The authors present analysis of the degree of influence of anthropogenic and technogenic load on the state of the environment of the territory and the incidence of malignant neoplasms in the population of the districts of the Southern industrial zone of Yakutia.

   The authors studied influence of environmental factors such as physical activity, physical activity per week, smoking and alcohol consumption on concomitant course of chronic obstructive pulmonary disease and chronic bronchitis with metabolic syndrome in the Yakut ethnic group in comparison with similar patients without metabolic syndrome. In the course of the study it was revealed that the frequency of occurrence of such factors, as physical activity, smoking, and alcohol consumption, in groups does not differ. At the same time, the higher index of a smoker and fewer hours spent per week on physical activity are more common in the Yakuts with chronic obstructive pulmonary disease and chronic bronchitis with metabolic syndrome that increases the risk of cardiovascular complications in this category of patients.

   The article analyzes the role of polymorphism of Toll-4 (Asp299Gly) and Toll-6 (Ser249Pro) receptor genes in the development of low antiviral protection in children with frequent episodes of acute respiratory infections. It is shown that the synthesis of cytokines IL-1-β, TNF-α decrease in the blood of patients with Toll-4 receptor gene polymorphism and IL-1RA content is increased in comparison with the group of diseased children without abnormal disturbances in signal receptors. Polymorphism in the Toll-6 receptor genes decreases the concentration of cytokines IL-1β, IL-8, TNF-α and IL-10. The concentration of IL-1RA is increased in Pro / Pro and Gly / Gly genotypes compared to the group of patients without polymorphic changes in the corresponding receptors. Genetic disorders in the synthesis of cytokines in the polymorphism of the Toll-4 (Asp299Gly) and Toll-6 (Ser249Pro) receptors are one of the reasons for the failure of antiviral protection in children who often have ARI.

   We studied the relationship between indicators of solar activity and the content of cortisol and aldosterone in the blood of able-bodied men with different temperament and high and low anxiety, hypertension. It is established that the increase in solar activity, atmospheric pressure, temperature and γ-background in jobs are closely related with the increase in the functional activity of cells of the beam (cortisol) and decrease activity of the cells in the glomerular layer (aldosterone) adrenal sympathotonics with a predominance of choleric and sanguine temperament. In these conditions parasympathotony with the prevalence of the phlegmatic and the melancholic temperament the functional activity of cells of the beam and the glomerular layer was opposite such choleric and sanguine. Multidirectional adaptive changes in activity of cells of the beam (cortisol) and glomerular (aldosterone) zones of the adrenal cortex in healthy choleric and sanguine and patients, in comparison with the phlegmatic and the melancholic, attest to the importance of temperament in adaptation to changes of heliogeophysical and meteorological factors. 

   This article dwells on whole-body MRI «Total Body» efficacy as the choice method for whole-body screening for the purpose of early diseases diagnostics. On the basis of whole-body MRI analyses during one and a half year we’ve got the results allowing speaking about a new precise and reliable method for revealing pathology of minimal dimensions in any organ, including malignant tumors.

   We consider the spheres of human activities to mobilize the body’s, intelligence’s, spirit’s resources and the concepts of the death, immortality and destiny. The modern universal approach is substantiated to the study of human problem.

   The study was conducted to assess the incidence of tyrosine kinase inhibitors toxicity and resistance to first-line therapy of chronic myeloid leukemia. The results demonstrated that indications to prescription of the second generation tyrosine kinase inhibitors are mostly due to significant non-hematologic toxicity. Optimal response to therapy requires regular clinical and laboratory monitoring for early detection of drug intolerance and resistance to first-line therapy.

   The article presents a study of the views of the health officials of the availability and quality of medical care for the circulatory system diseases in the institutions of the Far Eastern Federal District, based on the materials of sociological research from 2013 to 2015. Revealed passivity of the health officials to assess the situation and making the potential administrative decisions under the circulatory system diseases has a negative impact on the process of provision and the development of medical care to the population of the region and indicates the presence of defects in the health care management system. 

   This article presents an analysis of injuries of the eye and orbit by type of injury, severity, treatment and outcomes among adults in the Republic Sakha (Yakutia) in the period from 2014 to 2015, which revealed the following: the prevalence of home injuries (99%) among which majority of them were injuries of mild severity 66.4 % in 2014 and 64 % in 2015. Epidemiological data on the prevalence of eye injuries in the Republic Sakha (Yakutia), delayed hospitalization of emergency patients (from 40 till 70 %) demonstrate the necessity for timely diagnosis and hospitalization eye care hospital to provide specialized and, if necessary, of high-technology care for patients with acute conditions and incidence of gas and orbit, especially in remote areas of the country.

