The dynamic of the Yakutia population mortality for period from 1960 to 2010 is presented in this article. The article shows the main periods of mortality dynamics, analyzes the main causes of mortality and gives the forecast of Yakutia mortality indicators by 2030 taking into account the pace of economic development and human well-being.

Analyzed results of morbidities with lymphatic and blood-forming tissue malignant tumours of the Republic Sakha population in the period of 1991-2010 are presented. Most of them are men. Morbidity of men and women of all ages with haemoblastosis had a tendency to increase. Populous, territorial and temporal morbidity regularities are set up.

The article presents the results of a study of clinical outcomes in patients with several gastroduodenal diseases, depending on the allelic variants of the gene iceA Helicobacter pylori. The iceA1 strains were identified in 65,2% cases and iceA2 – in 34,7% cases. We found no associations according to gender of patients, their place of birth or residence. However, statistically significant differences in the distribution of iceA gene alleles were found depending on age of patients with chronic gastritis. Obtained results may indicate the early onset of chronic gastritis on carriers of iceA1 strains circulating in Yakutia.

In order to reduce the incidence of milk allergy among residents of Yakutia, Russia we studied an allelic and genotype variation of betalactoglobulin gene of cattle breed in the Republic of Sakha (Yakutia). Allele distribution analysis of beta-lactoglobulin gene among the studied breeds demonstrated that the frequency of allele B prevails in Kholmogor cattle, local selection of Simmental cattle and especially in Kalmyk cattle. The genotype associated with the low content of milk serum proteins, and therefore hypoallergenic milk is BB genotype. This genotype was observed most often in cows of Kalmyk breed and cows of local Simmental breed.
The use of marker-assisted selection in dairy cattle will facilitate the increase in number of individuals with BB genotype of beta-lactoglobulin gene which is critical for the reduction of incidence of atopic allergies in the Republic of Sakha (Yakutia).

The features of structural reorganization of thyrotropic endocrine cells of distal adenohypophysis of rats of puberty at experimental immunosuppression were under study. Immunosuppressive condition was modelled in animals by administration of a cytostatic drug cyclophosphamide.
It was found that the administration of cyclophosphamide to test animals of puberty causes an active response of thyrotropic endocrine cells of anterior pituitary, as evidenced by the development of polymorphic morphological changes, the nature and the severity of which depends on the terms after administration of cytostatic.

The authors investigated the level of personal and reactive anxiety in young people suffering from dentoalveolar anomalies considering orthodontic treatment techniques (vestibular or lingual braces). It was found that, despite the increased level of personal and reactive anxiety in young people with vestibular braces, there was a low level of anxiety, while in patients using lingual bracket system, a significant increase in the level of personal and reactive anxiety was marked, which can be regarded as moderate anxiety on quantitative evaluation.

On the basis of retrospective analysis the first documentation of patients having malignant tumour diagnosis of maxillary-facial part for the first time is given. The populous, territorial and temporal regularities of population morbidity in Yakutia are found out.

The article highlights the issues of improving the safety of endoscopic transpapillary interventions at choledocholithiasis to reduce the risk of its serious complications - bleeding and perforation of the duodenum wall, expanding indications for emergency and routine endoscopic retrograde cholangio - pancreatography with endoscopic papillosphincterotomy and mechanical stone extraction in patients with a high degree of operational risk (comorbid diseases, elderly and senile age).

The paper presents an assessment of the economic and medical efficiency of the automated complex for prophylactic medical examination ACPEP-ACPME (automated complex of preventive examination of population and automated complex for prophylactic medical examination) for dispensary / preventive examination of children in the areas of the Republic of Sakha (Yakutia).
Technology ACPEP-ACPME needed for preconditioning the list of children in need for advice by specialists. This is especially true in the districts of the republic, where narrow specialists come brigade on a small amount of days.

