The purpose of research: By the comparative analysis of risk factors of development of an ischemic stroke in group of patients with stroke depending on sex, the analysis of frequency of occurrence of risk factors in group of patients and group of the control in the Yakut ethnic group.
Materials and methods. By the method “case-control” we carried out research of major factors of risk of development of an ischemic stroke (an arterial hypertension, a heredity, cardiac pathology, diabetes mellitus, etc.) in two groups. The fi rst group have made 123 patients, the second one have made 129 healthy persons of the Yakut nationality comparable on sex and age. Research was spent on the basis of the Neurovascular branch of RH№2 - CUMC. The control group has been collected by a method of casual sample.
Results. On the fi rst place on frequency of occurrence, there is an arterial hypertension, then hereditary predisposition, on the last - diabetes mellitus and abusing alcohol. Smoking has been registered more at men (р<0,0005), and the overweight of body met more often at women (р<0,02). Statistically authentic increase of frequency of occurrence in group of sick such risk factors, as an arterial hypertension (р<0,001), smoking (р<0,00005), overweight of body (р<0,0005) is revealed.
Conclusions. In Yakutia the precise tendency to growth of the ischemic stroke, connected fi rst of all with high prevalence of an arterial hypertension, inadequacy of its treatment is marked.

Introduction. Neopterin (NP) concerns to pteridines which represent heterogeneous group of the substances derivative of the guanosinetriphosphate which level raises at activation of macrophages in reply to stimulation of interferon - γ. Increase of neopterin levels is marked in acute coronary syndrome and in the various pathological states, accompanied by infl ammatory-destructive changes.
The purpose of research. To study interrelation of the neopterin content in blood in patients with various forms of ishemic heart disease.
Materials and methods. 110 persons (43 women and 67 men) are included in research in the age of from 35 till 80 years (middle age has made 67,9±7,6 years): 17 patients with myocardial infarction, 38 patients with unstable angina pectoris, 40 patients with angina of exertion, 15 healthy persons. Besides routine clinical researches, in the all NP levels, sVCAM-1, interleukine-6 (IL-6) and C-reactive protein (CRP) by means of highsensitive immunoferment methods were defi ned.
Results. Neopterin levels authentically correlated with CRP content (r=0,42, p=0,01), IL-6 (r=0,36, p=0,03) and sVCAM-1 (r=0,42, p=0,043). Content of NP, sVCAM-1, IL-6 and CRP in blood of healthy persons and in patients with angina of exertion authentically did not differ. In comparison with the patients with angina of exertion, in patients with unstable angina pectoris neopterin levels are higher - 9,3±4,9 nmol/l vs 14,9±8,6 (p<0,05) and CRP - 4,9±3,9 mg/l vs 11,2±10,4 (p <0,05). The conclusion. Neopterin is a marker participating in IHD pathogenesis; its levels in blood correlate with expressiveness of a system infl ammation and are higher in patients with acute coronary syndrome (ACS).

The analysis of ultrasonic features of heart valve defeat in 129 children in the age of from 1 year till 15 years with the acquired heart valvular diseases in Republic Sakha (Yakutia) is lead. Ultrasonic attributes, characteristic for various stages of the diseases concerning principal causes of development of the acquired heart valvular diseases are studied: in an active and inactive phase of rheumatic carditis, at acute and subacute current of infective endocarditis, and also at infective endocarditis in the anamnesis. Recommendations on carrying out of ultrasonic research of heart for duly diagnostics and optimization of clinic supervision of children with the acquired heart valvular diseases are offered.

