years from beginning of disease, a prevalence of disturbances in distal parts of lower extremities. EMG showed decrease of nerve conduction velocity, amplitudes and distal latencies of M-responses and F-waves in motor, sensory and autonoimic nerves. Statistic analysis allowed to make the scheme for detection of neuropathic disturbances’ severity.

Damaging effect of hypoglycemia on the brain is caused by formation of substances adversely influencing on cerebral tissue metabolism in the oxidation process. Hypoglycemia syndrome can be of various clinical presentation, and in certain cases of asymptomatic course. In the presence of clinical semiology more often mild and moderately severe hypoglycemia is shown in the form of hyperexcitability syndrome, and profound one – distress syndrome.

Results of breast milk research of 236 women belonging to different ethnic groups of the Russian North are put in a work basis. It is revealed that the breast milk of women of the native small in numbers people of the North contains authentically less protein and carbohydrates, than of the Russian women and more fat and less protein, than of women-Yakuts.

Total number of 225 adolescents with clinical features of non-differentiated connective tissue dysplasia (NDCTD) at the different stages and 60 healthy adolescents were examined. The hemiluminiscent method was used for the estimation of biogenesis of free radicals in blood serum. In the group of NDCTD patients the indexes, reflecting the processes of free radical lipid oxidation reliably increased and antioxidant defense system activity decreased. Gender and age related differences in the processes of free radical oxidation were revealed in minimal and severe stages of NDCTD.

In 46 patients residents of Yakutia with destructive forms of pulmonary tuberculosis changes of respiratory function on the background of longterm treatment with an ACE inhibitor Enap 5mg were studied. It was found that Enap 5mg prolonged use (over 2 years) does not cause bronchial obstruction during the compensated tuberculosis, in the presence of initially moderate violations of pulmonary ventilation capacity against the background of chemotherapy in 50% of patients leads to improvement or partial improvement of ventilatory function.

This article is about the state of the immune status and the blood lymphocyte NAD(P)-depend dehydrogenises activities in patients with autoimmune thyroiditis (AIT) according to thyroid functions. The state of the immune status in women with АIТ has the general peculiarities of groups with various hormonal background that is described as uniform pathogenesis: decrease of the concentration of the CD19+-lymphocytes and IgM. The content of the CD8+- lymphocytes is decreased in both: subclinical and clinical hypothyroidism. The blood lymphocyte metabolism in patients with АIТ is depending on the thyroid gland function and has the characteristic peculiarities. They describe the differences of the thyroid regulation.

The object of study is an impact of “Abalakh” mineral water in the treatment of patients with chronic pancreatitis. There has been developed a method of drinking treatment of chronic pancreatitis in clinical remission with evaluation of its effectiveness.
The main features for providing high therapeutic effect are drinking schedule and temperature of the Abalakh mineral water.
At the same time, low – mineralized sodium hydrocarbonate weakly alkaline water is a starting and correction factor for regulation of disturbed functions of the digestive system.

The results of simultaneous investigations of unorganized citizens of Yamal aged 20-59 years are presented. The influence of chemical elements at the adaptation level to the harsh northern conditions of the Far North is investigated. The chemical elements that influence the reduction of the adaptation processes are defined. The dynamics of changes in the concentration of Fe, Mn, Zn, Co, Ca, taking into account the level of adaptability is studied.

Patients with metabolic syndrome who got ursodeoxycholic acid in complex treatment were examined. The indices of immunoreactive insulin, leptin were studied in dynamics with the use of immunoenzymatic method, the values of lipid spectrum, the data of ultrasound investigation of liver were determined.
It was revealed that inclusion of ursodeoxycholic acid into the complex treatment of patients with metabolic syndrome lead to the decrease of indices of immunoreactive insulin, leptin, atherogenic fractions of lipids playing a leading role in the development and progressing of metabolic syndrome.

There were presented the results of examination of patiens with acute and chronic pathology of nose and perirhinal sinuses associated or not with Chlamidiae infection involving medical social characteristics. The authors marked that the main place in the structure of medical social types of both Chlamidae infected and non-infected patients belonged to medical and social risk subjects. But we observed the decreased health level in respondents with confirmed chlamidiae infection and comparatively higher range of negative social factors.

The article shows the indices of prevalence and structure in chronic othorhinolaryngologic pathology in rural native and non-native people of Khakasia Republic. The results of cross-section research revealed high prevalence of the pathology in Ear-Nose-Throat-organs in rural population of the republic irrespective of ethnic belonging. Comparative analysis of prevalence indices corresponding to the Europoids and the Khakass determined the range of ethnic peculiarities in epidemiology of chronic diseases of ear, nose and throat.

A comparative analysis of efficacy and toxicity of standard chemotherapy scheme irinotecan +fluorouracil + leucovorin in patients with colon cancer in the Blochin’s Oncological Centre and chemotherapy department of Oncologic dispensary was held. Particular attention was paid to tolerability and toxicity of the given chemotherapy scheme. The findings suggest that the standard chemotherapy regimen irinotecan +fluorouracil + leucovorin is an effective and well tolerated treatment for colon cancer.