Complex laboratory research of solid tissues condition of the intact teeth extracted according to orthodontic indications among school age children living in conditions of the North-East of Russia has been carried out. The revealed quantitative and qualitative changes of enamel and dentine of second teeth create prerequisites for development of pathological processes of solid tissues of demineralizing character that respectively can be considered as specific regional risk factor. The obtained data also define need of carrying out further complex researches directed to detection of regional risk factors of the development of pathological processes of organs and tissues of oral cavity.

With the aim to identify the interactive questionnaire advantages and disadvantages a comparative analysis of this questionnaires developed by the specialists of the Ministry of Health of the Russian Federation (the Order the Russian Ministry of Health from May 14, 2015 № 240) and standard questionnaires used in the paper was held, as well as the survey of 122 potential patients for their opinion of the interactive questionnaire on official websites of the Ministry of Health institutions of the Khabarovskiy krai. Low initiative of patients on the Internet has been revealed. Up to 2/3 of respondents required further explanation on the questionnaire, which increases the number of unanswered questions and, in the case of the interactive version, it does not allow to register the respondent’s profile on the site. Absence of open issues restricts the ability of patients to express their own opinion. Imprecise wording of «service satisfaction» and «specialists» competence» in the proposed issues lead to the needs of clarifying information and increase the number of incorrect answers among the respondents.

Research purpose was development of suggestions for improvement of regulatory legal base of system of the oncological help to the population of the Republic of Sakha (Yakutia). Object of research was the oncological service of the region, and an object of research – its standard legal support. According to the author, priority the directions of development of the oncological help to inhabitants of the republic are enhancement of organizational structure of oncological service of the region, development of organizational regulations, standards of quality control of the organization of the oncological help, target indicators of medical productivity and cost efficiency of the oncological help at stages of its rendering, and also efficiency audit.

Practical training is aimed at comprehensive development of learners of all types of professional activity in the field of medical education, the formation of general and professional competences, as well as the acquisition of the necessary skills and practical experience. Practice-orientation of the educational process - a system of successive specific actions and methods of education, leading to planned results of the organization of educational process in Yakutsk College of Medicine. Modern learning technologies contribute to the integration of teaching and learning and professional practice of students.

It was investigated Vilyui child population of the region in the age from 6 to 10 years to study the characteristics of the element status and its influence on the prevalence of dental caries. The study found that children living in these regions, there are many violations of the content of chemical elements, which gives grounds to assume an important role of diselementosis in the pathogenesis of dental caries.

Severe accommodation conditions of the population have a negative influence on the functional condition of all organism, including organs and tissues of the oral cavity in the North. So, the improvement of the dental help to the population requires systematic strengthening of material and technical resources and personnel supply of treatment-and-prophylactic institution in the region. In general, it is necessary to develop and introduce the scientifically based recommendations considering specific regional features for optimization of health care to inhabitants of the North.

There were revealed numerous negative impacts of the diamond industry and Viluiskaya hydroelectric power plant on the aquatic environment and biological objects of the River Viluy basin, expressed to a greater extent in changing of the waters hydrochemical regime and, as its consequence, in violation of the structural and functional nature of the components of aquatic biota; change in the average biomass and abundance of planktonic populations ( phyto-and zooplankton) and benthic organisms, and in general - change the flow of energy in an aquatic ecosystem.

The aim of this study was factorial analysis of the main indicators of quality of life of the population of Primorsky Krai. The object of study –the state of the quality of life of the population in Primorsky Krai. It is revealed that the first main component includes nine of the twelve selected characteristics. The main component is described 81,7% of the total variance. The main component is dominated by variables like economic, social, demographic indicators, health indicators, indicators of housing conditions and also an indicator of ecological status. From obtained results follows that almost all the selected factors have different share of influence on the quality of life of the population, this once again proves the versatility and complexity of the concept of «quality of life».

