The purpose of research. Studying of a state of health, conditions and a way of life of rural population of able-bodied age in conditions of the Far North.
Materials and methods. Inspection in expeditionary conditions of 1949 person of able-bodied age, from them 1169 women and 780 men is lead. The state of health of the population of able-bodied age was studied by results of one-stage clinic - functional and laboratory inspection with the purpose of revealing of the basic classes of diseases. At studying conditions and a way of life of the population the method of socially-clinical questioning is used. The questionnaire is developed by experts of laboratory of medicosocial researches and the problem analysis and approved by scientifi cally-methodical council of the Yakut centre of science of Russian Academy of Medical Sciences and Government RS (Y) in 2005.
Results. Among the examined persons of able-bodied age at the moment of inspection of a pathology it is not revealed at 9,3 % the person, among men healthy it has appeared more (13,8 %), than among women (7,8 %). The others have on the average 2-3 diseases. The level of a pathological affection among the examined contingent has made 234,8 cases on 100 examined population of able-bodied age. At complex medical survey it is revealed in 1, 5 times of more pathology, than at taking medical advice, and diseases of bodies of digestion in 5,5 times, system of blood circulation - in 5 and endocrine system - in 6 times more. Sociallyhygienic questioning of the population of able-bodied age has shown, that on health of people of able-bodied age render complex infl uence such factors, as the use of alcoholic drinks, smoking, non-observance of a diet, character of a feed and a degree of physical activity.
The conclusion. Parameters of health of rural able-bodied population are on a low level. Elimination or decrease of bad habits would be one of reserves of improvement of a state of health of rural able-bodied population.

The purpose Studying of features of clinical current of a stomach ulcer depending on a degree of heaviness of disease at workers of Open Society “ Yakutugol “.
Results. The clinical inspection of patients of investigated groups including studying of complaints, the anamnesis of disease and a life, objective data, has shown, that at patients with heavy current of a stomach ulcer the brightest clinical picture with the expressed painful syndrome, the expressed displays of the refl ux dyspepsia, frequent relapses were observed. Also it was found out, that the stomach ulcer has features of current at workers of the coal industry in conditions of Southern Yakutia in comparison with other regions and patients of other trades.

The children of indigenous population of Republic of Sakha (Yakutia), irrespective of a racial accessory, are characterized by a complex of morphofunctional features of an organism which are formed on laws of оntоgеnеtic and bioloqy development, and also under infl uence of the ethnic factor and can be examined in quality differences of children monqoloidy and europeoidy in the age of 7-12 years.
Left-hand lateralisation of hemispheres was revealed among the most of children. But peculiarities of morphofunctional developments of children-monqoloidy in comparison with children-europeoidy concern the tendency mainly right-hand type lateralisation of hemispheres of a brain and ambidexters.

Topicality of the problems of microbe-infl ammatory processes of the urinary tract in pediatric practice is due to considerable share of urinary tract infections in structure of kidney malfunctions, due to the fact that urinary tract infections tend to progress and develop chronic kidney failure. 711 children with urinary tract infections were investigated. We study specifi c ethiology and fl owing of urinary tract infections at children. Comparative datas of different antibacterial and antireccurent treatment of urinary tract infections at children are given.

At the last time negative tendention of increasing of newborns with respiratory pathology rate occurs. At the same time new technologies of care let to save life of premature children. Clinical physiology of breathing is a new field of medical science and practice. Objective methods of breathing functions investigations at the newborns were absent till the present.

The purpose. Studying of features of current and defeat of a mucous membrane of bodies of the top section of a digestive tract (TSDT) at children of region of Yakutia.
Materials and methods. The material of results of studying of current chronic erosive and non-erosive gastroduodenisis, associated with helicobacteriosis at 204 children living in region of Yakutia is presented. Children of a indigenous nationality have made 62, 2 %, thus in most cases they were from agricultural areas of Yakutia. Diagnostics of pathology of a stomach and a duodenum has been ascertained with use of common clinic, biochemical analyses, and also tool methods - ultrasonic-diagnostics, fi broesophagogastroduodenoscopy (FEGDS), histologic and cytologic research of biopsy materials of mucous membrane of TSDT. Besides that “Helic-test” and “Helpil-test” for diagnostics of helicobacteriosis and degrees of seeding of mucous membrane of a stomach and duodenum have been executed.
Results and the conclusion. The analysis of the received results has revealed distinctions on expressiveness of defeat mucous membrane of a stomach and duodenum at children with helicobacteriosis depending on an ethnic accessory. The received results prove earlier diagnostics of pathology of TSDT and obligatory purpose of eradicational therapy under the established standards.

The purpose. An estimation of a condition of lipid exchange at city and rural population of Yakutia.
Materials and methods. 1719 organized and unorganized city and rural population of Yakutia of both sex in the age of from 18 till 75 years were investigated. Researches of a lipid spectrum were held by an enzymatic method on the biochemical analyzer “Cobas Mira Plus”.
Results. It is revealed, that at 35 % among the surveyed persons concentration of the general cholesterol in whey of blood was above norm and depended on age.
The conclusion. Dyslipidemia at inhabitants of Yakutia irrespective of an ethnic accessory has atherogenic character that demands the further research, and carrying out among the population of republic of preventive measures on preventions of development of cardiovascular diseases.

The purpose. An estimation of the immune status of patients with frostbites depending on a phase of injury process.
Materials and methods. 95 men with frostbites of a different degree of heaviness and localization in the age of from 18 till 62 years have been surveyed.
Results. For the fi rst time dynamics of changes of the immune status depending on a phase of injury process is researched. In the fi rst days of a cold trauma an immune defi cit of T-cell link is revealed (СД3 +, СД4 +, СД8 +), on later terms – decrease of a humoral link (СД24 +, IgA, IgM). The presented data testify that at the cold trauma there are infringements of cellular and humoral immunity, demanding immunomodulating therapy

98 patients with chronic virus hepatitis C (57 men and 41 women) at the age of 19 to 69 years were surveyed on the basis of hepatites department of the Yakut city clinical hospital. Clinical current of a chronic virus hepatitis C was characterized by wide spectrum hepatic and off-hepatic displays. It was noted, that the combination of damaging factors of the alcoholic and virus origin increases the frequency and speed of development of cirrhosis of a liver. Morphological research of bioptats of 40 patients with defi nition of indexes of histological activity and a sclerosis on Knodell scale showed the prevalence of a chronic hepatitis C of low and minimal activity with poorly expressed fi brosis. In some cases the degree of desmoplastic process in a liver mismatched the activity of infl ammatory process.

The purpose. Searching of immunogenetic HLA-a marker of a chronic virus hepatitis B (HVB).
Materials and methods. By means of molecular method HLA - genotyping in conformity with standards EFI (the European Federation of Immunogenetics) character of distribution of leucocytes antigens of class I and II loci A, B and DR among patients with a chronic hepatitis B in the Yakut population (n=64) is analyzed.
Results. In the Yakut population the statistical authentic association of a chronic virus hepatitis B with following antigens - HLAA23, A24, A26 and В18 and protective antigen HLA - B57 (p< 0,05) is established.
The conclusion. By results of research probably in the future by a multifactor method it would be possible to allocate the universal gene playing a role in transition of a hepatitis B in the chronic form. Searching of the immunogenetic markers HLA of a chronic virus hepatitis B, C and D in the Yakut population demands the further studying.