Questioning among the patients with diffuse dishormonal diseases of mammary glands, living in terrain of Republic Sakha (Yakutia) and consulted by the oncologist-mammologist, is made and the data of out-patient cards of patients for the purpose of studying of the endogen factors, characterizing function of reproductive system of organism, and the endocrine-metabolic infringements caused by concomitant and previous disQ

Results of the analysis of the clinical picture and pathologic anatomy of 4 cases of severe influenza during the period autumn-winter 2009 in the Republic Sakha (Yakutia) are presented. The predominance of the different phases of diffuse alveolar lesion with blocking of vascular walls of the alveoli with massive hyaline membranes, which indicates that purely viral pneumonias with development of early acute respiratory failure, infectious-toxic shock with the affection of several organs is noted. Adherence of bacterial flora does not always happen. Analysis of observations of the dead in the Republic of Sakha (Yakutia) suggests that regardless of the version of the influenza virus, pathological changes are stereotypic. It should also be noted that pulmonary ventilation was not carried out in any observation, and patients did not receive adequate antiviral therapy.

Osteoporosis is a widespread medical problem not only at women, but also at men that covers all population irrespective of a gender. Though osteoporotic frax . For tox

The effectiveness of the method of endoscopic nephropexy with a T-shaped polypropylene flap is shown, also the degree of blood supply disturbance in the kidney with nephroptosis and its normalization after the nephropexy. The result These researches let to involve the method of endoscopic nephropexy with a T-shaped polypropylene flap in the arsenal of nephroptosis operations at children.

Computed tomography study with inspiratory-expiratory test was performed in patients with bronchial asthma. It is revealed that regionar ventilation changes are correlated with severity and duration of the disease.

Based on analysis of treatment of 1673 women of reproductive age the efficiency of the cryogenic method in treatment of genitals benign diseases in outpatient conditions is highly appreciated. Epithelialization of the cryodestruction locus was 6-9 weeks, patients preserved work capacity.

In article formation stages of the general medical practice (family medicine) in Yakutia as the basic primary medical aid component are presented. Regulating documents on work of the general practitioner are resulted. Experience of introduction of structure of the general medical practice (family medicine) at regional level is resulted, the role of Medical institute of Northeast federal university named after M.K. Ammosov in preparation of experts is shown; unresolved problems are considered.

Problems of the metrological provision of the means of the measurements in the health care institutions of the Sakha Republic are highlighted in the article, analysis of the financing, amount and medical equipment’s roll call results are implemented. The necessity of the metrological roll call taking is shown.

The article presents analysis of temporary disablement allowance paid in the Republic of Sakha (Yakutia) in 2005-2009. Average daily allowance amount, payment days, average duration of the first case of temporary disablement are presented in the paper.

Influence of “Reindeer moss” biologically active additive (BAA) on biochemical indexes of blood of native volunteers with initially raised level of glucose and cholesterol is investigated. It is revealed that after three-week reception of drug at volunteers level of glucose, cholesterol and aterogen quotient and AsAT significantly decreases and quantity of correlation communications increases.

It was conducted a microbiological monitoring of microbe scenery of nosocomial infections instigators during the period of 1999 till 2008. We’ve got 178 strains of Gram-negative bacterium and 233 Gram-positive ones and 30 strains of other Gram-negative micro-organisms. Gram-positive bacteria are represented by coagula-negative and coagula-positive Staphylococcus, Streptococcus and Enterococcus but Gram-negative ones by fermented bacterium (FGNB): Escherichia coli, Klebsiella spp and other unfermented bacterium (UGNB): Ps.aeruginosa etc.

The dynamic analysis of a parity of antioxidant and proantioxidant indicators in organism in 37 patients after dental implantation at use of biologically active additive “Roksirin” was carried out. In the postoperative period for 14 days after reception of a preparation "Roksirin" were observed considerable (on 81,0 %) increase in indicators antioxidantion activity as concentration of components peroxide oxidations carbohydrates has not increased. Also for the second and third day after operation it was observed hypostasis reduction, redness and morbidities.

The analysis of results of thrombolytic therapy application in patients with acute myocardial infarction in Yakutsk is carried out. Alteplase and tenecteplase were applied as thrombolytic. It is shown that their application, since a pre-hospital stage, reduces time of reperfusion and reduces mortality at acute myocardial infarction.

Research was made during the period of a pandemic flu A/H1N1 2009. We did a retrospective analysis of 79 medical histories of patients with diagnosis “community-acquired pneumonia”. Clinical features, disease severity, localization of the process, presence of complications, treatment and outcome of the disease have been examined. The greatest group was compounded by young men with moderate current of pneumonia with prevalence of leucopenia in the blood clinical analysis. In treatment standard schemes of antibacterial therapy were used, in all cases clinical and radiological acknowledgement of pneumonia took place.

The structural analysis of cholagogus assortment resolved to application in the Russian Federation was made to estimate prospects of development of new domestic medicines and the improvement of available hepatoprotectors dosage forms.

The present paper is dedicated to a model of price regulation for medicines within distribution channel. It is proposed to divide medicines into three groups on a basis of price. It is recommended to introduce a guaranteed distribution and pharmacy margin for medicines from lower and upper groups, and a maximum margin rate for medicines from medium group.

One of the approaches to dissolve the problem of the toxicity of artificial cryoprotectors that have been applied in the cryopreservation of biospecimens can be using it together with natural cryoprotectors, produced by cold hardy organisms, such as insects. The positive results were received in the studies on using of extract of overwintering caterpillars Aporia crataegi L.in the cryopreservation of human lymphocytes. The extract seems to be an efficient stabilizer at multiply cycles of freezing – thawing.