For the first time the clinical and molecular-genetical investigation of 43 patients and 39 their relatives from 37 unrelated Yakut families with hereditary autosomal recessive nanism in Republic Sakha (Yakutia) were performed. The novel nonsense - mutation 4582insT in gene CUL7 causing rare in the world 3-M syndrome was identified. The Yakut patients with 3-M syndrome had a typical phenotype, but without typical radiological features (slender tubular bones and edges were ob-served only at one, tall vertebral bodies at 4 patients).

The purpose of the research work was the analysis of the Δ 32 association of the gene CCR5 polymorphism with the risk of the multiple sclerosis development in the Russian and the Yakut population living on the territory of the Yakutia.
Materials and methods: 63 patients with the reliable diagnosis of multiple sclerosis were examined according to the McDonald’s criteria and 253 unallied healthy people selected on the basis of similarity to patients by age, sex and nationality characteristics were also surveyed. The polymorphic version Δ 32 of CCR5 gene genotyping was carried out by polymerized chain reaction.
Results: The Yakut population has no carriers of gene CCR5 deletion. The Russian population living on the territory of the republic has the frequency of CCR5 Δ 32 allelic gene of 9,1%. There is a progressing speed increase in CCR5 Δ 32- positive patients in comparison with CCR5 Δ 32- negative ones (0.61±.013 versus 0.48±0.04).

Purpose. To establish morphological features of the changes of structural components of mucous membrane of stomach (MMS) in patients with НP-associated gastritis depending on an ethnos, sex and age.
Materials and methods. By morphometric method we examined tissue sampling of antral part of 400 patients with НP-associated gastritis diagnosis confirmed by histologic, cytologic and bacteriological methods, never earlier received antichelicobacterial therapy.
Results. Morphological feature of НP- associated gastritis in the population of Yakutia is the development of аtrophic processes in indigenous population at earlier age, than in non-indigenous population, that confirmed by authentic decrease in height of integumentary fossa epithelium and MMS, reduction of mucin-production, a deepening and reduction of quantity of gastric fossa and decrease in quantity of glands. The role of integumentary fossa epithelium in the early development of structural reorganization of a mucous membrane of a stomach is considered.
Conclusion. In patients of indigenous population the changes of structural components of mucous membrane of stomach develop at earlier age, than in non-indigenous population. The group of risk of the early development of atrophic changes of MMS among the population of Yakutia with НР-associated gastritis are the male people of indigenous population.

The purpose of research. The analysis of a radiological and computer - tomography pictures of sharp pneumonias at indigenous and the population of Yakutia.
Material and methods. Results of radiological inspection of 120 patients with out-of-hospital pneumonia of an indigenous (64) and none-indigenous (56) population in the age of from 17 till 78 years are analyzed.
Results. Features of X-ray and computer tomography pictures of a source and a share pneumonia at native and noneindigenous population of Yakutia are described, diagnostic opportunities of analog and computer radiological researches are shown also.
The conclusion. Computer tomography as a highly informative method may be recommended at out-of-hospital pneumonias for detailed elaboration of structures of pneumonic infiltrations, roots of lungs and changes of a pleura.

The assessment of the uterus scar full value after the cesarean section: the morphological aspects.
Purpose: The morphological assessment of uterus scars full value after the cesarean section. Materials and methods: The histological study of 23 postoperative uterus scars excised during the repeated planned cesarean section has been carried out.
Results: The full value uterus scars (in 69,6 % of cases) had formed in 4 years and later and were characterized by diffuse and microfocal fibrosis, minimum cellularity and low vascularization. 30,4% of uterus scars were not solid and consisted of large nidi of edematous immature connective tissue (with inclusions of distrophically changed mascular fibers) rich in cellular elements and capillary blood vessels with proliferating endothelium.
Conclusion: The post-cesarean section time period has determining importance for the connective tissue maturation and the full value scar forming

The purpose of research. To give the characteristic of delectability of mammary gland illnesses according to seeing of a doctor on the basis of the analysis of results of physical examination of women, past inspection in conditions of the specialized polyclinic.
Materials and methods. 2939 out-patient cards of women, past inspection at the mammologist, from them initial survey - 2724 persons are subjected the analysis. The indigenous population has made 30, 8 %, none-indigenous - 69,2, city-66,7, rural - 33,3%.
Results. The carried out research has allowed to ascertain high frequency of detection of mammary gland illnesses, including a cancer, at women of reproductive age, mainly at persons of a not native nationality and living in city conditions.
The conclusion. Revealed ethnic, populational characteristics of prevalence of mammary gland illnesses (including a cancer of mammary gland) prove necessity of their account at formation of the program of realization of routine inspections.