The purpose of research. An estimation of lipid exchange and state of pro - and antioxidant balance in patients with postmyocardial infarction cardiosclerosis.
Material and methods of research. Whey of blood of 57 sick men in the age of from 35 till 70 years with diagnosis PMICS was investigated. All patients have been divided into 2 groups: I - patients before revascularization -40 person, II - patients after revascularization - 17 person. The control group was made by 25 men without a pathology of cardiovascular system in the age of from 30 till 50 years. Blood was taken on an empty stomach from an elbow vein 10 days prior to and in 6 months after revascularization. LPO intensity, parameters of the general cholesterol and its fractions were estimated.
Results. In patients with PMICS expressed dyslipidemia and high speed of processes of lipid peroxide oxidation (LPO) were marked. In healthy men CLPO/AOP corresponded to 5,4. In the I group of patients this parameter was in 5 times higher, than in control, and was equaled to 26,8. In the II group of patients this parameter was in 1,8 times lower, than in patients of the I group, but in 2,8 times higher control values, and corresponded to 14,9.
The conclusion. In patients with PMICS accumulation of products of the LPO on a background of decrease in AOP activity is marked. The condition of pro- and antioxidant balance in postmyocardial infarction cardiosclerosis is displaced aside of prooxidant processes. Revascularization reduces LPO intensity and improves a condition of lipid exchange - level of triglycerides (TG) and cholesterol (Chl) in patients of the II group decreases in comparison with the I group.

The purpose of research. To reveal frequency and character of left ventricular hypertrophy (LVH), to analyse dependence of geometrical model of a left ventricle from a daily profi le of arterial pressure, and also to estimate interrelation of LVH with coeffi cient of compliance (CC) of an arterial wall in men and women with AH in conditions of Yakutsk.
Material and methods. We had surveyed 256 patients with the established data of stable current of AH of the I-II degrees. From them two groups by sex and two age subgroups have been allocated: from 18 till 35 years and from 36 till 55 years. In clinic the complex estimation of complaints of patients, the anamnesis of disease and life, results of clinical, laboratory, functional and tool researches were carried out. Daily monitoring of the AP was defi ned on the equipment of Inkart system (Russia) in conditions of a free impellent mode. For statistical data processing we used SAS program.
Conclusions. Concentric LVH is revealed in 21,9% of men and 12,4% of women, excentric LVH - in 11,9% of men and 15,5% of women with AH. According to DMAH in all groups the type of a daily profi le of the AH is non-dipper. CC of an arterial wall can be considered as marker of CLVH.

In recent years much attention has been paid to the study of the indices of fetoinfantile losses (FIL) including abortions and infantile deaths, recommended by World Health Organization. The aim and purpose of our research is to establish the dynamics and structure of fetoinfantile losses in the Amur Region. In the course of our research we analyzed 727 cases of fetus deaths whose weight was 1000 gms and above and infants who died in the age before a year is age in the period from 2002 up to 2006.

The submitted work is based on results of surgical treatment of 188 patients with acute cholecystitis in conditions of the central regional hospital. As a basis of research use of an integrated estimation of weight of the common condition of patients with acute cholecystitis has served. The technique of forecasting outcomes of surgical treatment is developed.

The purpose of research. Revealing of element structure of hair, wheys of blood of the population of the Central Yakutia.
Material and methods. Research of element structure of hair of a head, whey of blood by the method of atom-absorption spectrometry.
Results of research. High maintenance of Сu, Mg, Сa in hair of inhabitants of the villages concerning to the alas echosystem, in comparison with fl ood-lands echosystems is observed. Various levels of elements in whey of blood and in hair depending on sex are revealed.
The conclusion. The element structure of biosubstrata of the population of a taiga zone of Yakutia changes depending on some factors: ecological conditions, age, sex, etc.

The purpose of research: specifi cation of frequency of painful radicular syndrome in the early postoperative period and revealing of the possible reasons of their relapses.
Materials and methods. The analysis of the nearest results of operations in 239 patients operated concerning discogenic lumbosacral radiculitis was carried out. Effi ciency of operation on next day with application of Nurick scale, and also frequency of painful radicular syndrome relapse during stay of the operated patients in the hospital was studied.
Results. The excellent and good result on Nurick scale was received in 93,2 % of patients. Relapse of radicular pains of various intensity was marked in 26,5 % of cases.
The conclusion. The reasons of relapses of radicular pains may be: insuffi cient elimination of a compression of a nervous back, a surgical trauma, underestimation of such factors, as an accompanying stenosis of vertebral channel.