Complex of clinical and laboratory dental research of industrial areas population of North-East of Russia was conducted. Described above dictates the necessity of development and implementation of complex program of dental diseases prevention in practical health care of the region and improvement of medical aid to the industrial provinces population of Sakha Republic (Yakutia), taking into consideration the revealed changes of composition and properties of oral fluid and hard tissue of intact teeth.

The authors have made comparative analysis of the prevalence of risk factors of cerebrovascular disease in elderly and senile persons living in the Republic Sakha (Yakutia) and suffering chronic ischemia of the brain depending on ethnicity, age and gender. It is shown that ethnicity has great importance in the development of hypertension, atherosclerosis, coronary heart disease, diabetes and alcoholism.

The article characterizes the spatial aspects of the availability of drug supply for the population. The factors that shape the development of the pharmaceutical service in the Arctic regions of the Sakha Republic (Yakutia). Analyzed the availability of pharmaceutical care in Arctic regions compared to more densely populated and economically prosperous municipalities of the Republic.Proposed possible solutions to existing problems.

The comparative analysis of the mortality leading causes among the working age population in Republic Sakha (Yakutia) depending on ethnicity is presented in article. In the structure of mortality for period of 2005-2011 external causes were at the first place, the second – cardiovascular diseases and at the third one – malignant tumors. Ethnic differences were characterized by the fact that the non-natives died from the cardiovascular diseases, including the acute myocardial infarction, and malignant tumors, more often than the natives. In the non-natives the mortality from alcoholic cardiomyopathy and casual poisoning and exposure to alcohol was higher. Mortality from the external causes was higher among indigenous small in number people of the North than among the Yakuts and the non-natives. In the Yakuts in comparison with indigenous small in number peoples of the North the mortality from cardiovascular diseases and cerebrovascular accidents was higher.

In the article the role of polymorphisms of genes Toll-4 and Toll-6 receptor in the development of low antiviral defense of sickly children is examined. It is shown that in the blood of children the content of IgM, IgG and its subclasses increases, and the concentration of IgA is reduced. At the genetic mutations in (Asp 299 Gly) Toll-4 and (Ser 249 Pro) Toll-6 receptors synthesis of explored immunoglobulins is reduced, that is regarded as one of the reasons for the low antiviral defense of children with genetic defects in the immune system signaling receptors.

The analysis of the main risk factors for lung cancer, such as smoking, including passive one, industrial pollution of environment, air pollution, ionisated radiation and et al. It has been shown that lung cancer should be referred to a socially significant morbidity, prevention and treatment problems of which are not settled yet.

In the article the authors presented the data of longitudinal scientific investigation in hygienics, sanitary and epidemiology. The sanitaryhygienic’ and monitoring of consumer services’ quality management is based on object and objective appraisal of factual data and analytical index, which build in system perspective in medico-ecological remediation in anthropogenic technologically disturbed and territories of different medical geographical zones.
It is shown that the state sanitary and epidemiological supervision (together with the state environmental control, industrial and geological), forming a social and hygienic monitoring and interacting with a single service environmental monitoring, on the integral field ensures the effectiveness of the environmental system assessment (negative factors) and the risks to public health, development of forecasts and preventive recommendations.

The analysis of the main problems of the modern Russian medicine, such as insufficient funding for the spending on health care, the low quality of medical care. The second problem is caused by the crisis «Paternalistic» model of relations «doctor–patient». Instead of the proposed construction of “Partner” relationship.

Here is a study of the clinical and immunological efficacy of broncho-vaxom in the group of children with recurrent bronchitis. In the analysis of changes of the immune status in children with we recurrent bronchitis revealed the decline in T-cell component and components of complement, increased levels of CIK, a reduced level of IFN-γ FNO-ά. examined children with recurrent bronchitis medication used broncho-vaxom. The therapy was carried out ten-day course (1 capsule per day) for three months. As a result of drug therapy of broncho-vaxom marked improvement in immune status and the absence of recurrence of bronchitis for the next 3 months after the therapy.