   The article dwells on the study of the etiological factors of acute pneumonia in children, as well as changes in the immune status. It was revealed that the most frequent causative agent of pneumonia is Streptococci pneumonia; the second most frequent is Klebciella pneumonia, followed by a combination of C. pneumonia, Pseudomonas aureginosa, Chlamidia pneumonia. At analyzing the changes in the immune status in children with acute pneumonia, in comparison with the group of healthy children, the greatest decrease in T-cell (CD3 +, CD4 +, CD16 +), complement components C3 and C4, B-cell link of CD22 + was found.

   The article analyzes the data of neonatal screening for congenital hypothyroidism in the Republic Sakha (Yakutia) from 1996 to 2016. The study revealed that prevalence of congenital hypothyroidism in the Republic Sakha (Yakutia) for reported twenty years was lower than in other regions of the Russian Federation. Congenital hypothyroidism is three times more prevalent in girls, than in boys and is more often observed in children from countryside. Organization of neonatal screening for congenital hypothyroidism in the Republic Sakha (Yakutia) allowed achieving a high percentage of newborn screening, reducing observation time and early initiation of replacement therapy and prevention of disability of patients.

   The article is devoted to an actual problem of modern pediatrics – the incidence of pollinosis in children living in the Far North.

   The aim of the study was to investigate the etiological factors of hay fever in the child population of the Sakha Republic (Yakutia) according to allergen testing of school children suffering from hay fever – 100 people at the National center of Medicine, Yakutsk.

   Considering the obtained data on the importance of sensitization among children and adolescents of Sakha (Yakutia) Republic it is necessary to introduce the calendar dusting of plants in the work of allergists and pediatricians.  

   The article presents an analysis of the results of a screening examination of the cervix in women aged 18-85 years as a method for the early diagnosis of precancerous diseases and early forms of cervical cancer (CC). The examination included extended colposcopy, examination of cervical smears and cervical canal on oncocytology, a study for human papillomavirus (HPV) of the 16^th and 18^th types. As a result, cervical dysplasia of various severity levels and CC were identified among patients. In all women with the result of oncocytology PAP 4 and PAP5, HPV types 16 and 18 are defined, which confirms the viral etiology of CC. The wide introduction of screening programs can significantly reduce the morbidity and mortality from cervical cancer due to early diagnosis and timely treatment of precancerous cervical conditions. The detection and treatment of inflammatory and precancerous diseases of the cervix, such as dysplasia is one of the leading methods of preventing CC.

   The article presents an overview of the results of research by a number of authors concerning the relationship between I148M polymorphism of gene PNPLA3 variant and steatosis, fibrosis, liver cancer in patients with chronic hepatitis B and C.

   The article summarizes recent data on the safety and efficacy of preparation and transfusion of donor platelets. There are discussed the features of a) the recruitment and selection of donors; b) the advantages and disadvantages of different methods of platelet concentrates production; c) platelet concentrates inventory management; d) immunological and infectious safety of platelet concentrates; e) deal with undesired constituents remaining in platelet concentrates. There are made the practical recommendations for better choice of platelet concentrate for patient safety. In conclusion, it is noted that in Russia should be normalized timing for: buffy-coat isolation and pooling, platelet concentrate leukodepletion, as well as a gradual transition to 100 % transfusion of pathogen-reduced platelet concentrates.

   The article gives an overview of obesity as one of the main metabolic risk factors for cardiovascular diseases. The reasons of the development of obesity and pathogenetic mechanisms of complications development from the side of the cardiovascular system are considered against its background, as well as the risk to human health in the presence of visceral obesity. We present data on child obesity as a metabolic base of cardiovascular diseases at which a prolonged accumulation of adipose tissue leads to the most serious disorders of human organs and systems, primarily cardiovascular one.

   A literature review of foreign and domestic studies on hypoxic-ischemic encephalopathy in recent years has been conducted to assess the epidemiological situation in different countries of the world and in Russia, as well as to consider the risk factors for this pathology.

   The article provides a viewpoint, linking the decline in the suicide rate the last two decades throughout the world, according to the WHO data, with the development of information and communication technologies. Communication in social networks leads to a reduction of emotional alienation in people, contributes to the disappearance of feeling of loneliness. The feeling of community, involvement in various groups of people, joint activities lead to the realization of oneself as a full-fledged person, not prone to suicide.

   The article considers discussion issues of the Yakuts (Sakha) ethnogenesis. Comparing the results of the latest genetic studies with linguistic data, as well as with existing literature on the history, ethnography and social anthropology of the Sakha people, the authors discuss the little-studied aspects of global ethno-social transformations in the Middle Lena, which led to the formation of a peculiar gene pool of modern Sakha.

   The clinical case of early diagnostics of aortic arch doubling during the period of screening of pregnant woman in term of 22^nd gestation week is considered. The effect of early diagnostics of the given pathology on the clinical outcome is demonstrated. Management of pregnancy and newborn’s supervision at all stages of medical aid is described. 

   Yakut dermatovenerologic dispensary celebrated 90 years of its foundation in April 2017. The article presents information on its establishment, development, and the most prominent representatives of the clinic, the main medical, educational and scientific achievements.